{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:13:33Z","timestamp":1778145213667,"version":"3.51.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270297"],"award-info":[{"award-number":["82270297"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020371","name":"New Sunshine Charity Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020371","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011841","name":"Xinxiang Medical University","doi-asserted-by":"publisher","award":["300\/505410"],"award-info":[{"award-number":["300\/505410"]}],"id":[{"id":"10.13039\/501100011841","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.imlet.2023.09.003","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T16:36:09Z","timestamp":1694104569000},"page":"14-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Modulation of oxidized low-density lipoprotein-affected macrophage efferocytosis by mitochondrial calcium uniporter in a murine model"],"prefix":"10.1016","volume":"263","author":[{"given":"Na","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-fan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He-fan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng-le","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing-jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian-wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.imlet.2023.09.003_bib0001","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1016\/j.cell.2022.04.004","article-title":"Atherosclerosis: recent developments","volume":"185","author":"Bjorkegren","year":"2022","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.imlet.2023.09.003_bib0002","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41580-020-0232-1","article-title":"The clearance of dead cells by efferocytosis","volume":"21","author":"How macrophages deal with deathBoada-Romero","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.imlet.2023.09.003_bib0003","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41577-019-0240-6","article-title":"Efferocytosis in health and disease","volume":"20","author":"Doran","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.imlet.2023.09.003_bib0004","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41573-022-00470-y","article-title":"Drugging the efferocytosis process: concepts and opportunities","volume":"21","author":"Mehrotra","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.imlet.2023.09.003_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.839248","article-title":"Efferocytosis and its role in inflammatory disorders","volume":"10","author":"Ge","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.imlet.2023.09.003_bib0006","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.freeradbiomed.2004.10.028","article-title":"Oxidized low-density lipoprotein elicits an intracellular calcium rise and increases the binding activity of the transcription factor NFAT","volume":"38","author":"Maziere","year":"2005","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.imlet.2023.09.003_bib0007","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/JLB.2A1017-407RR","article-title":"Oxidized LDL phagocytosis during foam cell formation in atherosclerotic plaques relies on a PLD2-CD36 functional interdependence","volume":"103","author":"Ganesan","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.imlet.2023.09.003_bib0008","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.cellsig.2018.10.020","article-title":"Sterol regulatory element binding protein (SREBP) -1 mediates oxidized low-density lipoprotein (oxLDL) induced macrophage foam cell formation through NLRP3 inflammasome activation","volume":"53","author":"Varghese","year":"2019","journal-title":"Cell Signal"},{"issue":"19","key":"10.1016\/j.imlet.2023.09.003_bib0009","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194966","article-title":"Mitochondrial calcium uptake is instrumental to alternative macrophage polarization and phagocytic activity","volume":"20","author":"Tedesco","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.imlet.2023.09.003_bib0010","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/CIRCULATIONAHA.116.025684","article-title":"The role of efferocytosis in atherosclerosis","volume":"135","author":"Kojima","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.imlet.2023.09.003_bib0011","article-title":"Potential mechanisms and effects of efferocytosis in atherosclerosis","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)."},{"key":"10.1016\/j.imlet.2023.09.003_bib0012","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.202200277","article-title":"Constructing mal-efferocytic macrophage model and its atherosclerotic spheroids and rat model for therapeutic evaluation","author":"Zou","year":"2023","journal-title":"Adv. Biol. (Weinh)"},{"issue":"3","key":"10.1016\/j.imlet.2023.09.003_bib0013","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/FJC.0000000000001311","article-title":"The impaired mechanism and facilitated therapies of efferocytosis in atherosclerosis","volume":"80","author":"Wang","year":"2022","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.imlet.2023.09.003_bib0014","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.1038\/s41467-020-19272-0","article-title":"Crbn modulates calcium influx by regulating Orai1 during efferocytosis","volume":"11","author":"Moon","year":"2020","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.imlet.2023.09.003_bib0015","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1038\/s41467-022-30959-4","article-title":"Efferocytosis requires periphagosomal Ca(2+)-signaling and TRPM7-mediated electrical activity","volume":"13","author":"Schappe","year":"2022","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.imlet.2023.09.003_bib0016","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8122047","article-title":"Ca(2+) flux: searching for a role in efferocytosis of apoptotic cells in atherosclerosis","volume":"8","author":"Tajbakhsh","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.imlet.2023.09.003_bib0017","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.yjmcc.2020.10.015","article-title":"Calcium influx through the mitochondrial calcium uniporter holocomplex, MCUcx","volume":"151","author":"Boyman","year":"2021","journal-title":"J. Mol. Cell Cardiol."},{"issue":"35","key":"10.1016\/j.imlet.2023.09.003_bib0018","doi-asserted-by":"crossref","first-page":"21731","DOI":"10.1073\/pnas.2005976117","article-title":"Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca(2+) uptake","volume":"117","author":"Vais","year":"2020","journal-title":"Proc. Natl Acad. Sci. U S A"},{"issue":"2","key":"10.1016\/j.imlet.2023.09.003_bib0019","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s10787-021-00795-x","article-title":"Anti-inflammatory effects of Chrysophyllum cainito fruit extract in lipopolysaccharide-stimulated mouse peritoneal macrophages","volume":"29","author":"Arana-Argaez","year":"2021","journal-title":"Inflammopharmacology"},{"issue":"16","key":"10.1016\/j.imlet.2023.09.003_bib0020","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.1002\/anie.202000247","article-title":"Redox stability controls the cellular uptake and activity of ruthenium-based inhibitors of the mitochondrial calcium uniporter (MCU)","volume":"59","author":"Woods","year":"2020","journal-title":"Angew. Chem. Int. Ed Engl."},{"issue":"1","key":"10.1016\/j.imlet.2023.09.003_bib0021","first-page":"199","article-title":"Effects of MERTK inhibitors UNC569 and UNC1062 on the growth of acute myeloid leukaemia cells","volume":"38","author":"Koda","year":"2018","journal-title":"Anticancer Res."},{"key":"10.1016\/j.imlet.2023.09.003_bib0022","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.neuro.2021.10.007","article-title":"Resveratrol prevents haloperidol-induced mitochondria dysfunction through the induction of autophagy in SH-SY5Y cells","volume":"87","author":"Hu","year":"2021","journal-title":"Neurotoxicology"},{"issue":"160","key":"10.1016\/j.imlet.2023.09.003_bib0023","doi-asserted-by":"crossref","DOI":"10.3791\/60682","article-title":"Detection of total reactive oxygen species in adherent cells by 2\u2032,7\u2032-dichlorodihydrofluorescein diacetate staining","author":"Kim","year":"2020","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.imlet.2023.09.003_bib0024","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00395-021-00905-4","article-title":"Protective effect of HINT2 on mitochondrial function via repressing MCU complex activation attenuates cardiac microvascular ischemia-reperfusion injury","volume":"116","author":"Li","year":"2021","journal-title":"Basic Res. Cardiol."},{"issue":"3","key":"10.1016\/j.imlet.2023.09.003_bib0025","first-page":"197","article-title":"[Application of the Ca2+ indicator fluo-3 and fluo-4 in the process of H2O2 induced apoptosis of A549 cell]","volume":"17","author":"Zhang","year":"2014","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"10.1016\/j.imlet.2023.09.003_bib0026","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/978-3-319-54090-0_7","article-title":"F4\/80 as a major macrophage marker: the case of the peritoneum and spleen","volume":"62","author":"Dos Anjos Cassado","year":"2017","journal-title":"Results Probl. Cell Differ."},{"issue":"11","key":"10.1016\/j.imlet.2023.09.003_bib0027","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1253\/circj.CJ-16-0924","article-title":"Macrophage apoptosis and efferocytosis in the pathogenesis of atherosclerosis","volume":"80","author":"Linton","year":"2016","journal-title":"Circ. J."},{"issue":"7","key":"10.1016\/j.imlet.2023.09.003_bib0028","first-page":"389","article-title":"Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities","volume":"16","author":"Back","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.imlet.2023.09.003_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2021.02.025","article-title":"The ABCA1-efferocytosis axis: a new strategy to protect against atherosclerosis","volume":"518","author":"Chen","year":"2021","journal-title":"Clin. Chim Acta"},{"key":"10.1016\/j.imlet.2023.09.003_bib0030","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fcvm.2017.00086","article-title":"Mechanisms and consequences of defective efferocytosis in atherosclerosis","volume":"4","author":"Yurdagul","year":"2017","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.imlet.2023.09.003_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.731769","article-title":"Guanxinkang decoction attenuates the inflammation in atherosclerosis by regulating efferocytosis and MAPKs signaling pathway in LDLR(-\/-) mice and RAW264.7 cells","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.imlet.2023.09.003_bib0032","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev-cellbio-111315-125315","article-title":"Cell Removal: efferocytosis","volume":"33","author":"Henson","year":"2017","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.imlet.2023.09.003_bib0033","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/imcb.12206","article-title":"Efferocytosis: molecular mechanisms and pathophysiological perspectives","volume":"97","author":"Gheibi Hayat","year":"2019","journal-title":"Immunol. Cell Biol."},{"issue":"10","key":"10.1016\/j.imlet.2023.09.003_bib0034","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1161\/ATVBAHA.119.313115","article-title":"Mechanism of enhanced MerTK-dependent macrophage efferocytosis by extracellular vesicles","volume":"39","author":"de Couto","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.imlet.2023.09.003_bib0035","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/j.2040-4603.2017.tb00748.x","article-title":"Calcium transport and signaling in mitochondria","volume":"7","author":"Bravo-Sagua","year":"2017","journal-title":"Compr. Physiol."},{"issue":"4","key":"10.1016\/j.imlet.2023.09.003_bib0036","doi-asserted-by":"crossref","first-page":"C465","DOI":"10.1152\/ajpcell.00502.2020","article-title":"Molecular nature and physiological role of the mitochondrial calcium uniporter channel","volume":"320","author":"Alevriadou","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.imlet.2023.09.003_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2020.102322","article-title":"The molecular complexity of the mitochondrial calcium uniporter","volume":"93","author":"Feno","year":"2021","journal-title":"Cell Calcium"},{"issue":"19","key":"10.1016\/j.imlet.2023.09.003_bib0038","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019104285","article-title":"The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter","volume":"39","author":"Wu","year":"2020","journal-title":"EMBO J."},{"issue":"12","key":"10.1016\/j.imlet.2023.09.003_bib0039","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.cmet.2021.10.015","article-title":"Efferocytosis induces macrophage proliferation to help resolve tissue injury","volume":"33","author":"Gerlach","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.imlet.2023.09.003_bib0040","article-title":"Gas6 promotes microglia efferocytosis and suppresses inflammation through activating Axl\/Rac1 signaling in subarachnoid hemorrhage mice","author":"Tang","year":"2022","journal-title":"Transl. Stroke Res."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247823001463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247823001463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:42:38Z","timestamp":1759045358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247823001463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":40,"alternative-id":["S0165247823001463"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2023.09.003","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of oxidized low-density lipoprotein-affected macrophage efferocytosis by mitochondrial calcium uniporter in a murine model","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2023.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}