{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:09:13Z","timestamp":1790435353123,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T00:00:00Z","timestamp":1513728000000},"content-version":"vor","delay-in-days":384,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.immuni.2016.11.009","type":"journal-article","created":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T19:01:28Z","timestamp":1481655688000},"page":"1341-1354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":104,"title":["CD8 + T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections"],"prefix":"10.1016","volume":"45","author":[{"given":"Bing","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojun","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changya","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi A.","family":"Gullicksrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Harty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir P.","family":"Badovinac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Hui","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2016.11.009_bib1","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.immuni.2009.05.006","article-title":"Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T\u00a0cells","volume":"30","author":"Araki","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.11.009_bib2","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ni.2536","article-title":"Transcriptional insights into the CD8(+) T\u00a0cell response to infection and memory T\u00a0cell formation","volume":"14","author":"Best","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2016.11.009_bib3","doi-asserted-by":"crossref","first-page":"e1002230","DOI":"10.1371\/journal.ppat.1002230","article-title":"Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T\u00a0cell immune responses against West Nile virus infection","volume":"7","author":"Brien","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.immuni.2016.11.009_bib4","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/ni.3031","article-title":"Molecular regulation of effector and memory T\u00a0cell differentiation","volume":"15","author":"Chang","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2016.11.009_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1084\/jem.20081242","article-title":"Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs","volume":"206","author":"Cruz-Guilloty","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"issue":"Suppl 1","key":"10.1016\/j.immuni.2016.11.009_bib6","doi-asserted-by":"crossref","first-page":"i159","DOI":"10.1093\/bioinformatics\/bti1022","article-title":"Clustering short time series gene expression data","volume":"21","author":"Ernst","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2016.11.009_bib7","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/bioinformatics\/btq248","article-title":"Discover regulatory DNA elements using chromatin signatures and artificial neural network","volume":"26","author":"Firpi","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2016.11.009_bib8","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.4049\/jimmunol.1301949","article-title":"Dissecting the role of retinoic acid receptor isoforms in the CD8 response to infection","volume":"192","author":"Guo","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2016.11.009_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/nri2251","article-title":"Shaping and reshaping CD8+ T-cell memory","volume":"8","author":"Harty","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2016.11.009_bib10","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.immuni.2013.05.011","article-title":"Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization","volume":"38","author":"Hawkins","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.11.009_bib11","doi-asserted-by":"crossref","first-page":"E2191","DOI":"10.1073\/pnas.1320308111","article-title":"Global view of enhancer-promoter interactome in human cells","volume":"111","author":"He","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2016.11.009_bib12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature07829","article-title":"Histone modifications at human enhancers reflect global cell-type-specific gene expression","volume":"459","author":"Heintzman","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2016.11.009_bib13","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1084\/jem.20130392","article-title":"Differentiation of CD8 memory T\u00a0cells depends on Foxo1","volume":"210","author":"Hess Michelini","year":"2013","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2016.11.009_bib14","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cell.2013.09.053","article-title":"Super-enhancers in the control of cell identity and disease","volume":"155","author":"Hnisz","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2016.11.009_bib15","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1128\/MCB.05065-11","article-title":"An NK and T\u00a0cell enhancer lies 280 kilobase pairs 3\u2032 to the gata3 structural gene","volume":"31","author":"Hosoya-Ohmura","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.immuni.2016.11.009_bib16","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.1159806","article-title":"Anomalous type 17 response to viral infection by CD8+ T\u00a0cells lacking T-bet and eomesodermin","volume":"321","author":"Intlekofer","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.immuni.2016.11.009_bib17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.immuni.2007.07.010","article-title":"Inflammation directs memory precursor and short-lived effector CD8(+) T\u00a0cell fates via the graded expression of T-bet transcription factor","volume":"27","author":"Joshi","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.11.009_bib18","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.immuni.2013.07.013","article-title":"The transcription factor Foxo1 controls central-memory CD8+ T\u00a0cell responses to infection","volume":"39","author":"Kim","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.11.009_bib19","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1126\/science.1256271","article-title":"Immunogenetics. Chromatin state dynamics during blood formation","volume":"345","author":"Lara-Astiaso","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.immuni.2016.11.009_bib20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2011.12.014","article-title":"Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation","volume":"148","author":"Li","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2016.11.009_bib21","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1182\/blood-2012-08-447839","article-title":"A far downstream enhancer for murine Bcl11b controls its T-cell specific expression","volume":"122","author":"Li","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2016.11.009_bib22","doi-asserted-by":"crossref","first-page":"e1005219","DOI":"10.1371\/journal.ppat.1005219","article-title":"Phenotypic and Functional Alterations in Circulating Memory CD8\u00a0T Cells with Time after Primary Infection","volume":"11","author":"Martin","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.immuni.2016.11.009_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrg2957","article-title":"Enhancer function: new insights into the regulation of tissue-specific gene expression","volume":"12","author":"Ong","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.immuni.2016.11.009_bib24","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/ni.2039","article-title":"Immunological mechanisms of vaccination","volume":"12","author":"Pulendran","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2016.11.009_bib25","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.immuni.2014.11.001","article-title":"Distinct epigenetic signatures delineate transcriptional programs during virus-specific CD8(+) T\u00a0cell differentiation","volume":"41","author":"Russ","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.11.009_bib26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature11279","article-title":"The long-range interaction landscape of gene promoters","volume":"489","author":"Sanyal","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2016.11.009_bib27","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1084\/jem.20071641","article-title":"Functional and genomic profiling of effector CD8 T\u00a0cell subsets with distinct memory fates","volume":"205","author":"Sarkar","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2016.11.009_bib28","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ni.2937","article-title":"Epigenomic analysis of primary human T\u00a0cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility","volume":"15","author":"Seumois","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2016.11.009_bib29","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrg3682","article-title":"Transcriptional enhancers: from properties to genome-wide predictions","volume":"15","author":"Shlyueva","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.immuni.2016.11.009_bib30","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nature14154","article-title":"Super-enhancers delineate disease-associated regulatory nodes in T\u00a0cells","volume":"520","author":"Vahedi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2016.11.009_bib31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cell.2013.03.035","article-title":"Master transcription factors and mediator establish super-enhancers at key cell identity genes","volume":"153","author":"Whyte","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2016.11.009_bib32","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2010.06.014","article-title":"Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T\u00a0cell differentiation","volume":"33","author":"Wirth","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2016.11.009_bib33","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ni.3456","article-title":"Tcf1 and Lef1 transcription factors establish CD8(+) T\u00a0cell identity through intrinsic HDAC activity","volume":"17","author":"Xing","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2016.11.009_bib34","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.4049\/jimmunol.0901199","article-title":"Constitutive activation of Wnt signaling favors generation of memory CD8 T\u00a0cells","volume":"184","author":"Zhao","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2016.11.009_bib35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.immuni.2010.08.002","article-title":"Differentiation and persistence of memory CD8(+) T\u00a0cells depend on T\u00a0cell factor 1","volume":"33","author":"Zhou","year":"2010","journal-title":"Immunity"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761316304812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761316304812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T21:50:54Z","timestamp":1536184254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761316304812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1074761316304812"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2016.11.009","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2016.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}