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Med."},{"key":"10.1016\/j.imlet.2026.107143_bib0085","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0092-8674(00)00120-3","article-title":"Signaling takes shape in the immune system","volume":"103","author":"Dustin","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.imlet.2026.107143_bib0086","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41392-021-00823-w","article-title":"T cell receptor (TCR) signaling in health and disease","volume":"6","author":"Shah","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.imlet.2026.107143_bib0087","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.4049\/jimmunol.136.9.3282","article-title":"A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes","volume":"136","author":"Martin","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0088","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1084\/jem.180.5.1849","article-title":"The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro","volume":"180","author":"Inaba","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2026.107143_bib0089","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1084\/jem.174.3.625","article-title":"Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7","volume":"174","author":"Freeman","year":"1991","journal-title":"J. Exp. 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Chem."},{"key":"10.1016\/j.imlet.2026.107143_bib0117","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nature02916","article-title":"A role for the immunological synapse in lineage commitment of CD4 lymphocytes","volume":"431","author":"Maldonado","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2026.107143_bib0118","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S1074-7613(00)80671-8","article-title":"Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism","volume":"9","author":"Ouyang","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2026.107143_bib0119","doi-asserted-by":"crossref","first-page":"13823","DOI":"10.1073\/pnas.95.23.13823","article-title":"T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6","volume":"95","author":"Dent","year":"1998","journal-title":"Proc. Natl. Acad. Sci. 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Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0218","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1126\/science.1175870","article-title":"Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation","volume":"325","author":"Johnston","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.imlet.2026.107143_bib0219","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.4049\/jimmunol.181.4.2338","article-title":"Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression","volume":"181","author":"Cimmino","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0220","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/ni.3837","article-title":"Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection","volume":"18","author":"Botta","year":"2017","journal-title":"Nat. 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Med."},{"key":"10.1016\/j.imlet.2026.107143_bib0223","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4049\/jimmunol.0903505","article-title":"Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)","volume":"185","author":"Yusuf","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0224","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1084\/jem.20090303","article-title":"T follicular helper cells differentiate from Th2 cells in response to helminth antigens","volume":"206","author":"Glatman Zaretsky","year":"2009","journal-title":"J. Exp. 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Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0233","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S0140-6736(11)60874-X","article-title":"Identification of IL6R and chromosome 11q13.5 as risk loci for asthma","volume":"378","author":"Ferreira","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.imlet.2026.107143_bib0234","doi-asserted-by":"crossref","first-page":"10735","DOI":"10.1073\/pnas.1306691110","article-title":"Bach2 maintains T cells in a naive state by suppressing effector memory-related genes","volume":"110","author":"Tsukumo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.imlet.2026.107143_bib0235","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/j.jaci.2025.01.036","article-title":"Loss of Bach2 in T cells causes prolonged allergic inflammation through accumulation of effector T cells and disruption of epidermal barrier","volume":"155","author":"Omori-Miyake","year":"2025","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0236","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1126\/science.294.5548.1866","article-title":"Nuclear receptors and lipid physiology: opening the X-files","volume":"294","author":"Chawla","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.imlet.2026.107143_bib0237","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cell.2005.11.026","article-title":"The many faces of PPARgamma","volume":"123","author":"Lehrke","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.imlet.2026.107143_bib0238","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/toxsci\/kfg145","article-title":"Activation of PPARalpha and PPARgamma by environmental phthalate monoesters","volume":"74","author":"Hurst","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.imlet.2026.107143_bib0239","doi-asserted-by":"crossref","first-page":"12953","DOI":"10.1074\/jbc.270.22.12953","article-title":"An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)","volume":"270","author":"Lehmann","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2026.107143_bib0240","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1101\/gad.8.10.1224","article-title":"mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer","volume":"8","author":"Tontonoz","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.imlet.2026.107143_bib0241","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000515144","article-title":"The Concept of pathogenic TH2 cells: collegium internationale allergologicum update 2021","volume":"182","author":"Bertschi","year":"2021","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0242","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abi5586","article-title":"Clonally expanded, GPR15-expressing pathogenic effector T(H)2 cells are associated with eosinophilic esophagitis","volume":"6","author":"Morgan","year":"2021","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0243","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1084\/jem.20162069","article-title":"PPARgamma in dendritic cells and T cells drives pathogenic type-2 effector responses in lung inflammation","volume":"214","author":"Nobs","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2026.107143_bib0244","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.177720","article-title":"Single-cell molecular signature of pathogenic T helper subsets in type 2-associated disorders in humans","volume":"9","author":"Gazzinelli-Guimaraes","year":"2024","journal-title":"JCI. Insight."},{"key":"10.1016\/j.imlet.2026.107143_bib0245","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13683","article-title":"Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARgamma directs early activation of T cells","volume":"7","author":"Angela","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.imlet.2026.107143_bib0246","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.jaci.2012.05.018","article-title":"IL-33 induces innate lymphoid cell-mediated airway inflammation by activating mammalian target of rapamycin","volume":"130","author":"Salmond","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0247","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41385-020-00339-6","article-title":"PPARgamma enhances ILC2 function during allergic airway inflammation via transcription regulation of ST2","volume":"14","author":"Xiao","year":"2021","journal-title":"Mucosal. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0248","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1038\/s41467-023-38233-x","article-title":"PPAR-gamma regulates the effector function of human T helper 9 cells by promoting glycolysis","volume":"14","author":"Bertschi","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.imlet.2026.107143_bib0249","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat5943","article-title":"Human \"T(H)9\" cells are a subpopulation of PPAR-gamma(+) T(H)2 cells","volume":"4","author":"Micosse","year":"2019","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0250","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.4049\/jimmunol.153.9.3989","article-title":"IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma","volume":"153","author":"Schmitt","year":"1994","journal-title":"J. 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Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0256","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.immuni.2013.01.007","article-title":"Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP","volume":"38","author":"Yao","year":"2013","journal-title":"Immunity."},{"key":"10.1016\/j.imlet.2026.107143_bib0257","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/cei.12198","article-title":"Possible pathogenic role of T helper type 9 cells and interleukin (IL)-9 in atopic dermatitis","volume":"175","author":"Ma","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0258","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jaci.2011.12.965","article-title":"Activin A and TGF-beta promote T(H)9 cell-mediated pulmonary allergic pathology","volume":"129","author":"Jones","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0259","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.4049\/jimmunol.1601624","article-title":"STAT3 activation impairs the stability of Th9 cells","volume":"198","author":"Ulrich","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0260","doi-asserted-by":"crossref","first-page":"219ra218","DOI":"10.1126\/scitranslmed.3007828","article-title":"Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity","volume":"6","author":"Schlapbach","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.imlet.2026.107143_bib0261","article-title":"SATB1 regulates 3D genome architecture in T cells by constraining chromatin interactions surrounding CTCF-binding sites","volume":"42","author":"Wang","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.imlet.2026.107143_bib0262","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.celrep.2017.04.038","article-title":"Essential roles of SATB1 in specifying T lymphocyte subsets","volume":"19","author":"Kakugawa","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.imlet.2026.107143_bib0263","doi-asserted-by":"crossref","first-page":"6954","DOI":"10.1038\/s41467-022-34345-y","article-title":"The 3D enhancer network of the developing T cell genome is shaped by SATB1","volume":"13","author":"Zelenka","year":"2022","journal-title":"Nat. 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Pathog."},{"key":"10.1016\/j.imlet.2026.107143_bib0269","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1084\/jem.20170155","article-title":"The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination","volume":"215","author":"Yu","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2026.107143_bib0270","doi-asserted-by":"crossref","first-page":"4058","DOI":"10.1073\/pnas.070526297","article-title":"Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms","volume":"97","author":"Sun","year":"2000","journal-title":"Proc. Natl. Acad. Sci. 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Biol."},{"key":"10.1016\/j.imlet.2026.107143_bib0277","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/83158","article-title":"A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation","volume":"2","author":"Das","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0278","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/eji.200324687","article-title":"NF-kappa B synergizes with NF-AT and NF-IL6 in activation of the IL-4 gene in T cells","volume":"34","author":"Li-Weber","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0279","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/gene.2009.28","article-title":"Functional analysis of -351 interleukin-9 promoter polymorphism reveals an activator controlled by NF-kappaB","volume":"10","author":"Early","year":"2009","journal-title":"Genes Immun."},{"key":"10.1016\/j.imlet.2026.107143_bib0280","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.4049\/jimmunol.180.11.7240","article-title":"Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival","volume":"180","author":"Song","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0281","doi-asserted-by":"crossref","first-page":"8266","DOI":"10.1038\/ncomms9266","article-title":"GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation","volume":"6","author":"Xiao","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.imlet.2026.107143_bib0282","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellin.2022.100042","article-title":"Signaling and functions of interleukin-33 in immune regulation and diseases","volume":"1","author":"Yi","year":"2022","journal-title":"Cell Insight"},{"key":"10.1016\/j.imlet.2026.107143_bib0283","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1172\/JCI0215254","article-title":"Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation","volume":"110","author":"Hilliard","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imlet.2026.107143_bib0284","doi-asserted-by":"crossref","first-page":"6827","DOI":"10.4049\/jimmunol.163.12.6827","article-title":"NF-kappa B\/Rel transcription factors: c-Rel promotes airway hyperresponsiveness and allergic pulmonary inflammation","volume":"163","author":"Donovan","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0285","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.664218","article-title":"The NF-kappaB transcription factor c-Rel modulates group 2 innate lymphoid cell effector functions and drives allergic airway inflammation","volume":"12","author":"Mindt","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0286","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/imr.12199","article-title":"Complex interactions of transcription factors in mediating cytokine biology in T cells","volume":"261","author":"Li","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.imlet.2026.107143_bib0287","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1242\/jcs.01589","article-title":"AP-1 subunits: quarrel and harmony among siblings","volume":"117","author":"Hess","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.imlet.2026.107143_bib0288","doi-asserted-by":"crossref","first-page":"eadg3917","DOI":"10.1126\/sciimmunol.adg3917","article-title":"3D chromatin reprogramming primes human memory T(H)2 cells for rapid recall and pathogenic dysfunction","volume":"8","author":"Onrust-van Schoonhoven","year":"2023","journal-title":"Sci. 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Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0292","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.4049\/jimmunol.1102943","article-title":"CARMA1 controls Th2 cell-specific cytokine expression through regulating JunB and GATA3 transcription factors","volume":"188","author":"Blonska","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0293","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1084\/jem.188.10.1859","article-title":"c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms","volume":"188","author":"Ho","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2026.107143_bib0294","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1159\/000091602","article-title":"Regulation of GATA-3, c-maf and T-bet mRNA expression in bronchoalveolar lavage cells and bronchial biopsies after segmental allergen challenge","volume":"139","author":"Erpenbeck","year":"2006","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0295","doi-asserted-by":"crossref","first-page":"13026","DOI":"10.1073\/pnas.202474499","article-title":"An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines","volume":"99","author":"Hwang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.imlet.2026.107143_bib0296","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cell.2012.09.016","article-title":"A validated regulatory network for Th17 cell specification","volume":"151","author":"Ciofani","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.imlet.2026.107143_bib0297","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1093\/nar\/gkac256","article-title":"A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation","volume":"50","author":"Shetty","year":"2022","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.imlet.2026.107143_bib0298","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jaci.2013.09.049","article-title":"The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF-like (BATF), regulates lymphocyte- and mast cell-driven immune responses in the setting of allergic asthma","volume":"133","author":"Ubel","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0299","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1172\/JCI69489","article-title":"Th9 cell development requires a BATF-regulated transcriptional network","volume":"123","author":"Jabeen","year":"2013","journal-title":"J. Clin. 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Med."},{"key":"10.1016\/j.imlet.2026.107143_bib0303","doi-asserted-by":"crossref","first-page":"E3198","DOI":"10.1073\/pnas.1300950110","article-title":"Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells","volume":"110","author":"Shi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.imlet.2026.107143_bib0304","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/imm.12580","article-title":"Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells","volume":"147","author":"Suzuki","year":"2016","journal-title":"Immunology"},{"key":"10.1016\/j.imlet.2026.107143_bib0305","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1084\/jem.20081666","article-title":"Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells","volume":"206","author":"Zhu","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2026.107143_bib0306","doi-asserted-by":"crossref","first-page":"28216","DOI":"10.1074\/jbc.M804174200","article-title":"Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation","volume":"283","author":"Shinnakasu","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2026.107143_bib0307","doi-asserted-by":"crossref","first-page":"eadk1643","DOI":"10.1126\/sciimmunol.adk1643","article-title":"Age-associated CD4(+) T cells with B cell-promoting functions are regulated by ZEB2 in autoimmunity","volume":"9","author":"Goto","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0308","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107826","article-title":"The AP1 transcription factor Fosl2 promotes systemic autoimmunity and inflammation by repressing Treg development","volume":"31","author":"Renoux","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.imlet.2026.107143_bib0309","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ni.2937","article-title":"Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility","volume":"15","author":"Seumois","year":"2014","journal-title":"Nat. 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Chem."},{"key":"10.1016\/j.imlet.2026.107143_bib0317","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/ni0901-842","article-title":"Deletion of a coordinate regulator of type 2 cytokine expression in mice","volume":"2","author":"Mohrs","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0318","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ni.1966","article-title":"The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells","volume":"12","author":"Tanaka","year":"2011","journal-title":"Nat. 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Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0329","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S1074-7613(01)00125-X","article-title":"Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level","volume":"14","author":"Lee","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2026.107143_bib0330","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.immuni.2011.08.007","article-title":"Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types","volume":"35","author":"Wei","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2026.107143_bib0331","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/ni.2182","article-title":"Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity","volume":"13","author":"Liang","year":"2011","journal-title":"Nat. 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Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0335","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1093\/intimm\/10.12.1981","article-title":"Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region","volume":"10","author":"Takemoto","year":"1998","journal-title":"Int. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0336","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41588-020-0640-3","article-title":"Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases","volume":"52","author":"Ishigaki","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.imlet.2026.107143_bib0337","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.ajhg.2019.02.022","article-title":"Genetic architectures of childhood- and adult-onset asthma are partly distinct","volume":"104","author":"Ferreira","year":"2019","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.imlet.2026.107143_bib0338","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41577-018-0037-z","article-title":"Histone deacetylase function in CD4(+) T cells","volume":"18","author":"Ellmeier","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0339","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/imr.12943","article-title":"Epigenetic regulation of T cell adaptive immunity","volume":"300","author":"Frias","year":"2021","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.imlet.2026.107143_bib0340","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/ni808","article-title":"T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes","volume":"3","author":"Avni","year":"2002","journal-title":"Nat. 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Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0346","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cell.2009.06.049","article-title":"Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes","volume":"138","author":"Wang","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.imlet.2026.107143_bib0347","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.imlet.2026.107143_bib0348","doi-asserted-by":"crossref","first-page":"647","DOI":"10.4049\/jimmunol.169.2.647","article-title":"Cutting edge: changes in histone acetylation at the IL-4 and IFN-gamma loci accompany Th1\/Th2 differentiation","volume":"169","author":"Fields","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0349","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1074-7613(00)80605-6","article-title":"Helper T cell differentiation is controlled by the cell cycle","volume":"9","author":"Bird","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2026.107143_bib0350","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/mi.2014.44","article-title":"Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway","volume":"8","author":"Park","year":"2015","journal-title":"Mucosal. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0351","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.4049\/jimmunol.0903610","article-title":"Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production","volume":"185","author":"Grausenburger","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2026.107143_bib0352","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.70978","article-title":"Histone deacetylase 3 represses cholesterol efflux during CD4(+) T-cell activation","volume":"10","author":"Wilfahrt","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.imlet.2026.107143_bib0353","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/ni.2864","article-title":"CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2","volume":"15","author":"Boucheron","year":"2014","journal-title":"Nat. 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Autoimmun."},{"key":"10.1016\/j.imlet.2026.107143_bib0357","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114993","article-title":"HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections","volume":"43","author":"Penninger","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.imlet.2026.107143_bib0358","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI77088","article-title":"FOXP3+ regulatory T cell development and function require histone\/protein deacetylase 3","volume":"125","author":"Wang","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imlet.2026.107143_bib0359","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2312111121","article-title":"Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation","volume":"121","author":"Cheung","year":"2024","journal-title":"Proc. Natl. Acad. Sci. 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