{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:50:00Z","timestamp":1778568600867,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016073","name":"Key Technologies Research and Development Program of Anhui Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016073","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.imlet.2020.07.005","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T11:11:41Z","timestamp":1595329901000},"page":"62-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Injection of CD40 DNA vaccine ameliorates the autoimmune pathology of non-obese diabetic mice with Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1016","volume":"226","author":[{"given":"Ying-Bo","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi-Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Pei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Mei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.imlet.2020.07.005_bib0005","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0049-0172(00)80016-5","article-title":"Clinical evolution, and morbidity and mortality of primary Sjogren\u2019s syndrome","volume":"29","author":"Skopouli","year":"2000","journal-title":"Semin. Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.imlet.2020.07.005_bib0010","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/MD.0b013e318181e6af","article-title":"Primary Sjogren syndrome in Spain: clinical and immunologic expression in 1010 patients","volume":"87","author":"Ramos-Casals","year":"2008","journal-title":"Medicine"},{"issue":"10","key":"10.1016\/j.imlet.2020.07.005_bib0015","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0167-5699(96)10060-I","article-title":"The many roles of CD40 in cell-mediated inflammatory responses","volume":"17","author":"Stout","year":"1996","journal-title":"Immunol. Today"},{"issue":"3\u20134","key":"10.1016\/j.imlet.2020.07.005_bib0020","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1359-6101(03)00024-8","article-title":"The CD40-CD154 interaction in B cell-T cell liaisons","volume":"14","author":"Bishop","year":"2003","journal-title":"Cytokine Growth Factor Rev."},{"issue":"3","key":"10.1016\/j.imlet.2020.07.005_bib0025","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1073\/pnas.0810769106","article-title":"CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells","volume":"106","author":"Iezzi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"10.1016\/j.imlet.2020.07.005_bib0030","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.4049\/jimmunol.154.3.1470","article-title":"Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis","volume":"154","author":"Mohan","year":"1995","journal-title":"J. Immunol."},{"issue":"5126","key":"10.1016\/j.imlet.2020.07.005_bib0035","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1126\/science.7689748","article-title":"Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40","volume":"261","author":"Durie","year":"1993","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.imlet.2020.07.005_bib0040","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1073\/pnas.93.6.2499","article-title":"CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis","volume":"93","author":"Gerritse","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"7","key":"10.1016\/j.imlet.2020.07.005_bib0045","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/art.30381","article-title":"Associations between salivary gland histopathologic diagnoses and phenotypic features of Sjogren\u2019s syndrome among 1,726 registry participants","volume":"63","author":"Daniels","year":"2011","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.imlet.2020.07.005_bib0050","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1046\/j.1365-2249.2002.01752.x","article-title":"CD40 on salivary gland epithelial cells: high constitutive expression by cultured cells from Sjogren\u2019s syndrome patients indicating their intrinsic activation","volume":"127","author":"Dimitriou","year":"2002","journal-title":"Clin. Exp. Immunol."},{"issue":"7","key":"10.1016\/j.imlet.2020.07.005_bib0055","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/1744666X.2018.1485492","article-title":"CD40 as a therapeutic target in Sjogren\u2019s syndrome","volume":"14","author":"Jobling","year":"2018","journal-title":"Expert Rev. Clin. Immunol."},{"issue":"7","key":"10.1016\/j.imlet.2020.07.005_bib0060","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/annrheumdis-2018-213929","article-title":"Blockade of CD40-CD154 pathway interactions suppresses ectopic lymphoid structures and inhibits pathology in the NOD\/ShiLtJ mouse model of Sjogren\u2019s syndrome","volume":"78","author":"Wieczorek","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.imlet.2020.07.005_bib0065","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/978-0-387-89520-8_2","article-title":"Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges","volume":"647","author":"Law","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"issue":"489","key":"10.1016\/j.imlet.2020.07.005_bib0070","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aar6584","article-title":"A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity","volume":"11","author":"Karnell","year":"2019","journal-title":"Sci. Transl. Med."},{"issue":"6","key":"10.1016\/j.imlet.2020.07.005_bib0075","first-page":"1356","article-title":"Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyes","volume":"41","author":"Brignole","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.imlet.2020.07.005_bib0080","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-med-043015-123313","article-title":"Mechanisms and new strategies for primary Sjogren\u2019s syndrome","volume":"68","author":"Mavragani","year":"2017","journal-title":"Annu. Rev. Med."},{"issue":"1","key":"10.1016\/j.imlet.2020.07.005_bib0085","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/ar2375","article-title":"Biomarker profiles in serum and saliva of experimental Sjogren\u2019s syndrome: associations with specific autoimmune manifestations","volume":"10","author":"Delaleu","year":"2008","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.imlet.2020.07.005_bib0090","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00281-010-0204-1","article-title":"Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease","volume":"33","author":"Driver","year":"2011","journal-title":"Semin. Immunopathol."},{"issue":"1","key":"10.1016\/j.imlet.2020.07.005_bib0095","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/154411130201300103","article-title":"Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update","volume":"13","author":"Cha","year":"2002","journal-title":"Crit. Rev. Oral Biol. Med."},{"issue":"Suppl. 118(3)","key":"10.1016\/j.imlet.2020.07.005_bib0100","first-page":"209","article-title":"Animal models of Sjogren\u2019s syndrome: an update","volume":"37","author":"Xiao","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"issue":"2","key":"10.1016\/j.imlet.2020.07.005_bib0105","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ki.2012.374","article-title":"DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats","volume":"83","author":"Wang","year":"2013","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.imlet.2020.07.005_bib0110","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1601-0825.2011.01852.x","article-title":"Temporal changes in salivary glands of non-obese diabetic mice as a model for Sjogren\u2019s syndrome","volume":"18","author":"Roescher","year":"2012","journal-title":"Oral Dis."},{"issue":"6","key":"10.1016\/j.imlet.2020.07.005_bib0115","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/annrheumdis-2013-204584","article-title":"Th17 cells play a critical role in the development of experimental Sjogren\u2019s syndrome","volume":"74","author":"Lin","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"7","key":"10.1016\/j.imlet.2020.07.005_bib0120","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1136\/annrheumdis-2016-210448","article-title":"Standardisation of labial salivary gland histopathology in clinical trials in primary Sjogren\u2019s syndrome","volume":"76","author":"Fisher","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.imlet.2020.07.005_bib0125","doi-asserted-by":"crossref","first-page":"16047","DOI":"10.1038\/nrdp.2016.47","article-title":"Sjogren syndrome, nature reviews","volume":"2","author":"Brito-Zeron","year":"2016","journal-title":"Disease primers"},{"issue":"1","key":"10.1016\/j.imlet.2020.07.005_bib0130","first-page":"29","article-title":"Malignant B-cell lymphoma in a patient with primary Sjogren syndrome","volume":"132","author":"Varga","year":"1991","journal-title":"Orv. Hetil."},{"issue":"9","key":"10.1016\/j.imlet.2020.07.005_bib0135","first-page":"576","article-title":"Novel therapeutic strategies in primary Sjogren\u2019s syndrome","volume":"19","author":"Alunno","year":"2017","journal-title":"Isr. Med. Assoc. J."},{"issue":"Suppl. 118(3)","key":"10.1016\/j.imlet.2020.07.005_bib0140","first-page":"167","article-title":"Present and novel biologic drugs in primary Sjogren\u2019s syndrome","volume":"37","author":"Fasano","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"issue":"2","key":"10.1016\/j.imlet.2020.07.005_bib0145","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2174\/187221511796392114","article-title":"DNA vaccines: a mini review","volume":"5","author":"Saha","year":"2011","journal-title":"Recent Pat. DNA Gene Seq."},{"key":"10.1016\/j.imlet.2020.07.005_bib0150","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0065-2660(05)55002-8","article-title":"Human clinical trials of plasmid DNA vaccines","volume":"55","author":"Liu","year":"2005","journal-title":"Adv. Genet."},{"issue":"12","key":"10.1016\/j.imlet.2020.07.005_bib0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0051375","article-title":"Local administration of soluble CD40:fc to the salivary glands of non-obese diabetic mice does not ameliorate autoimmune inflammation","volume":"7","author":"Roescher","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.imlet.2020.07.005_bib0160","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1002\/art.23073","volume":"56","author":"Manoussakis","year":"2007","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.imlet.2020.07.005_bib0165","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/art.20789","article-title":"Novel role of CD40 in Fas-dependent apoptosis of cultured salivary epithelial cells from patients with Sjogren\u2019s syndrome","volume":"52","author":"Ping","year":"2005","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.imlet.2020.07.005_bib0170","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1267\/ahc.11010","article-title":"Distribution of dendritic cells in normal human salivary glands","volume":"44","author":"Le","year":"2011","journal-title":"Acta Histochem. Cytochem."},{"issue":"10","key":"10.1016\/j.imlet.2020.07.005_bib0175","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/pho.2016.4244","article-title":"Light-emitting diode at 460 +\/- 20 nm increases the production of IL-12 and IL-6 in murine dendritic cells","volume":"35","author":"Carvalho-Costa","year":"2017","journal-title":"Photomed. Laser Surg."},{"issue":"12","key":"10.1016\/j.imlet.2020.07.005_bib0180","first-page":"984","article-title":"Dendritic-cell control of pathogen-driven T-cell polarization, Nature reviews","volume":"3","author":"Kapsenberg","year":"2003","journal-title":"Immunology"},{"issue":"4","key":"10.1016\/j.imlet.2020.07.005_bib0185","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/labinvest.3780062","article-title":"Two different types of sialoadenitis in the NOD- and MRL\/lpr mouse models for Sjogren\u2019s syndrome: a differential role for dendritic cells in the initiation of sialoadenitis?","volume":"80","author":"van Blokland","year":"2000","journal-title":"Lab. Invest."},{"key":"10.1016\/j.imlet.2020.07.005_bib0190","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5045248","article-title":"Dendritic cells in systemic lupus erythematosus: from pathogenic players to therapeutic tools","volume":"2016","author":"Klarquist","year":"2016","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.imlet.2020.07.005_bib0195","doi-asserted-by":"crossref","DOI":"10.1007\/s00262-017-2027-6","article-title":"Phase I trial of antigen-targeted autologous dendritic cell-based vaccine with in vivo activation of inducible CD40 for advanced prostate cancer","author":"Sonpavde","year":"2017","journal-title":"Cancer Immunol. Immunother."},{"issue":"5","key":"10.1016\/j.imlet.2020.07.005_bib0200","doi-asserted-by":"crossref","first-page":"R170","DOI":"10.1186\/ar3493","article-title":"Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjogren\u2019s syndrome","volume":"13","author":"Yoshimoto","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.imlet.2020.07.005_bib0205","article-title":"Significance of Interleukin-6\/STAT pathway for the gene expression of REG ialpha, a New Autoantigen in Sjogren\u2019s syndrome patients, in salivary duct epithelial cells","author":"Fujimura","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"1","key":"10.1016\/j.imlet.2020.07.005_bib0210","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00296-015-3345-7","article-title":"Association of CD40 polymorphisms and haplotype with risk of systemic lupus erythematosus","volume":"36","author":"Wu","year":"2016","journal-title":"Rheumatol. Int."},{"issue":"9","key":"10.1016\/j.imlet.2020.07.005_bib0215","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1002\/art.38716","article-title":"Interleukin-6 deficiency corrects nephritis, lymphocyte abnormalities, and secondary Sjogren\u2019s syndrome features in lupus-prone Sle1.YAa mice","volume":"66","author":"Maier-Moore","year":"2014","journal-title":"Arthritis Rheumatol."},{"issue":"19","key":"10.1016\/j.imlet.2020.07.005_bib0220","doi-asserted-by":"crossref","first-page":"7547","DOI":"10.1073\/pnas.86.19.7547","article-title":"IgG1 plasmacytosis in interleukin 6 transgenic mice","volume":"86","author":"Suematsu","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"8","key":"10.1016\/j.imlet.2020.07.005_bib0225","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1601-0825.2009.01582.x","article-title":"Cytokines in Sjogren\u2019s syndrome","volume":"15","author":"Roescher","year":"2009","journal-title":"Oral Dis."},{"issue":"6","key":"10.1016\/j.imlet.2020.07.005_bib0230","first-page":"970","article-title":"Salivary cytokine profiles in primary Sjogren\u2019s syndrome differ from those in non-Sjogren sicca in terms of TNF-alpha levels and Th-1\/Th-2 ratios","volume":"29","author":"Kang","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"issue":"12","key":"10.1016\/j.imlet.2020.07.005_bib0235","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1093\/intimm\/dxp103","article-title":"Induction of TNF-alpha-converting enzyme-ectodomain shedding by pathogenic autoantibodies","volume":"21","author":"Sisto","year":"2009","journal-title":"Int. Immunol."},{"issue":"2","key":"10.1016\/j.imlet.2020.07.005_bib0240","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jaut.2010.06.020","article-title":"Pro-inflammatory role of Anti-Ro\/SSA autoantibodies through the activation of Furin-TACE-amphiregulin axis","volume":"35","author":"Lisi","year":"2010","journal-title":"J. Autoimmun."},{"issue":"12","key":"10.1016\/j.imlet.2020.07.005_bib0245","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1007\/s10495-006-0281-8","article-title":"Interferon-gamma sensitizes the human salivary gland cell line, HSG, to tumor necrosis factor-alpha induced activation of dual apoptotic pathways","volume":"11","author":"Kulkarni","year":"2006","journal-title":"Apoptosis"},{"issue":"6","key":"10.1016\/j.imlet.2020.07.005_bib0250","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0003-9969(02)00025-0","article-title":"Intracellular trafficking and surface expression of SS-A (Ro), SS-B (La), poly(ADP-ribose) polymerase and alpha-fodrin autoantigens during apoptosis in human salivary gland cells induced by tumour necrosis factor-alpha","volume":"47","author":"McArthur","year":"2002","journal-title":"Arch. Oral Biol."},{"issue":"12","key":"10.1016\/j.imlet.2020.07.005_bib0255","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1111\/ajt.14872","article-title":"Characterization of the in vitro and in vivo properties of CFZ533, a blocking and non-depleting anti-CD40 monoclonal antibody","volume":"18","author":"Ristov","year":"2018","journal-title":"Am. J. Transplant."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247820303539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247820303539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:38:04Z","timestamp":1759045084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247820303539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":51,"alternative-id":["S0165247820303539"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2020.07.005","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Injection of CD40 DNA vaccine ameliorates the autoimmune pathology of non-obese diabetic mice with Sj\u00f6gren\u2019s syndrome","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2020.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}