{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:30:15Z","timestamp":1791261015350,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":624,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.immuni.2011.09.011","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T23:45:22Z","timestamp":1320968722000},"page":"757-769","source":"Crossref","is-referenced-by-count":56,"title":["Receptor-like Tyrosine Phosphatases CD45 and CD148 Have Distinct Functions in Chemoattractant-Mediated Neutrophil Migration and Response to S.\u00a0aureus"],"prefix":"10.1016","volume":"35","author":[{"given":"Jing\u00a0W.","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Doan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela\u00a0H.","family":"Chau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford\u00a0A.","family":"Lowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2011.09.011_bib1","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1038\/sj.onc.1203923","article-title":"Selected glimpses into the activation and function of Src kinase","volume":"19","author":"Bjorge","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.immuni.2011.09.011_bib2","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1084\/jem.183.4.1707","article-title":"CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation","volume":"183","author":"Byth","year":"1996","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2011.09.011_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1074-7613(00)80511-7","article-title":"Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation","volume":"7","author":"Chan","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2011.09.011_bib4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/smim.1998.0122","article-title":"Positive and negative roles of the tyrosine kinase Lyn in B cell function","volume":"10","author":"DeFranco","year":"1998","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.immuni.2011.09.011_bib5","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1084\/jem.20052069","article-title":"Neutrophils from p40phox-\/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing","volume":"203","author":"Ellson","year":"2006","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2011.09.011_bib6","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.191.4.669","article-title":"Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn","volume":"191","author":"Fitzer-Attas","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2011.09.011_bib7","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1083\/jcb.139.5.1349","article-title":"Multistep navigation and the combinatorial control of leukocyte chemotaxis","volume":"139","author":"Foxman","year":"1997","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.immuni.2011.09.011_bib8","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.4049\/jimmunol.178.6.3874","article-title":"The\u00a0Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine","volume":"178","author":"Fumagalli","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2011.09.011_bib9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3109\/10428199909145726","article-title":"CD148, a new membrane tyrosine phosphatase involved in leukocyte function","volume":"35","author":"Gay\u00e0","year":"1999","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.immuni.2011.09.011_bib10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1083\/jcb.200202114","article-title":"An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients","volume":"159","author":"Heit","year":"2002","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.immuni.2011.09.011_bib11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1172\/JCI0214794","article-title":"Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases","volume":"109","author":"Hermiston","year":"2002","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2011.09.011_bib12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev.immunol.21.120601.140946","article-title":"CD45: a critical regulator of signaling thresholds in immune cells","volume":"21","author":"Hermiston","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2011.09.011_bib13","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1600-065X.2008.00752.x","article-title":"CD45, CD148, and Lyp\/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells","volume":"228","author":"Hermiston","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2011.09.011_bib14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(95)90171-X","article-title":"Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease","volume":"83","author":"Hibbs","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2011.09.011_bib15","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1084\/jem.20020515","article-title":"Sustained activation of Lyn tyrosine kinase in\u00a0vivo leads to autoimmunity","volume":"196","author":"Hibbs","year":"2002","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2011.09.011_bib16","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.tcb.2007.09.001","article-title":"Immunoreceptor-like signaling by beta 2 and beta 3 integrins","volume":"17","author":"Jakus","year":"2007","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.immuni.2011.09.011_bib17","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1038\/sj.jid.5701223","article-title":"Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging","volume":"128","author":"Kim","year":"2008","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.immuni.2011.09.011_bib18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0092-8674(93)90302-7","article-title":"Normal B lymphocyte development but impaired T\u00a0cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice","volume":"74","author":"Kishihara","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2011.09.011_bib19","doi-asserted-by":"crossref","first-page":"8289","DOI":"10.1073\/pnas.122244799","article-title":"A critical concentration of neutrophils is required for effective bacterial killing in suspension","volume":"99","author":"Li","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2011.09.011_bib20","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1067\/mpd.2000.109112","article-title":"Long-term follow-up and outcome of 39 patients with chronic granulomatous disease","volume":"137","author":"Liese","year":"2000","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.immuni.2011.09.011_bib21","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.4049\/jimmunol.173.4.2324","article-title":"Regulated expression of the receptor-like tyrosine phosphatase CD148 on hemopoietic cells","volume":"173","author":"Lin","year":"2004","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2011.09.011_bib22","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1182\/blood-2006-11-060103","article-title":"Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in\u00a0vivo","volume":"110","author":"Liu","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2011.09.011_bib23","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.molimm.2004.04.010","article-title":"Src-family kinases: rheostats of immune cell signaling","volume":"41","author":"Lowell","year":"2004","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.immuni.2011.09.011_bib24","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1083\/jcb.133.4.895","article-title":"Deficiency of Src family kinases p59\/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions","volume":"133","author":"Lowell","year":"1996","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.immuni.2011.09.011_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0955-0674(99)80023-4","article-title":"Regulation of tyrosine kinase cascades by G-protein-coupled receptors","volume":"11","author":"Luttrell","year":"1999","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.immuni.2011.09.011_bib26","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1002\/(SICI)1521-4141(199909)29:09<2923::AID-IMMU2923>3.0.CO;2-Y","article-title":"Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice","volume":"29","author":"Mee","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2011.09.011_bib27","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.4049\/jimmunol.162.2.1120","article-title":"Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck","volume":"162","author":"M\u00f3csai","year":"1999","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2011.09.011_bib28","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.4049\/jimmunol.164.8.4321","article-title":"Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases","volume":"164","author":"M\u00f3csai","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2011.09.011_bib29","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.iy.12.040194.003113","article-title":"The molecular biology of leukocyte chemoattractant receptors","volume":"12","author":"Murphy","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2011.09.011_bib30","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/1074-7613(95)90126-4","article-title":"Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice","volume":"3","author":"Nishizumi","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2011.09.011_bib31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ng0295-202","article-title":"Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production","volume":"9","author":"Pollock","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.immuni.2011.09.011_bib32","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.ejcb.2006.04.007","article-title":"Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR","volume":"85","author":"Sasaki","year":"2006","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.immuni.2011.09.011_bib33","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1126\/science.287.5455.1040","article-title":"Function of PI3Kgamma in thymocyte development, T\u00a0cell activation, and neutrophil migration","volume":"287","author":"Sasaki","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.immuni.2011.09.011_bib34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1600-065X.2008.00758.x","article-title":"Multiple roles of Lyn kinase in myeloid cell signaling and function","volume":"228","author":"Scapini","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2011.09.011_bib35","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0959-440X(97)80146-7","article-title":"Structures of Src-family tyrosine kinases","volume":"7","author":"Sicheri","year":"1997","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.immuni.2011.09.011_bib36","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0092-8674(94)90237-2","article-title":"A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits","volume":"77","author":"Stephens","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2011.09.011_bib37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0955-0674(02)00311-3","article-title":"Roles of PI3Ks in leukocyte chemotaxis and phagocytosis","volume":"14","author":"Stephens","year":"2002","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.immuni.2011.09.011_bib38","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1126\/science.7624799","article-title":"Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase","volume":"269","author":"Stoyanov","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.immuni.2011.09.011_bib39","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1182\/blood-2009-05-220806","article-title":"Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection","volume":"114","author":"Van Ziffle","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2011.09.011_bib40","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.pharmtox.48.121806.154841","article-title":"Chemokines and their receptors: drug targets in immunity and inflammation","volume":"48","author":"Viola","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.immuni.2011.09.011_bib41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1126\/science.8316840","article-title":"G protein-coupled signal transduction pathways for interleukin-8","volume":"261","author":"Wu","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.immuni.2011.09.011_bib42","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0960-9822(00)00024-5","article-title":"Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn","volume":"11","author":"Yu","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.immuni.2011.09.011_bib43","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1074\/jbc.M210028200","article-title":"The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation","volume":"278","author":"Zhang","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2011.09.011_bib44","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.immuni.2005.01.004","article-title":"The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B","volume":"22","author":"Zhang","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2011.09.011_bib45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.immuni.2007.11.024","article-title":"Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling","volume":"28","author":"Zhu","year":"2008","journal-title":"Immunity"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761311004006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761311004006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T22:06:41Z","timestamp":1686434801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761311004006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S1074761311004006"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2011.09.011","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}