{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:41:48Z","timestamp":1792611708019,"version":"4.5.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T00:00:00Z","timestamp":1437091200000},"content-version":"vor","delay-in-days":381,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.immuni.2014.05.018","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T11:49:46Z","timestamp":1405597786000},"page":"116-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":320,"title":["Serial Transfer of Single-Cell-Derived Immunocompetence Reveals Stemness of CD8+ Central Memory T Cells"],"prefix":"10.1016","volume":"41","author":[{"given":"Patricia","family":"Graef","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit\u00a0R.","family":"Buchholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Stemberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Flossdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Henkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schiemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Drexler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"H\u00f6fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley\u00a0R.","family":"Riddell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk\u00a0H.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2014.05.018_bib1","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/197452a0","article-title":"Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells","volume":"197","author":"Becker","year":"1963","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.05.018_bib2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1172\/JCI32103","article-title":"Adoptive transfer of effector CD8+ T\u00a0cells derived from central memory cells establishes persistent T\u00a0cell memory in primates","volume":"118","author":"Berger","year":"2008","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2014.05.018_bib3","doi-asserted-by":"crossref","first-page":"77ra38","DOI":"10.1126\/scitranslmed.3005930","article-title":"CD19-targeted T\u00a0cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia","volume":"5","author":"Brentjens","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2014.05.018_bib4","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.coi.2011.05.002","article-title":"CD8+ T\u00a0cell differentiation in the aging immune system: until the last clone standing","volume":"23","author":"Buchholz","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib5","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1126\/science.1235454","article-title":"Disparate individual fates compose robust CD8+ T\u00a0cell immunity","volume":"340","author":"Buchholz","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.05.018_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fimmu.2013.00031","article-title":"The smallest unit: effector and memory CD8(+) T\u00a0cell differentiation on the single cell level","volume":"4","author":"Buchholz","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib7","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1126\/science.1139393","article-title":"Asymmetric T lymphocyte division in the initiation of adaptive immune responses","volume":"315","author":"Chang","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.05.018_bib8","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.4049\/jimmunol.1200176","article-title":"Cutting edge: Asymmetric memory T\u00a0cell division in response to rechallenge","volume":"188","author":"Ciocca","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1084\/jem.20040613","article-title":"Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers","volume":"202","author":"Cobbold","year":"2005","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2014.05.018_bib10","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.immuni.2011.09.017","article-title":"An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T\u00a0cells","volume":"35","author":"Cui","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.05.018_bib11","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.stem.2007.05.015","article-title":"Long-term propagation of distinct hematopoietic differentiation programs in\u00a0vivo","volume":"1","author":"Dykstra","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.immuni.2014.05.018_bib12","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.1062589","article-title":"Arrested differentiation, the self-renewing memory lymphocyte, and vaccination","volume":"293","author":"Fearon","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.05.018_bib13","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nm.1982","article-title":"Wnt signaling arrests effector T\u00a0cell differentiation and generates CD8+ memory stem cells","volume":"15","author":"Gattinoni","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2014.05.018_bib14","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/nm.2446","article-title":"A human memory T\u00a0cell subset with stem cell-like properties","volume":"17","author":"Gattinoni","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2014.05.018_bib15","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nrc3322","article-title":"Paths to stemness: building the ultimate antitumour T\u00a0cell","volume":"12","author":"Gattinoni","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.immuni.2014.05.018_bib16","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1084\/jem.20091175","article-title":"One naive T\u00a0cell, multiple fates in CD8+ T\u00a0cell differentiation","volume":"207","author":"Gerlach","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2014.05.018_bib17","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1126\/science.1235487","article-title":"Heterogeneous differentiation patterns of individual CD8+ T\u00a0cells","volume":"340","author":"Gerlach","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.05.018_bib18","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa1215134","article-title":"Chimeric antigen receptor-modified T\u00a0cells for acute lymphoid leukemia","volume":"368","author":"Grupp","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2014.05.018_bib19","doi-asserted-by":"crossref","first-page":"8447","DOI":"10.1073\/pnas.0601040103","article-title":"Thymic output in aged mice","volume":"103","author":"Hale","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2014.05.018_bib20","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nm917","article-title":"Duration of antiviral immunity after smallpox vaccination","volume":"9","author":"Hammarlund","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2014.05.018_bib21","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1073\/pnas.0501437102","article-title":"Memory T\u00a0cells have gene expression patterns intermediate between naive and effector","volume":"102","author":"Holmes","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2014.05.018_bib22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/imr.12139","article-title":"Design and implementation of adoptive therapy with chimeric antigen receptor-modified T\u00a0cells","volume":"257","author":"Jensen","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2014.05.018_bib23","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/nri959","article-title":"Progressive differentiation and selection of the fittest in the immune response","volume":"2","author":"Lanzavecchia","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib24","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1073\/pnas.0511137103","article-title":"Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells","volume":"103","author":"Luckey","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2014.05.018_bib25","first-page":"594","article-title":"Superior T memory stem cell persistence supports long-lived T\u00a0cell memory","volume":"123","author":"Lugli","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2014.05.018_bib26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nature11393","article-title":"Distinct contribution of stem and progenitor cells to epidermal maintenance","volume":"489","author":"Mascr\u00e9","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.05.018_bib27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev-immunol-032713-120136","article-title":"Adoptive immunotherapy for cancer or viruses","volume":"32","author":"Maus","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib28","doi-asserted-by":"crossref","first-page":"6833","DOI":"10.4049\/jimmunol.165.12.6833","article-title":"Early programming of T\u00a0cell populations responding to bacterial infection","volume":"165","author":"Mercado","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.cb.11.110195.000343","article-title":"The biology of hematopoietic stem cells","volume":"11","author":"Morrison","year":"1995","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.immuni.2014.05.018_bib30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0092-8674(00)81867-X","article-title":"Regulatory mechanisms in stem cell biology","volume":"88","author":"Morrison","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2014.05.018_bib31","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.immuni.2011.09.019","article-title":"Th17 cells are long lived and retain a stem cell-like molecular signature","volume":"35","author":"Muranski","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.05.018_bib32","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.immuni.2009.10.002","article-title":"The quest for CD8+ memory stem cells","volume":"31","author":"Neuenhahn","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.05.018_bib33","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.immuni.2006.07.017","article-title":"CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen","volume":"25","author":"Neuenhahn","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.05.018_bib34","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.immuni.2012.01.002","article-title":"Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T\u00a0cell phenotypes","volume":"36","author":"Newell","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.05.018_bib35","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1201219","article-title":"Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment","volume":"333","author":"Notta","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.05.018_bib36","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.273.5272.242","article-title":"Long-term lymphohematopoietic reconstitution by a single CD34-low\/negative hematopoietic stem cell","volume":"273","author":"Osawa","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.05.018_bib37","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.immuni.2013.07.014","article-title":"Environmental cues dictate the fate of individual CD8+ T\u00a0cells responding to infection","volume":"39","author":"Plumlee","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.05.018_bib38","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.4049\/jimmunol.166.5.3402","article-title":"Organ-specific regulation of the CD8 T\u00a0cell response to Listeria monocytogenes infection","volume":"166","author":"Pope","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib39","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1056\/NEJMoa1103849","article-title":"Chimeric antigen receptor-modified T\u00a0cells in chronic lymphoid leukemia","volume":"365","author":"Porter","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2014.05.018_bib40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.immuni.2009.10.010","article-title":"The mTOR kinase determines effector versus memory CD8+ T\u00a0cell fate by regulating the expression of transcription factors T-bet and Eomesodermin","volume":"32","author":"Rao","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.05.018_bib41","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.immuni.2012.01.015","article-title":"Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T\u00a0cell differentiation","volume":"36","author":"Rao","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.05.018_bib42","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1084\/jem.192.12.1841","article-title":"Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6","volume":"192","author":"Reljic","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2014.05.018_bib43","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1146\/annurev.immunol.22.012703.104702","article-title":"Central memory and effector memory T\u00a0cell subsets: function, generation, and maintenance","volume":"22","author":"Sallusto","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib44","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1084\/jem.20071641","article-title":"Functional and genomic profiling of effector CD8 T\u00a0cell subsets with distinct memory fates","volume":"205","author":"Sarkar","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2014.05.018_bib45","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1002\/eji.200324224","article-title":"Differences in maintenance of CD8+ and CD4+ bacteria-specific effector-memory T\u00a0cell populations","volume":"33","author":"Schiemann","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib46","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1111\/j.1537-2995.2010.02940.x","article-title":"Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T\u00a0cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation","volume":"51","author":"Schmitt","year":"2011","journal-title":"Transfusion"},{"key":"10.1016\/j.immuni.2014.05.018_bib47","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature07043","article-title":"Imaging stem-cell-driven regeneration in mammals","volume":"453","author":"Schroeder","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.05.018_bib48","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nri2822","article-title":"Mapping the life histories of T\u00a0cells","volume":"10","author":"Schumacher","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib49","first-page":"327","article-title":"The distribution of colony-forming cells among spleen colonies","volume":"62","author":"Siminovitch","year":"1963","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.immuni.2014.05.018_bib50","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.cell.2011.05.033","article-title":"Strategies for homeostatic stem cell self-renewal in adult tissues","volume":"145","author":"Simons","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2014.05.018_bib51","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1073\/pnas.88.7.2788","article-title":"Clonal analysis of hematopoietic stem-cell differentiation in\u00a0vivo","volume":"88","author":"Smith","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2014.05.018_bib52","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cell.2010.09.016","article-title":"Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells","volume":"143","author":"Snippert","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2014.05.018_bib53","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.immuni.2008.07.017","article-title":"Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T\u00a0cells","volume":"29","author":"Snyder","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.05.018_bib54","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.2898810","article-title":"Purification and characterization of mouse hematopoietic stem cells","volume":"241","author":"Spangrude","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.05.018_bib55","first-page":"77","article-title":"Construction and isolation of recombinant MVA","volume":"269","author":"Staib","year":"2004","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.immuni.2014.05.018_bib56","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.immuni.2007.10.012","article-title":"A single naive CD8+ T\u00a0cell precursor can develop into diverse effector and memory subsets","volume":"27","author":"Stemberger","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.05.018_bib57","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.smim.2009.02.004","article-title":"Stem cell-like plasticity of na\u00efve and distinct memory CD8+ T\u00a0cell subsets","volume":"21","author":"Stemberger","year":"2009","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib58","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.cell.2012.08.015","article-title":"Chemokine guidance of central memory T\u00a0cells is critical for antiviral recall responses in lymph nodes","volume":"150","author":"Sung","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2014.05.018_bib59","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1073\/pnas.51.1.29","article-title":"A stochastic model of stem cell proliferation, based on the growth of spleen colony-forming cells","volume":"51","author":"Till","year":"1964","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2014.05.018_bib60","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.immuni.2009.03.015","article-title":"Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow","volume":"30","author":"Tokoyoda","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.05.018_bib61","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.cell.2013.04.007","article-title":"Single naive CD4+ T\u00a0cells from a diverse repertoire produce different effector cell types during infection","volume":"153","author":"Tubo","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2014.05.018_bib62","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.immuni.2009.09.015","article-title":"A distinct subset of self-renewing human memory CD8+ T\u00a0cells survives cytotoxic chemotherapy","volume":"31","author":"Turtle","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.05.018_bib63","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/ni.2140","article-title":"A platelet-mediated system for shuttling blood-borne bacteria to CD8\u03b1+ dendritic cells depends on glycoprotein GPIb and complement C3","volume":"12","author":"Verschoor","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib64","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.coi.2010.03.003","article-title":"From the thymus to longevity in the periphery","volume":"22","author":"Wakim","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib65","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1056\/NEJM199510193331603","article-title":"Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor","volume":"333","author":"Walter","year":"1995","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2014.05.018_bib66","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0092-8674(00)81692-X","article-title":"Stem cells: units of development, units of regeneration, and units in evolution","volume":"100","author":"Weissman","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2014.05.018_bib67","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.immunol.25.022106.141548","article-title":"Effector and memory CTL differentiation","volume":"25","author":"Williams","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2014.05.018_bib68","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1084\/jem.127.3.455","article-title":"Cytological evidence for a relationship between normal hemotopoietic colony-forming cells and cells of the lymphoid system","volume":"127","author":"Wu","year":"1968","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2014.05.018_bib69","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nm1326","article-title":"Host-reactive CD8+ memory stem cells in graft-versus-host disease","volume":"11","author":"Zhang","year":"2005","journal-title":"Nat. Med."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107476131400226X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107476131400226X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T10:26:24Z","timestamp":1538389584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107476131400226X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S107476131400226X"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2014.05.018","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718493935.793497435","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718493935.793499134","asserted-by":"object"}]},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serial Transfer of Single-Cell-Derived Immunocompetence Reveals Stemness of CD8+ Central Memory T Cells","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2014.05.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}