{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:48:05Z","timestamp":1792144085662,"version":"4.4.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.imlet.2019.10.017","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T13:17:37Z","timestamp":1572787057000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["HLA DR2b-binding peptides from human endogenous retrovirus envelope, Epstein-Barr virus and brain proteins in the context of molecular mimicry in multiple sclerosis"],"prefix":"10.1016","volume":"217","author":[{"given":"Ranjan","family":"Ramasamy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiyaz","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute-C.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2019.10.017_bib0005","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.23.021704.115707","article-title":"Immunology of multiple sclerosis","volume":"23","author":"Sospedra","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0010","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1146\/annurev-immunol-032414-112326","article-title":"The immunology of Epstein-Barr virus\u2013induced disease","volume":"33","author":"Taylor","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0015","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri3871","article-title":"Immunopathology of multiple sclerosis","volume":"15","author":"Dendrou","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0020","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fpsyt.2017.00047","article-title":"Vitamin-D deficiency as a potential environmental risk factor in multiple sclerosis, schizophrenia, and autism","volume":"8","author":"Kocovsk\u00e1","year":"2017","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.imlet.2019.10.017_bib0025","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/BOR.0b013e328362004d","article-title":"Multiple sclerosis: autoimmunity and viruses","volume":"25","author":"Cusick","year":"2013","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0030","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1212\/WNL.0b013e31823ed057","article-title":"Association of innate immune activation with latent Epstein-Barr virus in active MS lesions","volume":"78","author":"Tzartos","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.imlet.2019.10.017_bib0035","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jneuroim.2017.02.017","article-title":"Untreated relapsing remitting multiple sclerosis patients show antibody production against latent Epstein Barr Virus (EBV) antigens mainly in the periphery and innate immune IL-8 responses preferentially in the CNS","volume":"306","author":"Sisay","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0040","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S1474-4422(10)70094-6","article-title":"Multiple sclerosis: risk factors, prodromes, and potential causal pathways","volume":"9","author":"Ramagopalan","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0045","first-page":"214","article-title":"Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis","volume":"476","author":"International Multiple Sclerosis Genetics Consortium","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2019.10.017_bib0050","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/0140-6736(91)92579-Q","article-title":"Isolation of retrovirus from patients with multiple sclerosis","volume":"337","author":"Perron","year":"1991","journal-title":"Lancet"},{"issue":"Suppl. 201","key":"10.1016\/j.imlet.2019.10.017_bib0055","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/ane.12836","article-title":"Human endogenous retroviruses in the aetiology of MS","volume":"136","author":"Christensen","year":"2017","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.imlet.2019.10.017_bib0060","doi-asserted-by":"crossref","first-page":"15216","DOI":"10.1073\/pnas.1901283116","article-title":"pHERV-W envelope protein fuels microglial cell dependent damage of myelinated axons in multiple sclerosis","volume":"116","author":"Kremer","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"111","key":"10.1016\/j.imlet.2019.10.017_bib0065","article-title":"Endogenous retroviruses and multiple sclerosis-new pieces to the puzzle","volume":"13","author":"Nissen","year":"2013","journal-title":"BMC Neurol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0070","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3855\/jidc.6916","article-title":"The aliens inside human DNA: HERV-W\/MSRV\/syncytin-1 endogenous retroviruses and neurodegeneration","volume":"9","author":"Dolei","year":"2015","journal-title":"J. Infect. Dev. Countr."},{"issue":"647","key":"10.1016\/j.imlet.2019.10.017_bib0075","article-title":"Multiple sclerosis between genetics and infections: human endogenous retroviruses in monocytes and macrophages","volume":"6","author":"Morandi","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0080","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.imlet.2017.02.003","article-title":"Potential molecular mimicry between the human endogenous retrovirus W family envelope proteins and myelin proteins in multiple sclerosis","volume":"183","author":"Ramasamy","year":"2017","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.imlet.2019.10.017_bib0085","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3389\/fmicb.2013.00172","article-title":"Genomic analysis of ERVWE2 locus in patients with multiple sclerosis: absence of genetic association but potential role of human endogenous retrovirus type W elements in molecular mimicry with myelin antigen","volume":"4","author":"do Olival","year":"2013","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0090","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/35001608","article-title":"Syncytin-1 is a captive retroviral envelope protein involved in human placental morphogenesis","volume":"403","author":"Mi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2019.10.017_bib0095","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.3390\/v6114609","article-title":"Implication of human endogenous retrovirus envelope proteins in placental functions","volume":"6","author":"Lokossou","year":"2014","journal-title":"Viruses"},{"key":"10.1016\/j.imlet.2019.10.017_bib0100","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00441-014-1930-9","article-title":"Syncytin-1 in differentiating human myoblasts: relationship to caveolin-3 and myogenin","volume":"357","author":"Bjerregard","year":"2014","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.imlet.2019.10.017_bib0105","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.bone.2010.11.011","article-title":"Involvement of human endogenous retroviral syncytin-1 in human osteoclast fusion","volume":"48","author":"S\u00f8e","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.imlet.2019.10.017_bib0110","doi-asserted-by":"crossref","first-page":"W525","DOI":"10.1093\/nar\/gks438","article-title":"Immune epitope database analysis resource","volume":"40","author":"Kim","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.imlet.2019.10.017_bib0115","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3389\/fimmu.2015.00647","article-title":"Multiple sclerosis between genetics and infections: human endogenous retroviruses in monocytes and macrophages","volume":"6","author":"Morandi","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jneuroim.2015.12.006","article-title":"MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: relevance of GNbAC1 in multiple sclerosis treatment","volume":"291","author":"Madeira","year":"2016","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0125","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.4049\/jimmunol.1001543","article-title":"Increased frequencies of myelin oligodendrocyte glycoprotein\/MHC class II-binding CD4 cells in patients with multiple sclerosis","volume":"187","author":"Raddassi","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0130","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41586-019-0964-2","article-title":"\u03b2-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration","volume":"566","author":"Lodygin","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2019.10.017_bib0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000048","article-title":"A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach","volume":"4","author":"Wang","year":"2008","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0140","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/1471-2105-11-568","article-title":"B. Peters. Peptide binding predictions for HLA DR, DP and DQ molecules","volume":"11","author":"Wang","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.imlet.2019.10.017_bib0145","unstructured":"https:\/\/www.proimmune.com\/ecommerce\/page.php?page=reveal_class2. Accessed 24 May 2019."},{"key":"10.1016\/j.imlet.2019.10.017_bib0150","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0092-8674(95)90348-8","article-title":"Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein","volume":"80","author":"Wucherpfennig","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.imlet.2019.10.017_bib0155","doi-asserted-by":"crossref","first-page":"548","DOI":"10.4049\/jimmunol.169.1.548","article-title":"High immunogenicity of intracellular myelin oligodendrocyte glycoprotein epitopes","volume":"169","author":"Weissert","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147567","article-title":"Identifying patient-specific Epstein-Barr NuclearAntigen-1 genetic variation and potential autoreactive targets relevant to multiple sclerosis pathogenesis","volume":"11","author":"Tschochner","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.imlet.2019.10.017_bib0165","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.87.20.7968","article-title":"Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors","volume":"87","author":"Pette","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imlet.2019.10.017_bib0170","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jmb.2015.09.014","article-title":"The HADDOCK2.2 web server: user-friendly integrative modeling of biomolecular complexes","volume":"428","author":"van Zundert","year":"2016","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0175","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/ni1187","article-title":"Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor","volume":"6","author":"Hahn","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0180","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.imlet.2019.10.017_bib0185","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.immuni.2005.09.009","article-title":"Unusual features of self-peptide\/MHC binding by autoimmune T cell receptors","volume":"23","author":"Nicholson","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2019.10.017_bib0190","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1084\/jem.188.8.1511","article-title":"Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein","volume":"188","author":"Smith","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2019.10.017_bib0195","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12974-017-1049-5","article-title":"Transcriptional profile and Epstein-Barr virus infection status of laser-cut immune infiltrates from the brain of patients with progressive multiple sclerosis","volume":"15","author":"Veroni","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.imlet.2019.10.017_bib0200","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1038\/cti.2016.87","article-title":"Defective T-cell control of Epstein-Barr virus infection in multiple sclerosis","volume":"6","author":"Pender","year":"2017","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0205","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13073-019-0640-z","article-title":"Evidence from genome wide association studies implicates reduced control of Epstein-Barr virus infection in multiple sclerosis susceptibility","volume":"11","author":"Afrasiabi","year":"2019","journal-title":"Genome Med."},{"key":"10.1016\/j.imlet.2019.10.017_bib0210","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/acn3.636","article-title":"Heterogeneity in association of remote herpesvirus infections and pediatric MS","volume":"5","author":"Nourbakhsh","year":"2018","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192109","article-title":"Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells","volume":"13","author":"Hassani","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.imlet.2019.10.017_bib0220","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12967-018-1450-6","article-title":"HLA alleles modulate EBV viral load in multiple sclerosis","volume":"16","author":"Agostini","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.imlet.2019.10.017_bib0225","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12985-019-1137-5","article-title":"The Epstein-Barr virus EBNA1 protein modulates the alternative splicing of cellular genes","volume":"16","author":"Boudreault","year":"2019","journal-title":"Virol. J."},{"key":"10.1016\/j.imlet.2019.10.017_bib0230","first-page":"237","article-title":"Epstein-Barr virus lytic cycle reactivation","volume":"391","author":"McKenzie","year":"2015","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0235","doi-asserted-by":"crossref","first-page":"462","DOI":"10.3389\/fmicb.2018.00462","article-title":"HERV envelope proteins: physiological role and pathogenic potential in cancer and autoimmunity","volume":"9","author":"Grandi","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0240","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3389\/fmicb.2018.00265","article-title":"Human endogenous retroviruses and their putative role in the development of autoimmune disorders such as multiple sclerosis","volume":"9","author":"Gr\u00f6ger","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0245","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1007\/s12035-018-1255-x","article-title":"Do human endogenous retroviruses contribute to multiple sclerosis, and if so, how?","volume":"56","author":"Morris","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0250","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.micron.2019.02.005","article-title":"Cross-reactivity between myelin oligodendrocyte glycoprotein and human endogenous retrovirus W protein: nanotechnological evidence for the potential trigger of multiple sclerosis","volume":"120","author":"de Luca","year":"2019","journal-title":"Micron"},{"key":"10.1016\/j.imlet.2019.10.017_bib0255","doi-asserted-by":"crossref","DOI":"10.1111\/ene.13648","article-title":"Humoral immunity response to human endogenous retroviruses K\/W differentiates between amyotrophic lateral sclerosis and other neurological diseases","volume":"25","author":"Arru","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0260","article-title":"Antibody response against HERV-W env surface peptides differentiates multiple sclerosis and neuromyelitis optica spectrum disorder","volume":"3","author":"Arru","year":"2017","journal-title":"Mult. Scler. J. Exp. Transl. Clin."},{"key":"10.1016\/j.imlet.2019.10.017_bib0265","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1126\/scitranslmed.aat4301","article-title":"GDP-L-fucose synthase is a CD4+ T cell-specific autoantigen in DRB3*02:02 patients with multiple sclerosis","volume":"10","author":"Planas","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.imlet.2019.10.017_bib0270","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cell.2018.08.011","article-title":"Memory B cells activate brain-homing, autoreactive CD4+ T cells in multiple sclerosis","volume":"175","author":"Jelcic","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.imlet.2019.10.017_bib0275","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1212\/NXI.0000000000000022","article-title":"Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE","volume":"1","author":"Shetty","year":"2014","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.imlet.2019.10.017_bib0280","doi-asserted-by":"crossref","first-page":"984","DOI":"10.3389\/fimmu.2017.00984","article-title":"Human leukocyte antigen (HLA)-DRB1*15:01 and HLA-DRB5*01:01 present complementary peptide repertoires","volume":"8","author":"Scholz","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0285","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.coi.2017.08.013","article-title":"Immunomodulation in multiple sclerosis: promises and pitfalls","volume":"49","author":"Dendrou","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0290","doi-asserted-by":"crossref","first-page":"e955","DOI":"10.1212\/WNL.0000000000005118","article-title":"Effects of ATX-MS-1467 immunotherapy over 16 weeks in relapsing multiple sclerosis","volume":"90","author":"Chataway","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.imlet.2019.10.017_bib0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2019.04.013","article-title":"Modulation of MS-like disease by a multi epitope protein is mediated by induction of CD11c+CD11b+Gr1+ myeloid-derived dendritic cells","volume":"333","author":"Kaushansky","year":"2019","journal-title":"J. Neuroimmunol."},{"issue":"19","key":"10.1016\/j.imlet.2019.10.017_bib0300","first-page":"30306","article-title":"Combination of apoptotic T cell induction and self-peptide administration for therapy of experimental autoimmune encephalomyelitis","volume":"S2352-3964","author":"Kasagi","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.imlet.2019.10.017_bib0305","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1021\/acs.molpharmaceut.9b00063","article-title":"Antigen-drug conjugates as a novel therapeutic class for the treatment of antigen-specific autoimmune disorders","volume":"16","author":"Pickens","year":"2019","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.imlet.2019.10.017_bib0310","doi-asserted-by":"crossref","first-page":"5074","DOI":"10.4049\/jimmunol.1300407","article-title":"Small molecule inhibitor of antigen binding and presentation by HLA-DR2b as a therapeutic strategy for the treatment of multiple sclerosis","volume":"191","author":"Ji","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2019.10.017_bib0315","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1073\/pnas.1820039116","article-title":"Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial","volume":"116","author":"Zubizarreta","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imlet.2019.10.017_bib0320","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-019-1467-x","article-title":"Opposing T cell responses in experimental autoimmune encephalomyelitis","author":"Saligrama","year":"2019","journal-title":"Nature"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247819303359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247819303359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:35:56Z","timestamp":1759044956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247819303359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":64,"alternative-id":["S0165247819303359"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2019.10.017","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HLA DR2b-binding peptides from human endogenous retrovirus envelope, Epstein-Barr virus and brain proteins in the context of molecular mimicry in multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2019.10.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}