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(2004). Enterocyte-derived IL-15: a key to diruspted IEL homestasis and lymphomagenesis in coeliac disease. In Proceedings of the 10th Symposium on coeliac disease. Paris June 2-5 2003, N. Cerf-Bensussan, N. Brousse, S. Caillat-Zucman, C. Cellier, and J. Schmitz, eds. (Paris), pp. 119-124."},{"key":"10.1016\/j.immuni.2012.06.006_bib61","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.smim.2009.01.002","article-title":"Innate T\u00a0cell responses in human gut","volume":"21","author":"Meresse","year":"2009","journal-title":"Semin. 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