{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:33:18Z","timestamp":1791282798814,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,21]],"date-time":"2015-03-21T00:00:00Z","timestamp":1426896000000},"content-version":"vor","delay-in-days":385,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.immuni.2014.02.005","type":"journal-article","created":{"date-parts":[[2014,3,17]],"date-time":"2014-03-17T11:31:31Z","timestamp":1395055891000},"page":"367-377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":240,"title":["Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells"],"prefix":"10.1016","volume":"40","author":[{"given":"John\u00a0P.","family":"Ray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather\u00a0D.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian\u00a0J.","family":"Laidlaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew\u00a0M.","family":"Staron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan\u00a0M.","family":"Kaech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Craft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2014.02.005_bib1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.1992.tb01406.x","article-title":"Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples","volume":"127","author":"Abrams","year":"1992","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2014.02.005_bib2","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1084\/jem.20100064","article-title":"IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells","volume":"207","author":"Batten","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2014.02.005_bib3","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.immuni.2011.03.023","article-title":"ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6","volume":"34","author":"Choi","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.02.005_bib4","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.4049\/jimmunol.1203032","article-title":"Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation","volume":"190","author":"Choi","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2014.02.005_bib5","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.immuni.2009.01.011","article-title":"Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles","volume":"30","author":"Coffey","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.02.005_bib6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrrheum.2012.58","article-title":"Follicular helper T\u00a0cells in immunity and systemic autoimmunity","volume":"8","author":"Craft","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.immuni.2014.02.005_bib7","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","article-title":"Follicular helper CD4 T\u00a0cells (TFH)","volume":"29","author":"Crotty","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2014.02.005_bib8","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.immuni.2011.09.017","article-title":"An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T\u00a0cells","volume":"35","author":"Cui","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.02.005_bib9","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1084\/jem.20080321","article-title":"Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T\u00a0cells","volume":"205","author":"de Beaucoudrey","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2014.02.005_bib10","doi-asserted-by":"crossref","first-page":"e17739","DOI":"10.1371\/journal.pone.0017739","article-title":"IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T\u00a0cell (Tfh) differentiation","volume":"6","author":"Eto","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2014.02.005_bib11","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.immuni.2013.02.020","article-title":"Distinct memory CD4+ T\u00a0cells\u00a0with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection","volume":"38","author":"Hale","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.02.005_bib12","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1126\/science.1208421","article-title":"Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection","volume":"334","author":"Harker","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.02.005_bib13","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.4049\/jimmunol.176.6.3315","article-title":"Cutting Edge: The direct action of type I IFN on CD4 T\u00a0cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection","volume":"176","author":"Havenar-Daughton","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2014.02.005_bib14","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.4049\/jimmunol.179.8.5099","article-title":"Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation","volume":"179","author":"Haynes","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2014.02.005_bib15","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1126\/science.1175870","article-title":"Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation","volume":"325","author":"Johnston","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.02.005_bib16","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1084\/jem.20111174","article-title":"STAT5 is a potent negative regulator of TFH cell differentiation","volume":"209","author":"Johnston","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2014.02.005_bib17","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1084\/jem.20111504","article-title":"B and T\u00a0cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1","volume":"209","author":"Karnowski","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2014.02.005_bib18","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.immuni.2011.03.024","article-title":"Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone","volume":"34","author":"Kerfoot","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.02.005_bib19","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.immuni.2012.10.010","article-title":"Interferon-\u03b3 excess leads to pathogenic accumulation of follicular helper T\u00a0cells and germinal centers","volume":"37","author":"Lee","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.02.005_bib20","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1084\/jem.20081886","article-title":"Follicular helper T\u00a0cells are required for systemic autoimmunity","volume":"206","author":"Linterman","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2014.02.005_bib21","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1084\/jem.20091738","article-title":"IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses","volume":"207","author":"Linterman","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2014.02.005_bib22","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1084\/jem.20080218","article-title":"Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3","volume":"205","author":"Ma","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2014.02.005_bib23","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1182\/blood-2011-11-392985","article-title":"Functional STAT3 deficiency compromises the generation of human T follicular helper cells","volume":"119","author":"Ma","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2014.02.005_bib24","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1128\/JVI.76.9.4520-4525.2002","article-title":"Promotion of alpha\/beta interferon induction during in\u00a0vivo viral infection through alpha\/beta interferon receptor\/STAT1 system-dependent and -independent pathways","volume":"76","author":"Malmgaard","year":"2002","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.immuni.2014.02.005_bib25","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2011.08.016","article-title":"Differential expression of Ly6C and T-bet distinguish effector and memory Th1 CD4(+) cell properties during viral infection","volume":"35","author":"Marshall","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.02.005_bib26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nri3128","article-title":"Molecular programming of B cell memory","volume":"12","author":"McHeyzer-Williams","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2014.02.005_bib27","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nature06764","article-title":"Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome","volume":"452","author":"Milner","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.02.005_bib28","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.immuni.2011.11.012","article-title":"Early Th1 cell differentiation is marked by a Tfh cell-like transition","volume":"35","author":"Nakayamada","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.02.005_bib29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.immuni.2008.05.009","article-title":"Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages","volume":"29","author":"Nurieva","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.02.005_bib30","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.1176676","article-title":"Bcl6 mediates the development of T\u00a0follicular helper cells","volume":"325","author":"Nurieva","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.02.005_bib31","doi-asserted-by":"crossref","first-page":"11234","DOI":"10.1074\/jbc.M111.324046","article-title":"STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function","volume":"287","author":"Nurieva","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2014.02.005_bib32","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/ni.2242","article-title":"Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile","volume":"13","author":"Oestreich","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2014.02.005_bib33","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<390::AID-IMMU390>3.0.CO;2-O","article-title":"Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection","volume":"28","author":"Oxenius","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2014.02.005_bib34","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.1077002","article-title":"A critical role for IL-21 in regulating immunoglobulin production","volume":"298","author":"Ozaki","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.02.005_bib35","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.immuni.2011.09.009","article-title":"Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells","volume":"35","author":"Pepper","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.02.005_bib36","doi-asserted-by":"crossref","first-page":"313","DOI":"10.4049\/jimmunol.0904023","article-title":"In\u00a0vivo regulation of Bcl6 and T follicular helper cell development","volume":"185","author":"Poholek","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2014.02.005_bib37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jaci.2008.04.037","article-title":"Novel signal transducer and activator of transcription 3 (STAT3) mutations, reduced T(H)17 cell numbers, and variably defective STAT3 phosphorylation in hyper-IgE syndrome","volume":"122","author":"Renner","year":"2008","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.immuni.2014.02.005_bib38","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/ni0707-665","article-title":"Vagaries of conditional gene targeting","volume":"8","author":"Schmidt-Supprian","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2014.02.005_bib39","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1089\/jir.2006.26.804","article-title":"Blocking monoclonal antibodies specific for mouse IFN-\u03b1\/\u03b2 receptor subunit 1 (IFNAR-1) from mice immunized by in\u00a0vivo hydrodynamic transfection","volume":"26","author":"Sheehan","year":"2006","journal-title":"J.\u00a0Interferon Cytokine Res."},{"key":"10.1016\/j.immuni.2014.02.005_bib40","doi-asserted-by":"crossref","first-page":"35056","DOI":"10.1074\/jbc.273.52.35056","article-title":"The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities","volume":"273","author":"Song","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2014.02.005_bib41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.immuni.2010.12.013","article-title":"The transcription factor STAT3 is required for T helper 2 cell development","volume":"34","author":"Stritesky","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.02.005_bib42","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.cell.2013.04.007","article-title":"Single naive CD4+ T\u00a0cells from a diverse repertoire produce different effector cell types during infection","volume":"153","author":"Tubo","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2014.02.005_bib43","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nature03555","article-title":"A RING-type ubiquitin ligase family member required to repress follicular helper T\u00a0cells and autoimmunity","volume":"435","author":"Vinuesa","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.02.005_bib44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.immuni.2008.06.001","article-title":"A fundamental role for interleukin-21 in the generation of T follicular helper cells","volume":"29","author":"Vogelzang","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.02.005_bib45","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.4049\/jimmunol.1004128","article-title":"STAT3 negatively regulates type I IFN-mediated antiviral response","volume":"187","author":"Wang","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2014.02.005_bib46","doi-asserted-by":"crossref","first-page":"4498","DOI":"10.4049\/jimmunol.178.7.4498","article-title":"IL-12 and type-I IFN synergize for IFN-gamma production by CD4 T\u00a0cells, whereas neither are required for IFN-gamma production by CD8 T\u00a0cells after Listeria monocytogenes infection","volume":"178","author":"Way","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2014.02.005_bib47","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1073\/pnas.0237137100","article-title":"STAT3 deletion during hematopoiesis causes Crohn\u2019s disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity","volume":"100","author":"Welte","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2014.02.005_bib48","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/85294","article-title":"Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development","volume":"2","author":"Wolfer","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2014.02.005_bib49","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.immuni.2009.07.002","article-title":"The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment","volume":"31","author":"Yu","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.02.005_bib50","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1084\/jem.20091777","article-title":"IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism","volume":"207","author":"Zotos","year":"2010","journal-title":"J.\u00a0Exp. Med."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761314000739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761314000739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T14:18:40Z","timestamp":1565273920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761314000739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S1074761314000739"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2014.02.005","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcription Factor STAT3 and Type I Interferons Are Corepressive Insulators for Differentiation of Follicular Helper and T Helper 1 Cells","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2014.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}