{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:28:46Z","timestamp":1791066526821,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":989,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.immuni.2010.11.014","type":"journal-article","created":{"date-parts":[[2010,11,19]],"date-time":"2010-11-19T04:22:43Z","timestamp":1290140563000},"page":"671-684","source":"Crossref","is-referenced-by-count":125,"title":["Hes1 Is a Critical but Context-Dependent Mediator of\u00a0Canonical Notch Signaling in Lymphocyte Development and Transformation"],"prefix":"10.1016","volume":"33","author":[{"given":"Agnieszka A.","family":"Wendorff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Thomas","family":"Wunderlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens C.","family":"Br\u00fcning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Robson","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy","family":"Radtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2010.11.014_bib1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: Cell fate control and signal integration in development","volume":"284","author":"Artavanis-Tsakonas","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.immuni.2010.11.014_bib2","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1146\/annurev.pathmechdis.3.121806.154300","article-title":"Notch signaling in leukemia","volume":"3","author":"Aster","year":"2008","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.immuni.2010.11.014_bib3","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1084\/jem.20061442","article-title":"Hierarchy of Notch-Delta interactions promoting T\u00a0cell lineage commitment and maturation","volume":"204","author":"Besseyrias","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2010.11.014_bib4","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrm2009","article-title":"Notch signalling: A simple pathway becomes complex","volume":"7","author":"Bray","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.immuni.2010.11.014_bib5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1182\/blood-2006-08-039883","article-title":"Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia","volume":"110","author":"Chan","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2010.11.014_bib6","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/ni1234","article-title":"Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism","volume":"6","author":"Ciofani","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2010.11.014_bib7","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.4049\/jimmunol.172.9.5230","article-title":"Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation","volume":"172","author":"Ciofani","year":"2004","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2010.11.014_bib8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.immuni.2006.05.010","article-title":"Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation","volume":"25","author":"Ciofani","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.11.014_bib9","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ccr.2010.08.006","article-title":"The Notch\/Hes1 pathway sustains NF-\u03baB activation through CYLD repression in T\u00a0cell leukemia","volume":"18","author":"Espinosa","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2010.11.014_bib10","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1073\/pnas.0606476104","article-title":"Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer","volume":"104","author":"Fern\u00e1ndez-Majada","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2010.11.014_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.immuni.2008.10.016","article-title":"Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms","volume":"30","author":"Feyerabend","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.11.014_bib12","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1093\/nar\/gkm477","article-title":"Delta-Notch\u2014and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors","volume":"35","author":"Fischer","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2010.11.014_bib13","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1084\/jem.20091990","article-title":"ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in\u00a0vivo","volume":"207","author":"Gibb","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2010.11.014_bib14","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/ni1075","article-title":"Delta-like 1 is necessary for the generation of marginal zone B cells but not T\u00a0cells in\u00a0vivo","volume":"5","author":"Hozumi","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2010.11.014_bib15","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1084\/jem.20080134","article-title":"Delta-like 4 is indispensable in thymic environment specific for T\u00a0cell development","volume":"205","author":"Hozumi","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2010.11.014_bib16","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1101\/gad.9.24.3136","article-title":"Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects","volume":"9","author":"Ishibashi","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.immuni.2010.11.014_bib17","first-page":"827","article-title":"Genetic elements regulating HES-1 induction in Wnt-1-transformed PC12 cells","volume":"9","author":"Issack","year":"1998","journal-title":"Cell Growth Differ."},{"key":"10.1016\/j.immuni.2010.11.014_bib18","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4049\/jimmunol.164.1.256","article-title":"A role for pref-1 and HES-1 in thymocyte development","volume":"164","author":"Kaneta","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2010.11.014_bib19","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1038\/sj.onc.1205487","article-title":"Overexpression of the Notch target genes Hes in\u00a0vivo induces lymphoid and myeloid alterations","volume":"21","author":"Kawamata","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.immuni.2010.11.014_bib20","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1084\/jem.20080829","article-title":"Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T\u00a0cell lineage commitment","volume":"205","author":"Koch","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2010.11.014_bib21","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.7660125","article-title":"Inducible gene targeting in mice","volume":"269","author":"K\u00fchn","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.immuni.2010.11.014_bib22","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1182\/blood-2002-07-2051","article-title":"HES-1 preserves purified hematopoietic stem cells ex\u00a0vivo and accumulates side population cells in\u00a0vivo","volume":"101","author":"Kunisato","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2010.11.014_bib23","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1074-7613(01)00227-8","article-title":"A critical role for Dnmt1 and DNA methylation in T\u00a0cell development, function, and survival","volume":"15","author":"Lee","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.11.014_bib24","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.4049\/jimmunol.178.7.4214","article-title":"Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development","volume":"178","author":"Li","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2010.11.014_bib25","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1084\/jem.20081561","article-title":"Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1","volume":"205","author":"Li","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2010.11.014_bib26","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1084\/jem.20061020","article-title":"The requirement for Notch signaling at the beta-selection checkpoint in\u00a0vivo is absolute and independent of the pre-T cell receptor","volume":"203","author":"Maillard","year":"2006","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2010.11.014_bib27","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.stem.2008.02.011","article-title":"Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells","volume":"2","author":"Maillard","year":"2008","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.immuni.2010.11.014_bib28","doi-asserted-by":"crossref","first-page":"14920","DOI":"10.1073\/pnas.2436557100","article-title":"Notch signaling controls multiple steps of pancreatic differentiation","volume":"100","author":"Murtaugh","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2010.11.014_bib29","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1182\/blood-2009-05-222836","article-title":"Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia","volume":"115","author":"Nakahara","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2010.11.014_bib30","doi-asserted-by":"crossref","first-page":"18261","DOI":"10.1073\/pnas.0606108103","article-title":"NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth","volume":"103","author":"Palomero","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2010.11.014_bib31","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/nm1636","article-title":"Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia","volume":"13","author":"Palomero","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2010.11.014_bib32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1074-7613(00)80105-3","article-title":"Notch1 expression in early lymphopoiesis influences B versus T lineage determination","volume":"11","author":"Pui","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.11.014_bib33","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1074-7613(00)80054-0","article-title":"Deficient T\u00a0cell fate specification in mice with an induced inactivation of Notch1","volume":"10","author":"Radtke","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.11.014_bib34","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2010.01.004","article-title":"Notch signaling in the immune system","volume":"32","author":"Radtke","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.11.014_bib35","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S1074-7613(03)00111-0","article-title":"Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development","volume":"18","author":"Saito","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.11.014_bib36","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.immuni.2010.11.014_bib37","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.immuni.2008.12.016","article-title":"Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches","volume":"30","author":"Tan","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.11.014_bib38","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/ni793","article-title":"Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells","volume":"3","author":"Tanigaki","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2010.11.014_bib39","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1093\/intimm\/dxn076","article-title":"ADAM10 is essential for proteolytic activation of Notch during thymocyte development","volume":"20","author":"Tian","year":"2008","journal-title":"Int. Immunol."},{"key":"10.1016\/j.immuni.2010.11.014_bib40","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1101\/gad.13.9.1203","article-title":"The bHLH gene Hes1 is essential for expansion of early T\u00a0cell precursors","volume":"13","author":"Tomita","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.immuni.2010.11.014_bib41","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1006\/cimm.1997.1094","article-title":"T cell progenitors in the murine fetal liver: Differences from those in the adult bone marrow","volume":"177","author":"Watanabe","year":"1997","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.immuni.2010.11.014_bib42","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T\u00a0cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.immuni.2010.11.014_bib43","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1101\/gad.1450406","article-title":"c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia\/lymphoma","volume":"20","author":"Weng","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.immuni.2010.11.014_bib44","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/85294","article-title":"Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development","volume":"2","author":"Wolfer","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2010.11.014_bib45","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S1074-7613(02)00330-8","article-title":"Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes","volume":"16","author":"Wolfer","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2010.11.014_bib46","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1634\/stemcells.2005-0598","article-title":"HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding","volume":"24","author":"Yu","year":"2006","journal-title":"Stem Cells"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761310004206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761310004206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T14:28:16Z","timestamp":1544106496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761310004206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S1074761310004206"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2010.11.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.6669956.6824054","asserted-by":"object"}]},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}