{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:30:05Z","timestamp":1782185405259,"version":"3.54.5"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/200.483\/2018"],"award-info":[{"award-number":["E-26\/200.483\/2018"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.imlet.2024.106857","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T15:16:06Z","timestamp":1712675766000},"page":"106857","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Type 1 Diabetes Brazilian patients exhibit reduced frequency of recent thymic emigrants in regulatory CD4+CD25+Foxp3+T cells"],"prefix":"10.1016","volume":"267","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4952-2278","authenticated-orcid":false,"given":"Jeane de Souza","family":"Nogueira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamires Rodrigues","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Angst","family":"Secco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inez Silva","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Saldanha Matheus Fernandes","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Arnoldi","family":"Cobas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Gilson","family":"Costa dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia Brito","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-1821","authenticated-orcid":false,"given":"Lu\u00eds Crist\u00f3v\u00e3o","family":"Porto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.imlet.2024.106857_bib0001","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41574-019-0254-y","article-title":"The heterogeneous pathogenesis of type 1 diabetes mellitus","volume":"15","author":"Ilonen","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"issue":"14","key":"10.1016\/j.imlet.2024.106857_bib0002","doi-asserted-by":"crossref","first-page":"7493","DOI":"10.3390\/ijms22147493","article-title":"The multifactorial progression from the islet autoimmunity to type 1 diabetes in children","volume":"22","author":"Bauer","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.imlet.2024.106857_bib0003","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.diabres.2012.02.008","article-title":"Prevalence of adults with type 1 diabetes who meet the goals of care in daily clinical practice: a nationwide multicenter study in Brazil","volume":"97","author":"Gomes","year":"2012","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"10138","key":"10.1016\/j.imlet.2024.106857_bib0004","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1016\/S0140-6736(18)31320-5","article-title":"Type 1 diabetes","volume":"391","author":"DiMeglio","year":"2018","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.imlet.2024.106857_bib0005","doi-asserted-by":"crossref","DOI":"10.1172\/JCI142242","article-title":"Type 1 diabetes mellitus: much progress, many opportunities","volume":"131","author":"Powers","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imlet.2024.106857_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101565","article-title":"Beta cell and immune cell interactions in autoimmune type 1 diabetes: how they meet and talk to each other","volume":"64","author":"Scherm","year":"2022","journal-title":"Mol. Metab."},{"issue":"1","key":"10.1016\/j.imlet.2024.106857_bib0007","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2337\/diabetes.54.1.92","article-title":"Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes","volume":"54","author":"Lindley","year":"2005","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.imlet.2024.106857_bib0008","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/cei.12116","article-title":"CD4(+) CD45RA(-) FoxP3high activated regulatory T cells are functionally impaired and related to residual insulin-secreting capacity in patients with type 1 diabetes","volume":"173","author":"Haseda","year":"2013","journal-title":"Clin. Exp. Immunol."},{"issue":"5","key":"10.1016\/j.imlet.2024.106857_bib0009","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s10753-014-9878-1","article-title":"Elevated levels of serum IL-12 and IL-18 are associated with lower frequencies of CD4(+)CD25 (high)FOXP3 (+) regulatory t cells in young patients with type 1 diabetes","volume":"37","author":"Ryba-Stanislawowska","year":"2014","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.imlet.2024.106857_bib0010","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/cyto.b.21841","article-title":"A modified flow cytometry method for objective estimation of human CD4(+) regulatory T cells (CD4(+) Tregs) in peripheral blood, via CD4\/CD25\/CD45RO\/FoxP3 labeling","volume":"98","author":"Petsiou","year":"2020","journal-title":"Cytometry B. Clin. Cytom."},{"issue":"17\u201318","key":"10.1016\/j.imlet.2024.106857_bib0011","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1089\/hum.2021.024","article-title":"Regulatory T Cells and Diabetes Mellitus","volume":"32","author":"Qin","year":"2021","journal-title":"Hum. Gene Ther."},{"issue":"6","key":"10.1016\/j.imlet.2024.106857_bib0012","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23063155","article-title":"Self-antigens targeted by regulatory T Cells in type 1 diabetes","volume":"23","author":"Mitchell","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.imlet.2024.106857_bib0013","first-page":"1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25)","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol"},{"key":"10.1016\/j.imlet.2024.106857_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102461","article-title":"The progress and prospect of regulatory T cells in autoimmune diseases","volume":"111","author":"Zhang","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.imlet.2024.106857_bib0015","article-title":"Metabolism Characteristics of Th17 and Regulatory T Cells in autoimmune diseases","volume":"13","author":"Qin","year":"2022","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.imlet.2024.106857_bib0016","doi-asserted-by":"crossref","first-page":"7259","DOI":"10.4049\/jimmunol.173.12.7259","article-title":"CD25-T cells generate CD25+Foxp3+ regulatory T cells by peripheral expansion","volume":"173","author":"Curotto de Lafaille","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2024.106857_bib0017","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/978-981-15-6407-9_13","article-title":"TNF-TNFR2 signal plays a decisive role in the activation of CD4(+)Foxp3(+) Regulatory T Cells: implications in the treatment of autoimmune diseases and cancer","volume":"1278","author":"Islam","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.imlet.2024.106857_bib0018","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.4049\/jimmunol.167.3.1245","article-title":"CD4+ CD25high regulatory cells in human peripheral blood","volume":"167","author":"Baecher-Allan","year":"2001","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.imlet.2024.106857_bib0019","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nri2785","article-title":"FOXP3+ regulatory T cells in the human immune system","volume":"10","author":"Sakaguchi","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.imlet.2024.106857_bib0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4049\/jimmunol.0902379","article-title":"CD4(+) CD25(+) Foxp3(+) T regulatory cells with limited TCR diversity in control of autoimmunity","volume":"184","author":"Adeegbe","year":"2010","journal-title":"J. Immunol"},{"issue":"11","key":"10.1016\/j.imlet.2024.106857_bib0021","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1002\/eji.201141986","article-title":"High TCR diversity ensures optimal function and homeostasis of Foxp3+ regulatory T cells","volume":"41","author":"Fohse","year":"2011","journal-title":"Eur. J. Immunol"},{"issue":"2","key":"10.1016\/j.imlet.2024.106857_bib0022","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/imm.12555","article-title":"Enhanced renewal of regulatory T cells in relation to CD4(+) conventional T lymphocytes in the peripheral compartment","volume":"147","author":"Nogueira","year":"2016","journal-title":"Immunology"},{"issue":"16","key":"10.1016\/j.imlet.2024.106857_bib0023","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1073\/pnas.1221955110","article-title":"Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery","volume":"110","author":"Paiva","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.imlet.2024.106857_bib0024","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev-immunol-032712-100010","article-title":"The biology of recent thymic emigrants","volume":"31","author":"Fink","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imlet.2024.106857_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coi.2017.12.006","article-title":"Reinterpreting recent thymic emigrant function: defective or adaptive?","volume":"51","author":"Cunningham","year":"2018","journal-title":"Curr. Opin. Immunol."},{"issue":"3","key":"10.1016\/j.imlet.2024.106857_bib0026","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.4049\/jimmunol.180.3.1499","article-title":"Homeostasis of the naive CD4+ T cell compartment during aging","volume":"180","author":"Kilpatrick","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2024.106857_bib0027","first-page":"119","article-title":"Establishment and Maintenance of the Human Naive CD4(+) T-Cell Compartment. Front","volume":"4","author":"Silva","year":"2016","journal-title":"Pediatr"},{"issue":"11","key":"10.1016\/j.imlet.2024.106857_bib0028","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1002\/eji.200636976","article-title":"Correlation between recent thymic emigrants and CD31+ (PECAM-1) CD4+ T cells in normal individuals during aging and in lymphopenic children","volume":"37","author":"Junge","year":"2007","journal-title":"Eur. J. Immunol."},{"issue":"4","key":"10.1016\/j.imlet.2024.106857_bib0029","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1182\/blood-2008-02-139154","article-title":"Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets","volume":"113","author":"Kohler","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2024.106857_bib0030","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8785263","article-title":"High thymic output of effector CD4+ cells may lead to a Treg:\u2009T effector imbalance in the periphery in NOD mice","author":"Zhao","year":"2019","journal-title":"J. Immunol. Res."},{"issue":"2","key":"10.1016\/j.imlet.2024.106857_bib0031","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4049\/jimmunol.179.2.1322","article-title":"Prevalence of newly generated naive regulatory T cells (Treg) is critical for Treg suppressive function and determines Treg dysfunction in multiple sclerosis","volume":"179","author":"Haas","year":"2007","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.imlet.2024.106857_bib0032","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1136\/ard.2008.088112","article-title":"Thymic function in juvenile idiopathic arthritis","volume":"68","author":"Lorenzi","year":"2009","journal-title":"Ann. Rheum. Dis."},{"issue":"9","key":"10.1016\/j.imlet.2024.106857_bib0033","doi-asserted-by":"crossref","first-page":"e24272","DOI":"10.1371\/journal.pone.0024272","article-title":"Impaired thymic export and apoptosis contribute to regulatory T-cell defects in patients with chronic heart failure","volume":"6","author":"Tang","year":"2011","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.imlet.2024.106857_bib0034","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/icb.2015.51","article-title":"The role of recent thymic emigrant-regulatory T-cell (RTE-Treg) differentiation during pregnancy","volume":"93","author":"Wagner","year":"2015","journal-title":"Immunol. Cell Biol."},{"issue":"8","key":"10.1016\/j.imlet.2024.106857_bib0035","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/cid\/ciw030","article-title":"Recent Thymus Emigrant CD4+ T Cells Predict HIV Disease Progression in Patients With Perinatally Acquired HIV","volume":"62","author":"Zakhour","year":"2016","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.imlet.2024.106857_bib0036","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a007732","article-title":"Genetics of type 1 diabetes","volume":"2","author":"Noble","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"10035","key":"10.1016\/j.imlet.2024.106857_bib0037","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/S0140-6736(16)30582-7","article-title":"Genetic risk factors for type 1 diabetes","volume":"387","author":"Pociot","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.imlet.2024.106857_bib0038","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fendo.2020.00248","article-title":"Prediction and Prevention of Type 1 Diabetes","volume":"11","author":"Primavera","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"9","key":"10.1016\/j.imlet.2024.106857_bib0039","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.cmet.2023.06.018","article-title":"The pathogenic \"symphony\" in type 1 diabetes: a disorder of the immune system, beta cells, and exocrine pancreas","volume":"35","author":"Atkinson","year":"2023","journal-title":"Cell Metab"},{"issue":"3","key":"10.1016\/j.imlet.2024.106857_bib0040","first-page":"1","article-title":"Type 1 diabetes mellitus","volume":"17016","author":"Katsarou","year":"2017","journal-title":"Nature Rev. Disease Primers"},{"issue":"4","key":"10.1016\/j.imlet.2024.106857_bib0041","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/ni909","article-title":"An essential role for Scurfin in CD4+CD25+ T regulatory cells","volume":"4","author":"Khattri","year":"2003","journal-title":"Nature Immunol"},{"issue":"4","key":"10.1016\/j.imlet.2024.106857_bib0042","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nature Immunol"},{"key":"10.1016\/j.imlet.2024.106857_bib0043","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"issue":"17","key":"10.1016\/j.imlet.2024.106857_bib0044","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1073\/pnas.0509484103","article-title":"Single-cell analysis of normal and FOXP3-mutant human T cells. Foxp3 expression without regulatory T cell development","volume":"103","author":"Gavin","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.imlet.2024.106857_bib0045","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1084\/jem.20060772","article-title":"CD127 expression inversely correlates with Foxp3 and suppressive function of human CD4+ Treg cells","volume":"203","author":"Liu","year":"2006","journal-title":"J.Exp.Med"},{"issue":"7","key":"10.1016\/j.imlet.2024.106857_bib0046","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1084\/jem.20060468","article-title":"Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells","volume":"203","author":"Seddiki","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2024.106857_bib0047","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nri2023","article-title":"Interleukin-7 receptor expression: intelligent design","volume":"7","author":"Mazzucchelli","year":"2007","journal-title":"Nature Rev. Immunol."},{"key":"10.1016\/j.imlet.2024.106857_bib0048","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1055805","article-title":"Identification and classification of distinct surface markers of T regulatory cells","volume":"13","author":"Wegrzyn","year":"2023","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.imlet.2024.106857_bib0049","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/cei.12804","article-title":"Phenotypical characterization of regulatory T cells in humans and rodents","volume":"185","author":"Rodr\u0131guez-Perea","year":"2016","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imlet.2024.106857_bib0050","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-immunol-042718-041717","article-title":"Regulatory T cells and Human Disease","volume":"38","author":"Sakaguchi","year":"2020","journal-title":"Annu. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.imlet.2024.106857_bib0051","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.3892\/etm.2016.3157","article-title":"Characteristics of CD4+CD25+Foxp3+ regulatory T cells in patients with multiple organ dysfunction syndrome","volume":"11","author":"Zang","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.imlet.2024.106857_bib0052","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.3389\/fimmu.2019.02547","article-title":"Phenotypic analysis of human lymph nodes in subjects with new-onset type 1 diabetes and healthy individuals by flow cytometry","volume":"10","author":"Yang","year":"2019","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.imlet.2024.106857_bib0053","doi-asserted-by":"crossref","first-page":"dgaa588","DOI":"10.1210\/clinem\/dgaa588","article-title":"Vitamin D supplementation modulates ICOS+ and ICOS\u2212regulatory T cell in siblings of children with type 1 diabetes","volume":"105","author":"Savastio","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.imlet.2024.106857_bib0054","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000503143","article-title":"Changes in CD4+CD25+FoxP3+ regulatory T cells and serum cytokines in sublingual and subcutaneous immunotherapy in allergic rhinitis with or without asthma","volume":"181","author":"Xian","year":"2020","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"4","key":"10.1016\/j.imlet.2024.106857_bib0055","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1177\/09612033221083269","article-title":"The relation of CD4+CD25+Foxp3+ regulatory T cells concentration with disease activity and damage index in systemic lupus erythematosus","volume":"31","author":"Kamal","year":"2022","journal-title":"Lupus"},{"issue":"2","key":"10.1016\/j.imlet.2024.106857_bib0056","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/imm.12867","article-title":"Harnessing the power of regulatory T-cells to control autoimmune diabetes: overview and perspective","volume":"153","author":"Yu","year":"2018","journal-title":"Immunology"},{"issue":"17","key":"10.1016\/j.imlet.2024.106857_bib0057","doi-asserted-by":"crossref","first-page":"9501","DOI":"10.3390\/ijms22179501","article-title":"Impaired differentiation of highly proliferative ICOS(+)-Tregs is involved in the transition from low to high disease activity in systemic lupus erythematosus (SLE) Patients","volume":"22","author":"Kalble","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.imlet.2024.106857_bib0058","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jaut.2015.07.014","article-title":"Immunogenetics of type 1 diabetes: a comprehensive review","volume":"64","author":"Noble","year":"2015","journal-title":"J. Autoimmun."},{"issue":"10","key":"10.1016\/j.imlet.2024.106857_bib0059","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.autrev.2010.05.016","article-title":"HLA-Class II in Latin American patients with type 1 diabetes","volume":"9","author":"Rojas-Villarraga","year":"2010","journal-title":"Autoimmun. Rev."},{"issue":"6","key":"10.1016\/j.imlet.2024.106857_bib0060","doi-asserted-by":"crossref","first-page":"972","DOI":"10.3390\/genes13060972","article-title":"HLA genotypes and type 1 diabetes and its relationship to reported race\/skin color in their relatives: a brazilian multicenter study","volume":"13","author":"Gomes","year":"2022","journal-title":"Genes (Basel)"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247824000312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247824000312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T20:46:57Z","timestamp":1716842817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247824000312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":60,"alternative-id":["S0165247824000312"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2024.106857","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Type 1 Diabetes Brazilian patients exhibit reduced frequency of recent thymic emigrants in regulatory CD4+CD25+Foxp3+T cells","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2024.106857","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106857"}}