{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:07:58Z","timestamp":1790762878467,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"am","delay-in-days":353,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007241","name":"Universit\u00e9 Paris-Saclay","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002738","name":"Assistance Publique - H\u00f4pitaux de Paris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.imlet.2020.10.004","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T22:30:41Z","timestamp":1603233041000},"page":"129-134","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"special_numbering":"C","title":["STAT3 inhibition protects against neuroinflammation and BACE1 upregulation induced by systemic inflammation"],"prefix":"10.1016","volume":"228","author":[{"given":"P\u00e9rine","family":"Millot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"San","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangeline","family":"Bennana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Porte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Vignal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Hugon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Paquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Hosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Mouton-Liger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.imlet.2020.10.004_bib0005","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/intimm\/dxr077","article-title":"IL-1beta and TNFalpha-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis","volume":"23","author":"Mori","year":"2011","journal-title":"Int. Immunol."},{"issue":"1","key":"10.1016\/j.imlet.2020.10.004_bib0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4049\/jimmunol.1401867","article-title":"Mechanisms of Jak\/STAT signaling in immunity and disease","volume":"194","author":"Villarino","year":"2015","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.imlet.2020.10.004_bib0015","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1523\/JNEUROSCI.3516-14.2015","article-title":"The JAK\/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer\u2019s and Huntington\u2019s diseases","volume":"35","author":"Ben Haim","year":"2015","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.imlet.2020.10.004_bib0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-009-0532-1","article-title":"Classification and basic pathology of Alzheimer disease","volume":"118","author":"Duyckaerts","year":"2009","journal-title":"Acta Neuropathol."},{"issue":"20","key":"10.1016\/j.imlet.2020.10.004_bib0025","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1523\/JNEUROSCI.0519-10.2010","article-title":"Tyk2\/STAT3 signaling mediates beta-amyloid-induced neuronal cell death: implications in Alzheimer\u2019s disease","volume":"30","author":"Wan","year":"2010","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.imlet.2020.10.004_bib0030","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s40478-018-0606-1","article-title":"Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer\u2019s disease","volume":"6","author":"Ceyzeriat","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"issue":"2","key":"10.1016\/j.imlet.2020.10.004_bib0035","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809665","article-title":"Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer\u2019s disease model","volume":"11","author":"Reichenbach","year":"2019","journal-title":"EMBO Mol. Med."},{"issue":"4","key":"10.1016\/j.imlet.2020.10.004_bib0040","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"issue":"1","key":"10.1016\/j.imlet.2020.10.004_bib0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13195-017-0308-0","article-title":"PKR involvement in Alzheimer\u2019s disease","volume":"9","author":"Hugon","year":"2017","journal-title":"Alzheimers Res. Ther."},{"issue":"6","key":"10.1016\/j.imlet.2020.10.004_bib0050","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.bbadis.2012.01.009","article-title":"Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2alpha pathway","volume":"1822","author":"Mouton-Liger","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.imlet.2020.10.004_bib0055","doi-asserted-by":"crossref","first-page":"8489","DOI":"10.1038\/srep08489","article-title":"Neuroinflammation and Abeta accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation","volume":"5","author":"Carret-Rebillat","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.imlet.2020.10.004_bib0060","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.expneurol.2013.08.004","article-title":"Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes","volume":"248","author":"Liu","year":"2013","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.imlet.2020.10.004_bib0065","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neuron.2008.02.024","article-title":"Transcriptional regulation of beta-secretase by p25\/cdk5 leads to enhanced amyloidogenic processing","volume":"57","author":"Wen","year":"2008","journal-title":"Neuron"},{"issue":"8-9","key":"10.1016\/j.imlet.2020.10.004_bib0070","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.molimm.2009.02.018","article-title":"STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria","volume":"46","author":"Samavati","year":"2009","journal-title":"Mol. Immunol."},{"issue":"10","key":"10.1016\/j.imlet.2020.10.004_bib0075","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11101428","article-title":"STAT3 and STAT5 activation in solid cancers","volume":"11","author":"Igelmann","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.imlet.2020.10.004_bib0080","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.imlet.2017.07.005","article-title":"The anti-tumor activity of the STAT3 inhibitor STX-0119 occurs via promotion of tumor-infiltrating lymphocyte accumulation in temozolomide-resistant glioblastoma cell line","volume":"190","author":"Akiyama","year":"2017","journal-title":"Immunol. Lett."},{"issue":"10","key":"10.1016\/j.imlet.2020.10.004_bib0085","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/s41388-018-0547-y","article-title":"Targeting colon cancer with the novel STAT3 inhibitor bruceantinol","volume":"38","author":"Wei","year":"2019","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.imlet.2020.10.004_bib0090","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.ccell.2019.10.002","article-title":"A potent and selective small-molecule degrader of STAT3 achieves complete tumor regression in vivo","volume":"36","author":"Bai","year":"2019","journal-title":"Cancer Cell"},{"issue":"7","key":"10.1016\/j.imlet.2020.10.004_bib0095","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/cas.12683","article-title":"Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed\/refractory hematological malignancies","volume":"106","author":"Ogura","year":"2015","journal-title":"Cancer Sci."},{"issue":"2","key":"10.1016\/j.imlet.2020.10.004_bib0100","doi-asserted-by":"crossref","first-page":"510","DOI":"10.4143\/crt.2018.226","article-title":"Phase I dose-finding study of OPB-111077, a novel STAT3 inhibitor, in patients with advanced hepatocellular carcinoma","volume":"51","author":"Yoo","year":"2019","journal-title":"Cancer Res. Treat."},{"issue":"11","key":"10.1016\/j.imlet.2020.10.004_bib0105","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.chembiol.2006.09.018","article-title":"Stattic: a small-molecule inhibitor of STAT3 activation and dimerization","volume":"13","author":"Schust","year":"2006","journal-title":"Chem. Biol."},{"key":"10.1016\/j.imlet.2020.10.004_bib0110","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3389\/fnmol.2017.00367","article-title":"Impairment of hepcidin upregulation by lipopolysaccharide in the Interleukin-6 knockout mouse brain","volume":"10","author":"Zhang","year":"2017","journal-title":"Front. Mol. Neurosci."},{"issue":"6","key":"10.1016\/j.imlet.2020.10.004_bib0115","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.yjmcc.2012.09.007","article-title":"Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway","volume":"53","author":"Das","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"18","key":"10.1016\/j.imlet.2020.10.004_bib0120","doi-asserted-by":"crossref","first-page":"8416","DOI":"10.18632\/oncotarget.2314","article-title":"Inhibition of STAT3 signaling targets both tumor-initiating and differentiated cell populations in prostate cancer","volume":"5","author":"Han","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.imlet.2020.10.004_bib0125","first-page":"136","article-title":"Quantifying microglia morphology from photomicrographs of immunohistochemistry prepared tissue using ImageJ","author":"Young","year":"2018","journal-title":"J. Vis. Exp."},{"issue":"11","key":"10.1016\/j.imlet.2020.10.004_bib0130","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/jemt.20829","article-title":"3D reconstruction of histological sections: application to mammary gland tissue","volume":"73","author":"Arganda-Carreras","year":"2010","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.imlet.2020.10.004_bib0135","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fncel.2013.00003","article-title":"Quantitating the subtleties of microglial morphology with fractal analysis","volume":"7","author":"Karperien","year":"2013","journal-title":"Front. Cell. Neurosci."},{"issue":"5","key":"10.1016\/j.imlet.2020.10.004_bib0140","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration","volume":"55","author":"Qin","year":"2007","journal-title":"Glia"},{"issue":"1","key":"10.1016\/j.imlet.2020.10.004_bib0145","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0969-9961(03)00069-X","article-title":"Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice","volume":"14","author":"Sheng","year":"2003","journal-title":"Neurobiol. Dis."},{"issue":"6","key":"10.1016\/j.imlet.2020.10.004_bib0150","doi-asserted-by":"crossref","first-page":"e21456","DOI":"10.1371\/journal.pone.0021456","article-title":"Activation of PKR causes amyloid ss-peptide accumulation via de-repression of BACE1 expression","volume":"6","author":"Ill-Raga","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.imlet.2020.10.004_bib0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2012.01.009","article-title":"Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2\u03b1 pathway","author":"Mouton-Liger","year":"2012","journal-title":"BBA - Molecular Basis of Disease"},{"issue":"3","key":"10.1016\/j.imlet.2020.10.004_bib0160","doi-asserted-by":"crossref","first-page":"e12887","DOI":"10.1111\/acel.12887","article-title":"PKR knockout in the 5xFAD model of Alzheimer\u2019s disease reveals beneficial effects on spatial memory and brain lesions","volume":"18","author":"Tible","year":"2019","journal-title":"Aging Cell"},{"issue":"3","key":"10.1016\/j.imlet.2020.10.004_bib0165","doi-asserted-by":"crossref","first-page":"415","DOI":"10.4161\/auto.22910","article-title":"Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy","volume":"9","author":"Niso-Santano","year":"2013","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.imlet.2020.10.004_bib0170","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2012.09.013","article-title":"Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity","volume":"48","author":"Shen","year":"2012","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.imlet.2020.10.004_bib0175","doi-asserted-by":"crossref","first-page":"e54565","DOI":"10.1371\/journal.pone.0054565","article-title":"Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma","volume":"8","author":"Pan","year":"2013","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.imlet.2020.10.004_bib0180","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1523\/JNEUROSCI.4658-15.2016","article-title":"Inhibition of the JAK\/STAT pathway protects against alpha-synuclein-Induced neuroinflammation and dopaminergic neurodegeneration","volume":"36","author":"Qin","year":"2016","journal-title":"J. Neurosci."},{"issue":"Pt B","key":"10.1016\/j.imlet.2020.10.004_bib0185","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neulet.2013.10.051","article-title":"Characterization of the APP\/PS1 mouse model of Alzheimer\u2019s disease in senescence accelerated background","volume":"557","author":"Lok","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.imlet.2020.10.004_bib0190","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.brainres.2010.06.011","article-title":"Characterization of the 3xTg-AD mouse model of Alzheimer\u2019s disease: part 2. Behavioral and cognitive changes","volume":"1348","author":"Sterniczuk","year":"2010","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.imlet.2020.10.004_bib0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030558","article-title":"Drug Development for Alzheimer\u2019s Disease: Microglia Induced Neuroinflammation as a Target?","volume":"20","author":"Dong","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.imlet.2020.10.004_bib0200","first-page":"273","article-title":"Neflamapimod: clinical phase 2b-ready oral small molecule inhibitor of p38alpha to reverse synaptic dysfunction in early Alzheimer\u2019s disease","volume":"4","author":"Alam","year":"2017","journal-title":"J. Prev. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.imlet.2020.10.004_bib0205","doi-asserted-by":"crossref","first-page":"149","DOI":"10.14283\/jpad.2018.18","article-title":"Development of Azeliragon, an oral small molecule antagonist of the receptor for advanced glycation endproducts, for the potential slowing of loss of cognition in mild Alzheimer\u2019s disease","volume":"5","author":"Burstein","year":"2018","journal-title":"J. Prev. Alzheimers Dis."},{"key":"10.1016\/j.imlet.2020.10.004_bib0210","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bbi.2016.12.014","article-title":"Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-beta and cognitive function in APP\/PS1 mice","volume":"61","author":"Dempsey","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"10","key":"10.1016\/j.imlet.2020.10.004_bib0215","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1021\/ml2001455","article-title":"The discovery of VX-745: a novel and selective p38alpha kinase inhibitor","volume":"2","author":"Duffy","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"issue":"11","key":"10.1016\/j.imlet.2020.10.004_bib0220","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nrc2734","article-title":"STATs in cancer inflammation and immunity: a leading role for STAT3","volume":"9","author":"Yu","year":"2009","journal-title":"Nat. Rev. Cancer"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247820304004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247820304004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:40:03Z","timestamp":1759045203000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247820304004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":44,"alternative-id":["S0165247820304004"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2020.10.004","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"STAT3 inhibition protects against neuroinflammation and BACE1 upregulation induced by systemic inflammation","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2020.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}