{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:24:26Z","timestamp":1787592266697,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Fundacao de Amparo a Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Oswaldo Cruz Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.imlet.2026.107223","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:21:48Z","timestamp":1784676108000},"page":"107223","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Assessment of a recombinant influenza virus carrying interleukin 7 gene as a platform for novel immunotherapeutic approaches"],"prefix":"10.1016","volume":"282","author":[{"given":"Sarah Giarola da Silva","family":"Messias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ianca \u00c9velin Silva","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0770-0723","authenticated-orcid":false,"given":"Kimberly Freitas","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4400-9141","authenticated-orcid":false,"given":"Cristiana Couto","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza Pessoa","family":"de Mendon\u00e7a \u00c2ngelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"de Faria Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2633-539X","authenticated-orcid":false,"given":"Eliza Mathias","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana P\u00e1dua","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7569-8883","authenticated-orcid":false,"given":"L\u00eddia Paula","family":"Faustino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Augusto","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana Grazziela Alves Coelho","family":"dos Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Teixeira-Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4969-8812","authenticated-orcid":false,"given":"Lis Ribeiro do Valle","family":"Antonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Ant\u00f4nio Pascoal","family":"Xavier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6733-8722","authenticated-orcid":false,"given":"Olindo Assis","family":"Martins-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre de Magalh\u00e3es Vieira","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7532-3360","authenticated-orcid":false,"given":"M\u00e1rcio Sobreira Silva","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2026.107223_bib0002","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/S0140-6736(11)61051-9","article-title":"Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis","volume":"378","author":"Nair","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.imlet.2026.107223_bib0003","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1750-2659.2009.00073.x","article-title":"Estimates of US influenza-associated deaths made using four different methods","volume":"3","author":"Thompson","year":"2009","journal-title":"Influenza Other Respir Viruses."},{"key":"10.1016\/j.imlet.2026.107223_bib0005","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/QCO.0000000000000347","article-title":"Bacterial pneumonia as an influenza complication","volume":"30","author":"Martin-Loeches","year":"2017","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.imlet.2026.107223_bib0006","article-title":"Lethal synergism between influenza and Streptococcus pneumoniae","volume":"2","author":"Rudd","year":"2016","journal-title":"J. Infect. Pulm. Dis."},{"key":"10.1016\/j.imlet.2026.107223_bib0007","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1186\/s12879-018-3548-0","article-title":"The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a(H1N1)pdm09","volume":"18","author":"MacIntyre","year":"2018","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.imlet.2026.107223_bib0008","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jcv.2013.05.011","article-title":"Cytokine responses in patients with mild or severe influenza A(H1N1)pdm09","volume":"58","author":"Bradley-Stewart","year":"2013","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.imlet.2026.107223_bib0009","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.coviro.2012.02.013","article-title":"Pathogenesis of influenza virus infections: the good, the bad and the ugly","volume":"2","author":"Kuiken","year":"2012","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.imlet.2026.107223_bib0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1473-3099(13)70286-X","article-title":"Pathogenesis of influenza-induced acute respiratory distress syndrome","volume":"14","author":"Short","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.imlet.2026.107223_bib0011","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.coviro.2011.08.002","article-title":"Influenza virus vaccines: lessons from the 2009 H1N1 pandemic","volume":"1","author":"Broadbent","year":"2011","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.imlet.2026.107223_bib0012","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0140-6736(99)01241-6","volume":"354","author":"Cox","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.imlet.2026.107223_bib0013","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1002\/jmv.26990","article-title":"A brief review of influenza virus infection","volume":"93","author":"Javanian","year":"2021","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.imlet.2026.107223_bib0014","series-title":"Antiviral Drug Discovery and Development","first-page":"195","article-title":"Anti-influenza drug discovery and development: targeting the virus and its host by all possible means","author":"Olivier","year":"2021"},{"key":"10.1016\/j.imlet.2026.107223_bib0015","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/80868","article-title":"Interleukin-7 mediates the homeostasis of na\u00efve and memory CD8 T cells in vivo","volume":"1","author":"Schluns","year":"2000","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2026.107223_bib0016","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1009","article-title":"Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells","volume":"4","author":"Kaech","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2026.107223_bib0017","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050199","article-title":"Interleukin-7, but not thymic stromal lymphopoietin, plays a key role in the T cell response to influenza A virus","volume":"7","author":"Plumb","year":"2012","journal-title":"PLoS One."},{"key":"10.1016\/j.imlet.2026.107223_bib0018","doi-asserted-by":"crossref","first-page":"460","DOI":"10.4110\/in.2017.17.6.460","article-title":"Plasmacytoid dendritic cells contribute to the protective immunity induced by intranasal treatment with fc-fused interleukin-7 against Lethal Influenza Virus infection","volume":"17","author":"Kang","year":"2017","journal-title":"Immune Netw."},{"key":"10.1016\/j.imlet.2026.107223_bib0019","doi-asserted-by":"crossref","unstructured":"Kang MC, Choi D, Choi W, Park J, Namkoong H, Park S, et al. Intranasal introduction of fc-fused interleukin-7 provides long- lasting prophylaxis against lethal Influenza virus infection 2016;90:2273\u201384. https:\/\/doi.org\/10.1128\/JVI.02768-15.Editor.","DOI":"10.1128\/JVI.02768-15"},{"key":"10.1016\/j.imlet.2026.107223_bib0020","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nature02067","article-title":"Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1","volume":"426","author":"Opferman","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2026.107223_bib0021","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2008.11.002","article-title":"Homeostasis of naive and memory T cells","volume":"29","author":"Surh","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2026.107223_bib0022","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/S0092-8674(00)80289-5","article-title":"Bcl-2 can rescue T lymphocyte development in Interleukin-7 receptor-deficient mice but not in Mutant rag-1-\/- mice","volume":"89","author":"Maraskovsky","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.imlet.2026.107223_bib0023","series-title":"Orthomyxoviridae: The Viruses and Their Replication","author":"Shaw","year":"2007"},{"key":"10.1016\/j.imlet.2026.107223_bib0024","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1073\/pnas.0437772100","article-title":"Selective incorporation of influenza virus RNA segments into virions","volume":"100","author":"Fujii","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.imlet.2026.107223_bib0025","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1128\/JVI.78.6.3083-3088.2004","article-title":"Characterization of a neuraminidase-deficient influenza a virus as a potential gene delivery vector and a live vaccine","volume":"78","author":"Shinya","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.imlet.2026.107223_bib0026","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/14760584.2019.1582338","article-title":"Recombinant influenza A viruses as vaccine vectors","volume":"18","author":"Gerlach","year":"2019","journal-title":"Expert Rev. Vaccine."},{"key":"10.1016\/j.imlet.2026.107223_bib0027","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098685","article-title":"Protective immunity and safety of a genetically modified influenza virus vaccine","volume":"9","author":"Barbosa","year":"2014","journal-title":"PLoS One."},{"key":"10.1016\/j.imlet.2026.107223_bib0028","doi-asserted-by":"crossref","first-page":"77","DOI":"10.7774\/cevr.2012.1.1.77","article-title":"Recombinant influenza viruses as delivery vectors for hepatis B virus epitopes","volume":"1","author":"Song","year":"2012","journal-title":"Clin. Exp. Vaccine Res."},{"key":"10.1016\/j.imlet.2026.107223_bib0029","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41541-024-01033-5","article-title":"Intranasal influenza-vectored vaccine expressing pneumococcal surface protein A protects against Influenza and Streptococcus pneumoniae infections","volume":"9","author":"Cardoso","year":"2024","journal-title":"NPJ Vaccine."},{"key":"10.1016\/j.imlet.2026.107223_bib0030","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.virol.2005.09.050","article-title":"Recombinant influenza A viruses harboring optimized dicistronic NA segment with an extended native 5\u2019 terminal sequence: induction of heterospecific B and T cell responses in mice","volume":"345","author":"Vieira Machado","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.imlet.2026.107223_bib0031","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1128\/JVI.00910-07","article-title":"Garc A-sastre A. Rescue of influenza A virus from recombinant DNA","volume":"81","author":"Fodor","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.imlet.2026.107223_bib0032","doi-asserted-by":"crossref","first-page":"9345","DOI":"10.1073\/pnas.96.16.9345","article-title":"Generation of influenza A viruses entirely from cloned cDNAs","volume":"96","author":"Neumann","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.imlet.2026.107223_bib0033","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.virusres.2004.02.028","article-title":"Efficient generation and growth of influenza virus A\/PR\/8\/34 from eight cDNA fragments","volume":"103","author":"De Wit","year":"2004","journal-title":"Virus Res."},{"key":"10.1016\/j.imlet.2026.107223_bib0034","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s007050170002","article-title":"Universal primer set for the full-length amplification of all influenza A viruses","volume":"146","author":"Hoffmann","year":"2001","journal-title":"Arch Virol."},{"key":"10.1016\/j.imlet.2026.107223_bib0035","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1146\/annurev.pathmechdis.3.121806.154316","article-title":"The pathology of influenza virus infections","volume":"3","author":"Taubenberger","year":"2008","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.imlet.2026.107223_bib0036","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.imbio.2009.05.002","article-title":"Transferred T cells preferentially adhere in the BALT of CD26-deficient recipient lungs during asthma","volume":"215","author":"Schade","year":"2010","journal-title":"Immunobiology"},{"key":"10.1016\/j.imlet.2026.107223_bib0037","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/cmi.2017.150","article-title":"Application of light sheet microscopy for qualitative and quantitative analysis of bronchus-associated lymphoid tissue in mice","volume":"15","author":"Mzinza","year":"2018","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.imlet.2026.107223_bib0038","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrmicro3231","article-title":"The co-pathogenesis of influenza viruses with bacteria in the lung","volume":"12","author":"McCullers","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.imlet.2026.107223_bib0039","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.it.2005.01.004","article-title":"IL-7: maintaining T-cell memory and achieving homeostasis","volume":"26","author":"Bradley","year":"2005","journal-title":"Trends Immunol."},{"key":"10.1016\/j.imlet.2026.107223_bib0040","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1365-2567.2010.03325.x","article-title":"Interleukin-7 enhances memory CD8+ T-cell recall responses in health but its activity is impaired in human immunodeficiency virus infection","volume":"131","author":"O\u2019Connor","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.imlet.2026.107223_bib0041","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/viro.2001.1008","article-title":"Reverse genetics of influenza virus","volume":"287","author":"Neumann","year":"2001","journal-title":"Virology"},{"key":"10.1016\/j.imlet.2026.107223_bib0042","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.15252\/embj.201797924","article-title":"RNA polymerase I, bending the rules?","volume":"36","author":"Jochem","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.imlet.2026.107223_bib0043","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1093\/nar\/21.16.3607","article-title":"RNA polymerase I catalysed transcription of insert viral cDNA","volume":"21","author":"Zobel","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.imlet.2026.107223_bib0044","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1073\/pnas.0437772100","article-title":"Selective incorporation of influenza virus RNA segments into virions","volume":"100","author":"Fujii","year":"2003","journal-title":"Proc Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.imlet.2026.107223_bib0045","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0006-3002(57)90389-X","article-title":"Neuraminidase: the specific enzyme of influenza virus and ibrio cholerae","volume":"23","author":"Gottschalk","year":"1957","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.imlet.2026.107223_bib0046","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00281-017-0636-y","article-title":"New fronts emerge in the influenza cytokine storm","volume":"39","author":"Guo","year":"2017","journal-title":"Semin Immunopathol."},{"key":"10.1016\/j.imlet.2026.107223_bib0047","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/cmi.2015.74","article-title":"The cytokine storm of severe influenza and development of immunomodulatory therapy","volume":"13","author":"Liu","year":"2016","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.imlet.2026.107223_bib0048","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nm1091","article-title":"Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity","volume":"10","author":"Moyron-Quiroz","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.imlet.2026.107223_bib0049","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1089\/lrb.2013.0015","article-title":"Inducible bronchus-associated lymphoid tissue (iBALT) synergizes with local lymph nodes during antiviral CD4+ T cell responses","volume":"11","author":"Richert","year":"2013","journal-title":"Lymphat. Res. Biol."},{"key":"10.1016\/j.imlet.2026.107223_bib0050","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.4049\/jimmunol.1100987","article-title":"Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells","volume":"187","author":"Ho","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2026.107223_bib0051","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1084\/jem.20071365","article-title":"Clearance of influenza virus from the lung depends on migratory langerin+CD11b- but not plasmacytoid dendritic cells","volume":"205","author":"GeurtsvanKessel","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2026.107223_bib0052","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1172\/JCI60659","article-title":"Cross-presenting CD103+ dendritic cells are protected from influenza virus infection","volume":"122","author":"Helft","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.imlet.2026.107223_bib0053","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3389\/fimmu.2019.00611","article-title":"Inducible bronchus-associated lymphoid tissues (iBALT) serve as sites of B cell selection and maturation following influenza infection in mice","volume":"10","author":"Tan","year":"2019","journal-title":"Front Immunol."},{"key":"10.1016\/j.imlet.2026.107223_bib0054","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.coi.2011.07.016","article-title":"The pathogenesis of influenza virus infections: the contributions of virus and host factors","volume":"23","author":"Fukuyama","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.imlet.2026.107223_bib0055","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrmicro3231","article-title":"The co-pathogenesis of influenza viruses with bacteria in the lung","volume":"12","author":"McCullers","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.imlet.2026.107223_bib0056","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1164\/arrd.1986.134.5.1040","article-title":"Adherence of type I Streptococcus pneumoniae to tracheal epithelium of mice infected with influenza A\/PR8 virus","volume":"134","author":"Plotkowski","year":"1986","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.imlet.2026.107223_bib0057","first-page":"428","article-title":"Modifications of lung clearance mechanisms by acute influenza A infection","volume":"106","author":"Levandowski","year":"1985","journal-title":"J. Lab Clin. Med."},{"key":"10.1016\/j.imlet.2026.107223_bib0058","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41385-019-0212-y","article-title":"Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response","volume":"13","author":"Hassane","year":"2020","journal-title":"Mucosal. Immunol."},{"key":"10.1016\/j.imlet.2026.107223_bib0059","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4049\/jimmunol.0902841","article-title":"IL-7-dependent B lymphocytes are essential for the anti-polysaccharide response and protective immunity to Streptococcus pneumoniae","volume":"185","author":"Shriner","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2026.107223_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105292","article-title":"Relevance of angiotensin-(1-7) and its receptor mas in pneumonia caused by influenza virus and post-influenza pneumococcal infection","volume":"163","author":"Melo","year":"2021","journal-title":"Pharmacol. Res."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247826000969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247826000969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:31:42Z","timestamp":1787589102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247826000969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":58,"alternative-id":["S0165247826000969"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2026.107223","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessment of a recombinant influenza virus carrying interleukin 7 gene as a platform for novel immunotherapeutic approaches","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2026.107223","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of European Federation of Immunological Societies.","name":"copyright","label":"Copyright"}],"article-number":"107223"}}