{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T13:02:41Z","timestamp":1779282161475,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2609,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37 AI054636"],"award-info":[{"award-number":["R37 AI054636"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.immuni.2006.04.014","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T09:19:47Z","timestamp":1153905587000},"page":"55-65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["The B Cell Receptor Promotes B Cell Activation and Proliferation through a Non-ITAM Tyrosine in the Ig\u03b1 Cytoplasmic Domain"],"prefix":"10.1016","volume":"25","author":[{"given":"Heide Christine K.","family":"Patterson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Me","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidde","family":"Ploegh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Rajewsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2006.04.014_bib1","doi-asserted-by":"crossref","first-page":"6834","DOI":"10.4049\/jimmunol.167.12.6834","article-title":"Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation","volume":"167","author":"Allman","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0952-7915(00)00216-8","article-title":"B lymphocyte activation by contact-mediated interactions with T lymphocytes","volume":"13","author":"Bishop","year":"2001","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib3","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.4049\/jimmunol.155.7.3281","article-title":"Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM)","volume":"155","author":"Cambier","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib4","doi-asserted-by":"crossref","first-page":"6461","DOI":"10.1093\/emboj\/cdf658","article-title":"BLNK: molecular scaffolding through \u2018cis\u2019-mediated organization of signaling proteins","volume":"21","author":"Chiu","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.immuni.2006.04.014_bib5","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.coi.2004.03.007","article-title":"B-cell antigen receptor signaling requirements for targeting antigen to the MHC class II presentation pathway","volume":"16","author":"Clark","year":"2004","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib6","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1002\/1521-4141(200107)31:7<2126::AID-IMMU2126>3.0.CO;2-O","article-title":"Association of SLP-65\/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha","volume":"31","author":"Engels","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib7","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/eji.1830170414","article-title":"Expansion and functional activity of Ly-1+ B cells upon transfer of peritoneal cells into allotype-congenic, newborn mice","volume":"17","author":"Forster","year":"1987","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib8","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1073\/pnas.87.12.4781","article-title":"The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow","volume":"87","author":"Forster","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2006.04.014_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1074-7613(00)00002-9","article-title":"Xid-like phenotypes: a B cell signalosome takes shape","volume":"13","author":"Fruman","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2006.04.014_bib10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1074-7613(00)80591-9","article-title":"BLNK: a central linker protein in B cell activation","volume":"9","author":"Fu","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2006.04.014_bib11","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/(SICI)1521-4141(199904)29:04<1314::AID-IMMU1314>3.0.CO;2-4","article-title":"T-independent type 2 antigens induce B cell proliferation in multiple splenic sites, but exponential growth is confined to extrafollicular foci","volume":"29","author":"Garcia de Vinuesa","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib12","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/334676a0","article-title":"Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice","volume":"334","author":"Goodnow","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2006.04.014_bib13","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1034\/j.1600-065X.2000.00615.x","article-title":"Rel\/NF-kappaB transcription factors: key mediators of B-cell activation","volume":"176","author":"Gugasyan","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2006.04.014_bib14","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1146\/annurev.immunol.19.1.595","article-title":"B cell development pathways","volume":"19","author":"Hardy","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1074-7613(00)80012-6","article-title":"BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells","volume":"10","author":"Ishiai","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2006.04.014_bib16","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1074-7613(00)80130-2","article-title":"Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65","volume":"11","author":"Jumaa","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2006.04.014_bib17","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nature01608","article-title":"Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia","volume":"423","author":"Jumaa","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2006.04.014_bib18","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1128\/MCB.22.8.2524-2535.2002","article-title":"The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways","volume":"22","author":"Kabak","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.immuni.2006.04.014_bib19","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib20","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1073\/pnas.0511315103","article-title":"Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation","volume":"103","author":"Kim","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2006.04.014_bib21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1034\/j.1600-065X.2000.00609.x","article-title":"Immunobiology of the immature B cell: plasticity in the B-cell antigen receptor-induced response fine tunes negative selection","volume":"176","author":"King","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2006.04.014_bib22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/ni1163","article-title":"A leucine zipper in the N terminus confers membrane association to SLP-65","volume":"6","author":"Kohler","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib23","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1093\/intimm\/5.8.957","article-title":"Targeted disruption of the MHC class II Aa gene in C57BL\/6 mice","volume":"5","author":"Kontgen","year":"1993","journal-title":"Int. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1084\/jem.194.4.455","article-title":"Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine- based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail","volume":"194","author":"Kraus","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2006.04.014_bib25","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cell.2004.05.014","article-title":"Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha\/beta heterodimer","volume":"117","author":"Kraus","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2006.04.014_bib26","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1146\/annurev.immunol.17.1.555","article-title":"Genetic analysis of B cell antigen receptor signaling","volume":"17","author":"Kurosaki","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib27","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nri801","article-title":"Regulation of B-cell signal transduction by adaptor proteins","volume":"2","author":"Kurosaki","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib28","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1084\/jem.182.6.1815","article-title":"Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling","volume":"182","author":"Kurosaki","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2006.04.014_bib29","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1084\/jem.188.5.819","article-title":"Syk tyrosine kinase and B cell antigen receptor (BCR) immunoglobulin-alpha subunit determine BCR-mediated major histocompatibility complex class II-restricted antigen presentation","volume":"188","author":"Lankar","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2006.04.014_bib30","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.4049\/jimmunol.166.3.1507","article-title":"Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization","volume":"166","author":"Ma","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib31","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nri799","article-title":"Marginal-zone B cells","volume":"2","author":"Martin","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib32","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1126\/science.286.5446.1954","article-title":"An essential role for BLNK in human B cell development","volume":"286","author":"Minegishi","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.immuni.2006.04.014_bib33","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1146\/annurev.iy.13.040195.003255","article-title":"T cell-independent antigens type 2","volume":"13","author":"Mond","year":"1995","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib34","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1126\/science.286.5446.1949","article-title":"Requirement for B cell linker protein (BLNK) in B cell development","volume":"286","author":"Pappu","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.immuni.2006.04.014_bib35","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.4049\/jimmunol.174.4.2012","article-title":"Dual requirement for the Ig alpha immunoreceptor tyrosine-based activation motif (ITAM) and a conserved non-Ig alpha ITAM tyrosine in supporting Ig alpha beta-mediated B cell development","volume":"174","author":"Pike","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib36","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1093\/nar\/23.24.5080","article-title":"A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells","volume":"23","author":"Schwenk","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2006.04.014_bib37","doi-asserted-by":"crossref","first-page":"911","DOI":"10.4049\/jimmunol.137.3.911","article-title":"The choice between two distinct T cell determinants within a 23-amino acid region of lysozyme depends on their structural context","volume":"137","author":"Shastri","year":"1986","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib38","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.4049\/jimmunol.168.5.2127","article-title":"Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Igalpha","volume":"168","author":"Siemasko","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib39","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.4049\/jimmunol.170.12.5820","article-title":"Cutting edge: B cell receptor signals regulate BLyS receptor levels in mature B cells and their immediate progenitors","volume":"170","author":"Smith","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib40","doi-asserted-by":"crossref","first-page":"20055","DOI":"10.1074\/jbc.M010800200","article-title":"The adaptor protein BLNK is required for B cell antigen receptor-induced activation of nuclear factor-kappa B and cell cycle entry and survival of B lymphocytes","volume":"276","author":"Tan","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.immuni.2006.04.014_bib41","doi-asserted-by":"crossref","first-page":"6099","DOI":"10.4049\/jimmunol.170.12.6099","article-title":"Polyvalent antigens stabilize B cell antigen receptor surface signaling microdomains","volume":"170","author":"Thyagarajan","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2006.04.014_bib42","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1084\/jem.188.4.791","article-title":"SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation","volume":"188","author":"Wienands","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2006.04.014_bib43","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/intimm\/12.3.397","article-title":"B cell development and activation defects resulting in xid-like immunodeficiency in BLNK\/SLP-65-deficient mice","volume":"12","author":"Xu","year":"2000","journal-title":"Int. Immunol."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761306003013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761306003013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:50:03Z","timestamp":1761033003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761306003013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S1074761306003013"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2006.04.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1033580.387830","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1033580.389019","asserted-by":"object"}]},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The B Cell Receptor Promotes B Cell Activation and Proliferation through a Non-ITAM Tyrosine in the Ig\u03b1 Cytoplasmic Domain","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2006.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}