{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:52:38Z","timestamp":1788274358075,"version":"build-2803163510"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Ministry of Higher Education and Scientific Research in Tunisia","award":["LR00SP04"],"award-info":[{"award-number":["LR00SP04"]}]},{"name":"Ministry of Higher Education and Scientific Research in Tunisia","award":["LR11IPT04"],"award-info":[{"award-number":["LR11IPT04"]}]},{"name":"Transverse program of Institut Pasteur","award":["PTR-426"],"award-info":[{"award-number":["PTR-426"]}]},{"name":"RIIP"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.imlet.2019.04.001","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T12:05:10Z","timestamp":1555329910000},"page":"20-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Leishmania infantum LeIF and its recombinant polypeptides induce the maturation of dendritic cells in vitro: An insight for dendritic cells based vaccine"],"prefix":"10.1016","volume":"210","author":[{"given":"Mourad","family":"Barhoumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga S.","family":"Koutsoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Dotsika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikram","family":"Guizani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2019.04.001_bib0005","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fimmu.2014.00255","article-title":"Dendritic cell-targeted vaccines","volume":"5","author":"Cohn","year":"2014","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.imlet.2019.04.001_bib0010","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","article-title":"Toll-like receptors and their crosstalk with other innate receptors in infection and immunity","volume":"34","author":"Kawai","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2019.04.001_bib0015","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1146\/annurev.immunol.22.012703.104538","article-title":"Cell biology of antigen processing in vitro and in vivo","volume":"23","author":"Trombetta","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imlet.2019.04.001_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-308X(04)58001-6","article-title":"Leishmania spp.: on the interactions they establish with antigen-presenting cells of their mammalian hosts","volume":"58","author":"Antoine","year":"2004","journal-title":"Adv. Parasit."},{"issue":"3","key":"10.1016\/j.imlet.2019.04.001_bib0025","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/pim.12086","article-title":"Protective immunity against malaria after vaccination","volume":"36","author":"de Souza","year":"2014","journal-title":"Parasite Immunol."},{"issue":"8","key":"10.1016\/j.imlet.2019.04.001_bib0030","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.it.2014.04.006","article-title":"Tuberculosis vaccines--rethinking the current paradigm","volume":"35","author":"Andersen","year":"2014","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.imlet.2019.04.001_bib0035","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1080\/21645515.2015.1105415","article-title":"Dendritic cell targeted vaccines: recent progresses and challenges","volume":"12","author":"Chen","year":"2016","journal-title":"Hum. Vaccin. Immunother."},{"issue":"2","key":"10.1016\/j.imlet.2019.04.001_bib0040","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0952-7915(03)00015-3","article-title":"The use of dendritic cells in cancer immunotherapy","volume":"15","author":"Schuler","year":"2003","journal-title":"Curr. Opin. Immunol."},{"issue":"9185","key":"10.1016\/j.imlet.2019.04.001_bib0045","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0140-6736(98)10178-2","article-title":"Leishmaniasis","volume":"354","author":"Herwaldt","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.imlet.2019.04.001_bib0050","series-title":"Leishmaniases Encyclopedia of Environmental Health","first-page":"453","author":"Guizani","year":"2011"},{"issue":"5","key":"10.1016\/j.imlet.2019.04.001_bib0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035671","article-title":"Leishmaniasis worldwide and global estimates of its incidence","volume":"7","author":"Alvar","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.imlet.2019.04.001_bib0060","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1086\/314896","article-title":"Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani","volume":"180","author":"Lira","year":"1999","journal-title":"J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.imlet.2019.04.001_bib0065","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4103\/0974-777X.62887","article-title":"Drug resistance in leishmaniasis","volume":"2","author":"Chakravarty","year":"2010","journal-title":"J. Glob. Infect. Dis."},{"issue":"3","key":"10.1016\/j.imlet.2019.04.001_bib0070","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1038\/cti.2014.4","article-title":"Vaccines to prevent leishmaniasis","volume":"3","author":"Kumar","year":"2014","journal-title":"Clin. Transl. Immunology"},{"issue":"11","key":"10.1016\/j.imlet.2019.04.001_bib0075","first-page":"845","article-title":"The immunology of susceptibility and resistance to Leishmania major in mice, Nature reviews","volume":"2","author":"Sacks","year":"2002","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.imlet.2019.04.001_bib0080","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1600-065X.2010.00983.x","article-title":"Cell biology and immunology of Leishmania","volume":"240","author":"Mougneau","year":"2011","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.imlet.2019.04.001_bib0085","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0952-7915(02)00353-9","article-title":"Dendritic cells and immunity to leishmaniasis and toxoplasmosis","volume":"14","author":"Scott","year":"2002","journal-title":"Curr. Opin. Immunol."},{"issue":"7","key":"10.1016\/j.imlet.2019.04.001_bib0090","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.4049\/jimmunol.180.7.4355","article-title":"Modulation of dendritic cell function by Leishmania parasites","volume":"180","author":"Soong","year":"2008","journal-title":"J. Immunol."},{"issue":"15","key":"10.1016\/j.imlet.2019.04.001_bib0095","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.micinf.2004.10.004","article-title":"Dendritic cells in Leishmania infection","volume":"6","author":"Brandonisio","year":"2004","journal-title":"Microbes Infect."},{"key":"10.1016\/j.imlet.2019.04.001_bib0100","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3967436","article-title":"Dendritic cells and leishmania infection: adding layers of complexity to a complex disease","author":"Feijo","year":"2016","journal-title":"J. Immunol. Res."},{"issue":"5","key":"10.1016\/j.imlet.2019.04.001_bib0105","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1078\/0171-2985-00105","article-title":"Dendritic cell-based vaccination strategies: induction of protective immunity against leishmaniasis","volume":"204","author":"Moll","year":"2001","journal-title":"Immunobiology"},{"issue":"11","key":"10.1016\/j.imlet.2019.04.001_bib0110","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.4049\/jimmunol.164.11.5858","article-title":"IL-12p70 production by Leishmania major-harboring human dendritic cells is a CD40\/CD40 ligand-dependent process","volume":"164","author":"Marovich","year":"2000","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.imlet.2019.04.001_bib0115","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1084\/jem.188.8.1547","article-title":"Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity","volume":"188","author":"von Stebut","year":"1998","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.imlet.2019.04.001_bib0120","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/79734","article-title":"Dendritic cell regulation of TH1-TH2 development","volume":"1","author":"Moser","year":"2000","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.imlet.2019.04.001_bib0125","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.4049\/jimmunol.170.6.3171","article-title":"Dendritic cell (DC)-based protection against an intracellular pathogen is dependent upon DC-derived IL-12 and can be induced by molecularly defined antigens","volume":"170","author":"Berberich","year":"2003","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.imlet.2019.04.001_bib0130","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1002\/1521-4141(2000012)30:12<3498::AID-IMMU3498>3.0.CO;2-6","article-title":"Leishmania major-infected murine Langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous Leishmaniasis","volume":"30","author":"von Stebut","year":"2000","journal-title":"Eur. J. Immunol."},{"issue":"11","key":"10.1016\/j.imlet.2019.04.001_bib0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048727","article-title":"CXCL10 is critical for the generation of protective CD8 T cell response induced by antigen pulsed CpG-ODN activated dendritic cells","volume":"7","author":"Majumder","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.imlet.2019.04.001_bib0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003476","article-title":"T cell-derived IL-10 determines leishmaniasis disease outcome and is suppressed by a dendritic cell based vaccine","volume":"9","author":"Schwarz","year":"2013","journal-title":"PLoS Pathog."},{"issue":"36","key":"10.1016\/j.imlet.2019.04.001_bib0145","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1016\/j.vaccine.2010.06.077","article-title":"Fragments of antigen-loaded dendritic cells (DC) and DC-derived exosomes induce protective immunity against Leishmania major","volume":"28","author":"Schnitzer","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.imlet.2019.04.001_bib0150","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3389\/fimmu.2018.01227","article-title":"Translating observations from leishmanization into non-living vaccines: the potential of dendritic cell-based vaccination strategies against Leishmania","volume":"9","author":"Seyed","year":"2018","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.imlet.2019.04.001_bib0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067453","article-title":"Targeting leishmania major antigens to dendritic cells in vivo induces protective immunity","volume":"8","author":"Matos","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.imlet.2019.04.001_bib0160","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1084\/jem.181.4.1527","article-title":"A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12","volume":"181","author":"Skeiky","year":"1995","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.imlet.2019.04.001_bib0165","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.4049\/jimmunol.161.11.6171","article-title":"LeIF: a recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile","volume":"161","author":"Skeiky","year":"1998","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.imlet.2019.04.001_bib0170","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1365-3024.2011.01320.x","article-title":"Leishmania infantum LeIF and its recombinant polypeptides modulate interleukin IL-12p70, IL-10 and tumour necrosis factor-alpha production by human monocytes","volume":"33","author":"Barhoumi","year":"2011","journal-title":"Parasite Immunol."},{"issue":"1","key":"10.1016\/j.imlet.2019.04.001_bib0175","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.molbiopara.2004.02.009","article-title":"Proteomic analysis of Leishmania mexicana differentiation","volume":"136","author":"Nugent","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"issue":"12","key":"10.1016\/j.imlet.2019.04.001_bib0180","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1002\/pmic.200500853","article-title":"A combined proteomic and transcriptomic approach to the study of stage differentiation in Leishmania infantum","volume":"6","author":"McNicoll","year":"2006","journal-title":"Proteomics"},{"issue":"9","key":"10.1016\/j.imlet.2019.04.001_bib0185","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1128\/CVI.00060-07","article-title":"Testing of four Leishmania vaccine candidates in a mouse model of infection with Leishmania (Viannia) braziliensis, the main causative agent of cutaneous leishmaniasis in the New World","volume":"14","author":"Salay","year":"2007","journal-title":"Clin. Vaccine Immunol."},{"issue":"18","key":"10.1016\/j.imlet.2019.04.001_bib0190","doi-asserted-by":"crossref","first-page":"8381","DOI":"10.1073\/pnas.0914768107","article-title":"Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage","volume":"107","author":"Morales","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imlet.2019.04.001_bib0195","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jprot.2013.03.012","article-title":"Exoproteome dynamics in Leishmania infantum","volume":"84","author":"Santarem","year":"2013","journal-title":"J. Proteomics"},{"issue":"1","key":"10.1016\/j.imlet.2019.04.001_bib0200","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.molbiopara.2014.07.001","article-title":"Shotgun proteomics to unravel the complexity of the Leishmania infantum exoproteome and the relative abundance of its constituents","volume":"195","author":"Braga","year":"2014","journal-title":"Mol. Biochem. Parasitol."},{"issue":"2","key":"10.1016\/j.imlet.2019.04.001_bib0205","doi-asserted-by":"crossref","first-page":"R35","DOI":"10.1186\/gb-2008-9-2-r35","article-title":"Proteomic analysis of the secretome of Leishmania donovani","volume":"9","author":"Silverman","year":"2008","journal-title":"Genome Biol."},{"issue":"Pt. 6","key":"10.1016\/j.imlet.2019.04.001_bib0210","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1242\/jcs.056465","article-title":"An exosome-based secretion pathway is responsible for protein export from Leishmania and communication with macrophages","volume":"123","author":"Silverman","year":"2010","journal-title":"J. Cell. Sci."},{"issue":"10","key":"10.1016\/j.imlet.2019.04.001_bib0215","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1002\/eji.1830271024","article-title":"A Leishmania protein that modulates interleukin (IL)-12, IL-10 and tumor necrosis factor-alpha production and expression of B7-1 in human monocyte-derived antigen-presenting cells","volume":"27","author":"Probst","year":"1997","journal-title":"Eur. J. Immunol."},{"issue":"5\u20136","key":"10.1016\/j.imlet.2019.04.001_bib0220","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/pim.12026","article-title":"DEAD-box proteins, like Leishmania eIF4A, modulate interleukin (IL)-12, IL-10 and tumour necrosis factor-alpha production by human monocytes","volume":"35","author":"Barhoumi","year":"2013","journal-title":"Parasite Immunol."},{"issue":"4","key":"10.1016\/j.imlet.2019.04.001_bib0225","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/pim.12310","article-title":"Codelivery of DNA vaccination encoding LeIF gene and IL-12 increases protection against Leishmania major infection in BALB\/c mice","volume":"38","author":"Maspi","year":"2016","journal-title":"Parasite Immunol."},{"issue":"27\u201328","key":"10.1016\/j.imlet.2019.04.001_bib0230","article-title":"Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant","volume":"20","author":"Skeiky","year":"2002","journal-title":"Vaccine"},{"issue":"9","key":"10.1016\/j.imlet.2019.04.001_bib0235","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1128\/IAI.00394-07","article-title":"Leish-111f, a recombinant polyprotein vaccine that protects against visceral Leishmaniasis by elicitation of CD4+ T cells","volume":"75","author":"Coler","year":"2007","journal-title":"Infect. Immun."},{"issue":"10","key":"10.1016\/j.imlet.2019.04.001_bib0240","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/j.vaccine.2009.12.055","article-title":"Intranasal immunization with Leish-111f induces IFN-gamma production and protects mice from Leishmania major infection","volume":"28","author":"Sakai","year":"2010","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.imlet.2019.04.001_bib0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097319","article-title":"Leishmania eukaryotic initiation factor (LeIF) inhibits parasite growth in murine macrophages","volume":"9","author":"Koutsoni","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.imlet.2019.04.001_bib0250","article-title":"Animal models for the analysis of immune responses to leishmaniasis","author":"Sacks","year":"2001","journal-title":"Curr. Protoc. Immunol."},{"issue":"1","key":"10.1016\/j.imlet.2019.04.001_bib0255","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.trstmh.2011.08.012","article-title":"In vitro growth kinetics, differentiation and morphological characterisation of Tunisian Leishmania infantum parasites","volume":"106","author":"Kbaier-Hachemi","year":"2012","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"1","key":"10.1016\/j.imlet.2019.04.001_bib0260","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J. Immunol. Methods"},{"issue":"10","key":"10.1016\/j.imlet.2019.04.001_bib0265","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.4049\/jimmunol.172.10.6281","article-title":"Dendritic cells (DC) activated by CpG DNA ex vivo are potent inducers of host resistance to an intracellular pathogen that is independent of IL-12 derived from the immunizing DC","volume":"172","author":"Ramirez-Pineda","year":"2004","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.imlet.2019.04.001_bib0270","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1128\/IAI.69.2.906-911.2001","article-title":"Migration-inhibitory factor gene-deficient mice are susceptible to cutaneous Leishmania major infection","volume":"69","author":"Satoskar","year":"2001","journal-title":"Infect. Immun."},{"issue":"6673","key":"10.1016\/j.imlet.2019.04.001_bib0275","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.imlet.2019.04.001_bib0280","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc1359","article-title":"The promise of cancer vaccines","volume":"4","author":"Gilboa","year":"2004","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.imlet.2019.04.001_bib0285","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/nri746","article-title":"Mouse and human dendritic cell subtypes","volume":"2","author":"Shortman","year":"2002","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.imlet.2019.04.001_bib0290","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/sj.cr.7310017","article-title":"Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don\u2019t know","volume":"16","author":"Shi","year":"2006","journal-title":"Cell Res."},{"issue":"6","key":"10.1016\/j.imlet.2019.04.001_bib0295","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1586\/1744666X.2015.1037286","article-title":"Toll-like receptor signaling in parasitic infections","volume":"11","author":"Ashour","year":"2015","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.imlet.2019.04.001_bib0300","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/743169","article-title":"Regulation of dendritic cell function in inflammation","author":"Said","year":"2015","journal-title":"J. Immunol. Res."},{"issue":"3","key":"10.1016\/j.imlet.2019.04.001_bib0305","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S1074-7613(00)80436-7","article-title":"CD40 ligand is required for protective cell-mediated immunity to Leishmania major","volume":"4","author":"Campbell","year":"1996","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.imlet.2019.04.001_bib0310","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1074-7613(00)80435-5","article-title":"Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity","volume":"4","author":"Kamanaka","year":"1996","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.imlet.2019.04.001_bib0315","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1074-7613(00)80434-3","article-title":"Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection","volume":"4","author":"Soong","year":"1996","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.imlet.2019.04.001_bib0320","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/infdis\/174.6.1303","article-title":"Blockade of CD86 ameliorates Leishmania major infection by down-regulating the Th2 response","volume":"174","author":"Brown","year":"1996","journal-title":"J. Infect. Dis."},{"issue":"11","key":"10.1016\/j.imlet.2019.04.001_bib0325","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.162.11.6708","article-title":"Expression and contribution of B7-1 (CD80) and B7-2 (CD86) in the early immune response to Leishmania major infection","volume":"162","author":"Elloso","year":"1999","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.imlet.2019.04.001_bib0330","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1128\/IAI.69.2.665-672.2001","article-title":"Influence of costimulatory molecules on immune response to Leishmania major by human cells in vitro","volume":"69","author":"Brodskyn","year":"2001","journal-title":"Infect. Immun."},{"issue":"3","key":"10.1016\/j.imlet.2019.04.001_bib0335","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1128\/IAI.01090-07","article-title":"Toll-like receptors and leishmaniasis","volume":"76","author":"Tuon","year":"2008","journal-title":"Infect. Immun."},{"issue":"8","key":"10.1016\/j.imlet.2019.04.001_bib0340","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.4049\/jimmunol.170.8.4237","article-title":"Genetically resistant mice lacking MyD88-adapter protein display a high susceptibility to Leishmania major infection associated with a polarized Th2 response","volume":"170","author":"Muraille","year":"2003","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.imlet.2019.04.001_bib0345","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1128\/IAI.72.4.1920-1928.2004","article-title":"Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major","volume":"72","author":"Kropf","year":"2004","journal-title":"Infect. Immun."},{"issue":"12","key":"10.1016\/j.imlet.2019.04.001_bib0350","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1002\/eji.200737182","article-title":"TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis","volume":"37","author":"Liese","year":"2007","journal-title":"Eur. J. Immunol."},{"issue":"4","key":"10.1016\/j.imlet.2019.04.001_bib0355","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1084\/jem.20061293","article-title":"NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs","volume":"204","author":"Schleicher","year":"2007","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.imlet.2019.04.001_bib0360","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/eji.200535079","article-title":"RNA interference reveals a role for TLR2 and TLR3 in the recognition of Leishmania donovani promastigotes by interferon-gamma-primed macrophages","volume":"36","author":"Flandin","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imlet.2019.04.001_bib0365","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.imlet.2019.04.001_bib0370","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00430-012-0261-2","article-title":"Dendritic cells in Leishmania major infections: mechanisms of parasite uptake, cell activation and evidence for physiological relevance","volume":"201","author":"Kautz-Neu","year":"2012","journal-title":"Med. Microbiol. Immunol."},{"issue":"6","key":"10.1016\/j.imlet.2019.04.001_bib0375","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.4049\/jimmunol.170.6.3171","article-title":"Dendritic cell (DC)-based protection against an intracellular pathogen is dependent upon DC-derived IL-12 and can be induced by molecularly defined antigens","volume":"170","author":"Berberich","year":"2003","journal-title":"J. Immunol."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247818304176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247818304176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:35:15Z","timestamp":1759044915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247818304176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":75,"alternative-id":["S0165247818304176"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2019.04.001","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leishmania infantum LeIF and its recombinant polypeptides induce the maturation of dendritic cells in vitro: An insight for dendritic cells based vaccine","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2019.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}