{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:53:49Z","timestamp":1792677229743,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1755,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.immuni.2008.09.017","type":"journal-article","created":{"date-parts":[[2008,11,14]],"date-time":"2008-11-14T07:33:28Z","timestamp":1226648008000},"page":"819-833","source":"Crossref","is-referenced-by-count":164,"title":["Regulation of Hierarchical Clustering and Activation of Innate Immune Cells by Dendritic Cells"],"prefix":"10.1016","volume":"29","author":[{"given":"Suk-Jo","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Erh","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Reizis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Locksley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2008.09.017_bib1","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.4049\/jimmunol.171.3.1148","article-title":"Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T\u00a0cell responses","volume":"171","author":"Aichele","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib2","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.4049\/jimmunol.166.3.1796","article-title":"NK1.1+ cells and murine cytomegalovirus infection: What happens in\u00a0situ?","volume":"166","author":"Andrews","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib3","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.immuni.2008.06.013","article-title":"Bacterial entry to the splenic white pulp initiates antigen presentation to CD8(+) T\u00a0cells","volume":"29","author":"Aoshi","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2008.09.017_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1084\/jem.20040976","article-title":"Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes","volume":"200","author":"Auerbuch","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2008.09.017_bib5","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1084\/jem.20051474","article-title":"Natural killer cell behavior in lymph nodes revealed by static and real-time imaging","volume":"203","author":"Bajenoff","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2008.09.017_bib6","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1146\/annurev.immunol.18.1.767","article-title":"Immunobiology of dendritic cells","volume":"18","author":"Banchereau","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib7","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1084\/jem.20031051","article-title":"Memory CD8+ T\u00a0cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen","volume":"198","author":"Berg","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2008.09.017_bib8","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.4049\/jimmunol.175.3.1751","article-title":"Relative contributions of NK and CD8 T\u00a0cells to IFN-gamma mediated innate immune protection against Listeria monocytogenes","volume":"175","author":"Berg","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib9","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1084\/jem.20070991","article-title":"Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells","volume":"204","author":"Blasius","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2008.09.017_bib10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20040769","article-title":"Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection","volume":"200","author":"Carrero","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2008.09.017_bib11","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1084\/jem.20062648","article-title":"Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen","volume":"204","author":"Caton","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2008.09.017_bib12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1099\/00222615-44-4-295","article-title":"Early pathogenesis of Listeria monocytogenes infection in the mouse spleen","volume":"44","author":"Conlan","year":"1996","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.immuni.2008.09.017_bib13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1084\/jem.179.1.259","article-title":"Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody","volume":"179","author":"Conlan","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2008.09.017_bib14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev.immunol.23.021704.115628","article-title":"Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs","volume":"23","author":"Cyster","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib15","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.4049\/jimmunol.152.4.1836","article-title":"Administration of anti-granulocyte mAb RB6\u20138C5 impairs the resistance of mice to Listeria monocytogenes infection","volume":"152","author":"Czuprynski","year":"1994","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1084\/jem.194.1.29","article-title":"Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to Ly49H","volume":"194","author":"Daniels","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2008.09.017_bib17","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1398-9219.2004.00205.x","article-title":"Targeting of proteins derived from self-processing polyproteins containing multiple signal sequences","volume":"5","author":"de Felipe","year":"2004","journal-title":"Traffic"},{"key":"10.1016\/j.immuni.2008.09.017_bib18","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.4049\/jimmunol.167.9.5286","article-title":"Analysis of in\u00a0situ NK cell responses during viral infection","volume":"167","author":"Dokun","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib19","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/ni714","article-title":"Specific and nonspecific NK cell activation during virus infection","volume":"2","author":"Dokun","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib20","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1128\/IAI.59.9.2892-2900.1991","article-title":"Early gamma interferon production by natural killer cells is important in defense against murine listeriosis","volume":"59","author":"Dunn","year":"1991","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2008.09.017_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1600-065X.2007.00563.x","article-title":"The trafficking of natural killer cells","volume":"220","author":"Gregoire","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2008.09.017_bib22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1182\/blood-2002-10-3228","article-title":"Rapid recruitment of inflammatory monocytes is independent of neutrophil migration","volume":"102","author":"Henderson","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2008.09.017_bib23","doi-asserted-by":"crossref","first-page":"6846","DOI":"10.4049\/jimmunol.180.10.6846","article-title":"Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection","volume":"180","author":"Jia","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1074-7613(02)00365-5","article-title":"In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T\u00a0cells by exogenous cell-associated antigens","volume":"17","author":"Jung","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2008.09.017_bib25","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nature04517","article-title":"Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin\/Nalp3","volume":"440","author":"Kanneganti","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2008.09.017_bib26","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.immuni.2007.10.002","article-title":"Intracellular NOD-like receptors in host defense and disease","volume":"27","author":"Kanneganti","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2008.09.017_bib27","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.4049\/jimmunol.166.2.1097","article-title":"Bystander activation of CD8+ T\u00a0cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens","volume":"166","author":"Lertmemongkolchai","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib28","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1006\/cimm.1995.1125","article-title":"Analysis of the interrelationship between IL-12, TNF-alpha, and IFN-gamma production during murine listeriosis","volume":"163","author":"Liu","year":"1995","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib29","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.immuni.2007.03.006","article-title":"Dendritic cells prime natural killer cells by trans-presenting interleukin 15","volume":"26","author":"Lucas","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2008.09.017_bib30","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.coph.2006.03.009","article-title":"Two way communication between neutrophils and dendritic cells","volume":"6","author":"Ludwig","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.immuni.2008.09.017_bib31","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nri1997","article-title":"Inflammasome adaptors and sensors: Intracellular regulators of infection and inflammation","volume":"7","author":"Mariathasan","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf","volume":"430","author":"Mariathasan","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2008.09.017_bib33","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2008.09.017_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-065X.2006.00450.x","article-title":"Effector and regulatory events during natural killer-dendritic cell interactions","volume":"214","author":"Moretta","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2008.09.017_bib35","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/eji.200526024","article-title":"Distinct in\u00a0vivo dendritic cell activation by live versus killed Listeria monocytogenes","volume":"35","author":"Muraille","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib36","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature06664","article-title":"The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response","volume":"452","author":"Muruve","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2008.09.017_bib37","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.immuni.2006.07.017","article-title":"CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen","volume":"25","author":"Neuenhahn","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2008.09.017_bib38","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nri2057","article-title":"Whatever turns you on: Accessory-cell-dependent activation of NK cells by pathogens","volume":"7","author":"Newman","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib39","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1084\/jem.20040712","article-title":"Type I interferon production enhances susceptibility to Listeria monocytogenes infection","volume":"200","author":"O'Connell","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2008.09.017_bib40","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.4049\/jimmunol.176.7.4337","article-title":"Distinct roles of TLR2 and the adaptor ASC in IL-1beta\/IL-18 secretion in response to Listeria monocytogenes","volume":"176","author":"Ozoren","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib41","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nri1461","article-title":"Immune responses to Listeria monocytogenes","volume":"4","author":"Pamer","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib42","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.4049\/jimmunol.149.9.3040","article-title":"Cytokine expression in\u00a0vivo during murine listeriosis. Infection with live, virulent bacteria is required for monokine and lymphokine messenger RNA accumulation in the spleen","volume":"149","author":"Poston","year":"1992","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib43","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.1128\/IAI.61.12.5090-5096.1993","article-title":"Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice","volume":"61","author":"Rogers","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2008.09.017_bib44","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.4049\/jimmunol.169.7.3863","article-title":"Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice","volume":"169","author":"Seki","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib45","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib46","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S1074-7613(03)00330-3","article-title":"Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection","volume":"19","author":"Serbina","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2008.09.017_bib47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1074-7613(03)00171-7","article-title":"TNF\/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection","volume":"19","author":"Serbina","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2008.09.017_bib48","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.immuni.2005.12.003","article-title":"Recognition of cytosolic DNA activates an IRF3-dependent innate immune response","volume":"24","author":"Stetson","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2008.09.017_bib49","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nature06013","article-title":"DAI (DLM-1\/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response","volume":"448","author":"Takaoka","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2008.09.017_bib50","doi-asserted-by":"crossref","first-page":"718","DOI":"10.4049\/jimmunol.162.2.718","article-title":"The role of LY49 NK cell subsets in the regulation of murine cytomegalovirus infections","volume":"162","author":"Tay","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib51","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1002\/eji.200324003","article-title":"Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo","volume":"33","author":"Taylor","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib52","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1172\/JCI29919","article-title":"Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites","volume":"117","author":"Tsou","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2008.09.017_bib53","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/intimm\/dxh041","article-title":"Roles of caspase-1 in Listeria infection in mice","volume":"16","author":"Tsuji","year":"2004","journal-title":"Int. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib54","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0952-7915(97)80156-2","article-title":"Inter-relationship among macrophages, natural killer cells and neutrophils in early stages of Listeria resistance","volume":"9","author":"Unanue","year":"1997","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.immuni.2008.09.017_bib55","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1084\/jem.20071451","article-title":"CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells","volume":"204","author":"Vosshenrich","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2008.09.017_bib56","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1073\/pnas.0609692104","article-title":"Identification, activation, and selective in\u00a0vivo ablation of mouse NK cells via NKp46","volume":"104","author":"Walzer","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2008.09.017_bib57","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1084\/jem.20041961","article-title":"Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs","volume":"202","author":"Yoneyama","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2008.09.017_bib58","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1128\/IAI.72.2.1057-1064.2004","article-title":"Chemokine receptor 5 is dispensable for innate and adaptive immune responses to Listeria monocytogenes infection","volume":"72","author":"Zhong","year":"2004","journal-title":"Infect. Immun."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761308004676?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761308004676?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T22:52:55Z","timestamp":1684623175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761308004676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S1074761308004676"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2008.09.017","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1128889.585989","asserted-by":"object"}]},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}