{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:08:20Z","timestamp":1778638100897,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["KF-202305"],"award-info":[{"award-number":["KF-202305"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["RZ2022-06"],"award-info":[{"award-number":["RZ2022-06"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015083","name":"Peking University People&apos;s Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015083","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271755"],"award-info":[{"award-number":["82271755"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871230"],"award-info":[{"award-number":["81871230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.imlet.2024.106913","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T20:17:36Z","timestamp":1725308256000},"page":"106913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Reduced TRIM expression correlates with anomalous CD4 T cell activation in systemic lupus Erythematosus and its clinical diagnostic potential"],"prefix":"10.1016","volume":"270","author":[{"given":"Ayibaota","family":"Bahabayi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoyi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuying","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxin","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ainizati","family":"Hasimu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyue","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingzhang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7120-5626","authenticated-orcid":false,"given":"Chen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.imlet.2024.106913_bib0001","doi-asserted-by":"crossref","first-page":"Itc81","DOI":"10.7326\/AITC202006020","article-title":"Systemic lupus erythematosus","volume":"172","author":"Kiriakidou","year":"2020","journal-title":"Ann. Intern. Med."},{"issue":"1","key":"10.1016\/j.imlet.2024.106913_bib0002","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41392-023-01471-y","article-title":"T cells in health and disease","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Target Ther"},{"issue":"1","key":"10.1016\/j.imlet.2024.106913_bib0003","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2022-000660","article-title":"Phenotypical changes and clinical significance of CD4(+)\/CD8(+) T cells in SLE","volume":"9","author":"Yuan","year":"2022","journal-title":"Lupus Sci. Med."},{"issue":"2","key":"10.1016\/j.imlet.2024.106913_bib0004","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/ar3251","article-title":"Abnormalities of T cell signaling in systemic lupus erythematosus","volume":"13","author":"Moulton","year":"2011","journal-title":"Arthritis Res. Ther."},{"issue":"7","key":"10.1016\/j.imlet.2024.106913_bib0005","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1002\/art.11072","article-title":"Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor\/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus","volume":"48","author":"Nambiar","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.imlet.2024.106913_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102870","article-title":"Abnormalities of T cells in systemic lupus erythematosus: new insights in pathogenesis and therapeutic strategies","volume":"132","author":"Li","year":"2022","journal-title":"J. Autoimmun."},{"issue":"1","key":"10.1016\/j.imlet.2024.106913_bib0007","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12519-019-00229-3","article-title":"Immunological pathogenesis and treatment of systemic lupus erythematosus","volume":"16","author":"Pan","year":"2020","journal-title":"World J. Pediatric.: WJP"},{"issue":"3","key":"10.1016\/j.imlet.2024.106913_bib0008","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1084\/jem.188.3.561","article-title":"T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane","volume":"188","author":"Bruyns","year":"1998","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.imlet.2024.106913_bib0009","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1182\/blood-2005-06-2273","article-title":"Transmembrane adaptor molecules: a new category of lymphoid-cell markers","volume":"107","author":"Tedoldi","year":"2006","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.imlet.2024.106913_bib0010","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1084\/jem.193.11.1269","article-title":"The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain","volume":"193","author":"Kirchgessner","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2024.106913_bib0011","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev-cellbio-111315-125324","article-title":"TCR signal strength and T cell development","volume":"32","author":"Gascoigne","year":"2016","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.imlet.2024.106913_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.960866","article-title":"TRAT1 overexpression delays cancer progression and is associated with immune infiltration in lung adenocarcinoma","volume":"12","author":"Xiao","year":"2022","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.imlet.2024.106913_bib0013","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1007\/s11596-022-2625-1","article-title":"The roles and mechanisms of TRAT1 in the progression of non-small cell lung cancer","volume":"42","author":"Guo","year":"2022","journal-title":"Curr. Med. Sci."},{"key":"10.1016\/j.imlet.2024.106913_bib0014","article-title":"Changes in T lymphocyte subsets in different tumors before and after radiotherapy: a Meta-analysis","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.imlet.2024.106913_bib0015","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s43018-023-00521-2","article-title":"CD4(+) T cells in cancer","volume":"4","author":"Speiser","year":"2023","journal-title":"Nat Cancer"},{"issue":"23","key":"10.1016\/j.imlet.2024.106913_bib0016","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.1182\/bloodadvances.2021006591","article-title":"A single administration of hIL-7-hyFc induces long-lasting T-cell expansion with maintained effector functions","volume":"6","author":"Kim","year":"2022","journal-title":"Blood Adv"},{"issue":"1","key":"10.1016\/j.imlet.2024.106913_bib0017","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13073-021-00918-7","article-title":"Maintenance of the human memory T cell repertoire by subset and tissue site","volume":"13","author":"Miron","year":"2021","journal-title":"Genome Med."},{"issue":"9","key":"10.1016\/j.imlet.2024.106913_bib0018","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nri.2016.77","article-title":"Regulation of pattern recognition receptor signalling in plants","volume":"16","author":"Couto","year":"2016","journal-title":"Nature Rev. Immunol."},{"key":"10.1016\/j.imlet.2024.106913_bib0019","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1078118","article-title":"Comprehensive analysis of the immune pattern of T cell subsets in chronic myeloid leukemia before and after TKI treatment","volume":"14","author":"Yao","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imlet.2024.106913_bib0020","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1146\/annurev.immunol.22.012703.104702","article-title":"Central memory and effector memory T cell subsets: function, generation, and maintenance","volume":"22","author":"Sallusto","year":"2004","journal-title":"Annu. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.imlet.2024.106913_bib0021","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2008.11.002","article-title":"Homeostasis of naive and memory T cells","volume":"29","author":"Surh","year":"2008","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.imlet.2024.106913_bib0022","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/hepr.13472","article-title":"Increased proportion of functional subpopulations in circulating regulatory T cells in patients with chronic hepatitis B","volume":"50","author":"Liu","year":"2020","journal-title":"Hepatol. Res.: Off. J. Japan Soc. Hepatol."},{"issue":"1","key":"10.1016\/j.imlet.2024.106913_bib0023","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/cei.13485","article-title":"Activated inducible co-stimulator-positive programmed cell death 1-positive follicular helper T cells indicate disease activity and severity in ulcerative colitis patients","volume":"202","author":"Long","year":"2020","journal-title":"Clin. Exp. Immunol."},{"issue":"7","key":"10.1016\/j.imlet.2024.106913_bib0024","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/eji.202049093","article-title":"Altered follicular regulatory T (Tfr)- and helper T (Tfh)-cell subsets are associated with autoantibody levels in microscopic polyangiitis patients","volume":"51","author":"Long","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imlet.2024.106913_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102376","article-title":"Treg cells in health and autoimmune diseases: new insights from single cell analysis","volume":"110","author":"Scheinecker","year":"2020","journal-title":"J. Autoimmun."},{"issue":"1","key":"10.1016\/j.imlet.2024.106913_bib0026","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/imr.12411","article-title":"T follicular regulatory cells","volume":"271","author":"Sage","year":"2016","journal-title":"Immunol. Rev."},{"issue":"5","key":"10.1016\/j.imlet.2024.106913_bib0027","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/art.40430","article-title":"Increased circulating follicular Treg cells are associated with lower levels of autoantibodies in patients with rheumatoid arthritis in stable remission","volume":"70","author":"Liu","year":"2018","journal-title":"Arthritis Rheumatol. (Hoboken, NJ)"},{"key":"10.1016\/j.imlet.2024.106913_bib0028","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.intimp.2018.01.038","article-title":"Increased circulating CD4(+)CXCR5(+)FoxP3(+) follicular regulatory T cells correlated with severity of systemic lupus erythematosus patients","volume":"56","author":"Liu","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.imlet.2024.106913_bib0029","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fimmu.2020.00104","article-title":"The imbalance of circulating follicular helper T cells and follicular regulatory T cells is associated with disease activity in patients with ulcerative colitis","volume":"11","author":"Long","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imlet.2024.106913_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108877","article-title":"Changes in the expression of T-cell factor-1 in follicular helper T cells reflect the condition of systemic lupus erythematosus patients","volume":"108","author":"Zeng","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.imlet.2024.106913_bib0031","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"Tan","year":"1982","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.imlet.2024.106913_bib0032","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/978-1-4939-9009-2_25","article-title":"Laboratory guidelines for animal care","volume":"1920","author":"Couto","year":"2019","journal-title":"Method. Mol. Biol. (Clifton, NJ)"},{"issue":"13","key":"10.1016\/j.imlet.2024.106913_bib0033","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.imlet.2024.106913_bib0034","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/s41467-017-01728-5","article-title":"Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA","volume":"8","author":"Tian","year":"2017","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.imlet.2024.106913_bib0035","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/cyto.a.24509","article-title":"OMIP-079: cell cycle of CD4(+) and CD8(+) na\u00efve\/memory T cell subsets, and of Treg cells from mouse spleen","volume":"99","author":"Natalini","year":"2021","journal-title":"Cytometry Part A: J. Int. Soc. Anal. Cytol."},{"issue":"3","key":"10.1016\/j.imlet.2024.106913_bib0036","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/imm.13115","article-title":"Helios: still behind the clouds","volume":"158","author":"Thornton","year":"2019","journal-title":"Immunology"},{"issue":"6","key":"10.1016\/j.imlet.2024.106913_bib0037","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","article-title":"Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor","volume":"30","author":"Miyara","year":"2009","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.imlet.2024.106913_bib0038","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nri3839","article-title":"Perforin and granzymes: function, dysfunction and human pathology","volume":"15","author":"Voskoboinik","year":"2015","journal-title":"Nature Rev. Immunol."},{"issue":"6494","key":"10.1016\/j.imlet.2024.106913_bib0039","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaz7548","article-title":"Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells","volume":"368","author":"Zhou","year":"2020","journal-title":"Science (New York, NY)"},{"issue":"8","key":"10.1016\/j.imlet.2024.106913_bib0040","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s13238-020-00707-9","article-title":"Memory T cells: strategies for optimizing tumor immunotherapy","volume":"11","author":"Liu","year":"2020","journal-title":"Protein Cell"},{"key":"10.1016\/j.imlet.2024.106913_bib0041","article-title":"The immunomodulatory mechanisms for acupuncture practice","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imlet.2024.106913_bib0042","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.745109","article-title":"A correlation between differentiation phenotypes of infused T cells and anti-cancer immunotherapy","volume":"12","author":"Ren","year":"2021","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.imlet.2024.106913_bib0043","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.4049\/jimmunol.138.11.3640","article-title":"Analysis of the murine lymphokine-activated killer (LAK) cell phenomenon: dissection of effectors and progenitors into NK- and T-like cells","volume":"138","author":"Kalland","year":"1987","journal-title":"J. Immunol. (Baltimore, Md: 1950)"},{"issue":"1","key":"10.1016\/j.imlet.2024.106913_bib0044","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/s41467-020-20604-3","article-title":"Granzyme B inhibition reduces disease severity in autoimmune blistering diseases","volume":"12","author":"Hiroyasu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.imlet.2024.106913_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102498","article-title":"Correlation of the levels of DNA-binding inhibitor Id3 and regulatory T cells with SLE disease severity","volume":"113","author":"Liu","year":"2020","journal-title":"J. Autoimmun."},{"issue":"Suppl 2","key":"10.1016\/j.imlet.2024.106913_bib0046","doi-asserted-by":"crossref","first-page":"i78","DOI":"10.1136\/annrheumdis-2011-200641","article-title":"CD3 \u03b6 defects in systemic lupus erythematosus","volume":"71","author":"Takeuchi","year":"2012","journal-title":"Ann. Rheum. Dis."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247824000877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247824000877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:07:40Z","timestamp":1778634460000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247824000877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":46,"alternative-id":["S0165247824000877"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2024.106913","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced TRIM expression correlates with anomalous CD4 T cell activation in systemic lupus Erythematosus and its clinical diagnostic potential","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2024.106913","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 European Federation of Immunological Societies. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106913"}}