{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:20:33Z","timestamp":1790659233505,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T00:00:00Z","timestamp":1453248000000},"content-version":"vor","delay-in-days":384,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.immuni.2014.12.021","type":"journal-article","created":{"date-parts":[[2014,12,25]],"date-time":"2014-12-25T01:15:11Z","timestamp":1419470111000},"page":"186-198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Enhancer Sequence Variants and Transcription-Factor Deregulation Synergize to Construct Pathogenic Regulatory Circuits in B-Cell Lymphoma"],"prefix":"10.1016","volume":"42","author":[{"given":"Olivia\u00a0I.","family":"Koues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney\u00a0A.","family":"Kowalewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Wei","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah\u00a0C.","family":"Pyfrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer\u00a0A.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis\u00a0E.","family":"Sandoval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler\u00a0B.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey\u00a0J.","family":"Bednarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda\u00a0F.","family":"Cashen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline\u00a0E.","family":"Payton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene\u00a0M.","family":"Oltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2014.12.021_bib1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1126\/science.1217277","article-title":"Epigenomic enhancer profiling defines a signature of colon cancer","volume":"336","author":"Akhtar-Zaidi","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.12.021_bib2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.12.021_bib3","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.immuni.2007.07.009","article-title":"Germinal-center organization and cellular dynamics","volume":"27","author":"Allen","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2014.12.021_bib4","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1177\/1947601911423029","article-title":"Role of sp transcription factors in the regulation of cancer cell metabolism","volume":"2","author":"Archer","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.immuni.2014.12.021_bib5","doi-asserted-by":"crossref","first-page":"6766","DOI":"10.1038\/sj.onc.1210760","article-title":"Hox genes in hematopoiesis and leukemogenesis","volume":"26","author":"Argiropoulos","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.immuni.2014.12.021_bib6","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1073\/pnas.0804863106","article-title":"Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1","volume":"106","author":"Basu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2014.12.021_bib7","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nrc3130","article-title":"A decade of exploring the cancer epigenome - biological and translational implications","volume":"11","author":"Baylin","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.immuni.2014.12.021_bib8","doi-asserted-by":"crossref","first-page":"C189","DOI":"10.1152\/ajpcell.00347.2009","article-title":"The dual-specificity MAP kinase phosphatases: critical roles in development and cancer","volume":"299","author":"Bermudez","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.immuni.2014.12.021_bib9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Bernstein","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.12.021_bib10","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.4049\/jimmunol.0804272","article-title":"CXCR4 expression functionally discriminates centroblasts versus centrocytes within human germinal center B cells","volume":"182","author":"Caron","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2014.12.021_bib11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.ccr.2013.11.003","article-title":"Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma","volume":"24","author":"Chapuy","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2014.12.021_bib12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1182\/blood-2008-02-140616","article-title":"Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances","volume":"113","author":"Cheung","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2014.12.021_bib13","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nature07968","article-title":"Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma","volume":"459","author":"Compagno","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.12.021_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gr.164079.113","article-title":"Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits","volume":"24","author":"Corradin","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.immuni.2014.12.021_bib15","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1056\/NEJMoa041869","article-title":"Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells","volume":"351","author":"Dave","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2014.12.021_bib16","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1200\/JCO.1996.14.4.1333","article-title":"BCL-2\/JH rearrangements in circulating B cells of healthy blood donors and patients with nonmalignant diseases","volume":"14","author":"D\u00f6lken","year":"1996","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.immuni.2014.12.021_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature11245","article-title":"Architecture of the human regulatory network derived from ENCODE data","volume":"489","author":"Gerstein","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.12.021_bib18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ymeth.2009.03.003","article-title":"Isolation of active regulatory elements from eukaryotic chromatin using FAIRE (Formaldehyde Assisted Isolation of Regulatory Elements)","volume":"48","author":"Giresi","year":"2009","journal-title":"Methods"},{"key":"10.1016\/j.immuni.2014.12.021_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.coi.2006.01.007","article-title":"Transcription factors drive B cell development","volume":"18","author":"Hagman","year":"2006","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.immuni.2014.12.021_bib20","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2013.09.053","article-title":"Super-enhancers in the control of cell identity and disease","volume":"155","author":"Hnisz","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2014.12.021_bib21","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1182\/blood-2013-07-518605","article-title":"Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation","volume":"123","author":"Huang","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2014.12.021_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1101\/sqb.2013.78.020321","article-title":"The IRF family transcription factors at the interface of innate and adaptive immune responses","volume":"78","author":"Ikushima","year":"2013","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.immuni.2014.12.021_bib23","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3960\/jslrt.54.31","article-title":"Treatment of follicular lymphoma","volume":"54","author":"Izutsu","year":"2014","journal-title":"J.\u00a0Clin. Exp. Hematop."},{"key":"10.1016\/j.immuni.2014.12.021_bib24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature12634","article-title":"Mutational landscape and significance across 12 major cancer types","volume":"502","author":"Kandoth","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.12.021_bib25","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.18632\/oncotarget.653","article-title":"Recurrent targets of aberrant somatic hypermutation in lymphoma","volume":"3","author":"Khodabakhshi","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.immuni.2014.12.021_bib26","doi-asserted-by":"crossref","first-page":"1235587","DOI":"10.1126\/science.1235587","article-title":"Integrative Annotation of Variants from 1092 Humans: Application to Cancer Genomics","volume":"342","author":"Khurana","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.12.021_bib27","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri2217","article-title":"Germinal centres: role in B-cell physiology and malignancy","volume":"8","author":"Klein","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2014.12.021_bib28","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.1128\/MCB.00535-08","article-title":"Regulation of acetylation at the major histocompatibility complex class II proximal promoter by the 19S proteasomal ATPase Sug1","volume":"28","author":"Koues","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.immuni.2014.12.021_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.beha.2011.02.003","article-title":"Pathology, pathogenesis and molecular genetics of follicular NHL","volume":"24","author":"Leich","year":"2011","journal-title":"Best Pract. Res. Clin. Haematol."},{"key":"10.1016\/j.immuni.2014.12.021_bib30","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1056\/NEJMra0807082","article-title":"Aggressive lymphomas","volume":"362","author":"Lenz","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2014.12.021_bib31","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2014.12.021_bib32","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1182\/blood-2008-10-183632","article-title":"Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting","volume":"113","author":"Longo","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2014.12.021_bib33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35043102","article-title":"Human cancer cell lines: fact and fantasy","volume":"1","author":"Masters","year":"2000","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.immuni.2014.12.021_bib34","doi-asserted-by":"crossref","first-page":"D108","DOI":"10.1093\/nar\/gkj143","article-title":"TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes","volume":"34","author":"Matys","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2014.12.021_bib35","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1222794","article-title":"Systematic localization of common disease-associated variation in regulatory DNA","volume":"337","author":"Maurano","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.immuni.2014.12.021_bib36","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10351","article-title":"Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma","volume":"476","author":"Morin","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.12.021_bib37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature11212","article-title":"An expansive human regulatory lexicon encoded in transcription factor footprints","volume":"489","author":"Neph","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.12.021_bib38","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.celrep.2013.12.027","article-title":"Genetics of follicular lymphoma transformation","volume":"6","author":"Pasqualucci","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2014.12.021_bib39","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1182\/blood-2010-11-321265","article-title":"Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs","volume":"118","author":"Rehm","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2014.12.021_bib40","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/ni.2094","article-title":"Malignant pirates of the immune system","volume":"12","author":"Rui","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2014.12.021_bib41","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature11279","article-title":"The long-range interaction landscape of gene promoters","volume":"489","author":"Sanyal","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.12.021_bib42","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrc2826","article-title":"The Hox genes and their roles in oncogenesis","volume":"10","author":"Shah","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.immuni.2014.12.021_bib43","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1182\/blood-2010-09-308205","article-title":"Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL","volume":"117","author":"Slager","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2014.12.021_bib44","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1182\/blood.V100.4.1113.h81602001113_1113_1122","article-title":"Generation of polyclonal plasmablasts from peripheral blood B cells: a normal counterpart of malignant plasmablasts","volume":"100","author":"Tarte","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2014.12.021_bib45","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nature11232","article-title":"The accessible chromatin landscape of the human genome","volume":"489","author":"Thurman","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2014.12.021_bib46","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.immuni.2014.12.021_bib47","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3389\/fonc.2013.00300","article-title":"Genetic variation in the extended major histocompatibility complex and susceptibility to childhood acute lymphoblastic leukemia: a review of the evidence","volume":"3","author":"Urayama","year":"2013","journal-title":"Front Oncol"},{"key":"10.1016\/j.immuni.2014.12.021_bib48","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev-immunol-020711-075032","article-title":"Germinal centers","volume":"30","author":"Victora","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2014.12.021_bib49","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1182\/blood-2012-03-415380","article-title":"Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas","volume":"120","author":"Victora","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2014.12.021_bib50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12026-008-8055-8","article-title":"IRF8 regulates myeloid and B lymphoid lineage diversification","volume":"43","author":"Wang","year":"2009","journal-title":"Immunol. Res."},{"key":"10.1016\/j.immuni.2014.12.021_bib51","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cell.2013.03.035","article-title":"Master transcription factors and mediator establish super-enhancers at key cell identity genes","volume":"153","author":"Whyte","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2014.12.021_bib52","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1182\/blood-2010-11-321208","article-title":"Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation","volume":"117","author":"Yap","year":"2011","journal-title":"Blood"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761314004889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761314004889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:00:08Z","timestamp":1761033608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761314004889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S1074761314004889"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2014.12.021","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhancer Sequence Variants and Transcription-Factor Deregulation Synergize to Construct Pathogenic Regulatory Circuits in B-Cell Lymphoma","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2014.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}