{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:36:23Z","timestamp":1792679783392,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":391,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 633"],"award-info":[{"award-number":["SFB 633"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 650"],"award-info":[{"award-number":["SFB 650"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.immuni.2013.05.013","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T12:32:36Z","timestamp":1371731556000},"page":"1223-1235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":179,"title":["ROR\u03b3t+ Innate Lymphoid Cells Acquire a Proinflammatory Program upon Engagement of the Activating Receptor NKp44"],"prefix":"10.1016","volume":"38","author":[{"given":"Timor","family":"Glatzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Killig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Meisig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Ommert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merlin","family":"Luetke-Eversloh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Babic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Paclik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Bl\u00fcthgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Seidl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Seifarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn","family":"Gr\u00f6ne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoo","family":"Lenarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"St\u00f6lzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Fugmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Porgador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Karlas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Romagnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2013.05.013_bib1","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1002\/1521-4141(200109)31:9<2680::AID-IMMU2680>3.0.CO;2-A","article-title":"Recognition of viral hemagglutinins by NKp44 but not by NKp30","volume":"31","author":"Arnon","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2013.05.013_bib2","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1172\/JCI108719","article-title":"Isolation and functional characterization of human intestinal mucosal lymphoid cells","volume":"59","author":"Bull","year":"1977","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2013.05.013_bib3","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/nature08949","article-title":"Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology","volume":"464","author":"Buonocore","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2013.05.013_bib4","doi-asserted-by":"crossref","first-page":"e1339","DOI":"10.1371\/journal.pone.0001339","article-title":"Expression analysis of the ligands for the Natural Killer cell receptors NKp30 and NKp44","volume":"2","author":"Byrd","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2013.05.013_bib5","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nature07537","article-title":"A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity","volume":"457","author":"Cella","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2013.05.013_bib6","doi-asserted-by":"crossref","first-page":"10961","DOI":"10.1073\/pnas.1005641107","article-title":"Expansion of human NK-22 cells with IL-7, IL-2, and IL-1beta reveals intrinsic functional plasticity","volume":"107","author":"Cella","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2013.05.013_bib7","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.immuni.2010.10.012","article-title":"Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2","volume":"33","author":"Crellin","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2013.05.013_bib8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/ni.1668","article-title":"Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells","volume":"10","author":"Cupedo","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2013.05.013_bib9","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00251-012-0616-2","article-title":"Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7\u2019s historical relationship with the MHC","volume":"64","author":"Flajnik","year":"2012","journal-title":"Immunogenetics"},{"key":"10.1016\/j.immuni.2013.05.013_bib10","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/ni1322","article-title":"Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1","volume":"7","author":"Gazit","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2013.05.013_bib11","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1084\/jem.20101712","article-title":"IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease","volume":"208","author":"Geremia","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2013.05.013_bib12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fimmu.2012.00072","article-title":"Functional Differences between Human NKp44(-) and NKp44(+) RORC(+) Innate Lymphoid Cells","volume":"3","author":"Hoorweg","year":"2012","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.immuni.2013.05.013_bib13","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1189\/jlb.0408255","article-title":"CD5-low expression lymphocytes in canine peripheral blood show characteristics of natural killer cells","volume":"84","author":"Huang","year":"2008","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.immuni.2013.05.013_bib14","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1365-2567.2010.03394.x","article-title":"Expansion of 2B4+ natural killer (NK) cells and decrease in NKp46+ NK cells in response to influenza","volume":"132","author":"Jost","year":"2011","journal-title":"Immunology"},{"key":"10.1016\/j.immuni.2013.05.013_bib15","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1126\/science.1214914","article-title":"Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles","volume":"334","author":"Kiss","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.immuni.2013.05.013_bib16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/10061","article-title":"MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis","volume":"1","author":"Kotlyarov","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.immuni.2013.05.013_bib17","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/ni.2187","article-title":"AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch","volume":"13","author":"Lee","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2013.05.013_bib18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/ni.1681","article-title":"Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin","volume":"10","author":"Luci","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2013.05.013_bib19","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/35059110","article-title":"Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells","volume":"409","author":"Mandelboim","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2013.05.013_bib20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S1074-7613(00)80371-4","article-title":"Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells","volume":"7","author":"Mebius","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2013.05.013_bib21","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.2104","article-title":"Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161","volume":"12","author":"Mj\u00f6sberg","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2013.05.013_bib22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.19.1.197","article-title":"Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis","volume":"19","author":"Moretta","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2013.05.013_bib23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-immunol-031210-101312","article-title":"Regulation and functions of the IL-10 family of cytokines in inflammation and disease","volume":"29","author":"Ouyang","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2013.05.013_bib24","unstructured":"Ryon, J.J. (2001). Isolation of mononuclear cells from tonsillar tissue. Current\u00a0protocols in immunology \/ edited by John E. Coligan \u2026 [et\u00a0al.] Chapter 7, Unit 7 8."},{"key":"10.1016\/j.immuni.2013.05.013_bib25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ni.1684","article-title":"RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells","volume":"10","author":"Sanos","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2013.05.013_bib26","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.immuni.2008.11.001","article-title":"Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense","volume":"29","author":"Satoh-Takayama","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2013.05.013_bib27","doi-asserted-by":"crossref","first-page":"6579","DOI":"10.4049\/jimmunol.0901935","article-title":"The natural cytotoxicity receptor NKp46 is dispensable for IL-22-mediated innate intestinal immune defense against Citrobacter rodentium","volume":"183","author":"Satoh-Takayama","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2013.05.013_bib28","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev-immunol-020711-075053","article-title":"Innate lymphoid cells: emerging insights in development, lineage relationships, and function","volume":"30","author":"Spits","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2013.05.013_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20072713","article-title":"Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22","volume":"206","author":"Takatori","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2013.05.013_bib30","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1053\/j.gastro.2010.05.040","article-title":"Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn\u2019s disease","volume":"139","author":"Takayama","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.immuni.2013.05.013_bib31","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.immuni.2010.10.017","article-title":"Regulated expression of nuclear receptor ROR\u03b3t confers distinct functional fates to NK cell receptor-expressing ROR\u03b3t(+) innate lymphocytes","volume":"33","author":"Vonarbourg","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2013.05.013_bib32","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.immuni.2008.11.003","article-title":"Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease","volume":"29","author":"Zenewicz","year":"2008","journal-title":"Immunity"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761313002392?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761313002392?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:59:59Z","timestamp":1761033599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761313002392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S1074761313002392"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2013.05.013","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ROR\u03b3t+ Innate Lymphoid Cells Acquire a Proinflammatory Program upon Engagement of the Activating Receptor NKp44","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2013.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}