{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:44:55Z","timestamp":1790340295881,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"vor","delay-in-days":386,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.immuni.2015.04.022","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T00:36:46Z","timestamp":1436315806000},"page":"52-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":164,"title":["A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner"],"prefix":"10.1016","volume":"43","author":[{"given":"Li-Fan","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Gasteiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Shing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh","family":"Chaudhry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ping","family":"Hsin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula\u00a0D.","family":"Bos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn\u00a0L.","family":"Zawislak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunglim","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph\u00a0C.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina\u00a0S.","family":"Leslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Wha","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander\u00a0Y.","family":"Rudensky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2015.04.022_bib1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0092-8674(00)80047-1","article-title":"SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine","volume":"98","author":"Alexander","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2015.04.022_bib2","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.immuni.2009.06.024","article-title":"The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs","volume":"31","author":"Androulidaki","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2015.04.022_bib3","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1126\/science.1070884","article-title":"Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors","volume":"296","author":"Arase","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.immuni.2015.04.022_bib4","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/ni.f.209","article-title":"MicroRNAs: new regulators of immune cell development and function","volume":"9","author":"Baltimore","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2015.04.022_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2015.04.022_bib6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2015.04.022_bib7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.molcel.2014.09.018","article-title":"Endogenous miRNA and target concentrations determine susceptibility to potential ceRNA competition","volume":"56","author":"Bosson","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.immuni.2015.04.022_bib8","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.molcel.2014.03.045","article-title":"Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance","volume":"54","author":"Denzler","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.immuni.2015.04.022_bib9","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.immuni.2008.04.002","article-title":"MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation","volume":"28","author":"Dorsett","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2015.04.022_bib10","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.immuni.2012.12.006","article-title":"MicroRNA-155 is required for effector CD8+ T\u00a0cell responses to virus infection and cancer","volume":"38","author":"Dudda","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2015.04.022_bib11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1172\/JCI26169","article-title":"SOCS1 restricts dendritic cells\u2019 ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling","volume":"116","author":"Evel-Kabler","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2015.04.022_bib12","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/ni.2576","article-title":"The microRNA miR-155 controls CD8(+) T\u00a0cell responses by regulating interferon signaling","volume":"14","author":"Gracias","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2015.04.022_bib13","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1074-7613(03)00240-1","article-title":"Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity","volume":"19","author":"Hanada","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2015.04.022_bib14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.smim.2004.08.015","article-title":"Regulation of the immune system by SOCS family adaptor proteins","volume":"16","author":"Ilangumaran","year":"2004","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.immuni.2015.04.022_bib15","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S1074-7613(02)00446-6","article-title":"SOCS1\/JAB is a negative regulator of LPS-induced macrophage activation","volume":"17","author":"Kinjyo","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2015.04.022_bib16","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.4049\/jimmunol.0803162","article-title":"Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T\u00a0cells","volume":"182","author":"Kohlhaas","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2015.04.022_bib17","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.molcel.2012.10.002","article-title":"Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting","volume":"48","author":"Loeb","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.immuni.2015.04.022_bib18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.immuni.2008.11.010","article-title":"Foxp3-dependent microRNA155 confers competitive fitness to regulatory T\u00a0cells by targeting SOCS1 protein","volume":"30","author":"Lu","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2015.04.022_bib19","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1084\/jem.20140338","article-title":"The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation","volume":"211","author":"Lu","year":"2014","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2015.04.022_bib20","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0092-8674(00)80048-3","article-title":"SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality","volume":"98","author":"Marine","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2015.04.022_bib21","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.4049\/jimmunol.1003952","article-title":"Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis","volume":"187","author":"Murugaiyan","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2015.04.022_bib22","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1073\/pnas.0902636106","article-title":"Inositol phosphatase SHIP1 is a primary target of miR-155","volume":"106","author":"O\u2019Connell","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2015.04.022_bib23","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.immuni.2010.09.009","article-title":"MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T\u00a0cell development","volume":"33","author":"O\u2019Connell","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2015.04.022_bib24","doi-asserted-by":"crossref","first-page":"12885","DOI":"10.1073\/pnas.0806202105","article-title":"MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis","volume":"105","author":"Pichiorri","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2015.04.022_bib25","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1126\/science.1139253","article-title":"Requirement of bic\/microRNA-155 for normal immune function","volume":"316","author":"Rodriguez","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.immuni.2015.04.022_bib26","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1038\/ni.3026","article-title":"A microRNA upregulated in asthma airway T\u00a0cells promotes TH2 cytokine production","volume":"15","author":"Simpson","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2015.04.022_bib27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1084\/jem.20131142","article-title":"CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T\u00a0cell subsets","volume":"211","author":"Smigiel","year":"2014","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2015.04.022_bib28","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.immuni.2008.07.017","article-title":"Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T\u00a0cells","volume":"29","author":"Snyder","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2015.04.022_bib29","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.4049\/jimmunol.1301950","article-title":"MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways","volume":"191","author":"Sullivan","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2015.04.022_bib30","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature07665","article-title":"Adaptive immune features of natural killer cells","volume":"457","author":"Sun","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2015.04.022_bib31","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.immuni.2008.03.015","article-title":"MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase","volume":"28","author":"Teng","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2015.04.022_bib32","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1182\/blood-2012-12-467597","article-title":"Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cells","volume":"121","author":"Trotta","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2015.04.022_bib33","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.immuni.2007.10.009","article-title":"microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells","volume":"27","author":"Vigorito","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2015.04.022_bib34","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/imr.12057","article-title":"miR-155: an ancient regulator of the immune system","volume":"253","author":"Vigorito","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2015.04.022_bib35","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cell.2007.07.021","article-title":"MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb","volume":"131","author":"Xiao","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2015.04.022_bib36","doi-asserted-by":"crossref","first-page":"e46082","DOI":"10.1371\/journal.pone.0046082","article-title":"MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1","volume":"7","author":"Yao","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2015.04.022_bib37","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nri2093","article-title":"SOCS proteins, cytokine signalling and immune regulation","volume":"7","author":"Yoshimura","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2015.04.022_bib38","doi-asserted-by":"crossref","first-page":"6967","DOI":"10.1073\/pnas.1304410110","article-title":"Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155","volume":"110","author":"Zawislak","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2015.04.022_bib39","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jneuroim.2013.09.019","article-title":"MicroRNA-155\u00a0modulates Th1 and Th17 cell differentiation and is associated with multiple\u00a0sclerosis and experimental autoimmune encephalomyelitis","volume":"266","author":"Zhang","year":"2014","journal-title":"J.\u00a0Neuroimmunol."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761315002551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761315002551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T02:58:49Z","timestamp":1537498729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761315002551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1074761315002551"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2015.04.022","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2015.04.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}