{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:59:45Z","timestamp":1791349185122,"version":"4.3.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T00:00:00Z","timestamp":1508284800000},"content-version":"vor","delay-in-days":382,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.immuni.2016.09.009","type":"journal-article","created":{"date-parts":[[2016,10,8]],"date-time":"2016-10-08T02:23:45Z","timestamp":1475893425000},"page":"931-943","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":869,"title":["Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects"],"prefix":"10.1016","volume":"45","author":[{"given":"Romain","family":"Daill\u00e8re","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"V\u00e9tizou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Waldschmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Isnard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vichnou","family":"Poirier-Colame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie\u00a0P.M.","family":"Duong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Flament","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Lepage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u00a0Paula","family":"Roberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Routy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Jacquelot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Apetoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Becharef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Rusakiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Langella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Sokol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Kroemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Enot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Eggermont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Tartour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger","family":"Johannes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul-Louis","family":"Woerther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Chachaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Soria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Encouse","family":"Golden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Formenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Plebanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsa","family":"Madondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Rosenstiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Cattoir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo\u00a0Gomperts","family":"Boneca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Chamaillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Zitvogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2016.09.009_bib1","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1007\/s11274-014-1625-0","article-title":"Antibacterial, anti-inflammatory and probiotic potential of Enterococcus hirae isolated from the rumen of Bos primigenius","volume":"30","author":"Arokiyaraj","year":"2014","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.immuni.2016.09.009_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MOT.0000000000000150","article-title":"The influence of the microbiota on the immune response to transplantation","volume":"20","author":"Bartman","year":"2015","journal-title":"Curr. Opin. Organ Transplant."},{"key":"10.1016\/j.immuni.2016.09.009_bib3","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1200\/JCO.2005.04.5716","article-title":"Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4","volume":"24","author":"Beck","year":"2006","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.immuni.2016.09.009_bib4","first-page":"11","article-title":"Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma","volume":"10","author":"Berman","year":"2010","journal-title":"Cancer Immun."},{"key":"10.1016\/j.immuni.2016.09.009_bib5","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/476393a","article-title":"Antibiotic overuse: Stop the killing of beneficial bacteria","volume":"476","author":"Blaser","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2016.09.009_bib6","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature12480","article-title":"Dietary intervention impact on gut microbial gene richness","volume":"500","author":"Cotillard","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2016.09.009_bib7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/infdis\/jiu409","article-title":"Intestinal microbiota, microbial translocation, and systemic inflammation in chronic HIV infection","volume":"211","author":"Dinh","year":"2015","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.immuni.2016.09.009_bib8","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/icb.2012.79","article-title":"Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense","volume":"91","author":"Farache","year":"2013","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.immuni.2016.09.009_bib9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.immuni.2012.05.020","article-title":"Priming of natural killer cells by nonmucosal mononuclear phagocytes requires instructive signals from commensal microbiota","volume":"37","author":"Ganal","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.09.009_bib10","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1128\/JCM.00481-13","article-title":"Mortality in kittens is associated with a shift in ileum mucosa-associated enterococci from Enterococcus hirae to biofilm-forming Enterococcus faecalis and adherent Escherichia coli","volume":"51","author":"Ghosh","year":"2013","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.immuni.2016.09.009_bib11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.immuni.2015.01.010","article-title":"Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack","volume":"42","author":"Gur","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.09.009_bib12","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.1240527","article-title":"Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment","volume":"342","author":"Iida","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.immuni.2016.09.009_bib13","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1172\/JCI80071","article-title":"Chemokine receptor patterns in lymphocytes mirror metastatic spreading in melanoma","volume":"126","author":"Jacquelot","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2016.09.009_bib14","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ajg.2013.59","article-title":"Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta-analysis","volume":"108","author":"Kassam","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.immuni.2016.09.009_bib15","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1200\/JCO.2014.57.4244","article-title":"Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer","volume":"33","author":"Le","year":"2015","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.immuni.2016.09.009_bib16","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature12506","article-title":"Richness of human gut microbiome correlates with metabolic markers","volume":"500","author":"Le Chatelier","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2016.09.009_bib17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0140-6736(14)61403-3","article-title":"T\u00a0cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial","volume":"385","author":"Lee","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.immuni.2016.09.009_bib18","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrmicro3344","article-title":"The gut microbiota, bacterial metabolites and colorectal cancer","volume":"12","author":"Louis","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.immuni.2016.09.009_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1667\/RR13352.1","article-title":"Intestinal microbiota reduces genotoxic endpoints induced by high-energy protons","volume":"181","author":"Maier","year":"2014","journal-title":"Radiat. Res."},{"key":"10.1016\/j.immuni.2016.09.009_bib20","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1053\/j.gastro.2015.04.001","article-title":"Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial","volume":"149","author":"Moayyedi","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.immuni.2016.09.009_bib21","series-title":"Enterococci: From Commensals to Leading Causes of Drug Resistant Infection","article-title":"Enterococcal Bacteriocins and Antimicrobial Proteins that Contribute to Niche Control","author":"Nes","year":"2014"},{"key":"10.1016\/j.immuni.2016.09.009_bib22","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.chom.2014.05.003","article-title":"The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration","volume":"15","author":"Nigro","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2016.09.009_bib23","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2014.08.006","article-title":"Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease","volume":"158","author":"Palm","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2016.09.009_bib24","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1172\/JCI32205","article-title":"Microbial translocation augments the function of adoptively transferred self\/tumor-specific CD8+ T\u00a0cells via TLR4 signaling","volume":"117","author":"Paulos","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2016.09.009_bib25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1128\/mBio.00116-12","article-title":"A crypt-specific core microbiota resides in the mouse colon","volume":"3","author":"P\u00e9dron","year":"2012","journal-title":"MBio"},{"key":"10.1016\/j.immuni.2016.09.009_bib26","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1128\/AEM.01561-09","article-title":"Bacteria associated with immunoregulatory cells in mice","volume":"76","author":"Presley","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.immuni.2016.09.009_bib27","doi-asserted-by":"crossref","first-page":"6219","DOI":"10.1158\/0008-5472.CAN-05-4592","article-title":"Influence of antibiotic treatment on breast carcinoma development in proto-neu transgenic mice","volume":"66","author":"Rossini","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.immuni.2016.09.009_bib28","doi-asserted-by":"crossref","first-page":"5696","DOI":"10.4049\/jimmunol.169.10.5696","article-title":"Positional scanning-synthetic peptide library-based analysis of self- and pathogen-derived peptide cross-reactivity with tumor-reactive Melan-A-specific CTL","volume":"169","author":"Rubio-Godoy","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2016.09.009_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ccell.2014.11.009","article-title":"Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation","volume":"27","author":"Rutkowski","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2016.09.009_bib30","doi-asserted-by":"crossref","first-page":"172ra20","DOI":"10.1126\/scitranslmed.3004888","article-title":"Mucosal imprinting of vaccine-induced CD8+ T\u00a0cells is crucial to inhibit the growth of mucosal tumors","volume":"5","author":"Sandoval","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2016.09.009_bib31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.chom.2014.02.007","article-title":"Microbes, microbiota, and colon cancer","volume":"15","author":"Sears","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2016.09.009_bib32","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00281-011-0245-0","article-title":"Immunomodulatory effects of cyclophosphamide and implementations for vaccine design","volume":"33","author":"Sistigu","year":"2011","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.immuni.2016.09.009_bib33","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.aac4255","article-title":"Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy","volume":"350","author":"Sivan","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.immuni.2016.09.009_bib34","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1128\/IAI.01197-12","article-title":"Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization","volume":"81","author":"Ubeda","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2016.09.009_bib35","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1001\/jama.291.7.827","article-title":"Antibiotic use in relation to the risk of breast cancer","volume":"291","author":"Velicer","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.immuni.2016.09.009_bib36","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1126\/science.aad1329","article-title":"Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota","volume":"350","author":"V\u00e9tizou","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.immuni.2016.09.009_bib37","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.1240537","article-title":"The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide","volume":"342","author":"Viaud","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.immuni.2016.09.009_bib38","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1002\/eji.200535443","article-title":"The Shiga toxin B-subunit targets antigen in\u00a0vivo to dendritic cells and elicits anti-tumor immunity","volume":"36","author":"Vingert","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2016.09.009_bib39","doi-asserted-by":"crossref","first-page":"271ps1","DOI":"10.1126\/scitranslmed.3010473","article-title":"Cancer and the gut microbiota: an unexpected link","volume":"7","author":"Zitvogel","year":"2015","journal-title":"Sci. Transl. Med."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761316303788?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761316303788?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T16:59:20Z","timestamp":1536339560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761316303788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S1074761316303788"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2016.09.009","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726825210.793553581","asserted-by":"object"}]},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2016.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}