{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:23:28Z","timestamp":1786991008954,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QH116"],"award-info":[{"award-number":["ZR2020QH116"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.imlet.2022.11.001","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T21:50:23Z","timestamp":1667512223000},"page":"63-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Synergistic regulation of microglia differentiation by CD93 and integrin \u03b21 in the rat pneumococcal meningitis model"],"prefix":"10.1016","volume":"251-252","author":[{"given":"Nana","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.imlet.2022.11.001_bib0001","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.2217\/fmb.15.43","article-title":"Bacterial meningitis: insights into pathogenesis and evaluation of new treatment options: a perspective from experimental studies","volume":"10","author":"Liechti","year":"2015","journal-title":"Futur. Microbiol."},{"issue":"3","key":"10.1016\/j.imlet.2022.11.001_bib0002","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1056\/NEJMoa0800836","article-title":"Effect of pneumococcal conjugate vaccine on pneumococcal meningitis","volume":"360","author":"Hsu","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"21","key":"10.1016\/j.imlet.2022.11.001_bib0003","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1056\/NEJMoa1005384","article-title":"Emerging infections programs network, bacterial meningitis in the United States, 1998-2007","volume":"364","author":"Thigpen","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.imlet.2022.11.001_bib0004","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3389\/fmicb.2019.00576","article-title":"The role of microglia in bacterial meningitis: inflammatory response, experimental models and new neuroprotective therapeutic strategies","volume":"10","author":"Thorsdottir","year":"2019","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.imlet.2022.11.001_bib0005","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/imm.12974","article-title":"CD93 regulates central nervous system inflammation in two mouse models of autoimmune encephalomyelitis","volume":"155","author":"Griffiths","year":"2018","journal-title":"Immunology"},{"issue":"11","key":"10.1016\/j.imlet.2022.11.001_bib0006","doi-asserted-by":"crossref","first-page":"6407","DOI":"10.4049\/jimmunol.0902342","article-title":"CD93\/AA4.1: a novel regulator of inflammation in murine focal cerebral ischemia","volume":"184","author":"Harhausen","year":"2010","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.imlet.2022.11.001_bib0007","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1042\/bst0301010","article-title":"Structure-function studies of the receptors for complement C1q","volume":"30","author":"McGreal","year":"2002","journal-title":"Biochem. Soc. Trans."},{"issue":"4","key":"10.1016\/j.imlet.2022.11.001_bib0008","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.4049\/jimmunol.1700165","article-title":"Lung epithelial cell-derived microvesicles regulate macrophage migration via MicroRNA-17\/221-induced integrin \u03b21 recycling","volume":"199","author":"Lee","year":"2017","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.imlet.2022.11.001_bib0009","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1172\/JCI97459","article-title":"CD93 promotes \u03b21 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis","volume":"128","author":"Lugano","year":"2018","journal-title":"J. Clin. Investig."},{"issue":"4","key":"10.1016\/j.imlet.2022.11.001_bib0010","first-page":"634","article-title":"Crosstalk between CD93, C1q and GIPC in the regulation of pneumococcal meningitis inflammation","volume":"52","author":"Qiao","year":"2022","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"14","key":"10.1016\/j.imlet.2022.11.001_bib0011","doi-asserted-by":"crossref","first-page":"13906","DOI":"10.1074\/jbc.M413627200","article-title":"Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis","volume":"280","author":"Papadopoulos","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2022.11.001_bib0012","doi-asserted-by":"crossref","first-page":"401","DOI":"10.12688\/f1000research.13793.1","article-title":"A world without bacterial meningitis: how genomic epidemiology can inform vaccination strategy","volume":"7","author":"Rodrigues","year":"2018","journal-title":"F1000Res."},{"issue":"9963","key":"10.1016\/j.imlet.2022.11.001_bib0013","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"385","year":"2015","journal-title":"J. Lancet."},{"issue":"1","key":"10.1016\/j.imlet.2022.11.001_bib0014","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0166-2236(00)02024-5","article-title":"Neuronal injury in bacterial meningitis: mechanisms and implications for therapy","volume":"25","author":"Nau","year":"2002","journal-title":"Trends Neurosci."},{"issue":"5","key":"10.1016\/j.imlet.2022.11.001_bib0015","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nrn3722","article-title":"Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease","volume":"15","author":"Prinz","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.imlet.2022.11.001_bib0016","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3389\/fimmu.2014.00594","article-title":"Are \"resting\" microglia more \"m2\"?","volume":"5","author":"Cherry","year":"2014","journal-title":"Front. Immunol."},{"issue":"17","key":"10.1016\/j.imlet.2022.11.001_bib0017","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1111\/febs.14985","article-title":"C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation","volume":"286","author":"Khan","year":"2019","journal-title":"FEBS J."},{"issue":"8","key":"10.1016\/j.imlet.2022.11.001_bib0018","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.4049\/jimmunol.0904011","article-title":"Soluble CD93 induces differentiation of monocytes and enhances TLR responses","volume":"185","author":"Jeon","year":"2010","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.imlet.2022.11.001_bib0019","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-2796.2011.02364.x","article-title":"Plasma CD93 concentration is a potential novel biomarker for coronary artery disease","volume":"270","author":"M\u00e4larstig","year":"2011","journal-title":"J. Intern. Med."},{"issue":"3","key":"10.1016\/j.imlet.2022.11.001_bib0020","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2174\/138945012799424651","article-title":"CD93: recent advances and implications in disease","volume":"13","author":"Greenlee-Wacker","year":"2012","journal-title":"Curr. Drug Targets"},{"issue":"22","key":"10.1016\/j.imlet.2022.11.001_bib0021","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.4103\/1673-5374.145383","article-title":"CD93 and GIPC expression and localization during central nervous system inflammation","volume":"9","author":"Liu","year":"2014","journal-title":"Neural Regen. Res."},{"issue":"2","key":"10.1016\/j.imlet.2022.11.001_bib0022","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1074-7613(00)80419-7","article-title":"cDNA cloning and primary structure analysis of C1qR(P), the human C1q\/MBL\/SPA receptor that mediates enhanced phagocytosis in vitro","volume":"6","author":"Nepomuceno","year":"1997","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.imlet.2022.11.001_bib0023","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1189\/jlb.71.1.133","article-title":"Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning","volume":"71","author":"Steinberger","year":"2002","journal-title":"J. Leukoc. Biol."},{"issue":"10","key":"10.1016\/j.imlet.2022.11.001_bib0024","doi-asserted-by":"crossref","first-page":"5222","DOI":"10.4049\/jimmunol.168.10.5222","article-title":"Human C1qRp is identical with CD93 and the mNI-11 antigen but does not bind C1q","volume":"168","author":"McGreal","year":"2002","journal-title":"J. Immunol."},{"issue":"6560","key":"10.1016\/j.imlet.2022.11.001_bib0025","doi-asserted-by":"crossref","first-page":"eabj2685","DOI":"10.1126\/science.abj2685","article-title":"Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury","volume":"373","author":"Holden","year":"2021","journal-title":"Science"},{"issue":"6286","key":"10.1016\/j.imlet.2022.11.001_bib0026","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.imlet.2022.11.001_bib0027","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.4049\/jimmunol.175.2.1239","article-title":"CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma","volume":"175","author":"Bohlson","year":"2005","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.imlet.2022.11.001_bib0028","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nn1997","article-title":"Microglia: active sensor and versatile effector cells in the normal and pathologic brain","volume":"10","author":"Hanisch","year":"2007","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.imlet.2022.11.001_bib0029","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.imlet.2022.11.001_bib0030","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0031-6997(24)01359-0","article-title":"Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins","volume":"50","author":"Aplin","year":"1998","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.imlet.2022.11.001_bib0031","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1006\/exnr.2000.7575","article-title":"Effect of lipopolysaccharide on the morphology and integrin immunoreactivity of ramified microglia in the mouse brain and in cell culture","volume":"168","author":"Kloss","year":"2001","journal-title":"Exp. Neurol."},{"issue":"44","key":"10.1016\/j.imlet.2022.11.001_bib0032","doi-asserted-by":"crossref","first-page":"9838","DOI":"10.1523\/JNEUROSCI.2557-04.2004","article-title":"Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism","volume":"24","author":"Koenigsknecht","year":"2004","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.imlet.2022.11.001_bib0033","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.4049\/jimmunol.170.7.3850","article-title":"The extracellular matrix and cytokines regulate microglial integrin expression and activation","volume":"170","author":"Milner","year":"2003","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.imlet.2022.11.001_bib0034","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/(SICI)1096-9861(19990816)411:1<162::AID-CNE12>3.0.CO;2-W","article-title":"Integrin family of cell adhesion molecules in the injured brain: regulation and cellular localization in the normal and regenerating mouse facial motor nucleus","volume":"411","author":"Kloss","year":"1999","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.imlet.2022.11.001_bib0035","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0165-5728(90)90055-R","article-title":"Brain microglia constitutively express beta-2 integrins","volume":"30","author":"Akiyama","year":"1990","journal-title":"J. Neuroimmunol."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247822001493?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247822001493?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:41:23Z","timestamp":1759045283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247822001493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":35,"alternative-id":["S0165247822001493"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2022.11.001","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic regulation of microglia differentiation by CD93 and integrin \u03b21 in the rat pneumococcal meningitis model","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2022.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V. on behalf of European Federation of Immunological Societies.","name":"copyright","label":"Copyright"}]}}