{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T12:16:25Z","timestamp":1794399385496,"version":"4.9.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T00:00:00Z","timestamp":1489536000000},"content-version":"vor","delay-in-days":379,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.immuni.2016.02.006","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T16:43:45Z","timestamp":1456937025000},"page":"647-658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":415,"title":["Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens"],"prefix":"10.1016","volume":"44","author":[{"given":"Melody Y.","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cisalpino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranyaraajan","family":"Varadarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Hellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Shaw","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia","family":"Cascalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Inohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2016.02.006_bib1","first-page":"CD001090","article-title":"Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock","volume":"9","author":"Alejandria","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.immuni.2016.02.006_bib2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13054-015-0793-0","article-title":"The original sins of clinical trials with intravenous immunoglobulins in sepsis","volume":"19","author":"Almansa","year":"2015","journal-title":"Crit. Care"},{"key":"10.1016\/j.immuni.2016.02.006_bib3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1189\/jlb.0607372","article-title":"The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away","volume":"83","author":"Alverdy","year":"2008","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.immuni.2016.02.006_bib4","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.immuni.2016.02.006_bib5","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1172\/JCI30504","article-title":"CEACAM6 acts as a receptor for adherent-invasive E.\u00a0coli, supporting ileal mucosa colonization in Crohn disease","volume":"117","author":"Barnich","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2016.02.006_bib6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2567.2009.03173.x","article-title":"Toll-like receptors--sentries in the B-cell response","volume":"128","author":"Bekeredjian-Ding","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.immuni.2016.02.006_bib7","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1172\/JCI44447","article-title":"The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specific","volume":"121","author":"Benckert","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2016.02.006_bib8","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1084\/jem.20021633","article-title":"Regulatory T\u00a0cells selectively express toll-like receptors and are activated by lipopolysaccharide","volume":"197","author":"Caramalho","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2016.02.006_bib9","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1126\/science.272.5268.1649","article-title":"A quasi-monoclonal mouse","volume":"272","author":"Cascalho","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.immuni.2016.02.006_bib10","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.4049\/jimmunol.159.12.5795","article-title":"VH gene replacement in hyperselected B cells of the quasimonoclonal mouse","volume":"159","author":"Cascalho","year":"1997","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2016.02.006_bib11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nri3383","article-title":"Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes","volume":"13","author":"Cerutti","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2016.02.006_bib12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.coi.2011.07.010","article-title":"Pathobionts of the gastrointestinal microbiota and inflammatory disease","volume":"23","author":"Chow","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.immuni.2016.02.006_bib13","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1128\/IAI.66.3.1237-1243.1998","article-title":"M-cell surface beta1 integrin expression and invasin-mediated targeting of Yersinia pseudotuberculosis to mouse Peyer\u2019s patch M cells","volume":"66","author":"Clark","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2016.02.006_bib14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.smim.2011.11.005","article-title":"The function of secretory IgA in the context of the intestinal continuum of adaptive immune responses in host-microbial mutualism","volume":"24","author":"Geuking","year":"2012","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.immuni.2016.02.006_bib15","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1136\/gut.2010.224774","article-title":"Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection","volume":"60","author":"Haas","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.immuni.2016.02.006_bib16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1128\/CVI.05517-11","article-title":"Crohn\u2019s disease patients have more IgG-binding fecal bacteria than controls","volume":"19","author":"Harmsen","year":"2012","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.immuni.2016.02.006_bib17","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.immuni.2014.09.010","article-title":"Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage","volume":"41","author":"Hasegawa","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.02.006_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/09680519010070010101","article-title":"Outer membrane protein A (OmpA), peptidoglycan-associated lipoprotein (PAL), and murein lipoprotein (MLP) are released in experimental Gram-negative sepsis","volume":"7","author":"Hellman","year":"2001","journal-title":"J.\u00a0Endotoxin Res."},{"key":"10.1016\/j.immuni.2016.02.006_bib19","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1128\/IAI.68.5.2566-2572.2000","article-title":"Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein are released by Escherichia coli bacteria into serum","volume":"68","author":"Hellman","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2016.02.006_bib20","doi-asserted-by":"crossref","first-page":"e1000867","DOI":"10.1371\/journal.ppat.1000867","article-title":"Inadequate clearance of translocated bacterial products in HIV-infected humanized mice","volume":"6","author":"Hofer","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.immuni.2016.02.006_bib21","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/ni.2608","article-title":"Control of pathogens and pathobionts by the gut microbiota","volume":"14","author":"Kamada","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2016.02.006_bib22","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nri3430","article-title":"Role of the gut microbiota in immunity and inflammatory disease","volume":"13","author":"Kamada","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2016.02.006_bib23","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1128\/AAC.48.12.4574-4581.2004","article-title":"Bloodstream infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for mortality and treatment outcome, with special emphasis on antimicrobial therapy","volume":"48","author":"Kang","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.immuni.2016.02.006_bib24","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.immuni.2011.11.019","article-title":"B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage","volume":"36","author":"Kirkland","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.02.006_bib25","doi-asserted-by":"crossref","first-page":"e1002785","DOI":"10.1371\/journal.ppat.1002785","article-title":"Toll-like receptors promote mutually beneficial commensal-host interactions","volume":"8","author":"Kubinak","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.immuni.2016.02.006_bib26","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1053\/j.gastro.2011.11.039","article-title":"Peyer\u2019s patch dendritic cells sample antigens by extending dendrites through M cell-specific transcellular pores","volume":"142","author":"Lelouard","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.immuni.2016.02.006_bib27","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1086\/427815","article-title":"Bacterial peptidoglycan-associated lipoprotein: a naturally occurring toll-like receptor 2 agonist that is shed into serum and has synergy with lipopolysaccharide","volume":"191","author":"Liang","year":"2005","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.immuni.2016.02.006_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bmb\/ldh029","article-title":"Current status of bacterial translocation as a cause of surgical sepsis","volume":"71","author":"MacFie","year":"2004","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.immuni.2016.02.006_bib29","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.smim.2013.09.004","article-title":"Stratification and compartmentalisation of immunoglobulin responses to commensal intestinal microbes","volume":"25","author":"Macpherson","year":"2013","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.immuni.2016.02.006_bib30","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.1091334","article-title":"Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria","volume":"303","author":"Macpherson","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.immuni.2016.02.006_bib31","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1126\/science.288.5474.2222","article-title":"A primitive T\u00a0cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria","volume":"288","author":"Macpherson","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.immuni.2016.02.006_bib32","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1600-065X.2011.01072.x","article-title":"The habitat, double life, citizenship, and forgetfulness of IgA","volume":"245","author":"Macpherson","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2016.02.006_bib33","doi-asserted-by":"crossref","first-page":"F456","DOI":"10.1136\/fetalneonatal-2011-301373","article-title":"Gut microbial colonisation in premature neonates predicts neonatal sepsis","volume":"97","author":"Madan","year":"2012","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"10.1016\/j.immuni.2016.02.006_bib34","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/mi.2011.41","article-title":"Secretory IgA\u2019s complex roles in immunity and mucosal homeostasis in the gut","volume":"4","author":"Mantis","year":"2011","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.immuni.2016.02.006_bib35","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.metabol.2012.02.007","article-title":"Elevated IgG levels against specific bacterial antigens in obese patients with diabetes and in mice with diet-induced obesity and glucose intolerance","volume":"61","author":"Mohammed","year":"2012","journal-title":"Metabolism"},{"key":"10.1016\/j.immuni.2016.02.006_bib36","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1038\/emboj.2013.199","article-title":"Natural IgG antibodies provide innate protection against ficolin-opsonized bacteria","volume":"32","author":"Panda","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.immuni.2016.02.006_bib37","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.chom.2007.09.013","article-title":"IgA response to symbiotic bacteria as a mediator of gut homeostasis","volume":"2","author":"Peterson","year":"2007","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2016.02.006_bib38","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1038\/emboj.2013.235","article-title":"Protection by natural IgG: a sweet partnership with soluble lectins does the trick!","volume":"32","author":"Puga","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.immuni.2016.02.006_bib39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","article-title":"Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis","volume":"118","author":"Rakoff-Nahoum","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2016.02.006_bib40","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nri3190","article-title":"Integration of B cell responses through Toll-like receptors and antigen receptors","volume":"12","author":"Rawlings","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2016.02.006_bib41","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/86373","article-title":"Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria","volume":"2","author":"Rescigno","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2016.02.006_bib42","first-page":"26050","article-title":"The composition of the gut microbiota throughout life, with an emphasis on early life","volume":"26","author":"Rodr\u00edguez","year":"2015","journal-title":"Microb. Ecol. Health Dis."},{"key":"10.1016\/j.immuni.2016.02.006_bib43","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/0016-5085(94)90110-4","article-title":"The prevalence of gut translocation in humans","volume":"107","author":"Sedman","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1016\/j.immuni.2016.02.006_bib44","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/cc10597","article-title":"Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective","volume":"16","author":"Shankar-Hari","year":"2012","journal-title":"Crit. Care"},{"key":"10.1016\/j.immuni.2016.02.006_bib45","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.4049\/jimmunol.1001647","article-title":"Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in\u00a0vitro and in\u00a0vivo","volume":"186","author":"Shin","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2016.02.006_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00270315","article-title":"Murein-lipoprotein of Escherichia coli: a protein involved in the stabilization of bacterial cell envelope","volume":"167","author":"Suzuki","year":"1978","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/j.immuni.2016.02.006_bib47","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1073\/pnas.0307317101","article-title":"Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut","volume":"101","author":"Suzuki","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2016.02.006_bib48","doi-asserted-by":"crossref","first-page":"e113406","DOI":"10.1371\/journal.pone.0113406","article-title":"Composition of intestinal microbiota in immune-deficient mice kept in three different housing conditions","volume":"9","author":"Thoene-Reineke","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2016.02.006_bib49","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/ni.1991","article-title":"Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense","volume":"12","author":"Wei","year":"2011","journal-title":"Nat. Immunol."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761316300218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761316300218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T23:07:40Z","timestamp":1692227260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761316300218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S1074761316300218"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2016.02.006","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2016.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}