{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T18:01:18Z","timestamp":1778176878182,"version":"3.51.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Immunology Research Center of Tabriz University of Medical Sciences, Tabriz, Iran","award":["94\/91"],"award-info":[{"award-number":["94\/91"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.imlet.2018.11.002","type":"journal-article","created":{"date-parts":[[2018,11,6]],"date-time":"2018-11-06T02:25:13Z","timestamp":1541471113000},"page":"52-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Association analysis of ERAP1 gene single nucleotide polymorphism in susceptibility to ankylosing spondylitis in Iranian population"],"prefix":"10.1016","volume":"201","author":[{"given":"Farhad","family":"Babaie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrdad","family":"Ebrazeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Hemmatzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Sadat Mohammadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arezoo","family":"Gowhari Shabgah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrzad","family":"Hajaliloo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Asghar","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naghmeh","family":"Shirafkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5658-2511","authenticated-orcid":false,"given":"Gholamreza","family":"Azizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Babaloo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2018.11.002_bib0005","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.biopha.2018.05.097","article-title":"Role of innate immune system in the pathogenesis of ankylosing spondylitis","volume":"105","author":"Vanaki","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.imlet.2018.11.002_bib0010","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.rdc.2017.04.006","article-title":"Genetics and the causes of ankylosing spondylitis","volume":"43","author":"Hanson","year":"2017","journal-title":"Rheum. Dis. Clin."},{"issue":"8","key":"10.1016\/j.imlet.2018.11.002_bib0015","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.1002\/jcp.26500","article-title":"MicroRNA implications in the etiopathogenesis of ankylosing spondylitis","volume":"233","author":"Mohammadi","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.imlet.2018.11.002_bib0020","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/BOR.0000000000000297","article-title":"Ankylosing spondylitis: beyond genome-wide association studies","volume":"28","author":"O\u2019rielly","year":"2016","journal-title":"Curr. Opin. Rheumatol."},{"issue":"2","key":"10.1016\/j.imlet.2018.11.002_bib0025","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/14397595.2016.1206174","article-title":"New insights toward the pathogenesis of ankylosing spondylitis; genetic variations and epigenetic modifications","volume":"27","author":"Mahmoudi","year":"2017","journal-title":"Mod. Rheumatol."},{"issue":"11","key":"10.1016\/j.imlet.2018.11.002_bib0030","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1007\/s10067-016-3403-x","article-title":"Evaluation of DNMT1 gene expression profile and methylation of its promoter region in patients with ankylosing spondylitis","volume":"35","author":"Aslani","year":"2016","journal-title":"Clin. Rheumatol."},{"issue":"3","key":"10.1016\/j.imlet.2018.11.002_bib0035","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/gene.2017.17","article-title":"Promoter hypermethylation of BCL11B gene correlates with downregulation of gene transcription in ankylosing spondylitis patients","volume":"18","author":"Karami","year":"2017","journal-title":"Genes Immun."},{"issue":"6","key":"10.1016\/j.imlet.2018.11.002_bib0040","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1002\/jcp.26250","article-title":"The role of innate lymphoid cells in health and disease","volume":"233","author":"Mohammadi","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.imlet.2018.11.002_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2018.05.092","article-title":"HLA-B* 27 subtypes and their implications in the pathogenesis of ankylosing spondylitis","author":"Dashti","year":"2018","journal-title":"Gene"},{"issue":"6","key":"10.1016\/j.imlet.2018.11.002_bib0050","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrrheum.2017.56","article-title":"Pathogenesis of ankylosing spondylitis\u2014recent advances and future directions","volume":"13","author":"Ranganathan","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"issue":"11","key":"10.1016\/j.imlet.2018.11.002_bib0055","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/ng.2007.17","article-title":"Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants","volume":"39","author":"Burton","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.imlet.2018.11.002_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.imlet.2018.01.014","article-title":"The role of gut microbiota and IL-23\/IL-17 pathway in ankylosing spondylitis immunopathogenesis: New insights and updates","author":"Babaie","year":"2018","journal-title":"Immunol. Lett."},{"issue":"2","key":"10.1016\/j.imlet.2018.11.002_bib0065","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrrheum.2015.133","article-title":"Genetics of ankylosing spondylitis--insights into pathogenesis","volume":"12","author":"Brown","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"12","key":"10.1016\/j.imlet.2018.11.002_bib0070","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/ni859","article-title":"An IFN-\u03b3\u2013induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I\u2013presented peptides","volume":"3","author":"Saric","year":"2002","journal-title":"Nat. Immunol."},{"issue":"11","key":"10.1016\/j.imlet.2018.11.002_bib0075","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1002\/art.24933","article-title":"Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population","volume":"60","author":"Davidson","year":"2009","journal-title":"Arthritis Rheumatol."},{"issue":"4","key":"10.1016\/j.imlet.2018.11.002_bib0080","first-page":"294","article-title":"Association between endoplasmic reticulum aminopeptidase-1 (ERAP-1) and susceptibility to ankylosing spondylitis in Iran","volume":"11","author":"Mahmoudi","year":"2012","journal-title":"Iran. J. Allergy Asthma Immunol."},{"issue":"4","key":"10.1016\/j.imlet.2018.11.002_bib0085","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","article-title":"Evaluation of diagnostic criteria for ankylosing spondylitis","volume":"27","author":"Van Der Linden","year":"1984","journal-title":"Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.imlet.2018.11.002_bib0090","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1136\/mp.52.5.300","article-title":"HLA-B* 27 typing by sequence specific amplification without DNA extraction","volume":"52","author":"Sayer","year":"1999","journal-title":"Mol. Pathol."},{"issue":"2","key":"10.1016\/j.imlet.2018.11.002_bib0095","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/sj.cr.7290272","article-title":"SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci","volume":"15","author":"Yong","year":"2005","journal-title":"Cell Res."},{"issue":"7809","key":"10.1016\/j.imlet.2018.11.002_bib0100","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0140-6736(73)91360-3","article-title":"Ankylosing spondylitis and HL-A 27","volume":"301","author":"Brewerton","year":"1973","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.imlet.2018.11.002_bib0105","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ng.2667","article-title":"Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci","volume":"45","author":"Cortes","year":"2013","journal-title":"Nat. Genet."},{"issue":"2-3","key":"10.1016\/j.imlet.2018.11.002_bib0110","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12026-014-8576-2","article-title":"ERAP1 in the pathogenesis of ankylosing spondylitis","volume":"60","author":"Reeves","year":"2014","journal-title":"Immunol. Res."},{"issue":"8","key":"10.1016\/j.imlet.2018.11.002_bib0115","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/ng.873","article-title":"Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility","volume":"43","author":"Evans","year":"2011","journal-title":"Nat. Genet."},{"issue":"11","key":"10.1016\/j.imlet.2018.11.002_bib0120","doi-asserted-by":"crossref","first-page":"e3658","DOI":"10.1371\/journal.pone.0003658","article-title":"The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1","volume":"3","author":"Evnouchidou","year":"2008","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.imlet.2018.11.002_bib0125","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s00011-011-0374-x","article-title":"Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis","volume":"60","author":"Lee","year":"2011","journal-title":"Inflamm. Res."},{"issue":"8","key":"10.1016\/j.imlet.2018.11.002_bib0130","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1007\/s10067-016-3287-9","article-title":"Associations between ERAP1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis","volume":"35","author":"Lee","year":"2016","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.imlet.2018.11.002_bib0135","doi-asserted-by":"crossref","first-page":"7146","DOI":"10.1038\/ncomms8146","article-title":"Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1","volume":"6","author":"Cortes","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.imlet.2018.11.002_bib0140","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M112.019588","article-title":"Functional interaction of the ankylosing spondylitis associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo","author":"Garc\u00eda-Medel","year":"2012","journal-title":"Mol. Cell. Proteom."},{"issue":"4","key":"10.1016\/j.imlet.2018.11.002_bib0145","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1136\/annrheumdis-2011-200347","article-title":"Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis","volume":"71","author":"Haroon","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.imlet.2018.11.002_bib0150","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M114.039214","article-title":"Peptide handling by HLA-B27 subtypes influences their biological behavior, association with ankylosing spondylitis and susceptibility to ERAP1","author":"Garc\u00eda-Medel","year":"2014","journal-title":"Mol. Cell. Proteom."},{"issue":"49","key":"10.1016\/j.imlet.2018.11.002_bib0155","doi-asserted-by":"crossref","first-page":"17594","DOI":"10.1073\/pnas.1408882111","article-title":"Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis","volume":"111","author":"Reeves","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.imlet.2018.11.002_bib0160","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/art.33430","article-title":"Radiographic severity of ankylosing spondylitis is associated with polymorphism of the large multifunctional peptidase 2 gene in the Spondyloarthritis Research Consortium of Canada cohort","volume":"64","author":"Haroon","year":"2012","journal-title":"Arthritis Rheumatol."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247818302943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247818302943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T02:47:50Z","timestamp":1543546070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247818302943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":32,"alternative-id":["S0165247818302943"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2018.11.002","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association analysis of ERAP1 gene single nucleotide polymorphism in susceptibility to ankylosing spondylitis in Iranian population","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2018.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}