{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T19:27:57Z","timestamp":1789241277333,"version":"build-2803163510"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","award":["09150162010046"],"award-info":[{"award-number":["09150162010046"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005039","name":"Leids Universitair Medisch Centrum","doi-asserted-by":"publisher","award":["10894"],"award-info":[{"award-number":["10894"]}],"id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005039","name":"Leids Universitair Medisch Centrum","doi-asserted-by":"publisher","award":["11079"],"award-info":[{"award-number":["11079"]}],"id":[{"id":"10.13039\/501100005039","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021821","name":"Oncode Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021821","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.imlet.2025.107022","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T18:10:19Z","timestamp":1744654219000},"page":"107022","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["CD4+ T-cell help delivery to monocyte-derived dendritic cells promotes effector differentiation of helper and cytotoxic T cells"],"prefix":"10.1016","volume":"275","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3500-8649","authenticated-orcid":false,"given":"Douwe M.\u2008T.","family":"Bosma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2402-4245","authenticated-orcid":false,"given":"Julia","family":"Busselaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8568-6248","authenticated-orcid":false,"given":"Mo D.","family":"Staal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9249-8074","authenticated-orcid":false,"given":"Elselien","family":"Frijlink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3157-7262","authenticated-orcid":false,"given":"Matthias","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8595-4051","authenticated-orcid":false,"given":"Fiamma","family":"Salerno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8043-5009","authenticated-orcid":false,"given":"Jannie","family":"Borst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2025.107022_bib0001","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202149548","article-title":"Classical DC2 subsets and monocyte-derived DC: delineating the developmental and functional relationship","volume":"53","author":"Backer","year":"2023","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0002","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-immunol-061020-053707","article-title":"Dendritic cells revisited","volume":"39","author":"Cabeza-Cabrerizo","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0003","article-title":"Striking a balance: new perspectives on homeostatic dendritic cell maturation","author":"Bosteels","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0004","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1084\/jem.20170335","article-title":"Dendritic cell and antigen dispersal landscapes regulate T cell immunity","volume":"214","author":"Gerner","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2025.107022_bib0005","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.immuni.2012.07.011","article-title":"Histo-cytometry: a method for highly multiplex quantitative tissue imaging analysis applied to dendritic cell subset microanatomy in lymph nodes","volume":"37","author":"Gerner","year":"2012","journal-title":"Immunity."},{"key":"10.1016\/j.imlet.2025.107022_bib0006","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02169","article-title":"Determination of T follicular helper cell fate by dendritic cells","volume":"9","author":"Krishnaswamy","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0007","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s41423-020-0465-0","article-title":"Antigen presentation by dendritic cells and their instruction of CD4+ T helper cell responses","volume":"17","author":"Hilligan","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0008","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41577-018-0044-0","article-title":"CD4+ T cell help in cancer immunology and immunotherapy","volume":"18","author":"Borst","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0009","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/imr.12945","article-title":"Conversations that count: cellular interactions that drive T cell fate","volume":"300","author":"Duckworth","year":"2021","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.imlet.2025.107022_bib0010","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abg0336","article-title":"Effective CD4 T cell priming requires repertoire scanning by CD301b+ migratory cDC2 cells upon lymph node entry","volume":"6","author":"Tatsumi","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0011","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.1136080","article-title":"Differential antigen processing by dendritic cell subsets in vivo","volume":"315","author":"Dudziak","year":"2007","journal-title":"Sci."},{"key":"10.1016\/j.imlet.2025.107022_bib0012","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1084\/jem.192.12.1685","article-title":"CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo","volume":"192","author":"Den Haan","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2025.107022_bib0013","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-35615-5","article-title":"CD4+ helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment","volume":"14","author":"Lei","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.imlet.2025.107022_bib0014","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.1164206","article-title":"Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity","volume":"322","author":"Hildner","year":"2008","journal-title":"Sci."},{"key":"10.1016\/j.imlet.2025.107022_bib0015","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.immuni.2015.07.020","article-title":"Spatiotemporally distinct interactions with dendritic cell subsets facilitates CD4+ and CD8+ T cell activation to localized viral infection","volume":"43","author":"Hor","year":"2015","journal-title":"Immunity."},{"key":"10.1016\/j.imlet.2025.107022_bib0016","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.cell.2015.08.004","article-title":"Robust anti-viral immunity requires multiple distinct T cell-dendritic cell interactions","volume":"162","author":"Eickhoff","year":"2015","journal-title":"Cell."},{"key":"10.1016\/j.imlet.2025.107022_bib0017","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211519","article-title":"DCs at the center of help: origins and evolution of the three-cell-type hypothesis","volume":"219","author":"Wu","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2025.107022_bib0018","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/s41590-022-01324-w","article-title":"Mechanisms of CD40-dependent cDC1 licensing beyond costimulation","volume":"23","author":"Wu","year":"2022","journal-title":"Nat Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0019","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41423-024-01133-1","article-title":"CD4+ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors","volume":"21","author":"Lei","year":"2024","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0020","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/30989","article-title":"A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell","volume":"393","author":"Ridge","year":"1998","journal-title":"Nat."},{"key":"10.1016\/j.imlet.2025.107022_bib0021","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/30996","article-title":"Help for cytotoxic-T-cell responses is mediated by CD40 signalling","volume":"393","author":"Bennett","year":"1998","journal-title":"Nat."},{"key":"10.1016\/j.imlet.2025.107022_bib0022","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/31002","article-title":"T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions","volume":"393","author":"Schoenberger","year":"1998","journal-title":"Nat."},{"key":"10.1016\/j.imlet.2025.107022_bib0023","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13438-1","article-title":"CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities","volume":"10","author":"Ahrends","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.imlet.2025.107022_bib0024","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2017.10.009","article-title":"CD4+ T cell help confers a cytotoxic T cell effector program including coinhibitory receptor downregulation and increased tissue invasiveness","volume":"47","author":"Ahrends","year":"2017","journal-title":"Immunity."},{"key":"10.1016\/j.imlet.2025.107022_bib0025","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.immuni.2017.01.003","article-title":"CD8+ T cells orchestrate pDC-XCR1+ dendritic cell spatial and functional cooperativity to optimize priming","volume":"46","author":"Brewitz","year":"2017","journal-title":"Immunity."},{"key":"10.1016\/j.imlet.2025.107022_bib0026","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abb9435","article-title":"Innate cell microenvironments in lymph nodes shape the generation of T cell responses during type I inflammation","volume":"6","author":"Leal","year":"2021","journal-title":"Sci Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0027","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/ni.1707","article-title":"Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses","volume":"10","author":"Nakano","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0028","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.immuni.2007.01.017","article-title":"Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania","volume":"26","author":"Le\u00f3n","year":"2007","journal-title":"Immunity."},{"key":"10.1016\/j.imlet.2025.107022_bib0029","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.chom.2009.10.007","article-title":"Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection","volume":"6","author":"Hohl","year":"2009","journal-title":"Cell. Host. Microbe."},{"key":"10.1016\/j.imlet.2025.107022_bib0030","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.1073\/pnas.0900655106","article-title":"TNF\/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection","volume":"106","author":"Aldridge","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.imlet.2025.107022_bib0031","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.chom.2010.05.010","article-title":"Dynamic interplay among monocyte-derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi","volume":"7","author":"Ersland","year":"2010","journal-title":"Cell. Host. Microbe."},{"key":"10.1016\/j.imlet.2025.107022_bib0032","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.immuni.2012.03.026","article-title":"NK cell-derived interferon-\u03b3 orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection","volume":"36","author":"Goldszmid","year":"2012","journal-title":"Immunity."},{"key":"10.1016\/j.imlet.2025.107022_bib0033","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0034","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1084\/jem.194.9.1361","article-title":"Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues","volume":"194","author":"Palframan","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2025.107022_bib0035","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1084\/jem.20032152","article-title":"Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes","volume":"200","author":"Qu","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2025.107022_bib0036","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.01086","article-title":"Essential yet limited role for CCR2+ inflammatory monocytes during Mycobacterium tuberculosis-specific T cell priming","volume":"2","author":"Samstein","year":"2013","journal-title":"Elife."},{"key":"10.1016\/j.imlet.2025.107022_bib0037","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.molimm.2021.04.012","article-title":"Antigen presentation by mouse monocyte-derived cells: re-evaluating the concept of monocyte-derived dendritic cells","volume":"135","author":"Coillard","year":"2021","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00584","article-title":"Monocyte-derived dendritic cells are essential for CD8(+) T cell activation and antitumor responses after local immunotherapy","volume":"6","author":"Kuhn","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0039","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-06236-6","article-title":"Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12","volume":"7","author":"De Koker","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.imlet.2025.107022_bib0040","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1002\/eji.201142166","article-title":"Monocytes as effector cells: activated Ly-6C(high) mouse monocytes migrate to the lymph nodes through the lymph and cross-present antigens to CD8+ T cells","volume":"42","author":"Leiri\u00e3o","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0041","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.chom.2010.05.010","article-title":"Dynamic interplay among monocyte-derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi","volume":"7","author":"Ersland","year":"2010","journal-title":"Cell. Host. Microbe."},{"key":"10.1016\/j.imlet.2025.107022_bib0042","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.immuni.2020.04.005","article-title":"Inflammatory type 2 cDCs acquire features of cDC1s and macrophages to orchestrate immunity to respiratory virus infection","volume":"52","author":"Bosteels","year":"2020","journal-title":"Immunity."},{"key":"10.1016\/j.imlet.2025.107022_bib0043","doi-asserted-by":"crossref","first-page":"624","DOI":"10.4049\/jimmunol.1501202","article-title":"Monocyte-derived dendritic cells promote Th polarization, whereas conventional dendritic cells promote Th proliferation","volume":"196","author":"Chow","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0044","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4049\/jimmunol.1901046","article-title":"Monocyte-derived cells in tissue-resident memory T cell formation","volume":"204","author":"Chu","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0045","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1158\/0008-5472.CAN-15-3130","article-title":"CD27 Agonism plus PD-1 blockade recapitulates CD4+ T-cell help in therapeutic anticancer vaccination","volume":"76","author":"Ahrends","year":"2016","journal-title":"Cancer. Res."},{"key":"10.1016\/j.imlet.2025.107022_bib0046","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1158\/2326-6066.CIR-17-0408","article-title":"Subcellular localization of antigen in keratinocytes dictates delivery of CD4+ T-cell help for the CTL response upon therapeutic DNA vaccination into the skin","volume":"6","author":"Baba\u0142a","year":"2018","journal-title":"Cancer. Immunol. Res."},{"key":"10.1016\/j.imlet.2025.107022_bib0047","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1074-7613(94)80017-0","article-title":"Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides","volume":"1","author":"Alexander","year":"1994","journal-title":"Immunity."},{"key":"10.1016\/j.imlet.2025.107022_bib0048","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1089\/hum.2012.101","article-title":"Rational design of DNA vaccines for the induction of human papillomavirus type 16 E6- and E7-specific cytotoxic T-cell responses","volume":"23","author":"Oosterhuis","year":"2012","journal-title":"Hum. Gene. Ther."},{"key":"10.1016\/j.imlet.2025.107022_bib0049","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-19463-9","article-title":"Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles","volume":"11","author":"Hilligan","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.imlet.2025.107022_bib0050","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.immuni.2016.08.015","article-title":"Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species","volume":"45","author":"Guilliams","year":"2016","journal-title":"Immunity."},{"key":"10.1016\/j.imlet.2025.107022_bib0051","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20120030","article-title":"Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages","volume":"209","author":"Satpathy","year":"2012","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2025.107022_bib0052","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1002\/art.22854","article-title":"Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis","volume":"56","author":"Br\u00fchl","year":"2007","journal-title":"Arthritis. Rheum."},{"key":"10.1016\/j.imlet.2025.107022_bib0053","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.4049\/jimmunol.166.7.4697","article-title":"Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice","volume":"166","author":"Mack","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0054","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cels.2019.01.001","article-title":"Single-cell analysis of diverse pathogen responses defines a molecular roadmap for generating antigen-specific immunity","volume":"8","author":"Blecher-Gonen","year":"2019","journal-title":"Cell. Syst."},{"key":"10.1016\/j.imlet.2025.107022_bib0055","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.cell.2019.09.035","article-title":"Transcriptional basis of mouse and human dendritic cell heterogeneity","volume":"179","author":"Brown","year":"2019","journal-title":"Cell."},{"key":"10.1016\/j.imlet.2025.107022_bib0056","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/intimm\/14.4.367","article-title":"IFN-alpha enhances CD40 ligand-mediated activation of immature monocyte-derived dendritic cells","volume":"14","author":"Luft","year":"2002","journal-title":"Int. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0057","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-000588","article-title":"Monocyte-derived APCs are central to the response of PD1 checkpoint blockade and provide a therapeutic target for combination therapy","volume":"8","author":"Schetters","year":"2020","journal-title":"J. Immunother. Cancer."},{"key":"10.1016\/j.imlet.2025.107022_bib0058","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41590-023-01517-x","article-title":"CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity","volume":"24","author":"Gressier","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0059","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.immunol.16.1.111","article-title":"CD40 and CD154 in cell-mediated immunity","volume":"16","author":"Grewal","year":"1998","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0060","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.178.2.669","article-title":"CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40","volume":"178","author":"Alderson","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2025.107022_bib0061","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.ccell.2020.05.002","article-title":"Visualizing synaptic transfer of tumor antigens among dendritic cells","volume":"37","author":"Ruhland","year":"2020","journal-title":"Cancer. Cell."},{"key":"10.1016\/j.imlet.2025.107022_bib0062","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1002\/eji.201747042","article-title":"Active dissemination of cellular antigens by DCs facilitates CD8+ T-cell priming in lymph nodes","volume":"47","author":"Gurevich","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0063","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.immuni.2006.04.017","article-title":"Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming","volume":"25","author":"Allan","year":"2006","journal-title":"Immunity."},{"key":"10.1016\/j.imlet.2025.107022_bib0064","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.immuni.2019.04.002","article-title":"Lymphatic endothelial cells are essential components of the subcapsular sinus macrophage niche","volume":"50","author":"Mondor","year":"2019","journal-title":"Immunity."},{"key":"10.1016\/j.imlet.2025.107022_bib0065","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abf7777","article-title":"Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles","volume":"7","author":"Dick","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0066","article-title":"Cancer cells impair monocyte-mediated T cell stimulation to evade immunity","volume":"637","author":"Elewaut","year":"2025","journal-title":"Nat."},{"key":"10.1016\/j.imlet.2025.107022_bib0067","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1002\/eji.201141440","article-title":"T-zone localized monocyte-derived dendritic cells promote Th1 priming to Salmonella","volume":"41","author":"Flores-Langarica","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0068","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1158\/2326-6066.CIR-17-0316","article-title":"PD-L1 Binds to B7-1 only In Cis on the same cell surface","volume":"6","author":"Chaudhri","year":"2018","journal-title":"Cancer. Immunol. Res."},{"key":"10.1016\/j.imlet.2025.107022_bib0069","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.immuni.2019.11.003","article-title":"PD-L1:CD80 Cis-Heterodimer triggers the Co-stimulatory receptor CD28 while repressing the inhibitory PD-1 and CTLA-4 Pathways","volume":"51","author":"Zhao","year":"2019","journal-title":"Immunity."},{"key":"10.1016\/j.imlet.2025.107022_bib0070","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1126\/science.aav7062","article-title":"Restriction of PD-1 function by cis-PD-L1\/CD80 interactions is required for optimal T cell responses","volume":"364","author":"Sugiura","year":"2019","journal-title":"Sci."},{"key":"10.1016\/j.imlet.2025.107022_bib0071","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-immunol-020711-074950","article-title":"The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting","volume":"31","author":"Merad","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0072","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41590-020-0596-6","article-title":"Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells","volume":"21","author":"De Giovanni","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0073","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aal2192","article-title":"Single-cell RNA-seq and computational analysis using temporal mixture modeling resolves TH1\/TFH fate bifurcation in malaria","volume":"2","author":"L\u00f6nnberg","year":"2017","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.imlet.2025.107022_bib0074","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.167.3.1558","article-title":"DNA fusion vaccine designed to induce cytotoxic T Cell responses against defined peptide motifs: implications for cancer vaccines","volume":"167","author":"Rice","year":"2001","journal-title":"J. Immunol."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247825000550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247825000550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:05:39Z","timestamp":1762250739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247825000550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":74,"alternative-id":["S0165247825000550"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2025.107022","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD4+ T-cell help delivery to monocyte-derived dendritic cells promotes effector differentiation of helper and cytotoxic T cells","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2025.107022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Leiden University Medical Center. Published by Elsevier B.V. on behalf of European Federation of Immunological Societies.","name":"copyright","label":"Copyright"}],"article-number":"107022"}}