{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:45:07Z","timestamp":1791279907586,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":838,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.immuni.2011.03.015","type":"journal-article","created":{"date-parts":[[2011,4,23]],"date-time":"2011-04-23T00:51:24Z","timestamp":1303519884000},"page":"527-540","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":332,"title":["An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma"],"prefix":"10.1016","volume":"34","author":[{"given":"Mirjam","family":"Kool","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique\u00a0A.M.","family":"Willart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno","family":"van\u00a0Nimwegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Bergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Pouliot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u00a0Christian","family":"Virchow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Osorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caetano","family":"Reis\u00a0e\u00a0Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamida","family":"Hammad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart\u00a0N.","family":"Lambrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2011.03.015_bib1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1172\/JCI114499","article-title":"Dependence on O2- generation by xanthine oxidase of pathogenesis of influenza virus infection in mice","volume":"85","author":"Akaike","year":"1990","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2011.03.015_bib2","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/nature02991","article-title":"Essential role for the p110delta phosphoinositide 3-kinase in the allergic response","volume":"431","author":"Ali","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2011.03.015_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nri2254","article-title":"Immunology of asthma and chronic obstructive pulmonary disease","volume":"8","author":"Barnes","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.immuni.2009.08.014","article-title":"Innate cells and T helper 2 cell immunity in airway inflammation","volume":"31","author":"Barrett","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2011.03.015_bib5","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1172\/JCI28075","article-title":"MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals","volume":"116","author":"Chen","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2011.03.015_bib6","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1189\/jlb.70.4.659","article-title":"Crystal-induced neutrophil activation. VII. Involvement of Syk in the responses to monosodium urate crystals","volume":"70","author":"Desaulniers","year":"2001","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.immuni.2011.03.015_bib7","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.4049\/jimmunol.170.9.4457","article-title":"IL-6 production by pulmonary dendritic cells impedes Th1 immune responses","volume":"170","author":"Dodge","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib8","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.4049\/jimmunol.179.5.2910","article-title":"Proteinase-activated receptor-2 promotes allergic sensitization to an inhaled antigen through a TNF-mediated pathway","volume":"179","author":"Ebeling","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib9","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1084\/jem.20021340","article-title":"Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen","volume":"196","author":"Eisenbarth","year":"2002","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2011.03.015_bib10","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nature06939","article-title":"Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants","volume":"453","author":"Eisenbarth","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2011.03.015_bib11","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1002\/eji.200838549","article-title":"The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity","volume":"38","author":"Franchi","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib12","doi-asserted-by":"crossref","first-page":"18810","DOI":"10.1074\/jbc.M610762200","article-title":"Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria","volume":"282","author":"Franchi","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2011.03.015_bib13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nri2275","article-title":"Dendritic cells and epithelial cells:\u00a0Linking innate and adaptive immunity in asthma","volume":"8","author":"Hammad","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nm.1946","article-title":"House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells","volume":"15","author":"Hammad","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2011.03.015_bib15","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1084\/jem.20101563","article-title":"Inflammatory dendritic cells\u2014not basophils\u2014are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen","volume":"207","author":"Hammad","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2011.03.015_bib16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1164\/ajrccm.158.1.9709116","article-title":"Upregulation of xanthine oxidase by lipopolysaccharide, interleukin-1, and hypoxia. Role in acute lung injury","volume":"158","author":"Hassoun","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.immuni.2011.03.015_bib17","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/ni.1631","article-title":"Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization","volume":"9","author":"Hornung","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib18","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nm1617","article-title":"Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells","volume":"13","author":"Idzko","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2011.03.015_bib19","doi-asserted-by":"crossref","first-page":"11968","DOI":"10.1074\/jbc.274.17.11968","article-title":"Characterization of the 70-kDa peroxisomal membrane protein, an ATP binding cassette transporter","volume":"274","author":"Imanaka","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2011.03.015_bib20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1074-7613(02)00365-5","article-title":"In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T\u00a0cells by exogenous cell-associated antigens","volume":"17","author":"Jung","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2011.03.015_bib21","doi-asserted-by":"crossref","first-page":"6350","DOI":"10.4049\/jimmunol.0902673","article-title":"Human eosinophils recognize endogenous danger signal crystalline uric acid and produce proinflammatory cytokines mediated by autocrine ATP","volume":"184","author":"Kobayashi","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib22","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.4049\/jimmunol.181.6.3755","article-title":"Cutting edge: Alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome","volume":"181","author":"Kool","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib23","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1084\/jem.20071087","article-title":"Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells","volume":"205","author":"Kool","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2011.03.015_bib24","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1189\/jlb.0604325","article-title":"Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization","volume":"76","author":"Kuipers","year":"2004","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.immuni.2011.03.015_bib25","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.immuni.2009.08.008","article-title":"Biology of lung dendritic cells at the origin of asthma","volume":"31","author":"Lambrecht","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2011.03.015_bib26","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.4049\/jimmunol.178.8.5271","article-title":"Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release","volume":"178","author":"Li","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4049\/jimmunol.181.1.17","article-title":"Cutting edge: Inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3","volume":"181","author":"Li","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib28","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jaci.2006.02.034","article-title":"The course of allergen-induced leukocyte infiltration in human and experimental asthma","volume":"118","author":"Lommatzsch","year":"2006","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib29","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2011.03.015_bib30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nri2510","article-title":"Towards an understanding of the adjuvant action of aluminium","volume":"9","author":"Marrack","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2011.03.015_bib32","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1165\/rcmb.2005-0298OC","article-title":"Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation","volume":"34","author":"Matsubara","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.immuni.2011.03.015_bib33","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.1071059","article-title":"The danger model: A renewed sense of self","volume":"296","author":"Matzinger","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.immuni.2011.03.015_bib34","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.4049\/jimmunol.0900164","article-title":"Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity","volume":"183","author":"McKee","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib35","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jaci.2008.12.006","article-title":"Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways","volume":"123","author":"Nathan","year":"2009","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib36","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.immuni.2008.09.013","article-title":"Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells","volume":"29","author":"Ng","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2011.03.015_bib37","doi-asserted-by":"crossref","first-page":"28595","DOI":"10.1074\/jbc.M805766200","article-title":"Role of xanthine oxidase activation and reduced glutathione depletion in rhinovirus induction of inflammation in respiratory epithelial cells","volume":"283","author":"Papi","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2011.03.015_bib38","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nri2735","article-title":"How are T(H)2-type immune responses initiated and amplified?","volume":"10","author":"Paul","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib39","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/ni.1740","article-title":"MHC class II-dependent basophil-CD4+ T\u00a0cell interactions promote T(H)2 cytokine-dependent immunity","volume":"10","author":"Perrigoue","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib40","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1164\/rccm.200806-974OC","article-title":"Toll\/IL-1 signaling is critical for house dust mite-specific helper T\u00a0cell type 2 and 17 [corrected] responses","volume":"179","author":"Phipps","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.immuni.2011.03.015_bib41","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1172\/JCI200522462","article-title":"MyD88-dependent induction of allergic Th2 responses to intranasal antigen","volume":"115","author":"Piggott","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2011.03.015_bib42","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1189\/jlb.0307174","article-title":"Crystal-induced neutrophil activation. IX. Syk-dependent activation of class Ia phosphatidylinositol 3-kinase","volume":"82","author":"Popa-Nita","year":"2007","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.immuni.2011.03.015_bib43","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jaci.2009.02.026","article-title":"IL-33-activated dendritic cells induce an atypical TH2-type response","volume":"123","author":"Rank","year":"2009","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib44","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1084\/jem.185.3.461","article-title":"Interleukin-6 directs the differentiation of IL-4-producing CD4+ T\u00a0cells","volume":"185","author":"Rinc\u00f3n","year":"1997","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2011.03.015_bib45","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1600-065X.2008.00713.x","article-title":"Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites","volume":"226","author":"Saenz","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2011.03.015_bib46","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1089\/ars.2009.2625","article-title":"Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: Roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport, and NADPH oxidase","volume":"11","author":"Santos","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.immuni.2011.03.015_bib47","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/eji.200323801","article-title":"The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model","volume":"33","author":"Schmitz","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib48","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature01991","article-title":"Molecular identification of a danger signal that alerts the immune system to dying cells","volume":"425","author":"Shi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2011.03.015_bib49","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ni1558","article-title":"A mechanism for the initiation of allergen-induced T helper type 2 responses","volume":"9","author":"Sokol","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib50","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/ni.1738","article-title":"Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response","volume":"10","author":"Sokol","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib51","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/ni.1883","article-title":"The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling","volume":"11","author":"Tang","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib52","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature07548","article-title":"Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein","volume":"457","author":"Trompette","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2011.03.015_bib53","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S1471-4906(03)00237-0","article-title":"Xanthine oxidoreductase is central to the evolution and function of the innate immune system","volume":"24","author":"Vorbach","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib54","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.coi.2010.01.004","article-title":"The role of NOD-like receptors in shaping adaptive immunity","volume":"22","author":"Williams","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib55","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1124\/jpet.103.052316","article-title":"The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents","volume":"306","author":"Yamamoto","year":"2003","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.immuni.2011.03.015_bib56","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/ni.1737","article-title":"Basophils contribute to T(H)2-IgE responses in\u00a0vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T\u00a0cells","volume":"10","author":"Yoshimoto","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2011.03.015_bib57","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/ni1247","article-title":"Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice","volume":"6","author":"Zhou","year":"2005","journal-title":"Nat. Immunol."}],"updated-by":[{"DOI":"10.1016\/j.immuni.2011.04.012","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2011,4,22]],"date-time":"2011-04-22T00:00:00Z","timestamp":1303430400000}}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761311001221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761311001221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:56:11Z","timestamp":1761033371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761311001221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S1074761311001221"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2011.03.015","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.11097956.12056054","asserted-by":"object"}]},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An Unexpected Role for Uric Acid as an Inducer of T Helper 2 Cell Immunity to Inhaled Antigens and Inflammatory Mediator of Allergic Asthma","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2011.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}