{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T16:10:11Z","timestamp":1777306211885,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30973003"],"award-info":[{"award-number":["30973003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30901993"],"award-info":[{"award-number":["30901993"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Administration of TCM of Jiangsu Province","award":["LZ11093"],"award-info":[{"award-number":["LZ11093"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.imlet.2017.05.008","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T13:46:35Z","timestamp":1494942395000},"page":"61-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["A novel mouse model of chronic prostatitis\/chronic pelvic pain syndrome induced by immunization of special peptide fragment with aluminum hydroxide adjuvant"],"prefix":"10.1016","volume":"187","author":[{"given":"Farhan Ullah","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Awais Ullah","family":"Ihsan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waqas","family":"Nawaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Zahid","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqian","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.imlet.2017.05.008_bib0005","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0090-4295(96)00234-8","article-title":"Chronic prostatitis: results of an Internet survey","volume":"48","author":"Alexander","year":"1996","journal-title":"Urology"},{"issue":"4","key":"10.1016\/j.imlet.2017.05.008_bib0010","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/S0022-5347(01)63564-X","article-title":"How common is prostatitis? A national survey of physician visits","volume":"159","author":"Collins","year":"1998","journal-title":"J. Urol."},{"key":"10.1016\/j.imlet.2017.05.008_bib0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev.med.57.011205.135654","article-title":"Prostatitis\/chronic pelvic pain syndrome","volume":"57","author":"Habermacher","year":"2006","journal-title":"Annu. Rev. Med."},{"issue":"3","key":"10.1016\/j.imlet.2017.05.008_bib0020","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0022-5347(01)66359-6","article-title":"Sickness impact of chronic nonbacterial prostatitis and its correlates","volume":"155","author":"Wenninger","year":"1996","journal-title":"J. Urol."},{"issue":"7","key":"10.1016\/j.imlet.2017.05.008_bib0025","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/j.1464-410X.2012.11088.x","article-title":"alpha-blockers, antibiotics and anti-inflammatories have a role in the management of chronic prostatitis\/chronic pelvic pain syndrome","volume":"110","author":"Thakkinstian","year":"2012","journal-title":"BJU Int."},{"issue":"4","key":"10.1016\/j.imlet.2017.05.008_bib0030","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1097\/01.ju.0000159198.83103.01","article-title":"Pentosan polysulfate sodium therapy for men with chronic pelvic pain syndrome: a multicenter, randomized, placebo controlled study","volume":"173","author":"Nickel","year":"2005","journal-title":"J. Urol."},{"issue":"25","key":"10.1016\/j.imlet.2017.05.008_bib0035","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1056\/NEJMoa0803240","article-title":"Alfuzosin and symptoms of chronic prostatitis-chronic pelvic pain syndrome","volume":"359","author":"Nickel","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.imlet.2017.05.008_bib0040","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0090-4295(92)90520-7","article-title":"Cytomegalovirus prostatitis","volume":"40","author":"Benson","year":"1992","journal-title":"Urology"},{"issue":"4","key":"10.1016\/j.imlet.2017.05.008_bib0045","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1745-7262.2005.00060.x","article-title":"Chronic prostatitis in Korea: a nationwide postal survey of practicing urologists in 2004","volume":"7","author":"Ku","year":"2005","journal-title":"Asian J. Androl."},{"issue":"6","key":"10.1016\/j.imlet.2017.05.008_bib0050","doi-asserted-by":"crossref","first-page":"R415","DOI":"10.1152\/ajpregu.00147.2012","article-title":"A novel murine model of chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS) induced by immunization with a spermine binding protein (p25) peptide","volume":"304","author":"Altuntas","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"7","key":"10.1016\/j.imlet.2017.05.008_bib0055","first-page":"2031","article-title":"An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans","volume":"119","author":"Hou","year":"2009","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.imlet.2017.05.008_bib0060","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/clin.1995.1035","article-title":"Mast cells in accessory glands of experimentally induced prostatitis in male Wistar rats","volume":"74","author":"Rivero","year":"1995","journal-title":"Clin. Immunol. Immunopathol."},{"issue":"2","key":"10.1016\/j.imlet.2017.05.008_bib0065","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/clim.2002.5281","article-title":"Prostatein or steroid binding protein (PSBP) induces experimental autoimmune prostatitis (EAP) in NOD mice","volume":"105","author":"Rivero","year":"2002","journal-title":"Clin. Immunol."},{"issue":"4","key":"10.1016\/j.imlet.2017.05.008_bib0070","first-page":"290","article-title":"Morphological and molecular biological peculiarities of the experimental autoimmune prostatitis rat model","volume":"11","author":"Zhou","year":"2005","journal-title":"Zhonghua Nan Ke Xue"},{"issue":"1","key":"10.1016\/j.imlet.2017.05.008_bib0075","first-page":"123","article-title":"Experimental autoimmune prostatitis after neonatal thymectomy in the mouse","volume":"60","author":"Taguchi","year":"1985","journal-title":"Clin. Exp. Immunol."},{"issue":"3","key":"10.1016\/j.imlet.2017.05.008_bib0080","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.4049\/jimmunol.179.3.1559","article-title":"Spontaneous and prostatic steroid binding protein peptide-induced autoimmune prostatitis in the nonobese diabetic mouse","volume":"179","author":"Penna","year":"2007","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.imlet.2017.05.008_bib0085","doi-asserted-by":"crossref","first-page":"R1268","DOI":"10.1152\/ajpregu.00836.2007","article-title":"Experimental autoimmune prostatitis induces chronic pelvic pain","volume":"294","author":"Rudick","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"1","key":"10.1016\/j.imlet.2017.05.008_bib0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/sj.pcan.4500930","article-title":"Experimental rodent models of prostatitis: limitations and potential","volume":"10","author":"Vykhovanets","year":"2007","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"6","key":"10.1016\/j.imlet.2017.05.008_bib0095","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.urology.2012.07.030","article-title":"Prostate extract with aluminum hydroxide injection as a novel animal model for chronic prostatitis\/chronic pelvic pain syndrome","volume":"80","author":"Qi","year":"2012","journal-title":"Urology"},{"issue":"2","key":"10.1016\/j.imlet.2017.05.008_bib0100","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.urology.2007.11.127","article-title":"Differential expression profile of cold (TRPA1) and cool (TRPM8) receptors in human urogenital organs","volume":"72","author":"Du","year":"2008","journal-title":"Urology"},{"issue":"12","key":"10.1016\/j.imlet.2017.05.008_bib0105","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/pros.20791","article-title":"Prostatic inflammation and obstructive voiding in the adult Noble rat: impact of the testosterone to estradiol ratio in serum","volume":"68","author":"Bernoulli","year":"2008","journal-title":"Prostate"},{"issue":"4","key":"10.1016\/j.imlet.2017.05.008_bib0110","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0022-5347(01)64957-7","article-title":"Inflammation in benign prostatic hyperplasia: correlation with prostate specific antigen value","volume":"157","author":"Irani","year":"1997","journal-title":"J. Urol."},{"issue":"5","key":"10.1016\/j.imlet.2017.05.008_bib0115","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrurol.2014.63","article-title":"Immune mediators of chronic pelvic pain syndrome","volume":"11","author":"Murphy","year":"2014","journal-title":"Nat. Rev. Urol."},{"issue":"2","key":"10.1016\/j.imlet.2017.05.008_bib0120","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1207\/s15324796abm3002_3","article-title":"Stress is associated with subsequent pain and disability among men with nonbacterial prostatitis\/pelvic pain","volume":"30","author":"Ullrich","year":"2005","journal-title":"Ann. Behav. Med."},{"issue":"3","key":"10.1016\/j.imlet.2017.05.008_bib0125","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000052453","article-title":"Immunocytological analysis of leukocyte subpopulations in urine specimens before and after prostatic massage","volume":"39","author":"Ludwig","year":"2001","journal-title":"Eur. Urol."},{"issue":"4","key":"10.1016\/j.imlet.2017.05.008_bib0130","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.1007\/s11033-011-1271-7","article-title":"Effect of surgical castration on expression of TRPM8 in urogenital tract of male rats","volume":"39","author":"Yang","year":"2012","journal-title":"Mol. Biol. Rep."},{"issue":"3","key":"10.1016\/j.imlet.2017.05.008_bib0135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12672-010-0063-1","article-title":"Testosterone regulates tight junction proteins and influences prostatic autoimmune responses","volume":"2","author":"Meng","year":"2011","journal-title":"Horm. Cancer"},{"issue":"3","key":"10.1016\/j.imlet.2017.05.008_bib0140","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/01.ju.0000136002.76898.04","article-title":"Mechanisms in prostatitis\/chronic pelvic pain syndrome","volume":"172","author":"Pontari","year":"2004","journal-title":"J. Urol."},{"key":"10.1016\/j.imlet.2017.05.008_bib0145","first-page":"57","article-title":"The current research on the relationship of cytokines and chronicle prostatitis","volume":"19","author":"Duan","year":"2005","journal-title":"Chin. J. Androl."},{"issue":"5","key":"10.1016\/j.imlet.2017.05.008_bib0150","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S0090-4295(98)00390-2","article-title":"Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis\/chronic pelvic pain syndrome","volume":"52","author":"Alexander","year":"1998","journal-title":"Urology"},{"issue":"1","key":"10.1016\/j.imlet.2017.05.008_bib0155","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0022-5347(05)67497-6","article-title":"IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis","volume":"164","author":"Nadler","year":"2000","journal-title":"J. Urol."},{"issue":"3","key":"10.1016\/j.imlet.2017.05.008_bib0160","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1879-5226(10)60028-0","article-title":"Urine and serum C-reactive protein levels as potential biomarkers of lower urinary tract symptoms","volume":"21","author":"Chuang","year":"2010","journal-title":"Urol. Sci."},{"key":"10.1016\/j.imlet.2017.05.008_bib0165","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1385\/1-59259-083-7:65","article-title":"Aluminum compounds as vaccine adjuvants #","author":"Gupta","year":"2000","journal-title":"T Vaccine Adjuv."},{"issue":"6","key":"10.1016\/j.imlet.2017.05.008_bib0170","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1084\/jem.20032220","article-title":"In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination","volume":"199","author":"Bonifaz","year":"2004","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.imlet.2017.05.008_bib0175","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/ilar.46.3.280","article-title":"Jr: adjuvants and antibody production: dispelling the myths associated with Freund's complete and other adjuvants","volume":"46","author":"Stills","year":"2005","journal-title":"ILAR J."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247817301669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247817301669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T22:17:10Z","timestamp":1537827430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247817301669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":35,"alternative-id":["S0165247817301669"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2017.05.008","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel mouse model of chronic prostatitis\/chronic pelvic pain syndrome induced by immunization of special peptide fragment with aluminum hydroxide adjuvant","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2017.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}