{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:01:18Z","timestamp":1793138478995,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004564","name":"Republika Srbija Ministarstvo nauke i tehnolo\u0161kog razvoja","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.imlet.2024.106852","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T02:28:21Z","timestamp":1710815301000},"page":"106852","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Brain inflammation in experimental autoimmune encephalomyelitis induced in Dark Agouti rats with spinal cord homogenate"],"prefix":"10.1016","volume":"267","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-1994","authenticated-orcid":false,"given":"Goran","family":"Stegnjai\u0107","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1076-0543","authenticated-orcid":false,"given":"Bojan","family":"Jevti\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9657-2094","authenticated-orcid":false,"given":"Milica","family":"Lazarevi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0110ur\u0111ica","family":"Ignjatovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2128-3738","authenticated-orcid":false,"given":"Mirko","family":"Tomi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-9977","authenticated-orcid":false,"given":"Neda","family":"Nikolovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7649-0304","authenticated-orcid":false,"given":"Ivana","family":"Bjelobaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0866-7286","authenticated-orcid":false,"given":"Miljana","family":"Mom\u010dilovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9094-5248","authenticated-orcid":false,"given":"Mirjana","family":"Dimitrijevi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5613-9306","authenticated-orcid":false,"given":"\u0110or\u0111e","family":"Miljkovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0781-8828","authenticated-orcid":false,"given":"Suzana","family":"Stanisavljevi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2024.106852_bib0001","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jaut.2014.06.004","article-title":"From classic to spontaneous and humanized models of multiple sclerosis: impact on understanding pathogenesis and drug development","volume":"54","author":"Ben-Nun","year":"2014","journal-title":"J. Autoimmun."},{"issue":"354","key":"10.1016\/j.imlet.2024.106852_bib0002","article-title":"Complete Freund's adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies","volume":"15","author":"Lazarevi\u0107","year":"2021","journal-title":"J. Neuroimmunol."},{"issue":"Pt 1","key":"10.1016\/j.imlet.2024.106852_bib0003","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/brain\/116.1.147","article-title":"Blood-brain barrier breakdown in MBP-specific T cell induced experimental allergic encephalomyelitis. A quantitative in vivo MRI study","volume":"116","author":"Namer","year":"1993","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.imlet.2024.106852_bib0004","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1189\/jlb.70.6.849","article-title":"Modes of action of Freund's adjuvants in experimental models of autoimmune diseases","volume":"70","author":"Billiau","year":"2001","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.imlet.2024.106852_bib0005","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1460-9568.2004.03514.x","article-title":"Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS","volume":"20","author":"Raghavendra","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.imlet.2024.106852_bib0006","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jneumeth.2017.04.003","article-title":"Consistent induction of chronic experimental autoimmune encephalomyelitis in C57BL\/6 mice for the longitudinal study of pathology and repair","volume":"1","author":"Hasselmann","year":"2017","journal-title":"J. Neurosci. Methods"},{"issue":"7745","key":"10.1016\/j.imlet.2024.106852_bib0007","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41586-019-0964-2","article-title":"\u03b2-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration","volume":"566","author":"Lodygin","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2024.106852_bib0008","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clim.2017.04.014","article-title":"Effector and regulatory B cells in multiple sclerosis","volume":"184","author":"Staun-Ram","year":"2017","journal-title":"Clin. Immunol."},{"issue":"7","key":"10.1016\/j.imlet.2024.106852_bib0009","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/(SICI)1521-4141(199807)28:07<2188::AID-IMMU2188>3.0.CO;2-B","article-title":"Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern","volume":"28","author":"Dahlman","year":"1998","journal-title":"Eur. J. Immunol."},{"issue":"7","key":"10.1016\/j.imlet.2024.106852_bib0010","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1039\/C6FO00321D","article-title":"Reduction of anxiety-like and depression-like behaviors in rats after one month of drinking Aronia melanocarpa berry juice","volume":"7","author":"Tomi\u0107","year":"2016","journal-title":"Food Funct."},{"issue":"3","key":"10.1016\/j.imlet.2024.106852_bib0011","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1590\/S0100-879X1997000300002","article-title":"Animal models of anxiety: an ethological perspective","volume":"30","author":"Rodgers","year":"1997","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"3","key":"10.1016\/j.imlet.2024.106852_bib0012","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat","volume":"14","author":"Pellow","year":"1985","journal-title":"J. Neurosci. Methods"},{"issue":"1","key":"10.1016\/j.imlet.2024.106852_bib0013","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bbr.2006.03.016","article-title":"Models of anxiety: responses of rats to novelty in an open space and an enclosed space","volume":"171","author":"Ennaceur","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.imlet.2024.106852_bib0014","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yhbeh.2017.09.008","article-title":"Disturbances of systemic and hippocampal insulin sensitivity in macrophage migration inhibitory factor (MIF) knockout male mice lead to behavioral changes associated with decreased PSA-NCAM levels","volume":"96","author":"Djordjevic","year":"2017","journal-title":"Horm. Behav."},{"issue":"23","key":"10.1016\/j.imlet.2024.106852_bib0015","doi-asserted-by":"crossref","first-page":"8853","DOI":"10.1523\/JNEUROSCI.20-23-08853.2000","article-title":"Impaired recognition memory in rats after damage to the hippocampus","volume":"20","author":"Clark","year":"2000","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.imlet.2024.106852_bib0016","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-5728(95)00153-0","article-title":"Protracted, relapsing and demyelinating experimental autoimmune encephalomyelitis in DA rats immunized with syngeneic spinal cord and incomplete Freund's adjuvant","volume":"63","author":"Lorentzen","year":"1995","journal-title":"J. Neuroimmunol."},{"issue":"1\u20132","key":"10.1016\/j.imlet.2024.106852_bib0017","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0165-5728(01)00320-4","article-title":"Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate","volume":"117","author":"Yang","year":"2001","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.imlet.2024.106852_bib0018","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fnbeh.2020.00145","article-title":"To approach or avoid: an introductory overview of the study of anxiety using rodent assays","volume":"14","author":"La-Vu","year":"2020","journal-title":"Front. Behav. Neurosci."},{"issue":"96","key":"10.1016\/j.imlet.2024.106852_bib0019","first-page":"e52434","article-title":"Use of the Open Field Maze to measure locomotor and anxiety-like behavior in mice","author":"Seibenhener","year":"2015","journal-title":"J. Vis. Exp."},{"issue":"2","key":"10.1016\/j.imlet.2024.106852_bib0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn. Process."},{"issue":"1","key":"10.1016\/j.imlet.2024.106852_bib0021","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2009.10.014","article-title":"Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion","volume":"626","author":"Barkus","year":"2010","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.imlet.2024.106852_bib0022","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1037\/0735-7044.118.1.63","article-title":"Amygdala and ventral hippocampus contribute differentially to mechanisms of fear and anxiety","volume":"118","author":"McHugh","year":"2004","journal-title":"Behav. Neurosci."},{"issue":"2","key":"10.1016\/j.imlet.2024.106852_bib0023","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.bbr.2011.03.068","article-title":"Hippocampal GluR1 associates with behavior in the elevated plus maze and shows sex differences","volume":"222","author":"Xiang","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"22","key":"10.1016\/j.imlet.2024.106852_bib0024","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1093\/hmg\/ddac135","article-title":"Cerebellar contribution to threat probability in a SCA6 mouse model","volume":"31","author":"Bohne","year":"2022","journal-title":"Hum. Mol. Genet."},{"issue":"6","key":"10.1016\/j.imlet.2024.106852_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101240","article-title":"Ablation of ventral midbrain\/pons GABA neurons induces mania-like behaviors with altered sleep homeostasis and dopamine D2R-mediated sleep reduction","volume":"23","author":"Honda","year":"2020","journal-title":"iScience"},{"issue":"1\u20132","key":"10.1016\/j.imlet.2024.106852_bib0026","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11010-009-0088-3","article-title":"Hippocampal neurodegeneration in experimental autoimmune encephalomyelitis (EAE): potential role of inflammation activated myeloperoxidase","volume":"328","author":"Sajad","year":"2009","journal-title":"Mol. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.imlet.2024.106852_bib0027","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/labinvest.2010.6","article-title":"Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE","volume":"90","author":"Ziehn","year":"2010","journal-title":"Lab. Invest."},{"issue":"1","key":"10.1016\/j.imlet.2024.106852_bib0028","doi-asserted-by":"crossref","first-page":"e54666","DOI":"10.1371\/journal.pone.0054666","article-title":"Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis","volume":"8","author":"Nistic\u00f2","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.imlet.2024.106852_bib0029","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neuroscience.2015.03.008","article-title":"Hippocampal function is compromised in an animal model of multiple sclerosis","volume":"309","author":"Novkovic","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.imlet.2024.106852_bib0030","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.neuroscience.2013.06.025","article-title":"Neurodegeneration and inflammation in hippocampus in experimental autoimmune encephalomyelitis induced in rats by one\u2013time administration of encephalitogenic T cells","volume":"248","author":"Kurkowska-Jastrz\u0119bska","year":"2013","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.imlet.2024.106852_bib0031","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/WNR.0000000000000920","article-title":"Multiple pathological mechanisms contribute to hippocampal damage in the experimental autoimmune encephalomyelitis model of multiple sclerosis","volume":"29","author":"Kyran","year":"2018","journal-title":"Neuroreport"},{"issue":"2","key":"10.1016\/j.imlet.2024.106852_bib0032","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1007\/s12035-019-01774-8","article-title":"Oxidative stress and lymphocyte alterations in chronic relapsing experimental allergic encephalomyelitis in the rat hippocampus and protective effects of an ethanolamine phosphate salt","volume":"57","author":"Perianes-Cachero","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.imlet.2024.106852_bib0033","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1750-3639.2010.00444.x","article-title":"An animal model of cortical and callosal pathology in multiple sclerosis","volume":"21","author":"Mangiardi","year":"2011","journal-title":"Brain Pathol."},{"issue":"1","key":"10.1016\/j.imlet.2024.106852_bib0034","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2967\/jnumed.120.259325","article-title":"Longitudinal imaging of T cells and inflammatory demyelination in a preclinical model of multiple sclerosis using 18F-FAraG PET and MRI","volume":"63","author":"Guglielmetti","year":"2022","journal-title":"J. Nucl. Med."},{"issue":"Pt 12","key":"10.1016\/j.imlet.2024.106852_bib0035","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1093\/brain\/awt279","article-title":"Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats","volume":"136","author":"Gardner","year":"2013","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.imlet.2024.106852_bib0036","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.4049\/jimmunol.179.5.2774","article-title":"CXCR3 signaling reduces the severity of experimental autoimmune encephalomyelitis by controlling the parenchymal distribution of effector and regulatory T cells in the central nervous system","volume":"179","author":"M\u00fcller","year":"2007","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.imlet.2024.106852_bib0037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160158","article-title":"Inhibition of vascular endothelial growth factor receptor 2 exacerbates loss of lower motor neurons and axons during experimental autoimmune encephalomyelitis","volume":"11","author":"Stanojlovic","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.imlet.2024.106852_bib0038","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jneumeth.2017.04.003","article-title":"Consistent induction of chronic experimental autoimmune encephalomyelitis in C57BL\/6 mice for the longitudinal study of pathology and repair","volume":"284","author":"Hasselmann","year":"2017","journal-title":"J. Neurosci. Methods"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247824000269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247824000269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T20:46:32Z","timestamp":1716842792000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247824000269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":38,"alternative-id":["S0165247824000269"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2024.106852","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain inflammation in experimental autoimmune encephalomyelitis induced in Dark Agouti rats with spinal cord homogenate","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2024.106852","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106852"}}