{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:29:04Z","timestamp":1790188144150,"version":"4.1.0"},"reference-count":211,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.imlet.2021.07.004","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T17:38:43Z","timestamp":1626716323000},"page":"1-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Efficient roles of miR-146a in cellular and molecular mechanisms of neuroinflammatory disorders: An effectual review in neuroimmunology"],"prefix":"10.1016","volume":"238","author":[{"given":"Mona","family":"Aslani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Shahabeddin","family":"Mortazavi-Jahromi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1996-2747","authenticated-orcid":false,"given":"Abbas","family":"Mirshafiey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.imlet.2021.07.004_bib0001","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/S1474-4422(17)30299-5","article-title":"Global, regional, and national burden of neurological disorders during 1990\u20132015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"16","author":"Feigin","year":"2017","journal-title":"The Lancet Neurol."},{"issue":"6","key":"10.1016\/j.imlet.2021.07.004_bib0002","doi-asserted-by":"crossref","first-page":"e67121","DOI":"10.1371\/journal.pone.0067121","article-title":"Mapping molecular association networks of nervous system diseases via large-scale analysis of published research","volume":"8","author":"Hu","year":"2013","journal-title":"PLoS One"},{"issue":"06","key":"10.1016\/j.imlet.2021.07.004_bib0003","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1055\/s-0030-1252051","article-title":"Prevalence of Central Nervous System Diseases\u2013A Large Retrospective Cohort Study of Adolescents","volume":"40","author":"Pollak","year":"2009","journal-title":"Neuropediatrics"},{"issue":"11","key":"10.1016\/j.imlet.2021.07.004_bib0004","doi-asserted-by":"crossref","first-page":"6053","DOI":"10.4049\/jimmunol.0902308","article-title":"MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation","volume":"184","author":"Ma","year":"2010","journal-title":"J. Immunol."},{"issue":"22","key":"10.1016\/j.imlet.2021.07.004_bib0005","doi-asserted-by":"crossref","first-page":"9250","DOI":"10.1073\/pnas.1105469108","article-title":"Wolbachia uses host microRNAs to manipulate host gene expression and facilitate colonization of the dengue vector Aedes aegypti","volume":"108","author":"Hussain","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.imlet.2021.07.004_bib0006","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/08923973.2020.1742734","article-title":"The role of \u03b2-d-mannuronic acid, as a new non-steroidal anti-inflammatory drug on expression of miR-146a, IRAK1, TRAF6, NF-\u03baB and pro-inflammatory cytokines following a clinical trial in rheumatoid arthritis patients","volume":"42","author":"Mortazavi-Jahromi","year":"2020","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.imlet.2021.07.004_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.imlet.2020.07.008","article-title":"A comprehensive review on miR-146a molecular mechanisms in a wide spectrum of immune and non-immune inflammatory diseases","author":"Mortazavi-Jahromi","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.imlet.2021.07.004_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165937","article-title":"The role of synaptic microRNAs in Alzheimer's disease","author":"Kumar","year":"2020","journal-title":"Biochimica et Biophysica Acta (BBA)-Mol. Basis of Dis."},{"key":"10.1016\/j.imlet.2021.07.004_bib0009","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.conb.2017.02.014","article-title":"miRNAs in synapse development and synaptic plasticity","volume":"45","author":"Hu","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"issue":"3","key":"10.1016\/j.imlet.2021.07.004_bib0010","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1371\/journal.pbio.0030085","article-title":"Principles of microRNA\u2013target recognition","volume":"3","author":"Brennecke","year":"2005","journal-title":"PLoS biol."},{"issue":"7027","key":"10.1016\/j.imlet.2021.07.004_bib0011","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature03315","article-title":"Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs","volume":"433","author":"Lim","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2021.07.004_bib0012","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbi.2015.04.018","article-title":"MicroRNA-146a-5p attenuates neuropathic pain via suppressing TRAF6 signaling in the spinal cord","volume":"49","author":"Lu","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"46","key":"10.1016\/j.imlet.2021.07.004_bib0013","doi-asserted-by":"crossref","first-page":"31315","DOI":"10.1074\/jbc.M805371200","article-title":"An NF-\u03baB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells","volume":"283","author":"Lukiw","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.imlet.2021.07.004_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200602","article-title":"Distinct expression of the neurotoxic microRNA family let-7 in the cerebrospinal fluid of patients with Alzheimer's disease","volume":"13","author":"Derkow","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13229-018-0219-3","article-title":"Role of miR-146a in neural stem cell differentiation and neural lineage determination: relevance for neurodevelopmental disorders","volume":"9","author":"Nguyen","year":"2018","journal-title":"Mol. autism"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep28148","article-title":"A panel of serum MiRNA biomarkers for the diagnosis of severe to mild traumatic brain injury in humans","volume":"6","author":"Bhomia","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.imlet.2021.07.004_bib0017","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3389\/fnins.2019.00916","article-title":"Role of the immune system in the development of the central nervous system","volume":"13","author":"Nakajima","year":"2019","journal-title":"Front. neurosci."},{"issue":"12","key":"10.1016\/j.imlet.2021.07.004_bib0018","doi-asserted-by":"crossref","first-page":"R511","DOI":"10.1016\/j.cub.2008.04.010","article-title":"The origin of the myelination program in vertebrates","volume":"18","author":"Zalc","year":"2008","journal-title":"Curr. Biol."},{"issue":"5","key":"10.1016\/j.imlet.2021.07.004_bib0019","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1084\/jem.20091419","article-title":"Regulation of learning and memory by meningeal immunity: a key role for IL-4","volume":"207","author":"Derecki","year":"2010","journal-title":"J. Exp. Med."},{"issue":"7","key":"10.1016\/j.imlet.2021.07.004_bib0020","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.4049\/jimmunol.1103096","article-title":"Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity","volume":"188","author":"Prado","year":"2012","journal-title":"J. Immunol."},{"issue":"7560","key":"10.1016\/j.imlet.2021.07.004_bib0021","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louveau","year":"2015","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.imlet.2021.07.004_bib0022","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1084\/jem.20102657","article-title":"Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain","volume":"208","author":"Anandasabapathy","year":"2011","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.imlet.2021.07.004_bib0023","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.4049\/jimmunol.0901852","article-title":"Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease","volume":"184","author":"Reynolds","year":"2010","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0024","first-page":"13","article-title":"CD4+ T cells mediate cytotoxicity in neurodegenerative diseases","volume":"119","author":"Appel","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imlet.2021.07.004_bib0025","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbi.2013.04.007","article-title":"Toll-like receptor 9 deficiency impacts sensory and motor behaviors","volume":"32","author":"Khariv","year":"2013","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep26199","article-title":"Major Histocompatibility Complex class I proteins are critical for maintaining neuronal structural complexity in the aging brain","volume":"6","author":"Lazarczyk","year":"2016","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.imlet.2021.07.004_bib0027","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/intimm\/12.7.1015","article-title":"Expression of a complete and functional complement system by human neuronal cells in vitro","volume":"12","author":"Thomas","year":"2000","journal-title":"Int. Immunol."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11064-010-0252-x","article-title":"Central and peripheral cytokines mediate immune-brain connectivity","volume":"36","author":"Besedovsky","year":"2011","journal-title":"Neurochem. Res."},{"issue":"11","key":"10.1016\/j.imlet.2021.07.004_bib0029","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1111\/j.1460-9568.1993.tb00210.x","article-title":"Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain","volume":"5","author":"Sch\u00f6bitz","year":"1993","journal-title":"Eur. J. Neurosci."},{"issue":"4","key":"10.1016\/j.imlet.2021.07.004_bib0030","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1046\/j.1471-4159.1997.69041668.x","article-title":"Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1\u03b2","volume":"69","author":"Valli\u00e8res","year":"1997","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.imlet.2021.07.004_bib0031","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neuroscience.2006.10.055","article-title":"Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS","volume":"145","author":"Oka","year":"2007","journal-title":"Neuroscience"},{"issue":"7087","key":"10.1016\/j.imlet.2021.07.004_bib0032","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/nature04671","article-title":"Synaptic scaling mediated by glial TNF-\u03b1","volume":"440","author":"Stellwagen","year":"2006","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0033","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1096\/fj.11-192716","article-title":"Genetic deletion of TNF receptor suppresses excitatory synaptic transmission via reducing AMPA receptor synaptic localization in cortical neurons","volume":"26","author":"He","year":"2012","journal-title":"FASEB J."},{"issue":"1-2","key":"10.1016\/j.imlet.2021.07.004_bib0034","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jneuroim.2005.07.013","article-title":"Dopamine by itself activates either D2, D3 or D1\/D5 dopaminergic receptors in normal human T-cells and triggers the selective secretion of either IL-10, TNF\u03b1 or both","volume":"169","author":"Besser","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.imlet.2021.07.004_bib0035","first-page":"2019","author":"Cramer","year":"2019","journal-title":"Mediators Inflamm."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0036","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(99)00259-1","article-title":"Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines","volume":"266","author":"Sato","year":"1999","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-018-0183-x","article-title":"Diagnosis of major depressive disorder based on changes in multiple plasma neurotransmitters: a targeted metabolomics study","volume":"8","author":"Pan","year":"2018","journal-title":"Translational psychiatry"},{"issue":"1-2","key":"10.1016\/j.imlet.2021.07.004_bib0038","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000119011","article-title":"Direct innervation of lymphoid organs: substrate for neurotransmitter signaling of cells of the immune system","volume":"28","author":"Felten","year":"1993","journal-title":"Neuropsychobiology"},{"issue":"8","key":"10.1016\/j.imlet.2021.07.004_bib0039","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1002\/art.23628","article-title":"An early sympathetic nervous system influence exacerbates collagen-induced arthritis via CD4+ CD25+ cells","volume":"58","author":"H\u00e4rle","year":"2008","journal-title":"Arthritis & Rheumatism: Official J. Am. College of Rheumatol."},{"issue":"6","key":"10.1016\/j.imlet.2021.07.004_bib0040","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1189\/jlb.0209107","article-title":"The sympathetic nervous system modulates CD4+ FoxP3+ regulatory T cells via a TGF-\u03b2-dependent mechanism","volume":"86","author":"Bhowmick","year":"2009","journal-title":"J. Leukoc. Biol."},{"issue":"13","key":"10.1016\/j.imlet.2021.07.004_bib0041","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1073\/pnas.0808851106","article-title":"Sympathetic nervous system control of anti-influenza CD8+ T cell responses","volume":"106","author":"Grebe","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"12","key":"10.1016\/j.imlet.2021.07.004_bib0042","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.1128\/IAI.69.12.7234-7241.2001","article-title":"Effect of 6-hydroxydopamine on host resistance against Listeria monocytogenes infection","volume":"69","author":"Miura","year":"2001","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.imlet.2021.07.004_bib0043","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/sur.2012.126","article-title":"The vagus nerve and the inflammatory reflex: wandering on a new treatment paradigm for systemic inflammation and sepsis","volume":"13","author":"Huston","year":"2012","journal-title":"Surg. Infect. (Larchmt)"},{"issue":"6","key":"10.1016\/j.imlet.2021.07.004_bib0044","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1189\/jlb.0405224","article-title":"Crosstalk between chemokines and neuronal receptors bridges immune and nervous systems","volume":"78","author":"Zhang","year":"2005","journal-title":"J. Leukoc. Biol."},{"issue":"3","key":"10.1016\/j.imlet.2021.07.004_bib0045","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.neulet.2003.11.024","article-title":"Expression of chemokine receptors CXCR4, CCR2, CCR5 and CX3CR1 in neural progenitor cells isolated from the subventricular zone of the adult rat brain","volume":"355","author":"Ji","year":"2004","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.imlet.2021.07.004_bib0046","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1095\/biolreprod.103.022368","article-title":"Immunity and \u03b2-endorphin concentrations in hypothalamus and plasma in rats with steroid-induced polycystic ovaries: effect of low-frequency electroacupuncture","volume":"70","author":"Stener-Victorin","year":"2004","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.imlet.2021.07.004_bib0047","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/jcbfm.2014.207","article-title":"Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-\u03baB activation","volume":"35","author":"Wu","year":"2015","journal-title":"J. Cerebral Blood Flow & Metabolism"},{"key":"10.1016\/j.imlet.2021.07.004_bib0048","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3389\/fimmu.2020.01110","article-title":"Absence of miRNA-146a Differentially Alters Microglia Function and Proteome","volume":"11","author":"Martin","year":"2020","journal-title":"Front. Immunol."},{"issue":"33","key":"10.1016\/j.imlet.2021.07.004_bib0049","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-\u03baB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"12","key":"10.1016\/j.imlet.2021.07.004_bib0050","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.4049\/jimmunol.1500615","article-title":"Coordinated regulation of miR-155 and miR-146a genes during induction of endotoxin tolerance in macrophages","volume":"195","author":"Doxaki","year":"2015","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.imlet.2021.07.004_bib0051","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1084\/jem.20101823","article-title":"miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice","volume":"208","author":"Boldin","year":"2011","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.imlet.2021.07.004_bib0052","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.cell.2010.08.012","article-title":"Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses","volume":"142","author":"Lu","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-05196-3","article-title":"Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b","volume":"9","author":"Cho","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0054","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/imm.12347","article-title":"Silencing mi R-146a influences B cells and ameliorates experimental autoimmune myasthenia gravis","volume":"144","author":"Zhang","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.imlet.2021.07.004_bib0055","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neulet.2013.09.014","article-title":"Altered expression of miR-146a in myasthenia gravis","volume":"555","author":"Lu","year":"2013","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms7436","article-title":"MicroRNA-146a regulates ICOS\u2013ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres","volume":"6","author":"Pratama","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.imlet.2021.07.004_bib0057","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3389\/fnins.2020.00311","article-title":"MiR-146a Ameliorates Hemoglobin-Induced Microglial Inflammatory Response via TLR4\/IRAK1\/TRAF6 Associated Pathways","volume":"14","author":"Liu","year":"2020","journal-title":"Front. Neurosci."},{"issue":"17","key":"10.1016\/j.imlet.2021.07.004_bib0058","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1128\/MCB.05821-11","article-title":"MicroRNA-146a inhibits glioma development by targeting Notch1","volume":"31","author":"Mei","year":"2011","journal-title":"Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.imlet.2021.07.004_bib0059","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1523\/JNEUROSCI.0600-12.2013","article-title":"Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes","volume":"33","author":"Jovi\u010di\u0107","year":"2013","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0060","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1474-9726.2011.00757.x","article-title":"Dysregulated expression of miR-146a contributes to age-related dysfunction of macrophages","volume":"11","author":"Jiang","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.imlet.2021.07.004_bib0061","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fncel.2014.00152","article-title":"Microglia change from a reactive to an age-like phenotype with the time in culture","volume":"8","author":"Caldeira","year":"2014","journal-title":"Front. cellular neurosci."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-63282-3","article-title":"immune and central nervous system-related miRnAs expression profiling in monocytes of multiple sclerosis patients","volume":"10","author":"Amoruso","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.imlet.2021.07.004_bib0063","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fnmol.2015.00005","article-title":"Increase in NF-\u03baB-sensitive miRNA-146a and miRNA-155 in multiple sclerosis (MS) and pro-inflammatory neurodegeneration","volume":"8","author":"Devier","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.imlet.2021.07.004_bib0064","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2018.12.004","article-title":"Integrational analysis of miRNAs data sets as a plausible missing linker between Epstein-Barr virus and vitamin D in relapsing remitting MS patients","volume":"689","author":"Teymoori-Rad","year":"2019","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0065","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s12974-019-1590-5","article-title":"Analysis of miRNA signatures in CSF identifies upregulation of miR-21 and miR-146a\/b in patients with multiple sclerosis and active lesions","volume":"16","author":"Mu\u00f1oz-San Mart\u00edn","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.imlet.2021.07.004_bib0066","series-title":"Neuroinflammation in the normal appearing white matter of multiple sclerosis brain causes abnormalities at the node of Ranvier","author":"Gallego","year":"2020"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0067","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neulet.2011.08.021","article-title":"Expression and genetic analysis of miRNAs involved in CD4+ cell activation in patients with multiple sclerosis","volume":"504","author":"Fenoglio","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"9","key":"10.1016\/j.imlet.2021.07.004_bib0068","doi-asserted-by":"crossref","first-page":"e24604","DOI":"10.1371\/journal.pone.0024604","article-title":"Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis","volume":"6","author":"Waschbisch","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0069","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000369695","article-title":"Genetic association of MiR-146a with multiple sclerosis susceptibility in the Chinese population","volume":"35","author":"Li","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.imlet.2021.07.004_bib0070","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ana.23967","article-title":"miR-155 as a multiple sclerosis\u2013relevant regulator of myeloid cell polarization","volume":"74","author":"Moore","year":"2013","journal-title":"Ann. Neurol."},{"issue":"10","key":"10.1016\/j.imlet.2021.07.004_bib0071","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1093\/brain\/awz245","article-title":"MicroRNA-223 protects neurons from degeneration in experimental autoimmune encephalomyelitis","volume":"142","author":"Morquette","year":"2019","journal-title":"Brain"},{"issue":"1-2","key":"10.1016\/j.imlet.2021.07.004_bib0072","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jneuroim.2012.02.012","article-title":"MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions","volume":"246","author":"Lescher","year":"2012","journal-title":"J. Neuroimmunol."},{"issue":"12","key":"10.1016\/j.imlet.2021.07.004_bib0073","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1093\/brain\/awp300","article-title":"MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47","volume":"132","author":"Junker","year":"2009","journal-title":"Brain"},{"issue":"10","key":"10.1016\/j.imlet.2021.07.004_bib0074","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1172\/JCI94012","article-title":"miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity","volume":"127","author":"Li","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imlet.2021.07.004_bib0075","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3389\/fimmu.2018.00490","article-title":"Experimental demyelination and axonal loss are reduced in MicroRNA-146a deficient mice","volume":"9","author":"Martin","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imlet.2021.07.004_bib0076","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.nbd.2019.01.019","article-title":"MiR-146a promotes oligodendrocyte progenitor cell differentiation and enhances remyelination in a model of experimental autoimmune encephalomyelitis","volume":"125","author":"Zhang","year":"2019","journal-title":"Neurobiol. Dis."},{"issue":"5","key":"10.1016\/j.imlet.2021.07.004_bib0077","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jbspin.2010.05.013","article-title":"A polymorphism in the 3\u2019-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility","volume":"77","author":"Chatzikyriakidou","year":"2010","journal-title":"Joint Bone Spine"},{"issue":"2","key":"10.1016\/j.imlet.2021.07.004_bib0078","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.imlet.2011.09.006","article-title":"Increased microRNA-146a\/b, TRAF6 gene and decreased IRAK1 gene expressions in the peripheral mononuclear cells of patients with Sj\u00f6gren's syndrome","volume":"141","author":"Zilahi","year":"2012","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.imlet.2021.07.004_bib0079","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116829","article-title":"LncRNA NEAT1 promotes hepatic lipid accumulation via regulating miR-146a-5p\/ROCK1 in nonalcoholic fatty liver disease","volume":"235","author":"Chen","year":"2019","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0080","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s13105-014-0378-4","article-title":"Deregulation of NF-\u043aB\u2013miR-146a negative feedback loop may be involved in the pathogenesis of diabetic neuropathy","volume":"71","author":"Yousefzadeh","year":"2015","journal-title":"J. Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.imlet.2021.07.004_bib0081","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1101\/gad.1761509","article-title":"Selective stabilization of mammalian microRNAs by 3\u2032 adenylation mediated by the cytoplasmic poly (A) polymerase GLD-2","volume":"23","author":"Katoh","year":"2009","journal-title":"Genes Dev."},{"issue":"9","key":"10.1016\/j.imlet.2021.07.004_bib0082","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/ncb1931","article-title":"Zcchc11-dependent uridylation of microRNA directs cytokine expression","volume":"11","author":"Jones","year":"2009","journal-title":"Nat. Cell Biol."},{"issue":"5815","key":"10.1016\/j.imlet.2021.07.004_bib0083","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.1138050","article-title":"Redirection of silencing targets by adenosine-to-inosine editing of miRNAs","volume":"315","author":"Kawahara","year":"2007","journal-title":"Science"},{"issue":"19","key":"10.1016\/j.imlet.2021.07.004_bib0084","doi-asserted-by":"crossref","first-page":"12155","DOI":"10.1093\/nar\/gku844","article-title":"ADAR2 induces reproducible changes in sequence and abundance of mature microRNAs in the mouse brain","volume":"42","author":"Vesely","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"2","key":"10.1016\/j.imlet.2021.07.004_bib0085","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2011.09.029","article-title":"Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs","volume":"147","author":"Tay","year":"2011","journal-title":"Cell"},{"issue":"7301","key":"10.1016\/j.imlet.2021.07.004_bib0086","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/nature09144","article-title":"A coding-independent function of gene and pseudogene mRNAs regulates tumour biology","volume":"465","author":"Poliseno","year":"2010","journal-title":"Nature"},{"issue":"7441","key":"10.1016\/j.imlet.2021.07.004_bib0087","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"issue":"7441","key":"10.1016\/j.imlet.2021.07.004_bib0088","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"issue":"46","key":"10.1016\/j.imlet.2021.07.004_bib0089","doi-asserted-by":"crossref","first-page":"33037","DOI":"10.1074\/jbc.M113.492496","article-title":"NOD2-nitric oxide-responsive microRNA-146a activates Sonic hedgehog signaling to orchestrate inflammatory responses in murine model of inflammatory bowel disease","volume":"288","author":"Ghorpade","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep16163","article-title":"MiR-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting Wnt1 and Wnt5a","volume":"5","author":"Du","year":"2015","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.imlet.2021.07.004_bib0091","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.4161\/rna.21998","article-title":"Dose-dependent differential mRNA target selection and regulation by let-7a-7f and miR-17-92 cluster microRNAs","volume":"9","author":"Shu","year":"2012","journal-title":"RNA biol."},{"key":"10.1016\/j.imlet.2021.07.004_bib0092","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.3389\/fgene.2019.01330","article-title":"Improving bioinformatics prediction of microRNA targets by ranks aggregation","volume":"10","author":"Quillet","year":"2020","journal-title":"Front. Genetics"},{"key":"10.1016\/j.imlet.2021.07.004_bib0093","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3389\/fimmu.2020.00142","article-title":"miR-146a in myasthenia gravis thymus bridges innate immunity with autoimmunity and is linked to therapeutic effects of corticosteroids","volume":"11","author":"Bortone","year":"2020","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.imlet.2021.07.004_bib0094","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1074\/jbc.C600252200","article-title":"Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors","volume":"282","author":"Woods","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"7200","key":"10.1016\/j.imlet.2021.07.004_bib0095","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature07086","article-title":"SMAD proteins control DROSHA-mediated microRNA maturation","volume":"454","author":"Davis","year":"2008","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.imlet.2021.07.004_bib0096","doi-asserted-by":"crossref","first-page":"7269","DOI":"10.1073\/pnas.0802682105","article-title":"Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma","volume":"105","author":"Jazdzewski","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"10","key":"10.1016\/j.imlet.2021.07.004_bib0097","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1093\/nar\/gkt247","article-title":"Reprogramming of microRNAs by adenosine-to-inosine editing and the selective elimination of edited microRNA precursors in mouse oocytes and preimplantation embryos","volume":"41","author":"Garc\u00eda-L\u00f3pez","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0098","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nsmb1041","article-title":"Modulation of microRNA processing and expression through RNA editing by ADAR deaminases","volume":"13","author":"Yang","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"29","key":"10.1016\/j.imlet.2021.07.004_bib0099","doi-asserted-by":"crossref","first-page":"10073","DOI":"10.1073\/pnas.0804218105","article-title":"The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis","volume":"105","author":"Yu","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.imlet.2021.07.004_bib0100","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1186\/ar1959","article-title":"Autoimmune targeting of key components of RNA interference","volume":"8","author":"Jakymiw","year":"2006","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.imlet.2021.07.004_bib0101","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1158\/0008-5472.CAN-05-3632","article-title":"Rapid alteration of microRNA levels by histone deacetylase inhibition","volume":"66","author":"Scott","year":"2006","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.imlet.2021.07.004_bib0102","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1002\/art.39398","article-title":"Type I Interferon Inhibition of MicroRNA-146a Maturation Through Up-Regulation of Monocyte Chemotactic Protein\u2013Induced Protein 1 in Systemic Lupus Erythematosus","volume":"67","author":"Qu","year":"2015","journal-title":"Arthritis & Rheumatol."},{"issue":"3","key":"10.1016\/j.imlet.2021.07.004_bib0103","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1007\/s12035-018-1220-8","article-title":"Cortical neurotoxic astrocytes with early ALS pathology and miR-146a deficit replicate gliosis markers of symptomatic SOD1G93A mouse model","volume":"56","author":"Gomes","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.imlet.2021.07.004_bib0104","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fncel.2019.00109","article-title":"Phenotypic effects of wild-type and mutant SOD1 expression in N9 murine microglia at steady state, inflammatory and immunomodulatory conditions","volume":"13","author":"Vaz","year":"2019","journal-title":"Front. cellular neurosci."},{"key":"10.1016\/j.imlet.2021.07.004_bib0105","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3389\/fnins.2017.00731","article-title":"Small RNA sequencing of sporadic amyotrophic lateral sclerosis cerebrospinal fluid reveals differentially expressed miRNAs related to neural and glial activity","volume":"11","author":"Waller","year":"2018","journal-title":"Front. neurosci."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0106","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1756-6606-6-26","article-title":"Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels","volume":"6","author":"Campos-Melo","year":"2013","journal-title":"Molecular brain"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0107","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5414\/NP300889","article-title":"Circulating microRNAs as biomarkers of muscle differentiation and atrophy in ALS","volume":"35","author":"Tasca","year":"2016","journal-title":"Clin Neuropathol"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0108","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1742-2094-8-19","article-title":"Deleterious effects of lymphocytes at the early stage of neurodegeneration in an animal model of amyotrophic lateral sclerosis","volume":"8","author":"Tada","year":"2011","journal-title":"J. neuroinflammation"},{"issue":"5","key":"10.1016\/j.imlet.2021.07.004_bib0109","first-page":"4207","article-title":"Downregulated glia interplay and increased miRNA-155 as promising markers to track ALS at an early stage","volume":"55","author":"Cunha","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0110","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/jnc.14229","article-title":"Screening the expression characteristics of several miRNAs in G93A-SOD1 transgenic mouse: altered expression of miRNA-124 is associated with astrocyte differentiation by targeting Sox2 and Sox9","volume":"145","author":"Zhou","year":"2018","journal-title":"J. Neurochem."},{"issue":"9","key":"10.1016\/j.imlet.2021.07.004_bib0111","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1172\/JCI62636","article-title":"Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS","volume":"122","author":"Butovsky","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imlet.2021.07.004_bib0112","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jns.2017.07.008","article-title":"Micro-RNAs in ALS muscle: Differences in gender, age at onset and disease duration","volume":"380","author":"Pegoraro","year":"2017","journal-title":"J. Neurol. Sci."},{"issue":"10","key":"10.1016\/j.imlet.2021.07.004_bib0113","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1167\/iovs.16-19213","article-title":"Role of miR-146a in the Regulation of Inflammation in an In Vitro Model of graves' Orbitopathy","volume":"57","author":"Jang","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.imlet.2021.07.004_bib0114","doi-asserted-by":"crossref","first-page":"S158","DOI":"10.1016\/j.freeradbiomed.2018.04.522","article-title":"Upregulation of miR-146a attenuates ALS mouse cortical astrocytes reactivity and decrease miRNA-inflammatory associated exosomal cargo","volume":"120","author":"Barbosa","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.imlet.2021.07.004_bib0115","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3389\/fnins.2017.00273","article-title":"Exosomes from NSC-34 cells transfected with hSOD1-G93A are enriched in miR-124 and drive alterations in microglia phenotype","volume":"11","author":"Pinto","year":"2017","journal-title":"Front. neurosci."},{"issue":"3","key":"10.1016\/j.imlet.2021.07.004_bib0116","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.3892\/mmr.2015.3968","article-title":"A single nucleotide polymorphism in primary\u2011microRNA\u2011146a reduces the expression of mature microRNA\u2011146a in patients with Alzheimer's disease and is associated with the pathogenesis of Alzheimer's disease","volume":"12","author":"Zhang","year":"2015","journal-title":"Mol. Med. reports"},{"key":"10.1016\/j.imlet.2021.07.004_bib0117","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neurobiolaging.2019.06.005","article-title":"miR-146a and miR-181a are involved in the progression of mild cognitive impairment to Alzheimer's disease","volume":"82","author":"Ansari","year":"2019","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.imlet.2021.07.004_bib0118","doi-asserted-by":"crossref","first-page":"26697","DOI":"10.1038\/srep26697","article-title":"MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0119","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neurobiolaging.2013.07.005","article-title":"MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid","volume":"35","author":"M\u00fcller","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"5","key":"10.1016\/j.imlet.2021.07.004_bib0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0126423","article-title":"MicroRNA profiling of CSF reveals potential biomarkers to detect Alzheimers disease","volume":"10","author":"Denk","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.imlet.2021.07.004_bib0121","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3233\/JAD-130932","article-title":"MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer's disease","volume":"39","author":"Kiko","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.imlet.2021.07.004_bib0122","first-page":"2015","article-title":"Serum microRNA profiles serve as novel biomarkers for the diagnosis of Alzheimer's disease","author":"Dong","year":"2015","journal-title":"Dis. Markers"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0123","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13024-018-0285-1","article-title":"Deregulation of neuronal miRNAs induced by amyloid-\u03b2 or TAU pathology","volume":"13","author":"Sierksma","year":"2018","journal-title":"Molecular neurodegeneration"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0124","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neulet.2010.09.079","article-title":"Increased expression of miRNA-146a in Alzheimer's disease transgenic mouse models","volume":"487","author":"Li","year":"2011","journal-title":"Neurosci. Lett."},{"issue":"20","key":"10.1016\/j.imlet.2021.07.004_bib0125","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1093\/bioinformatics\/btt423","article-title":"Identification of active transcription factor and miRNA regulatory pathways in Alzheimer's disease","volume":"29","author":"Jiang","year":"2013","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.imlet.2021.07.004_bib0126","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neulet.2011.05.044","article-title":"Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells","volume":"499","author":"Li","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.imlet.2021.07.004_bib0127","series-title":"Methods in cell biology","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/B978-0-12-544172-8.00008-6","article-title":"Analysis of microRNA expression and function","author":"Van Wynsberghe","year":"2011"},{"issue":"50","key":"10.1016\/j.imlet.2021.07.004_bib0128","doi-asserted-by":"crossref","first-page":"38951","DOI":"10.1074\/jbc.M110.178848","article-title":"Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-\u03baB in stressed human astroglial cells and in Alzheimer disease","volume":"285","author":"Cui","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.imlet.2021.07.004_bib0129","first-page":"3668","article-title":"The role of miR-146a in MPTP treated mice with Parkinson's disease","volume":"12","author":"Wu","year":"2019","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.imlet.2021.07.004_bib0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ensci.2018.09.002","article-title":"Differential expression of miRNA 155 and miRNA 146a in Parkinson's disease patients","volume":"13","author":"Caggiu","year":"2018","journal-title":"eNeurologicalSci"},{"issue":"6","key":"10.1016\/j.imlet.2021.07.004_bib0131","first-page":"945","article-title":"Circulating Inflammatory miRNAs Associated with Parkinson's","volume":"10","author":"Oliveira","year":"2020","journal-title":"Dis. Pathophysiol., Biomolecules"},{"issue":"30","key":"10.1016\/j.imlet.2021.07.004_bib0132","doi-asserted-by":"crossref","first-page":"7687","DOI":"10.1523\/JNEUROSCI.0143-07.2008","article-title":"Neuroinflammation and oxidation\/nitration of \u03b1-synuclein linked to dopaminergic neurodegeneration","volume":"28","author":"Gao","year":"2008","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0133","doi-asserted-by":"crossref","first-page":"e1376","DOI":"10.1371\/journal.pone.0001376","article-title":"Nitrated \u03b1\u2013synuclein immunity accelerates degeneration of nigral dopaminergic neurons","volume":"3","author":"Benner","year":"2008","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.imlet.2021.07.004_bib0134","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/cbf.3224","article-title":"Serum miR-221 serves as a biomarker for Parkinson's disease","volume":"34","author":"Ma","year":"2016","journal-title":"Cell Biochem. Funct."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0135","first-page":"1","article-title":"Isosteviol sodium protects against ischemic stroke by modulating microglia\/macrophage polarization via disruption of GAS5\/miR-146a-5p sponge","volume":"9","author":"Zhang","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.imlet.2021.07.004_bib0136","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bbrc.2010.05.007","article-title":"Altered microRNAs in STHdhQ111\/HdhQ111 cells: miR-146a targets TBP","volume":"396","author":"Sinha","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0137","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/glia.23050","article-title":"Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific","volume":"65","author":"Jansen","year":"2017","journal-title":"Glia"},{"issue":"12","key":"10.1016\/j.imlet.2021.07.004_bib0138","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1097\/WNR.0b013e32832e34ee","article-title":"Distinct neuroinflammatory profile in post-mortem human Huntington's disease","volume":"20","author":"Silvestroni","year":"2009","journal-title":"Neuroreport"},{"issue":"3","key":"10.1016\/j.imlet.2021.07.004_bib0139","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1093\/brain\/awt355","article-title":"HTT-lowering reverses Huntington's disease immune dysfunction caused by NF\u03baB pathway dysregulation","volume":"137","author":"Tr\u00e4ger","year":"2014","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.imlet.2021.07.004_bib0140","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.4161\/rna.8.6.16035","article-title":"Micro RNA-214,-150,-146a and-125b target Huntingtin gene","volume":"8","author":"Sinha","year":"2011","journal-title":"RNA biol."},{"issue":"2","key":"10.1016\/j.imlet.2021.07.004_bib0141","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2174\/2211536604666150713105606","article-title":"Delayed Cell Cycle Progression in STHdhQ111\/HdhQ111 Cells, a Cell Model for Huntington's Disease Mediated by microRNA-19a, microRNA-146a and microRNA-432","volume":"4","author":"Das","year":"2015","journal-title":"MicroRNA"},{"issue":"8","key":"10.1016\/j.imlet.2021.07.004_bib0142","doi-asserted-by":"crossref","first-page":"e23837","DOI":"10.1371\/journal.pone.0023837","article-title":"Regulation of miR-146a by RelA\/NFkB and p53 in ST Hdh Q111\/Hdh Q111 Cells, a Cell Model of Huntington's Disease","volume":"6","author":"Ghose","year":"2011","journal-title":"PLoS One"},{"issue":"21","key":"10.1016\/j.imlet.2021.07.004_bib0143","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1007\/s00018-013-1307-3","article-title":"Checkpoint kinase 1 in DNA damage response and cell cycle regulation","volume":"70","author":"Patil","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"issue":"7","key":"10.1016\/j.imlet.2021.07.004_bib0144","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.4049\/jimmunol.175.7.4320","article-title":"TLR signaling tailors innate immune responses in human microglia and astrocytes","volume":"175","author":"Jack","year":"2005","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.imlet.2021.07.004_bib0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0163479","article-title":"Cerebrospinal fluid inflammatory biomarkers reflect clinical severity in Huntington's disease","volume":"11","author":"Rodrigues","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0146","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nsmb.1762","article-title":"MicroRNA assassins: factors that regulate the disappearance of miRNAs","volume":"17","author":"Kai","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"5895","key":"10.1016\/j.imlet.2021.07.004_bib0147","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1126\/science.1163728","article-title":"Degradation of microRNAs by a family of exoribonucleases in Arabidopsis","volume":"321","author":"Ramachandran","year":"2008","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.imlet.2021.07.004_bib0148","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.cell.2007.10.032","article-title":"Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression","volume":"131","author":"Diederichs","year":"2007","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0149","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0092-8674(01)00431-7","article-title":"Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing","volume":"106","author":"Grishok","year":"2001","journal-title":"Cell"},{"issue":"16","key":"10.1016\/j.imlet.2021.07.004_bib0150","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1101\/gad.1565607","article-title":"A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway","volume":"21","author":"O'Carroll","year":"2007","journal-title":"Genes Dev."},{"issue":"10","key":"10.1016\/j.imlet.2021.07.004_bib0151","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1101\/gad.1201404","article-title":"The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development","volume":"18","author":"Vaucheret","year":"2004","journal-title":"Genes Dev."},{"issue":"7263","key":"10.1016\/j.imlet.2021.07.004_bib0152","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/nature08349","article-title":"Active turnover modulates mature microRNA activity in Caenorhabditis elegans","volume":"461","author":"Chatterjee","year":"2009","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.imlet.2021.07.004_bib0153","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1111\/j.1460-9568.2010.07122.x","article-title":"Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy","volume":"31","author":"Aronica","year":"2010","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0154","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep14143","article-title":"MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy\u2013comparison with human epileptic samples","volume":"5","author":"Roncon","year":"2015","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.imlet.2021.07.004_bib0155","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/jamaneurol.2015.0941","article-title":"Neuroinflammation in temporal lobe epilepsy measured using positron emission tomographic imaging of translocator protein","volume":"72","author":"Gershen","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.imlet.2021.07.004_bib0156","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.eplepsyres.2016.09.019","article-title":"Elevated serum miR-106b and miR-146a in patients with focal and generalized epilepsy","volume":"127","author":"An","year":"2016","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.imlet.2021.07.004_bib0157","first-page":"2017","article-title":"Intranasal delivery of miR-146a mimics delayed seizure onset in the lithium-pilocarpine mouse model","author":"Tao","year":"2017","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.imlet.2021.07.004_bib0158","first-page":"2015","article-title":"Expression of Inflammation-Associated MicroRNAs in Epilepsy","author":"Leal","year":"2015","journal-title":"XLI Annual Meeting of the Portuguese Society for Immunol."},{"key":"10.1016\/j.imlet.2021.07.004_bib0159","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.nbd.2013.10.026","article-title":"Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy","volume":"62","author":"Gorter","year":"2014","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0160","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1471-2202-13-115","article-title":"MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus","volume":"13","author":"Hu","year":"2012","journal-title":"BMC neurosci."},{"key":"10.1016\/j.imlet.2021.07.004_bib0161","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nbd.2016.12.007","article-title":"Blockade of the IL-1R1\/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy","volume":"99","author":"Iori","year":"2017","journal-title":"Neurobiol. Dis."},{"issue":"4","key":"10.1016\/j.imlet.2021.07.004_bib0162","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nm.2127","article-title":"Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures","volume":"16","author":"Maroso","year":"2010","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.imlet.2021.07.004_bib0163","doi-asserted-by":"crossref","first-page":"e44789","DOI":"10.1371\/journal.pone.0044789","article-title":"MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response","volume":"7","author":"Iyer","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.imlet.2021.07.004_bib0164","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/j.1528-1167.2012.03540.x","article-title":"Interleukin-1\u03b2 and microRNA-146a in an immature rat model and children with mesial temporal lobe epilepsy","volume":"53","author":"Omran","year":"2012","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.imlet.2021.07.004_bib0165","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/epi.16502","article-title":"Circulating miR-146a and miR-134 in predicting drug-resistant epilepsy in patients with focal impaired awareness seizures","volume":"61","author":"Leontariti","year":"2020","journal-title":"Epilepsia"},{"issue":"5","key":"10.1016\/j.imlet.2021.07.004_bib0166","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1248\/bpb.b18-00937","article-title":"MicroRNA-146a-5p Downregulates the Expression of P-Glycoprotein in Rats with Lithium\u2013Pilocarpine-Induced Status Epilepticus","volume":"42","author":"Deng","year":"2019","journal-title":"Biol. Pharm. Bull."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0167","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1157.1995.tb01657.x","article-title":"MDR1 gene expression in brain of patients with medically intractable epilepsy","volume":"36","author":"Tishler","year":"1995","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0168","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/sj.onc.1206056","article-title":"NF-\u03ba B transcription factor induces drug resistance through MDR1 expression in cancer cells","volume":"22","author":"Bentires-Alj","year":"2003","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0169","first-page":"1030","article-title":"Association between NF-\u03baB expression and drug resistance of liver cancer","volume":"17","author":"Liu","year":"2019","journal-title":"Oncol. Lett."},{"issue":"8","key":"10.1016\/j.imlet.2021.07.004_bib0170","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.kjms.2017.05.010","article-title":"Regulatory effects of miR-146a\/b on the function of endothelial progenitor cells in acute ischemic stroke in mice","volume":"33","author":"Su","year":"2017","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"2","key":"10.1016\/j.imlet.2021.07.004_bib0171","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.celrep.2018.12.055","article-title":"TRIM9-mediated resolution of neuroinflammation confers neuroprotection upon ischemic stroke in mice","volume":"27","author":"Zeng","year":"2019","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.imlet.2021.07.004_bib0172","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/8432","article-title":"NF-\u03baB is activated and promotes cell death in focal cerebral ischemia","volume":"5","author":"Schneider","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.imlet.2021.07.004_bib0173","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2147\/IJGM.S213535","article-title":"The expression of microRNA 146a in patients with ischemic stroke: an observational study","volume":"12","author":"Kotb","year":"2019","journal-title":"Int. J. General Med."},{"issue":"6","key":"10.1016\/j.imlet.2021.07.004_bib0174","doi-asserted-by":"crossref","first-page":"e66393","DOI":"10.1371\/journal.pone.0066393","article-title":"microRNAs involved in regulating spontaneous recovery in embolic stroke model","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0175","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12035-015-9655-7","article-title":"MicroRNA-146a promotes oligodendrogenesis in stroke","volume":"54","author":"Liu","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.imlet.2021.07.004_bib0176","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/cei.12800","article-title":"Differential regulation of miR-146a\/FAS and miR-21\/FASLG axes in autoimmune lymphoproliferative syndrome due to FAS mutation (ALPS-FAS)","volume":"185","author":"Marega","year":"2016","journal-title":"Clinical & Experimental Immunol."},{"issue":"24","key":"10.1016\/j.imlet.2021.07.004_bib0177","first-page":"4875","article-title":"Forced miR-146a expression causes autoimmune lymphoproliferative syndrome in mice via downregulation of Fas in germinal center B cells","volume":"121","author":"Guo","year":"2013","journal-title":"Blood, The J. Am. Society of Hematol."},{"issue":"suppl_1","key":"10.1016\/j.imlet.2021.07.004_bib0178","doi-asserted-by":"crossref","DOI":"10.1161\/str.46.suppl_1.wmp86","article-title":"Abstract W MP86: Microrna-146a modulates neurogenesis and oligodendrogenesis after stroke","volume":"46","author":"Liu","year":"2015","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.imlet.2021.07.004_bib0179","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1161\/ATVBAHA.112.252619","article-title":"Combination therapy with VELCADE and tissue plasminogen activator is neuroprotective in aged rats after stroke and targets microRNA-146a and the toll-like receptor signaling pathway","volume":"32","author":"Zhang","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.imlet.2021.07.004_bib0180","first-page":"1","article-title":"The role of microRNA in neuronal inflammation and survival in the post ischemic brain: a review","author":"Li","year":"2017","journal-title":"Neurol. Res."},{"issue":"3","key":"10.1016\/j.imlet.2021.07.004_bib0181","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2174\/1567202612666150605121709","article-title":"Differential regulation of microRNAs in patients with ischemic stroke","volume":"12","author":"Li","year":"2015","journal-title":"Current neurovascular res."},{"issue":"47","key":"10.1016\/j.imlet.2021.07.004_bib0182","doi-asserted-by":"crossref","first-page":"9269","DOI":"10.1523\/JNEUROSCI.0147-18.2019","article-title":"Extracellular vesicles and neurodegenerative diseases","volume":"39","author":"Hill","year":"2019","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.imlet.2021.07.004_bib0183","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.15252\/emmm.201606271","article-title":"Identification of a novel mechanism of blood\u2013brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles","volume":"8","author":"Balusu","year":"2016","journal-title":"EMBO Mol. Med."},{"issue":"4","key":"10.1016\/j.imlet.2021.07.004_bib0184","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.bbrc.2016.09.090","article-title":"The role of extracellular vesicles in neurodegenerative diseases","volume":"483","author":"Quek","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.imlet.2021.07.004_bib0185","first-page":"3920","article-title":"MicroRNA\u2011146a protects against intracerebral hemorrhage by inhibiting inflammation and oxidative stress","volume":"18","author":"Qu","year":"2019","journal-title":"Experimental and therapeutic med."},{"issue":"4","key":"10.1016\/j.imlet.2021.07.004_bib0186","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1177\/0271678X19839501","article-title":"MicroRNA and their target mRNAs change expression in whole blood of patients after intracerebral hemorrhage","volume":"40","author":"Cheng","year":"2020","journal-title":"J. Cerebral Blood Flow & Metabolism"},{"issue":"7","key":"10.1016\/j.imlet.2021.07.004_bib0187","first-page":"3348","article-title":"MicroRNA-21 and microRNA-146a negatively regulate the secondary inflammatory response of microglia after intracerebral hemorrhage","volume":"11","author":"Wang","year":"2018","journal-title":"Int. J. Clinical and Experimental Pathol."},{"issue":"4","key":"10.1016\/j.imlet.2021.07.004_bib0188","doi-asserted-by":"crossref","first-page":"402","DOI":"10.4103\/0028-3886.28115","article-title":"Brain edema after intracerebral hemorrhage in rats: the role of inflammation","volume":"54","author":"Zhang","year":"2006","journal-title":"Neurol. India"},{"issue":"3","key":"10.1016\/j.imlet.2021.07.004_bib0189","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/0300060516630852","article-title":"Differential expression of circulating microRNAs in blood and haematoma samples from patients with intracerebral haemorrhage","volume":"44","author":"Wang","year":"2016","journal-title":"J. Int. Med. Res."},{"issue":"9","key":"10.1016\/j.imlet.2021.07.004_bib0190","first-page":"2809","article-title":"MicroRNA-23a-3p promotes the perihematomal edema formation after intracerebral hemorrhage via ZO-1","volume":"22","author":"Hu","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"9","key":"10.1016\/j.imlet.2021.07.004_bib0191","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1177\/0271678X18769513","article-title":"The intracerebral hemorrhage blood transcriptome in humans differs from the ischemic stroke and vascular risk factor control blood transcriptomes","volume":"39","author":"Stamova","year":"2019","journal-title":"J. Cerebral Blood Flow & Metabolism"},{"issue":"7","key":"10.1016\/j.imlet.2021.07.004_bib0192","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133783","article-title":"Association of altered serum microRNAs with perihematomal edema after acute intracerebral hemorrhage","volume":"10","author":"Zhu","year":"2015","journal-title":"PLoS One"},{"issue":"20","key":"10.1016\/j.imlet.2021.07.004_bib0193","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000006775","article-title":"The role of circulating miR-146a in patients with rheumatoid arthritis treated by Tripterygium wilfordii Hook F","volume":"96","author":"Chen","year":"2017","journal-title":"Medicine (Baltimore)."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0194","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000486769","article-title":"Circulating MiR-146a may be a potential biomarker of coronary heart disease in patients with subclinical hypothyroidism","volume":"45","author":"Quan","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"8","key":"10.1016\/j.imlet.2021.07.004_bib0195","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1194\/jlr.R083915","article-title":"Role of sphingolipids in the biogenesis and biological activity of extracellular vesicles","volume":"59","author":"Verderio","year":"2018","journal-title":"J. Lipid Res."},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0196","first-page":"e12001","article-title":"Biomarker potential of brain-secreted extracellular vesicles in blood in Alzheimer's disease, Alzheimer's & Dementia: Diagnosis","volume":"12","author":"Badhwar","year":"2020","journal-title":"Assessment & Disease Monitoring"},{"key":"10.1016\/j.imlet.2021.07.004_bib0197","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fnmol.2020.00079","article-title":"Brain Derived Exosomes Are a Double-Edged Sword in Alzheimer's Disease","volume":"13","author":"Song","year":"2020","journal-title":"Front. mol. neurosci."},{"issue":"21","key":"10.1016\/j.imlet.2021.07.004_bib0198","doi-asserted-by":"crossref","first-page":"10937","DOI":"10.1093\/nar\/gks832","article-title":"Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells","volume":"40","author":"Bellingham","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"67","key":"10.1016\/j.imlet.2021.07.004_bib0199","doi-asserted-by":"crossref","first-page":"9695","DOI":"10.1039\/D0CC04249H","article-title":"First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases","volume":"56","author":"Gabr","year":"2020","journal-title":"Chem. Commun."},{"issue":"5","key":"10.1016\/j.imlet.2021.07.004_bib0200","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.pharep.2017.04.015","article-title":"Introduction of \u03b2-d-mannuronic acid (M2000) as a novel NSAID with immunosuppressive property based on COX-1\/COX-2 activity and gene expression","volume":"69","author":"Mirshafiey","year":"2017","journal-title":"Pharmacological reports"},{"issue":"2","key":"10.1016\/j.imlet.2021.07.004_bib0201","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1081\/IPH-200067751","article-title":"Novel immunosuppressive therapy by M2000 in experimental multiple sclerosis","volume":"27","author":"Mirshafiey","year":"2005","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"3","key":"10.1016\/j.imlet.2021.07.004_bib0202","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.pharep.2017.01.021","article-title":"Pharmacological effects of \u03b2-d-mannuronic acid (M2000) on miR-146a, IRAK1, TRAF6 and NF-\u03baB gene expression, as target molecules in inflammatory reactions","volume":"69","author":"Mortazavi-Jahromi","year":"2017","journal-title":"Pharmacological reports"},{"key":"10.1016\/j.imlet.2021.07.004_bib0203","first-page":"1","article-title":"A controlled, randomized phase II clinical trial for efficacy and safety evaluation of mannuronic acid in secondary progressive form of multiple sclerosis","author":"Najafi","year":"2020","journal-title":"Int. J. Neurosci. (just-accepted)"},{"issue":"1","key":"10.1016\/j.imlet.2021.07.004_bib0204","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/1533317516678086","article-title":"Effects of M2000 (D-mannuronic acid) on learning, memory retrieval, and associated determinants in a rat model of Alzheimer's disease","volume":"32","author":"Athari Nik Azm","year":"2017","journal-title":"Am. J. Alzheimer's Disease & Other Dementias\u00ae"},{"issue":"6","key":"10.1016\/j.imlet.2021.07.004_bib0205","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/acn3.414","article-title":"Effects of fumarates on inflammatory human astrocyte responses and oligodendrocyte differentiation","volume":"4","author":"Galloway","year":"2017","journal-title":"Ann. clin. translational neurol."},{"issue":"8","key":"10.1016\/j.imlet.2021.07.004_bib0206","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1096\/fj.201701533R","article-title":"Exosome-associated miRNA profile as a prognostic tool for therapy response monitoring in multiple sclerosis patients","volume":"32","author":"Manna","year":"2018","journal-title":"FASEB J."},{"issue":"8","key":"10.1016\/j.imlet.2021.07.004_bib0207","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.neurobiolaging.2014.02.012","article-title":"Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease","volume":"35","author":"Dinkins","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"4","key":"10.1016\/j.imlet.2021.07.004_bib0208","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat. Biotechnol."},{"issue":"12","key":"10.1016\/j.imlet.2021.07.004_bib0209","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/stem.1409","article-title":"MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles","volume":"31","author":"Xin","year":"2013","journal-title":"Stem Cells"},{"issue":"18","key":"10.1016\/j.imlet.2021.07.004_bib0210","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201904040","article-title":"Exosomes and nanoengineering: a match made for precision therapeutics","volume":"32","author":"Tran","year":"2020","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.imlet.2021.07.004_bib0211","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s12195-016-0458-3","article-title":"Elucidation of exosome migration across the blood\u2013brain barrier model in vitro","volume":"9","author":"Chen","year":"2016","journal-title":"Cell. Mol. Bioeng."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247821001139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247821001139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:39:05Z","timestamp":1759045145000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247821001139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":211,"alternative-id":["S0165247821001139"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2021.07.004","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficient roles of miR-146a in cellular and molecular mechanisms of neuroinflammatory disorders: An effectual review in neuroimmunology","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2021.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}