{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:35:27Z","timestamp":1792730127120,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:00:00Z","timestamp":1392940800000},"content-version":"vor","delay-in-days":385,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.immuni.2012.10.019","type":"journal-article","created":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T09:45:58Z","timestamp":1360921558000},"page":"349-359","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":149,"title":["Mast Cell Interleukin-10 Drives Localized Tolerance in Chronic Bladder Infection"],"prefix":"10.1016","volume":"38","author":[{"given":"Cheryl\u00a0Y.","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley\u00a0L.","family":"St.\u00a0John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soman\u00a0N.","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2012.10.019_bib1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1006\/smim.1998.0140","article-title":"Mast cells and basophils in innate immunity","volume":"10","author":"Abraham","year":"1998","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib2","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nri2782","article-title":"Mast cell-orchestrated immunity to pathogens","volume":"10","author":"Abraham","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib3","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2006-7-9-r80","article-title":"The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins","volume":"7","author":"Adachi","year":"2006","journal-title":"Genome Biol."},{"key":"10.1016\/j.immuni.2012.10.019_bib4","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1503\/cmaj.061590","article-title":"Urine proteomics: the present and future of measuring urinary protein components in disease","volume":"177","author":"Barratt","year":"2007","journal-title":"CMAJ"},{"key":"10.1016\/j.immuni.2012.10.019_bib5","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/ni1210-1077","article-title":"Regulatory ripples","volume":"11","author":"Belkaid","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000233766","article-title":"Comparative aspects of mast cell heterogeneity in different species and sites","volume":"77","author":"Bienenstock","year":"1985","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib7","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1167\/iovs.05-0635","article-title":"Differential regulation of key stages in early corneal wound healing by TGF-beta isoforms and their inhibitors","volume":"47","author":"Carrington","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.immuni.2012.10.019_bib8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.mib.2011.10.007","article-title":"Plasticity in mast cell responses during bacterial infections","volume":"15","author":"Chan","year":"2012","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.immuni.2012.10.019_bib9","doi-asserted-by":"crossref","first-page":"9827","DOI":"10.1073\/pnas.93.18.9827","article-title":"Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract","volume":"93","author":"Connell","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2012.10.019_bib10","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib11","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.immuni.2011.03.028","article-title":"Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens","volume":"34","author":"Dudeck","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2012.10.019_bib12","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.4049\/jimmunol.151.5.2390","article-title":"Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance","volume":"151","author":"Enk","year":"1993","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1056\/NEJMcp030027","article-title":"Clinical practice. Acute uncomplicated urinary tract infection in women","volume":"349","author":"Fihn","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2012.10.019_bib14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2105\/AJPH.80.3.331","article-title":"Recurring urinary tract infection: incidence and risk factors","volume":"80","author":"Foxman","year":"1990","journal-title":"Am. J. Public Health"},{"issue":"Suppl 1A","key":"10.1016\/j.immuni.2012.10.019_bib15","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1016\/S0002-9343(02)01054-9","article-title":"Epidemiology of urinary tract infections: incidence, morbidity, and economic costs","volume":"113","author":"Foxman","year":"2002","journal-title":"Am. J. Med."},{"key":"10.1016\/j.immuni.2012.10.019_bib16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1600-065X.2010.00923.x","article-title":"The PD-1 pathway in tolerance and autoimmunity","volume":"236","author":"Francisco","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2012.10.019_bib17","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/ni1503","article-title":"Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B","volume":"8","author":"Grimbaldeston","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib18","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/IAI.31.2.564-570.1981","article-title":"Adhesion, hemagglutination, and virulence of Escherichia coli causing urinary tract infections","volume":"31","author":"Hagberg","year":"1981","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2012.10.019_bib19","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1128\/IAI.40.1.273-283.1983","article-title":"Ascending, unobstructed urinary tract infection in mice caused by pyelonephritogenic Escherichia coli of human origin","volume":"40","author":"Hagberg","year":"1983","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2012.10.019_bib20","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1086\/315006","article-title":"Neutrophil recruitment and resistance to urinary tract infection","volume":"180","author":"Haraoka","year":"1999","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.immuni.2012.10.019_bib21","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1056\/NEJM199608153350703","article-title":"A prospective study of risk factors for symptomatic urinary tract infection in young women","volume":"335","author":"Hooton","year":"1996","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2012.10.019_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/clinids\/22.1.91","article-title":"Recurrence of urinary tract infection in a primary care setting: analysis of a 1-year follow-up of 179 women","volume":"22","author":"Ik\u00e4heimo","year":"1996","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.immuni.2012.10.019_bib23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1128\/CMR.4.1.80","article-title":"Virulence factors in Escherichia coli urinary tract infection","volume":"4","author":"Johnson","year":"1991","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.immuni.2012.10.019_bib24","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/ni.f.216","article-title":"New developments in mast cell biology","volume":"9","author":"Kalesnikoff","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1146\/annurev.iy.07.040189.000423","article-title":"Heterogeneity of mast cells and phenotypic change between subpopulations","volume":"7","author":"Kitamura","year":"1989","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1034\/j.1600-0528.2002.017408.x","article-title":"Local control of the immune response in the liver","volume":"174","author":"Knolle","year":"2000","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2012.10.019_bib27","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.4049\/jimmunol.164.7.3855","article-title":"An essential role of mast cells in the development of airway hyperresponsiveness in a murine asthma model","volume":"164","author":"Kobayashi","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib28","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1053\/jpsu.2000.6868","article-title":"Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair","volume":"35","author":"Liechty","year":"2000","journal-title":"J.\u00a0Pediatr. Surg."},{"key":"10.1016\/j.immuni.2012.10.019_bib29","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/nature05010","article-title":"Mast cells are essential intermediaries in regulatory T-cell tolerance","volume":"442","author":"Lu","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2012.10.019_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/381077a0","article-title":"Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha","volume":"381","author":"Malaviya","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2012.10.019_bib31","doi-asserted-by":"crossref","first-page":"8110","DOI":"10.1073\/pnas.96.14.8110","article-title":"The mast cell tumor necrosis factor alpha response to FimH-expressing Escherichia coli is mediated by the glycosylphosphatidylinositol-anchored molecule CD48","volume":"96","author":"Malaviya","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2012.10.019_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.imlet.2003.10.005","article-title":"Contribution of mast cells to bacterial clearance and their proliferation during experimental cystitis induced by type 1 fimbriated E.\u00a0coli","volume":"91","author":"Malaviya","year":"2004","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.immuni.2012.10.019_bib33","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1084\/jem.183.3.937","article-title":"Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes","volume":"183","author":"Malisan","year":"1996","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2012.10.019_bib34","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/ni1005","article-title":"Mast cell-derived tumor necrosis factor\u00a0induces hypertrophy of draining lymph nodes during infection","volume":"4","author":"McLachlan","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib35","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nri2233","article-title":"Creating immune privilege: active local suppression that benefits friends, but protects foes","volume":"8","author":"Mellor","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib36","doi-asserted-by":"crossref","first-page":"8829","DOI":"10.1073\/pnas.97.16.8829","article-title":"Bad bugs and beleaguered bladders: interplay between uropathogenic Escherichia coli and innate host defenses","volume":"97","author":"Mulvey","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2012.10.019_bib37","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1128\/IAI.69.7.4572-4579.2001","article-title":"Establishment of a persistent Escherichia coli reservoir during the acute phase of a bladder infection","volume":"69","author":"Mulvey","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2012.10.019_bib38","doi-asserted-by":"crossref","first-page":"14170","DOI":"10.1073\/pnas.0602136103","article-title":"Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract","volume":"103","author":"Mysorekar","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2012.10.019_bib39","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nrurol.2010.101","article-title":"Host-pathogen interactions in urinary tract infection","volume":"7","author":"Nielubowicz","year":"2010","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.immuni.2012.10.019_bib40","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.2353\/ajpath.2008.070559","article-title":"Mast cells regulate the magnitude and the cytokine microenvironment of the contact hypersensitivity response","volume":"172","author":"Norman","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.immuni.2012.10.019_bib41","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1128\/IAI.41.3.942-949.1983","article-title":"Genetics of digalactoside-binding adhesin from\u00a0a uropathogenic Escherichia coli strain","volume":"41","author":"Normark","year":"1983","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2012.10.019_bib42","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0140-6736(64)90988-2","article-title":"Serum-antibody leves as an indication of clinically inapparent pyelonephritis","volume":"2","author":"Percival","year":"1964","journal-title":"Lancet"},{"key":"10.1016\/j.immuni.2012.10.019_bib43","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nrmicro1529","article-title":"The silent path to thousands of merozoites: the Plasmodium liver stage","volume":"4","author":"Prud\u00eancio","year":"2006","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.immuni.2012.10.019_bib44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1196\/annals.1443.023","article-title":"Mast cells: multifaceted immune cells with diverse roles in health and disease","volume":"1143","author":"Rao","year":"2008","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.immuni.2012.10.019_bib45","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/infdis\/143.3.404","article-title":"Bacteria-specific antibody in the urine of patients with acute pyelonephritis and cystitis","volume":"143","author":"Ratner","year":"1981","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.immuni.2012.10.019_bib46","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1128\/IAI.37.2.749-754.1982","article-title":"Serological response to Escherichia coli pili in pyelonephritis","volume":"37","author":"Rene","year":"1982","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2012.10.019_bib47","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1128\/jcm.8.5.575-579.1978","article-title":"Immune response in urinary tract infection determined by radioimmunoassay and immunofluorescence: serum antibody levels against infecting bacterium and Enterobacteriaceae common antigen","volume":"8","author":"Sanford","year":"1978","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.immuni.2012.10.019_bib48","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.4049\/jimmunol.159.6.2858","article-title":"IL-10 improves lung injury and survival in Pseudomonas aeruginosa pneumonia","volume":"159","author":"Sawa","year":"1997","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib49","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.chom.2009.09.004","article-title":"Mast cells augment adaptive immunity by orchestrating dendritic cell trafficking through infected tissues","volume":"6","author":"Shelburne","year":"2009","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2012.10.019_bib50","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1371\/journal.ppat.0030060","article-title":"A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells","volume":"3","author":"Song","year":"2007","journal-title":"PLoS Pathog."},{"issue":"1B","key":"10.1016\/j.immuni.2012.10.019_bib51","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0002-9343(83)90073-6","article-title":"Measurement of pyuria and its relation to bacteriuria","volume":"75","author":"Stamm","year":"1983","journal-title":"Am. J. Med."},{"key":"10.1016\/j.immuni.2012.10.019_bib52","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.4049\/jimmunol.159.10.4772","article-title":"Induction of tolerance by IL-10-treated dendritic cells","volume":"159","author":"Steinbrink","year":"1997","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib53","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1182\/blood.V93.5.1634","article-title":"Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T\u00a0cells resulting in a failure to lyse tumor cells","volume":"93","author":"Steinbrink","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2012.10.019_bib54","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.4049\/jimmunol.176.5.3080","article-title":"Antigen-specific responses accelerate bacterial clearance in the bladder","volume":"176","author":"Thumbikat","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2012.10.019_bib55","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1600-0625.2009.01032.x","article-title":"Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency","volume":"19","author":"Vanderford","year":"2010","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.immuni.2012.10.019_bib56","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nature05165","article-title":"Immunology: protection and privilege","volume":"442","author":"Waldmann","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2012.10.019_bib57","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1084\/jem.192.3.455","article-title":"Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice","volume":"192","author":"Williams","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2012.10.019_bib58","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/bmj.2.5356.524","article-title":"Studies of urinary tract infections in infancy and childhood. I. Antibody response in different types of urinary tract infections caused by coliform bacteria","volume":"2","author":"Winberg","year":"1963","journal-title":"BMJ"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761313000502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761313000502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T15:17:01Z","timestamp":1688051821000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761313000502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S1074761313000502"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2012.10.019","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mast Cell Interleukin-10 Drives Localized Tolerance in Chronic Bladder Infection","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2012.10.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}