{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:18:22Z","timestamp":1768681102259,"version":"3.49.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.imlet.2020.04.008","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T11:36:07Z","timestamp":1587555367000},"page":"10-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Capsid proteins of foot-and-mouth disease virus interact with TLR2 and CD14 to induce cytokine production"],"prefix":"10.1016","volume":"223","author":[{"given":"Yi-Te","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Po","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hsun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pau-Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Mei","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.imlet.2020.04.008_bib0005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1574-695X.2008.00409.x","article-title":"Evading the host immune response: how foot-and-mouth disease virus has become an effective pathogen","volume":"53","author":"Grubman","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.imlet.2020.04.008_bib0010","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S1286-4579(02)01644-1","article-title":"Foot-and-mouth disease virus : biology and prospects for disease control","volume":"4","author":"S\u00e1iz","year":"2002","journal-title":"Microbes Infect."},{"key":"10.1016\/j.imlet.2020.04.008_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1051\/vetres:2001106","article-title":"Foot-and-mouth disease virus : a long known virus, but a current threat","volume":"32","author":"Sobrino","year":"2001","journal-title":"Vet. Res."},{"key":"10.1016\/j.imlet.2020.04.008_bib0020","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1128\/CMR.17.2.465-493.2004","article-title":"Foot-and-mouth disease","volume":"17","author":"Grubman","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.imlet.2020.04.008_bib0025","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1016\/S0264-410X(02)00242-6","article-title":"Further studies on the early protective responses of pigs following immunisation with high potency foot-and-mouth disease vaccine","volume":"20","author":"Barnett","year":"2002","journal-title":"vaccine"},{"issue":"4","key":"10.1016\/j.imlet.2020.04.008_bib0030","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.imlet.2020.04.008_bib0035","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.imlet.2013.05.007","article-title":"Cell mediated innate responses of cattle and swine are diverse during foot-and-mouth disease virus (FMDV) infection: a unique landscape of innate immunity","volume":"152","author":"Toka","year":"2013","journal-title":"Immunol Lett"},{"key":"10.1016\/j.imlet.2020.04.008_bib0040","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10875-005-7829-1","article-title":"Manifold mechanisms of Toll-like receptor-ligand recognition","volume":"25","author":"Ishii","year":"2005","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.imlet.2020.04.008_bib0045","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.med.59.061206.112455","article-title":"The effect of Toll-like receptors and Toll-like receptor genetics in human disease","volume":"59","author":"Garantziotis","year":"2008","journal-title":"Annu. Rev. Med."},{"issue":"21","key":"10.1016\/j.imlet.2020.04.008_bib0050","doi-asserted-by":"crossref","first-page":"15319","DOI":"10.1074\/jbc.R700009200","article-title":"Toll-like receptors and Type I interferons","volume":"282","author":"Uematsu","year":"2007","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.imlet.2020.04.008_bib0055","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.4049\/jimmunol.177.6.3515","article-title":"Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection","volume":"177","author":"Bafica","year":"2006","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.imlet.2020.04.008_bib0060","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.coi.2008.07.001","article-title":"TLR accessory molecules","volume":"20","author":"Akashi-Takamura","year":"2008","journal-title":"Curr Opin Immunol"},{"issue":"1","key":"10.1016\/j.imlet.2020.04.008_bib0065","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jcpa.2005.06.011","article-title":"Cytokine and Toll-like receptor mRNAs in the nasal-associated lymphoid tissues of cattle during foot-and-mouth disease virus infection","volume":"134","author":"Zhang","year":"2006","journal-title":"J Comp Pathol"},{"issue":"1","key":"10.1016\/j.imlet.2020.04.008_bib0070","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.virusres.2011.04.005","article-title":"Identification of the role of RIG-I, MDA-5 and TLR3 in sensing RNA viruses in porcine epithelial cells using lentivirus-driven RNA interference","volume":"159","author":"Husser","year":"2011","journal-title":"Virus Res"},{"issue":"7","key":"10.1016\/j.imlet.2020.04.008_bib0075","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1292\/jvms.62.677","article-title":"Characteristics of foot and mouth disease virus in Taiwan","volume":"62","author":"Huang","year":"2000","journal-title":"J Vet Med Sci"},{"issue":"8","key":"10.1016\/j.imlet.2020.04.008_bib0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023317","article-title":"Recombinant VP1, an Akt inhibitor, suppresses progression of hepatocellular carcinoma by inducing apoptosis and modulation of CCL2 production","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.imlet.2020.04.008_bib0085","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3109\/08830185.2013.774391","article-title":"Pathogen Recognition Receptors: Ligands and Signaling Pathways by Toll-Like Receptors","volume":"32","author":"Sasai","year":"2013","journal-title":"International reviews of immunology"},{"issue":"4","key":"10.1016\/j.imlet.2020.04.008_bib0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010250","article-title":"Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments","volume":"5","author":"Dietrich","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.imlet.2020.04.008_bib0095","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1189\/jlb.0907656","article-title":"Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36","volume":"84","author":"Nilsen","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.imlet.2020.04.008_bib0100","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1286-4579(00)00298-7","article-title":"CD14, new aspects of ligand and signal diversity","volume":"2","author":"Landmann","year":"2000","journal-title":"Microbes Infect."},{"key":"10.1016\/j.imlet.2020.04.008_bib0105","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.imlet.2020.04.008_bib0110","doi-asserted-by":"crossref","first-page":"e0202408","DOI":"10.1371\/journal.pone.0202408","article-title":"Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression","volume":"13","author":"Sampaio","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.imlet.2020.04.008_bib0115","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1128\/JVI.77.8.4588-4596.2003","article-title":"Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2","volume":"77","author":"Compton","year":"2003","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.imlet.2020.04.008_bib0120","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1128\/JVI.00671-08","article-title":"Respiratory syncytical virus activates innate immunity through Toll-like receptor 2","volume":"83","author":"Murawski","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.imlet.2020.04.008_bib0125","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1189\/jlb.0207128","article-title":"Toll-like receptor 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins","volume":"82","author":"Chang","year":"2007","journal-title":"Journal of Leukocyte Biology"},{"issue":"8","key":"10.1016\/j.imlet.2020.04.008_bib0130","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1128\/JVI.03175-15","article-title":"alphavbeta3 Integrin Boosts the Innate Immune Response Elicited in Epithelial Cells through Plasma Membrane and Endosomal Toll-Like Receptors","volume":"90","author":"Casiraghi","year":"2016","journal-title":"J Virol"},{"key":"10.1016\/j.imlet.2020.04.008_bib0135","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3389\/fimmu.2013.00214","article-title":"Vaccine adjuvants: mode of action","volume":"4","author":"De Gregorio","year":"2013","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.imlet.2020.04.008_bib0140","doi-asserted-by":"crossref","first-page":"10135","DOI":"10.1038\/s41598-019-46596-9","article-title":"Construction, Expression and Evaluation of Recombinant VP2 Protein for serotype-independent Detection of FMDV Seropositive Animals in Egypt","volume":"9","author":"Salem","year":"2019","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.imlet.2020.04.008_bib0145","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1080\/15548627.2017.1405187","article-title":"Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1","volume":"14","author":"Sun","year":"2018","journal-title":"Autophagy"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247819306145?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247819306145?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:36:35Z","timestamp":1759044995000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247819306145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":29,"alternative-id":["S0165247819306145"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2020.04.008","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Capsid proteins of foot-and-mouth disease virus interact with TLR2 and CD14 to induce cytokine production","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2020.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}