{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:29:21Z","timestamp":1791419361048,"version":"4.3.3"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T00:00:00Z","timestamp":1484784000000},"content-version":"vor","delay-in-days":384,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.immuni.2015.12.002","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T22:59:54Z","timestamp":1452639594000},"page":"88-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Apoptosis-Inducing-Factor-Dependent Mitochondrial Function Is Required for T Cell but Not B Cell Function"],"prefix":"10.1016","volume":"44","author":[{"given":"Sandra","family":"Milasta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher\u00a0P.","family":"Dillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver\u00a0E.","family":"Sturm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine\u00a0C.","family":"Verbist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor\u00a0L.","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Quarato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott\u00a0A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Frase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura\u00a0J.","family":"Janke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u00a0Scott","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul\u00a0G.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas\u00a0R.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2015.12.002_bib1","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1523\/JNEUROSCI.23-06-02314.2003","article-title":"A noninvasive genetic\/pharmacologic strategy for visualizing cell morphology and clonal relationships in the mouse","volume":"23","author":"Badea","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.immuni.2015.12.002_bib2","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1084\/jem.20110306","article-title":"A role for apoptosis-inducing factor in T\u00a0cell development","volume":"209","author":"Banerjee","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2015.12.002_bib3","doi-asserted-by":"crossref","first-page":"e3208","DOI":"10.1371\/journal.pone.0003208","article-title":"The variability of the harlequin mouse phenotype resembles that of human mitochondrial-complex I-deficiency syndromes","volume":"3","author":"B\u00e9nit","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2015.12.002_bib4","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1038\/nprot.2013.111","article-title":"Generation of T\u00a0cell receptor-retrogenic mice: improved retroviral-mediated stem cell gene transfer","volume":"8","author":"Bettini","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.immuni.2015.12.002_bib5","doi-asserted-by":"crossref","first-page":"9918","DOI":"10.1073\/pnas.0603950103","article-title":"Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal","volume":"103","author":"Brown","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2015.12.002_bib6","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0300-9084(02)01374-3","article-title":"Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria","volume":"84","author":"Cand\u00e9","year":"2002","journal-title":"Biochimie"},{"key":"10.1016\/j.immuni.2015.12.002_bib7","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.4049\/jimmunol.1302062","article-title":"Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells","volume":"192","author":"Caro-Maldonado","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2015.12.002_bib8","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.freeradbiomed.2009.01.010","article-title":"Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria","volume":"46","author":"Chinta","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.immuni.2015.12.002_bib9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0014-5793(00)01731-2","article-title":"Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis","volume":"476","author":"Daugas","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.immuni.2015.12.002_bib10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1096\/fasebj.14.5.729","article-title":"Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis","volume":"14","author":"Daugas","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.immuni.2015.12.002_bib11","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.mam.2004.03.001","article-title":"Mitochondria in health and disease: perspectives on a new mitochondrial biology","volume":"25","author":"Duchen","year":"2004","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.immuni.2015.12.002_bib12","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.molcel.2015.04.020","article-title":"Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis","volume":"58","author":"Hangen","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.immuni.2015.12.002_bib13","doi-asserted-by":"crossref","first-page":"12070","DOI":"10.1073\/pnas.92.26.12070","article-title":"T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination","volume":"92","author":"Hennet","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2015.12.002_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/nprot.2006.61","article-title":"Generation of T-cell receptor retrogenic mice: Abstract: Nature Protocols","author":"Holst","year":"2006","journal-title":"Nature Protocols"},{"key":"10.1016\/j.immuni.2015.12.002_bib15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nmeth858","article-title":"Rapid analysis of T-cell selection in\u00a0vivo using T\u00a0cell-receptor retrogenic mice","volume":"3","author":"Holst","year":"2006","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2015.12.002_bib16","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/ni.1611","article-title":"Scalable signaling mediated by T\u00a0cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity","volume":"9","author":"Holst","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2015.12.002_bib17","doi-asserted-by":"crossref","first-page":"5313","DOI":"10.4049\/jimmunol.1002404","article-title":"Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy","volume":"186","author":"Jia","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2015.12.002_bib18","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1244360","article-title":"mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome","volume":"342","author":"Johnson","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.immuni.2015.12.002_bib19","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/35069004","article-title":"Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death","volume":"410","author":"Joza","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2015.12.002_bib20","doi-asserted-by":"crossref","first-page":"10261","DOI":"10.1128\/MCB.25.23.10261-10272.2005","article-title":"Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy","volume":"25","author":"Joza","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.immuni.2015.12.002_bib21","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1749-6632.2009.04681.x","article-title":"AIF: not just an apoptosis-inducing factor","volume":"1171","author":"Joza","year":"2009","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.immuni.2015.12.002_bib22","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.celrep.2012.10.009","article-title":"T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation","volume":"2","author":"Kami\u0144ski","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2015.12.002_bib23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature01034","article-title":"The harlequin mouse mutation downregulates apoptosis-inducing factor","volume":"419","author":"Klein","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2015.12.002_bib24","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cmet.2008.02.004","article-title":"Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy","volume":"7","author":"Kruse","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2015.12.002_bib25","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/S1357-2725(02)00077-8","article-title":"Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease","volume":"34","author":"Nicholls","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.immuni.2015.12.002_bib26","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1172\/JCI118798","article-title":"Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase","volume":"98","author":"Pitkanen","year":"1996","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2015.12.002_bib27","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cell.2007.08.047","article-title":"Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes","volume":"131","author":"Pospisilik","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2015.12.002_bib28","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.4049\/jimmunol.0801143","article-title":"Autophagy is essential for mitochondrial clearance in mature T lymphocytes","volume":"182","author":"Pua","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2015.12.002_bib29","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.cell.2013.05.016","article-title":"Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis","volume":"153","author":"Qiu","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2015.12.002_bib30","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/nar\/25.6.1317","article-title":"B lymphocyte-specific, Cre-mediated mutagenesis in mice","volume":"25","author":"Rickert","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2015.12.002_bib31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0005-2728(98)00033-4","article-title":"Human Complex I deficiency: Clinical spectrum and involvement of oxygen free radicals in the pathogenicity of the defect. Biochimica Et Biophysica Acta (BBA) -","volume":"1364","author":"Robinson","year":"1998","journal-title":"Bioenergetics"},{"key":"10.1016\/j.immuni.2015.12.002_bib32","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1172\/JCI64264","article-title":"Mitochondrial complex I activity and NAD+\/NADH balance regulate breast cancer progression","volume":"123","author":"Santidrian","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2015.12.002_bib33","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.immuni.2012.10.020","article-title":"Mitochondria are required for antigen-specific T\u00a0cell activation through reactive oxygen species signaling","volume":"38","author":"Sena","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2015.12.002_bib34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0005-2728(99)00051-1","article-title":"Modulation of oxidative phosphorylation of human kidney 293 cells by transfection with the internal rotenone-insensitive NADH\u2013quinone oxidoreductase (NDI1) gene of Saccharomyces cerevisiae","volume":"1412","author":"Seo","year":"1999","journal-title":"Bioenergetics"},{"key":"10.1016\/j.immuni.2015.12.002_bib35","doi-asserted-by":"crossref","first-page":"37774","DOI":"10.1074\/jbc.M007033200","article-title":"Use of the NADH-quinone oxidoreductase (NDI1) gene of Saccharomyces cerevisiae as a possible cure for complex I defects in human cells","volume":"275","author":"Seo","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2015.12.002_bib36","doi-asserted-by":"crossref","unstructured":"Seo, B.B., Nakamaru-Ogiso, E., Cruz, P., Flotte, T.R., Yagi, T., and Matsuno-Yagi, A. (2004). Functional Expression of the Single Subunit NADH Dehydrogenase in Mitochondria In\u00a0Vivo: A Potential Therapy for Complex I Deficiencies. http:\/\/dx.doi.org\/10.1089\/Hum.2004.15.887.","DOI":"10.1089\/hum.2004.15.887"},{"key":"10.1016\/j.immuni.2015.12.002_bib37","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-213X-1-4","article-title":"Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus","volume":"1","author":"Srinivas","year":"2001","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.immuni.2015.12.002_bib38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/17135","article-title":"Molecular characterization of mitochondrial apoptosis-inducing factor","volume":"397","author":"Susin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2015.12.002_bib39","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrm2952","article-title":"Mitochondria and cell death: outer membrane permeabilization and beyond","volume":"11","author":"Tait","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.immuni.2015.12.002_bib40","doi-asserted-by":"crossref","first-page":"11272","DOI":"10.1073\/pnas.0504783102","article-title":"Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease","volume":"102","author":"Takeuchi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2015.12.002_bib41","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1038\/sj.emboj.7600461","article-title":"AIF deficiency compromises oxidative phosphorylation","volume":"23","author":"Vahsen","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.immuni.2015.12.002_bib42","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.immuni.2011.09.021","article-title":"The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation","volume":"35","author":"Wang","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2015.12.002_bib43","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1073\/pnas.1003428107","article-title":"Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity","volume":"107","author":"Weinberg","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2015.12.002_bib44","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1083\/jcb.200404138","article-title":"An AIF orthologue regulates apoptosis in yeast","volume":"166","author":"Wissing","year":"2004","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.immuni.2015.12.002_bib45","doi-asserted-by":"crossref","first-page":"852","DOI":"10.4049\/jimmunol.177.2.852","article-title":"Electron transport complex I is required for CD8+ T\u00a0cell function","volume":"177","author":"Yi","year":"2006","journal-title":"J.\u00a0Immunol."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761315005038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761315005038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T10:39:29Z","timestamp":1567507169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761315005038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S1074761315005038"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2015.12.002","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apoptosis-Inducing-Factor-Dependent Mitochondrial Function Is Required for T Cell but Not B Cell Function","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2015.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}