{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T21:01:30Z","timestamp":1765486890909,"version":"3.44.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.imlet.2023.03.004","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T12:22:49Z","timestamp":1678882969000},"page":"9-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Mechanistic insights into immunopathogenesis of murine cerebral malaria: Cues from \u201cyoung\u201d C57BL\/6J and BALB\/c mice"],"prefix":"10.1016","volume":"256-257","author":[{"given":"Shweta","family":"Rai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meetali","family":"Girdhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fouzia","family":"Siraj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheetal","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju","family":"Katyal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2023.03.004_bib0001","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0169-4758(94)90237-2","article-title":"The cytokine theory of human cerebral malaria","volume":"10","author":"Clark","year":"1994","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.imlet.2023.03.004_bib0002","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/S0020-7519(97)00121-5","article-title":"The biological basis of malarial disease","volume":"27","author":"Clark","year":"1997","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0003","first-page":"1473","article-title":"Tumor necrosis factor-alpha expression in the brain during fatal murine cerebral malaria: evidence for production by microglia and astrocytes","volume":"150","author":"Medana","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0004","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1128\/IAI.68.9.5364-5376.2000","article-title":"Immunopathology of cerebral malaria: morphological evidence of parasite sequestration in murine brain microvasculature","volume":"68","author":"Hearn","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imlet.2023.03.004_bib0005","first-page":"204","article-title":"Mouse models of blood-stage malaria infections: immune responses and cytokines involved in protection and pathology","volume":"80","author":"Langhorne","year":"2002","journal-title":"Chem. Immunol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0006","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nri1311","article-title":"Innate immunity to malaria","volume":"4","author":"Stevenson","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0007","first-page":"103","article-title":"Experimental models of cerebral malaria","volume":"297","author":"Engwerda","year":"2005","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0008","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nm986","article-title":"Differentiating the pathologies of cerebral malaria by postmortem parasite counts","volume":"10","author":"Taylor","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.imlet.2023.03.004_bib0009","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1017\/S0031182009991715","article-title":"Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease","volume":"137","author":"de Souza","year":"2010","journal-title":"Parasitology"},{"key":"10.1016\/j.imlet.2023.03.004_bib0010","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1126\/science.1103717","article-title":"A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses","volume":"307","author":"Hall","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.imlet.2023.03.004_bib0011","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.7761856","article-title":"Stable transfection of malaria parasite blood stages","volume":"268","author":"van Dijk","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.imlet.2023.03.004_bib0012","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0169-4758(98)01248-4","article-title":"Transfection systems for animal models of malaria","volume":"14","author":"Tomas","year":"1998","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.imlet.2023.03.004_bib0013","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1128\/IAI.01783-06","article-title":"CD4+ CD25+ regulatory T cells suppress CD4+ T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesis","volume":"75","author":"Nie","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imlet.2023.03.004_bib0014","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1365-3024.2000.00295.x","article-title":"Differential immunoglobulin E and cytokine responses in BALB\/c and C57Bl\/6 mice during repeated infections with blood-stage Plasmodium chabaudi malaria","volume":"22","author":"Helmby","year":"2000","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0015","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0016","doi-asserted-by":"crossref","first-page":"e13124","DOI":"10.1371\/journal.pone.0013124","article-title":"A rapid murine coma and behavior scale for quantitative assessment of murine cerebral malaria","volume":"5","author":"Carroll","year":"2010","journal-title":"PLOS One"},{"key":"10.1016\/j.imlet.2023.03.004_bib0017","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005470","article-title":"Experimental cerebral malaria spreads along the rostral migratory stream","volume":"12","author":"Hoffmann","year":"2016","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.imlet.2023.03.004_bib0018","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.ajpath.2011.01.016","article-title":"The neuropathology of fatal cerebral malaria in malawian children","volume":"178","author":"Dorovini-Zis","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0019","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002982","article-title":"Neuroimmunological blood brain barrier opening in experimental cerebral malaria","volume":"8","author":"Nacer","year":"2012","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.imlet.2023.03.004_bib0020","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0076-6879(07)00823-3","article-title":"Nitrite and nitrate measurement by Griess reagent in human plasma: evaluation of interferences and standardization","volume":"440","author":"Giustarini","year":"2008","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0021","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri1394","article-title":"Neonatal adaptive immunity comes of age","volume":"4","author":"Adkins","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0022","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00436-010-2121-6","article-title":"Histopathological studies in two strains of semi-immune mice infected with Plasmodium berghei ANKA after chronic exposure","volume":"108","author":"Helegbe","year":"2011","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.imlet.2023.03.004_bib0023","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3347\/kjp.2013.51.3.289","article-title":"Age-related CD4 + CD25 + Foxp3 + regulatory T-cell responses during Plasmodium berghei ANKA infection in mice susceptible or resistant to cerebral malaria","volume":"51","author":"Shan","year":"2013","journal-title":"Korean J. Parasitol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0024","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0035-9203(90)90258-G","article-title":"An estimation of the number of malaria sporozoites ejected by a feeding mosquito","volume":"84","author":"Rosenberg","year":"1990","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.imlet.2023.03.004_bib0025","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-2915.1991.tb00523.x","article-title":"Quantitation of malaria sporozoites transmitted in vitro during salivation by wild Afrotropical Anopheles","volume":"5","author":"Beier","year":"1991","journal-title":"Med. Vet. Entomol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0026","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0169-4758(92)90176-3","article-title":"For a few parasites more: inoculum size, vector control and strain-specific immunity to malaria","volume":"8","author":"Lines","year":"1992","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.imlet.2023.03.004_bib0027","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0169-4758(93)90010-D","article-title":"Malaria sporozoites: survival, transmission and disease control","volume":"9","author":"Beier","year":"1993","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.imlet.2023.03.004_bib0028","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1600-0463.2007.apm_659.x","article-title":"Calcium channel antagonist (nifedipine) attenuates Plasmodium berghei-specific T cell immune responses in Balb\/C mice","volume":"115","author":"Moshal","year":"2007","journal-title":"APMIS"},{"key":"10.1016\/j.imlet.2023.03.004_bib0029","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fcimb.2014.00104","article-title":"The systemic pathology of cerebral malaria in African children","volume":"4","author":"Milner","year":"2014","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0030","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.049410","article-title":"Cerebral malaria - modelling interactions at the blood-brain barrier in vitro","volume":"15","author":"Adams","year":"2022","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.imlet.2023.03.004_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.741370","article-title":"The potential roles of glial cells in the neuropathogenesis of cerebral malaria","volume":"11","author":"Andoh","year":"2021","journal-title":"Front Cell Infect. Microbiol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0032","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0006-8993(92)91004-X","article-title":"Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death","volume":"587","author":"Boje","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.imlet.2023.03.004_bib0033","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0008-8749(92)90131-8","article-title":"Production of nitrite by neonatal rat microglial cells\/brain macrophages","volume":"141","author":"Zielasek","year":"1992","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0034","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S1473-3099(02)00344-4","article-title":"The immune response to Plasmodium falciparum malaria","volume":"2","author":"Malaguarnera","year":"2002","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.imlet.2023.03.004_bib0035","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1128\/IAI.01475-07","article-title":"Common strategies to prevent and modulate experimental cerebral malaria in mouse strains with different susceptibilities","volume":"76","author":"Randall","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imlet.2023.03.004_bib0036","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35005132","article-title":"The structure of malaria pigment beta-haematin","volume":"404","author":"Pagola","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2023.03.004_bib0037","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0035-9203(98)90954-3","article-title":"The effect of synthetic malaria pigment (beta-haematin) on adhesion molecule expression and interleukin-6 production by human endothelial cells","volume":"92","author":"Taramelli","year":"1998","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.imlet.2023.03.004_bib0038","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.4049\/jimmunol.171.8.4243","article-title":"Hemozoin increases IFN-gamma-inducible macrophage nitric oxide generation through extracellular signal-regulated kinase- and NF-kappa B-dependent pathways","volume":"171","author":"Jaramillo","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0039","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/clinids\/19.1.117","article-title":"Putative pathophysiological interactions of cytokines and phagocytic cells in severe human falciparum malaria","volume":"19","author":"Urquhart","year":"1994","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.imlet.2023.03.004_bib0040","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1046\/j.1365-2567.1997.00290.x","article-title":"Interleukin-10 modulates susceptibility in experimental cerebral malaria","volume":"91","author":"Kossodo","year":"1997","journal-title":"Immunology"},{"key":"10.1016\/j.imlet.2023.03.004_bib0041","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4049\/jimmunol.157.2.798","article-title":"In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha","volume":"157","author":"Gazzinelli","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0042","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1046\/j.1365-2249.1997.4401337.x","article-title":"Elevated plasma levels of IgE in Plasmodium falciparum-primed individuals reflect an increased ratio of IL-4 to interferon-gamma (IFN-gamma)-producing cells","volume":"109","author":"Elghazali","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0043","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1365-2249.1993.tb05951.x","article-title":"Differential induction of helper T cell subsets during blood-stage Plasmodium chabaudi AS infection in resistant and susceptible mice","volume":"92","author":"Stevenson","year":"1993","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0044","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/sj.gene.6363660","article-title":"Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes","volume":"1","author":"Lipoldov\u00e1","year":"2000","journal-title":"Genes Immun."},{"key":"10.1016\/j.imlet.2023.03.004_bib0045","doi-asserted-by":"crossref","first-page":"4532","DOI":"10.4049\/jimmunol.159.9.4532","article-title":"TNF-alpha and IL-4 synergistically increase vascular cell adhesion molecule-1 expression in cultured vascular smooth muscle cells","volume":"159","author":"Barks","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2023.03.004_bib0046","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1084\/jem.176.4.1183","article-title":"Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1","volume":"176","author":"Ockenhouse","year":"1992","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2023.03.004_bib0047","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1203\/PDR.0b013e3181eee738","article-title":"Cerebral malaria: mechanisms of brain injury and strategies for improved neurocognitive outcome","volume":"68","author":"Idro","year":"2010","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.imlet.2023.03.004_bib0048","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1136\/adc.81.2.185","article-title":"Nitric oxide and infectious diseases","volume":"81","author":"Burgner","year":"1999","journal-title":"Arch. Dis. Child."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247823000391?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247823000391?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:42:16Z","timestamp":1759045336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247823000391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":48,"alternative-id":["S0165247823000391"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2023.03.004","relation":{},"ISSN":["0165-2478"],"issn-type":[{"type":"print","value":"0165-2478"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic insights into immunopathogenesis of murine cerebral malaria: Cues from \u201cyoung\u201d C57BL\/6J and BALB\/c mice","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2023.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}