{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T11:25:04Z","timestamp":1792581904672,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T00:00:00Z","timestamp":1376697600000},"content-version":"vor","delay-in-days":3242,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.immuni.2004.08.011","type":"journal-article","created":{"date-parts":[[2004,10,21]],"date-time":"2004-10-21T14:49:05Z","timestamp":1098370145000},"page":"527-538","source":"Crossref","is-referenced-by-count":1391,"title":["Retinoic Acid Imprints Gut-Homing Specificity on T Cells"],"prefix":"10.1016","volume":"21","author":[{"given":"Makoto","family":"Iwata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asami","family":"Hirakiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Eshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kagechika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieko","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Young","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2004.08.011_BIB1","doi-asserted-by":"crossref","first-page":"14708","DOI":"10.1074\/jbc.275.19.14708","article-title":"Successive expression and activation of NFAT family members during thymocyte differentiation","volume":"275","author":"Adachi","year":"2000","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.immuni.2004.08.011_BIB2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0014-5793(98)00355-X","article-title":"Retinal dehydrogenase gene expression in stomach and small intestine of rats during postnatal development and in vitamin A deficiency","volume":"426","author":"Bhat","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1016\/j.immuni.2004.08.011_BIB3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0065-2776(08)60022-X","article-title":"Lymphocyte trafficking and regional immunity","volume":"72","author":"Butcher","year":"1999","journal-title":"Adv. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1084\/jem.20011502","article-title":"Rapid acquisition of tissue-specific homing phenotypes by CD4+ T cells activated in cutaneous or mucosal lymphoid tissues","volume":"195","author":"Campbell","year":"2002","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.immuni.2004.08.011_BIB5","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.4049\/jimmunol.152.4.1515","article-title":"In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function","volume":"152","author":"Cantorna","year":"1994","journal-title":"J. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB6","doi-asserted-by":"crossref","first-page":"388","DOI":"10.4049\/jimmunol.142.2.388","article-title":"Characterization of a helper T lymphocyte defect in vitamin A-deficient mice","volume":"142","author":"Carman","year":"1989","journal-title":"J. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.humimm.2003.10.006","article-title":"Identification and characterization of intestinal Peyer's patch interferon-\u03b1 producing (plasmacytoid) dendritic cells","volume":"65","author":"Castellaneta","year":"2004","journal-title":"Hum. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB8","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/S0022-2275(20)32523-2","article-title":"Differentiation of human epidermal keratinocytes is accompanied by increased expression of CRABP-II and increased cellular concentration of retinoic acids","volume":"39","author":"Chatellard-Gruaz","year":"1998","journal-title":"J. Lipid Res"},{"key":"10.1016\/j.immuni.2004.08.011_BIB9","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1042\/bj2440489","article-title":"Terminal-group oxidation of retinol by mouse epidermis","volume":"244","author":"Connor","year":"1987","journal-title":"Biochem. J"},{"key":"10.1016\/j.immuni.2004.08.011_BIB10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1172\/JCI3001","article-title":"The combined roles of P- and E-selectins in atheroscrelosis","volume":"102","author":"Dong","year":"1998","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.immuni.2004.08.011_BIB11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0026-0495(96)90062-1","article-title":"Vitamin A status affects the development of diabetes and insulitis in BB rats","volume":"45","author":"Driscoll","year":"1996","journal-title":"Metabolism"},{"key":"10.1016\/j.immuni.2004.08.011_BIB12","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1046\/j.1432-1327.2000.01497.x","article-title":"Families of retinoid dehydrogenases regulating vitamin A function. Production of visual pigment and retinoic acid","volume":"267","author":"Duester","year":"2000","journal-title":"Eur. J. Biochem"},{"key":"10.1016\/j.immuni.2004.08.011_BIB13","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1093\/intimm\/7.12.1905","article-title":"Homing of lymphocytes into islets of Langerhans in prediabetic non-obese diabetic mice is not restricted to autoreactive T cells","volume":"7","author":"Faveeuw","year":"1995","journal-title":"Int. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1084\/jem.20011353","article-title":"Pancreatic lymph nodes are required for priming of \u03b2 cell reactive T cells in NOD mice","volume":"196","author":"Gagnerault","year":"2002","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.immuni.2004.08.011_BIB15","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1084\/jem.148.6.1661","article-title":"The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions","volume":"148","author":"Guy-Grand","year":"1978","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.immuni.2004.08.011_BIB16","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.4049\/jimmunol.152.7.3282","article-title":"Role of \u03b14-integrins in lymphocyte homing to mucosal tissues in vivo","volume":"152","author":"Hamann","year":"1994","journal-title":"J. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB17","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1093\/jn\/132.12.3736","article-title":"Retinoic acid enhances the T helper 2 cell development that is essential for robust antibody responses through its action on antigen-presenting cells","volume":"132","author":"Hoag","year":"2002","journal-title":"J. Nutr"},{"key":"10.1016\/j.immuni.2004.08.011_BIB18","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1084\/jem.191.8.1381","article-title":"Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3\u03b1, MIP-3\u03b2, and secondary lymphoid organ chemokine","volume":"191","author":"Iwasaki","year":"2000","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.immuni.2004.08.011_BIB19","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.4049\/jimmunol.149.10.3302","article-title":"Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes","volume":"149","author":"Iwata","year":"1992","journal-title":"J. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB20","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/intimm\/dxg101","article-title":"Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors","volume":"15","author":"Iwata","year":"2003","journal-title":"Int. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB21","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1002\/eji.200324405","article-title":"Diabetogenic T cells are primed both in pancreatic and gut-associated lymph nodes in NOD mice","volume":"33","author":"Jaakkola","year":"2003","journal-title":"Eur. J. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB22","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1084\/jem.20031244","article-title":"Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT)","volume":"198","author":"Johansson-Lindbom","year":"2003","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.immuni.2004.08.011_BIB23","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1021\/jm00119a021","article-title":"Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity","volume":"31","author":"Kagechika","year":"1988","journal-title":"J. Med. Chem"},{"key":"10.1016\/j.immuni.2004.08.011_BIB24","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.4049\/jimmunol.162.9.5173","article-title":"Differential homing commitments of antigen-specific T cells after oral or parenteral immunization in humans","volume":"162","author":"Kantele","year":"1999","journal-title":"J. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB25","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0092-8674(95)90202-3","article-title":"Nonsteroid nuclear receptor","volume":"83","author":"Kastner","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2004.08.011_BIB26","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1084\/jem.192.5.761","article-title":"Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment","volume":"192","author":"Kunkel","year":"2000","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.immuni.2004.08.011_BIB27","series-title":"Current Protocols in Immunology","article-title":"Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells","author":"Lefran\u00e7ois","year":"1999"},{"key":"10.1016\/j.immuni.2004.08.011_BIB28","doi-asserted-by":"crossref","first-page":"15360","DOI":"10.1074\/jbc.274.22.15360","article-title":"Identification of a novel class of retinoic acid receptor \u03b2-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells","volume":"274","author":"Li","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.immuni.2004.08.011_BIB29","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s002510050422","article-title":"The \u03b27 integrin gene (Itgb-7) promoter is responsive to TGF-\u03b21","volume":"48","author":"Lim","year":"1998","journal-title":"Immunogenetics"},{"key":"10.1016\/j.immuni.2004.08.011_BIB30","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0092-8674(00)80137-3","article-title":"The \u03b1(1,3)fucosyltransferase FucT-VII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis","volume":"86","author":"Maly","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2004.08.011_BIB31","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(95)90200-7","article-title":"The RXR heterodimers and orphan receptors","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2004.08.011_BIB32","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1126\/science.1058867","article-title":"Preferential localization of effector memory cells in nonlymphoid tissue","volume":"291","author":"Masopust","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.immuni.2004.08.011_BIB33","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature01726","article-title":"Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells","volume":"424","author":"Mora","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2004.08.011_BIB34","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1128\/IAI.63.8.2867-2872.1995","article-title":"Impaired human responses to tetanus toxoid in vitamin A-deficient SCID mice reconstituted with human peripheral blood lymphocytes","volume":"63","author":"Molrine","year":"1995","journal-title":"Infect. Immun"},{"key":"10.1016\/j.immuni.2004.08.011_BIB35","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1388-1981(99)00117-1","article-title":"Interactions of retinoid binding proteins and enzymes in retinoid metabolism","volume":"1440","author":"Napoli","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.immuni.2004.08.011_BIB36","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4049\/jimmunol.154.1.450","article-title":"Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course","volume":"154","author":"Racke","year":"1995","journal-title":"J. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB37","doi-asserted-by":"crossref","first-page":"291S","DOI":"10.1093\/jn\/133.1.291S","article-title":"Retinoid production and catabolism","volume":"133","author":"Ross","year":"2003","journal-title":"J. Nutr"},{"key":"10.1016\/j.immuni.2004.08.011_BIB38","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2004.08.011_BIB39","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0140-6736(86)91157-8","article-title":"Impact of vitamin A supplementation on childhood mortality","volume":"1","author":"Sommer","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.immuni.2004.08.011_BIB40","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/1521-4141(200205)32:5<1445::AID-IMMU1445>3.0.CO;2-E","article-title":"Intestinal dendritic cells increase T cell expression of \u03b14\u03b27 integrin","volume":"32","author":"Stagg","year":"2002","journal-title":"Eur. J. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB41","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.4049\/jimmunol.168.9.4495","article-title":"Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway","volume":"168","author":"Stephensen","year":"2002","journal-title":"J. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB42","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1172\/JCI0215988","article-title":"CCL25 mediates the localization of recently activated CD8\u03b1\u03b2+ lymphocytes to the small-intestinal mucosa","volume":"110","author":"Svensson","year":"2002","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.immuni.2004.08.011_BIB43","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1021\/jm0255320","article-title":"Novel retinoid X receptor antagonists","volume":"45","author":"Takahashi","year":"2002","journal-title":"J. Med. Chem"},{"key":"10.1016\/j.immuni.2004.08.011_BIB44","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1021\/jm9704309","article-title":"Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers","volume":"40","author":"Umemiya","year":"1997","journal-title":"J. Med. Chem"},{"key":"10.1016\/j.immuni.2004.08.011_BIB45","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1042\/bj2990459","article-title":"Isomerization of all-trans-retinoic acid to 9-cis-retinoic acid","volume":"299","author":"Urbach","year":"1994","journal-title":"Biochem. J"},{"key":"10.1016\/j.immuni.2004.08.011_BIB46","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1056\/NEJM200010053431407","article-title":"T-cell function and migration. Two sides of the same coin","volume":"343","author":"von Andrian","year":"2000","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.immuni.2004.08.011_BIB47","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/0003-9861(92)90399-H","article-title":"Retinoic acid can be produced from excentric cleavage of \u03b2-carotene in human intestinal mucosa","volume":"293","author":"Wang","year":"1992","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1016\/j.immuni.2004.08.011_BIB48","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1084\/jem.194.7.953","article-title":"Migratory properties of naive, effector, and memory CD8+ T cells","volume":"194","author":"Weninger","year":"2001","journal-title":"J. Exp. Med"},{"key":"10.1016\/j.immuni.2004.08.011_BIB49","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/1521-4141(200001)30:1<262::AID-IMMU262>3.0.CO;2-0","article-title":"The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9","volume":"30","author":"Wurbel","year":"2000","journal-title":"Eur. J. Immunol"},{"key":"10.1016\/j.immuni.2004.08.011_BIB50","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1073\/pnas.90.13.6170","article-title":"9-cis-retinoic acid inhibits activation-driven T-cell apoptosis","volume":"90","author":"Yang","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2004.08.011_BIB51","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.2337\/diacare.46.10.1542","article-title":"Involvement of \u03b27 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the development of diabetes in obese diabetic mice","volume":"46","author":"Yang","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2004.08.011_BIB52","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/1097-4652(200102)186:2<220::AID-JCP1018>3.0.CO;2-N","article-title":"Cellular expression of retinal dehydrogenase types 1 and 2","volume":"186","author":"Zhai","year":"2001","journal-title":"J. Cell. Physiol"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107476130400247X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107476130400247X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T13:00:14Z","timestamp":1682773214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107476130400247X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S107476130400247X"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2004.08.011","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1021920.251774","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1021920.249625","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1021920.253704","asserted-by":"object"}]},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}