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Oncol."},{"key":"10.1016\/j.imlet.2025.107064_bib0088","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0262455","article-title":"Clinical efficacy of nivolumab is associated with tertiary lymphoid structures in surgically resected primary tumors of recurrent gastric cancer","volume":"17","author":"Mori","year":"2022","journal-title":"PLoS. One"},{"key":"10.1016\/j.imlet.2025.107064_bib0089","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s00262-022-03310-5","article-title":"Intratumoral tertiary lymphoid structures promote patient survival and immunotherapy response in head neck squamous cell carcinoma","volume":"72","author":"Liu","year":"2023","journal-title":"Cancer Immunol. Immunther."},{"key":"10.1016\/j.imlet.2025.107064_bib0090","doi-asserted-by":"crossref","unstructured":"A.L. Ferguson, T. Beddow, E. Patrick, E. Willie, M.S. Elliott, T.H. Low, J. Wykes, M.H. Hui, C.E. Palme, M. Boyer, J.R. Clark, J.H. Lee, U. Palendira, R. 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