{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:23:42Z","timestamp":1792571022309,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1112,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.immuni.2010.06.014","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T04:27:59Z","timestamp":1278649679000},"page":"128-140","source":"Crossref","is-referenced-by-count":245,"title":["Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation"],"prefix":"10.1016","volume":"33","author":[{"given":"Thomas C.","family":"Wirth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Hui","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime T.","family":"Sabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Bair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Harty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir P.","family":"Badovinac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2010.06.014_bib1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nm.f.1774","article-title":"CD8+ T\u00a0cell efficacy in vaccination and disease","volume":"14","author":"Appay","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2010.06.014_bib2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/ni804","article-title":"Programmed contraction of CD8(+) T\u00a0cells after infection","volume":"3","author":"Badovinac","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2010.06.014_bib3","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.4049\/jimmunol.170.10.4933","article-title":"Regulation of CD8+ T\u00a0cells undergoing primary and secondary responses to infection in the same host","volume":"170","author":"Badovinac","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2010.06.014_bib4","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nm1257","article-title":"Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination","volume":"11","author":"Badovinac","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2010.06.014_bib5","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.immuni.2007.04.013","article-title":"Initial T\u00a0cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T\u00a0cell response to infection","volume":"26","author":"Badovinac","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.06.014_bib6","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1182\/blood-2005-09-3851","article-title":"c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis","volume":"107","author":"Bianchi","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2010.06.014_bib7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1074-7613(00)80469-0","article-title":"Massive expansion of antigen-specific CD8+ T\u00a0cells during an acute virus infection","volume":"8","author":"Butz","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.06.014_bib8","doi-asserted-by":"crossref","first-page":"7837","DOI":"10.4049\/jimmunol.175.12.7837","article-title":"Identification of T\u00a0cell-restricted genes, and signatures for different T\u00a0cell responses, using\u00a0a comprehensive collection of microarray datasets","volume":"175","author":"Chtanova","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2010.06.014_bib9","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nm.1982","article-title":"Wnt signaling arrests effector T\u00a0cell differentiation and generates CD8+ memory stem cells","volume":"15","author":"Gattinoni","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2010.06.014_bib10","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.immuni.2010.02.001","article-title":"Integrating genomic signatures for immunologic discovery","volume":"32","author":"Haining","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.06.014_bib11","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.4049\/jimmunol.174.11.6791","article-title":"Dynamic regulation of IFN-gamma signaling in antigen-specific CD8+ T\u00a0cells responding to infection","volume":"174","author":"Haring","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2010.06.014_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nri2251","article-title":"Shaping and reshaping CD8+ T-cell memory","volume":"8","author":"Harty","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2010.06.014_bib13","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1084\/jem.20070322","article-title":"Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T\u00a0cells","volume":"204","author":"Hikono","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2010.06.014_bib14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0092-8674(94)90169-4","article-title":"T cell receptor antagonist peptides induce positive selection","volume":"76","author":"Hogquist","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2010.06.014_bib15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.immuni.2010.06.014_bib16","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2010.06.014_bib17","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1084\/jem.20052237","article-title":"Secondary memory CD8+ T\u00a0cells are more protective but slower to acquire a central-memory phenotype","volume":"203","author":"Jabbari","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2010.06.014_bib18","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.immuni.2009.11.007","article-title":"Diversity in T\u00a0cell memory: An embarrassment of riches","volume":"31","author":"Jameson","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.06.014_bib19","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0092-8674(02)01139-X","article-title":"Molecular and functional profiling of memory CD8 T\u00a0cell differentiation","volume":"111","author":"Kaech","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2010.06.014_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.immuni.2009.11.010","article-title":"Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T\u00a0cells favors terminal-effector differentiation in\u00a0vivo","volume":"32","author":"Kalia","year":"2010","journal-title":"Immunity"},{"issue":"Database issue","key":"10.1016\/j.immuni.2010.06.014_bib21","doi-asserted-by":"crossref","first-page":"D354","DOI":"10.1093\/nar\/gkj102","article-title":"From genomics to chemical genomics: New developments in KEGG","volume":"34","author":"Kanehisa","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2010.06.014_bib22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1196\/annals.1396.043","article-title":"Cytomegalovirus infection: A driving force in human T\u00a0cell immunosenescence","volume":"1114","author":"Koch","year":"2007","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.immuni.2010.06.014_bib23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.0105-2896.2006.00393.x","article-title":"Development, trafficking, and function of memory T-cell subsets","volume":"211","author":"Lefran\u00e7ois","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2010.06.014_bib24","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(03)00430-6","article-title":"Multiple tumor suppressor pathways negatively regulate telomerase","volume":"113","author":"Lin","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2010.06.014_bib25","doi-asserted-by":"crossref","first-page":"831","DOI":"10.4049\/jimmunol.177.2.831","article-title":"Stimulation history dictates memory CD8 T\u00a0cell phenotype: Implications for prime-boost vaccination","volume":"177","author":"Masopust","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2010.06.014_bib26","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1084\/jem.20080314","article-title":"Protective influenza-specific CD8 T\u00a0cell responses require interactions with dendritic cells in the lungs","volume":"205","author":"McGill","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.immuni.2010.06.014_bib27","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1091\/mbc.E07-05-0406","article-title":"Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition","volume":"18","author":"Mejlvang","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.immuni.2010.06.014_bib28","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.immuni.2008.02.020","article-title":"Human effector and memory CD8+ T\u00a0cell responses to smallpox and yellow fever vaccines","volume":"28","author":"Miller","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.06.014_bib29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2009.11.012","article-title":"Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T\u00a0cells","volume":"32","author":"Pipkin","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.06.014_bib30","first-page":"297","article-title":"Aspects of human cytomegalovirus latency and reactivation","volume":"325","author":"Reeves","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.immuni.2010.06.014_bib31","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two\u00a0subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2010.06.014_bib32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4049\/jimmunol.0803355","article-title":"IL-15 regulates both quantitative and qualitative features of the memory CD8 T\u00a0cell pool","volume":"184","author":"Sandau","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2010.06.014_bib33","doi-asserted-by":"crossref","first-page":"14017","DOI":"10.1073\/pnas.0805452105","article-title":"Memory CD8 T\u00a0cell responses exceeding a large but definable threshold provide long-term immunity to malaria","volume":"105","author":"Schmidt","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2010.06.014_bib34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri2274","article-title":"T-cell quality in memory and protection: Implications for vaccine design","volume":"8","author":"Seder","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2010.06.014_bib35","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.coi.2007.06.004","article-title":"CD8 T\u00a0cell dysfunction during chronic viral infection","volume":"19","author":"Shin","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.immuni.2010.06.014_bib36","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.immuni.2009.06.019","article-title":"A role for the transcriptional repressor Blimp-1 in CD8(+) T\u00a0cell exhaustion during chronic viral infection","volume":"31","author":"Shin","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.06.014_bib37","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2010.06.014_bib38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nmeth.1315","article-title":"mRNA-Seq whole-transcriptome analysis of a single cell","volume":"6","author":"Tang","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2010.06.014_bib39","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/nature07486","article-title":"Memory CD8 T-cell compartment grows in size with immunological experience","volume":"457","author":"Vezys","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2010.06.014_bib40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/ni889","article-title":"Lineage relationship and protective immunity of memory CD8 T\u00a0cell subsets","volume":"4","author":"Wherry","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2010.06.014_bib41","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.immuni.2007.09.006","article-title":"Molecular signature of CD8+ T\u00a0cell exhaustion during chronic viral infection","volume":"27","author":"Wherry","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.06.014_bib42","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.immuni.2008.02.014","article-title":"Rapid culling of the CD4+ T\u00a0cell repertoire in the transition from effector to memory","volume":"28","author":"Williams","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.06.014_bib43","doi-asserted-by":"crossref","first-page":"5895","DOI":"10.4049\/jimmunol.175.9.5895","article-title":"Molecular signatures distinguish human central memory from effector memory CD8 T\u00a0cell subsets","volume":"175","author":"Willinger","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.immuni.2010.06.014_bib44","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.it.2003.11.009","article-title":"Jump-starting the immune system: Prime-boosting comes of age","volume":"25","author":"Woodland","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.immuni.2010.06.014_bib45","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2007.11.016","article-title":"T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma","volume":"28","author":"Yang","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.06.014_bib46","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.4049\/jimmunol.0901199","article-title":"Constitutive activation of Wnt signaling favors generation of memory CD8 T\u00a0cells","volume":"184","author":"Zhao","year":"2010","journal-title":"J. Immunol."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761310002402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761310002402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T18:50:43Z","timestamp":1559242243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761310002402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S1074761310002402"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2010.06.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.7192959.793505129","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.7192959.7437055","asserted-by":"object"}]},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}