{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:56:13Z","timestamp":1791924973007,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":379,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.immuni.2016.10.001","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T17:00:58Z","timestamp":1477414858000},"page":"1093-1107","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"title":["Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality"],"prefix":"10.1016","volume":"45","author":[{"given":"Xiao","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baowei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilai","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingtian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changsheng","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen\u00a0Y.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-zhuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-Fu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2016.10.001_bib1","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1128\/IAI.00923-13","article-title":"Toll-like receptor 7 mediates early innate immune responses to malaria","volume":"81","author":"Baccarella","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2016.10.001_bib2","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.4049\/jimmunol.1300114","article-title":"IFNAR1 controls progression to cerebral malaria in children and CD8+ T\u00a0cell brain pathology in Plasmodium berghei-infected mice","volume":"190","author":"Ball","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2016.10.001_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.chom.2016.01.007","article-title":"Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice","volume":"19","author":"Channappanavar","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2016.10.001_bib4","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/nri3742","article-title":"Innate sensing of malaria parasites","volume":"14","author":"Gazzinelli","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2016.10.001_bib5","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.immuni.2013.05.007","article-title":"Cytosolic sensing of viruses","volume":"38","author":"Goubau","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.10.001_bib6","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.4049\/jimmunol.1102143","article-title":"TLR9 and MyD88 are crucial for the development of protective immunity to malaria","volume":"188","author":"Gowda","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2016.10.001_bib7","doi-asserted-by":"crossref","first-page":"243713","DOI":"10.1155\/2014\/243713","article-title":"Interferons and interferon regulatory factors in malaria","volume":"2014","author":"Gun","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.immuni.2016.10.001_bib8","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1002\/eji.201141539","article-title":"Type I interferons suppress CD4+ T-cell-dependent parasite control during blood-stage Plasmodium infection","volume":"41","author":"Haque","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2016.10.001_bib9","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1172\/JCI70698","article-title":"Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity","volume":"124","author":"Haque","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2016.10.001_bib10","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2016.10.001_bib11","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/ni.f.205","article-title":"Immunity to malaria: more questions than answers","volume":"9","author":"Langhorne","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2016.10.001_bib12","doi-asserted-by":"crossref","first-page":"E374","DOI":"10.1073\/pnas.1102261108","article-title":"Linkage maps from multiple genetic crosses and loci linked to growth-related virulent phenotype in Plasmodium yoelii","volume":"108","author":"Li","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2016.10.001_bib13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ijpara.2012.04.006","article-title":"Innate recognition of malarial parasites by mammalian hosts","volume":"42","author":"Liehl","year":"2012","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.immuni.2016.10.001_bib14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nm.3424","article-title":"Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection","volume":"20","author":"Liehl","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2016.10.001_bib15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev.immunol.23.021704.115633","article-title":"IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors","volume":"23","author":"Liu","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2016.10.001_bib16","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1084\/jem.20112675","article-title":"Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage","volume":"209","author":"Meredith","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2016.10.001_bib17","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nm.3073","article-title":"Malaria biology and disease pathogenesis: insights for new treatments","volume":"19","author":"Miller","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2016.10.001_bib18","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.celrep.2014.03.018","article-title":"Interferon-mediated innate immune responses against malaria parasite liver stages","volume":"7","author":"Miller","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2016.10.001_bib19","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S1074-7613(02)00449-1","article-title":"SOCS-1 participates in negative regulation of LPS responses","volume":"17","author":"Nakagawa","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.10.001_bib20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1084\/jem.20040712","article-title":"Type I interferon production enhances susceptibility to Listeria monocytogenes infection","volume":"200","author":"O\u2019Connell","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2016.10.001_bib21","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1002\/eji.201343327","article-title":"Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood-stage Plasmodium berghei ANKA","volume":"43","author":"Palomo","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2016.10.001_bib22","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.immuni.2013.05.004","article-title":"Immune sensing of DNA","volume":"38","author":"Paludan","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.10.001_bib23","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nm.3083","article-title":"Immune mechanisms in malaria: new insights in vaccine development","volume":"19","author":"Riley","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2016.10.001_bib24","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.immuni.2011.05.016","article-title":"Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome","volume":"35","author":"Sharma","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.10.001_bib25","doi-asserted-by":"crossref","first-page":"E710","DOI":"10.1073\/pnas.1420217112","article-title":"Suppression of\u00a0systemic autoimmunity by the innate immune adaptor STING","volume":"112","author":"Sharma","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2016.10.001_bib26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nri1311","article-title":"Innate immunity to malaria","volume":"4","author":"Stevenson","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2016.10.001_bib27","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.immuni.2016.10.001_bib28","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.immuni.2010.11.020","article-title":"Plasmacytoid dendritic cell ablation impacts early interferon responses and antiviral NK and CD8(+) T\u00a0cell accrual","volume":"33","author":"Swiecki","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.10.001_bib29","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2016.10.001_bib30","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1126\/science.1235214","article-title":"Persistent LCMV infection is controlled by blockade of type I interferon signaling","volume":"340","author":"Teijaro","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.immuni.2016.10.001_bib31","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1126\/science.1233665","article-title":"Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses","volume":"339","author":"Teles","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.immuni.2016.10.001_bib32","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.2353\/ajpath.2007.060889","article-title":"Murine cerebral malaria development is independent of toll-like receptor signaling","volume":"170","author":"Togbe","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.immuni.2016.10.001_bib33","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ijpara.2009.11.005","article-title":"Classical CD11c+ dendritic cells, not plasmacytoid dendritic cells, induce T\u00a0cell responses to Plasmodium chabaudi malaria","volume":"40","author":"Voisine","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.immuni.2016.10.001_bib34","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1600-065X.2011.01049.x","article-title":"dsRNA sensors and plasmacytoid dendritic cells in host defense and autoimmunity","volume":"243","author":"Wang","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2016.10.001_bib35","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1126\/science.1235208","article-title":"Blockade of chronic type I interferon signaling to control persistent LCMV infection","volume":"340","author":"Wilson","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.immuni.2016.10.001_bib36","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.4049\/jimmunol.0903824","article-title":"Protein-DNA complex is the exclusive malaria parasite component that activates dendritic cells and triggers innate immune responses","volume":"184","author":"Wu","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2016.10.001_bib37","doi-asserted-by":"crossref","first-page":"E511","DOI":"10.1073\/pnas.1316467111","article-title":"Strain-specific innate immune signaling pathways determine malaria parasitemia dynamics and host mortality","volume":"111","author":"Wu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761316303892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761316303892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T08:24:20Z","timestamp":1536308660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761316303892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["S1074761316303892"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2016.10.001","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2016.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}