{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:31:23Z","timestamp":1791487883746,"version":"4.3.4"},"reference-count":64,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T00:00:00Z","timestamp":1485475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.immuni.2017.01.005","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T02:16:16Z","timestamp":1487124976000},"page":"233-244","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":320,"title":["A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells"],"prefix":"10.1016","volume":"46","author":[{"given":"Giada","family":"Mondanelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Pallotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciriana","family":"Orabona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Albini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta","family":"Iacono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Belladonna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Vacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Fallarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Macchiarulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ugel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Bronte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Gevi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lello","family":"Zolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auke","family":"Verhaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maikel","family":"Peppelenbosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia Maria Cristina","family":"Mazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Bicciato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmina","family":"Laouar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Santambrogio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Puccetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Volpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Grohmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2017.01.005_bib1","doi-asserted-by":"crossref","first-page":"e10147","DOI":"10.7554\/eLife.10147","article-title":"Evolution of an ancient protein function involved in organized multicellularity in animals","volume":"5","author":"Anderson","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.immuni.2017.01.005_bib2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2017.01.005_bib3","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.4049\/jimmunol.181.8.5194","article-title":"Cutting edge: Autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells","volume":"181","author":"Belladonna","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.molmed.2008.11.006","article-title":"TGF-beta and kynurenines as the key to infectious tolerance","volume":"15","author":"Belladonna","year":"2009","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.immuni.2017.01.005_bib5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature13323","article-title":"Aryl hydrocarbon receptor control of a disease tolerance defence pathway","volume":"511","author":"Bessede","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2017.01.005_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cytogfr.2009.11.008","article-title":"Transforming growth factor beta (TGF-beta) and inflammation in cancer","volume":"21","author":"Bierie","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.immuni.2017.01.005_bib7","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1158\/0008-5472.CAN-11-2158","article-title":"Is Co-option a prevailing mechanism during cancer progression?","volume":"71","author":"Billaud","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.immuni.2017.01.005_bib8","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.4049\/jimmunol.155.4.2077","article-title":"Transforming growth factor-beta stimulates arginase activity in macrophages. Implications for the regulation of macrophage cytotoxicity","volume":"155","author":"Boutard","year":"1995","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib9","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nri1668","article-title":"Regulation of immune responses by L-arginine metabolism","volume":"5","author":"Bronte","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib10","doi-asserted-by":"crossref","first-page":"e1149674","DOI":"10.1080\/2162402X.2016.1149674","article-title":"Trial Watch-Small molecules targeting the immunological tumor microenvironment for cancer therapy","volume":"5","author":"Buqu\u00e9","year":"2016","journal-title":"OncoImmunology"},{"key":"10.1016\/j.immuni.2017.01.005_bib11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00726-013-1572-3","article-title":"Inflammation, carcinogenesis and neurodegeneration studies in transgenic animal models for polyamine research","volume":"46","author":"Cervelli","year":"2014","journal-title":"Amino Acids"},{"key":"10.1016\/j.immuni.2017.01.005_bib12","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/ni.2088","article-title":"IDO: more than an enzyme","volume":"12","author":"Chen","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3389\/fgene.2015.00227","article-title":"Gene duplication and the evolution of moonlighting proteins","volume":"6","author":"Espinosa-Cant\u00fa","year":"2015","journal-title":"Front. Genet."},{"key":"10.1016\/j.immuni.2017.01.005_bib14","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.4049\/jimmunol.176.11.6752","article-title":"The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T\u00a0cell receptor zeta-chain and induce a regulatory phenotype in naive T\u00a0cells","volume":"176","author":"Fallarino","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib15","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/S0167-5699(98)01328-0","article-title":"The evolution of self-tolerance: a new cell arises to meet the challenge of self-reactivity","volume":"19","author":"Fazekas de St Groth","year":"1998","journal-title":"Immunol. Today"},{"key":"10.1016\/j.immuni.2017.01.005_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrg2703","article-title":"Origin and evolution of the adaptive immune system: genetic events and selective pressures","volume":"11","author":"Flajnik","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.immuni.2017.01.005_bib17","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib18","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nrc1454","article-title":"Polyamines and cancer: old molecules, new understanding","volume":"4","author":"Gerner","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.immuni.2017.01.005_bib19","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.chom.2014.02.003","article-title":"Host immune response to infection and cancer: unexpected commonalities","volume":"15","author":"Goldszmid","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2017.01.005_bib20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nri704","article-title":"Transforming growth factor-beta in T-cell biology","volume":"2","author":"Gorelik","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1600-065X.2010.00915.x","article-title":"Control of immune response by amino acid metabolism","volume":"236","author":"Grohmann","year":"2010","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2017.01.005_bib22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fimmu.2015.00058","article-title":"The Coevolution of IDO1 and AhR in the Emergence of Regulatory T-Cells in Mammals","volume":"6","author":"Grohmann","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib23","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/ni846","article-title":"CTLA-4-Ig regulates tryptophan catabolism in\u00a0vivo","volume":"3","author":"Grohmann","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib24","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.4049\/jimmunol.171.5.2581","article-title":"Functional plasticity of dendritic cell subsets as mediated by CD40 versus B7 activation","volume":"171","author":"Grohmann","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib25","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S1471-4906(03)00072-3","article-title":"Tolerance, DCs and tryptophan: much ado about IDO","volume":"24","author":"Grohmann","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib26","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nm1563","article-title":"Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy","volume":"13","author":"Grohmann","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2017.01.005_bib27","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1158\/0008-5472.CAN-04-3244","article-title":"Haploinsufficiency for odc modifies mouse skin tumor susceptibility","volume":"65","author":"Guo","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.immuni.2017.01.005_bib28","doi-asserted-by":"crossref","first-page":"e27360","DOI":"10.4161\/onci.27360","article-title":"Polyamine blockade promotes antitumor immunity","volume":"3","author":"Hayes","year":"2014","journal-title":"OncoImmunology"},{"key":"10.1016\/j.immuni.2017.01.005_bib29","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1083\/jcb.122.4.903","article-title":"Polyamines are essential for cell transformation by pp60v-src: delineation of molecular events relevant for the transformed phenotype","volume":"122","author":"H\u00f6ltt\u00e4","year":"1993","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.immuni.2017.01.005_bib30","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/ni1197","article-title":"Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma","volume":"6","author":"Laouar","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib31","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.it.2007.03.008","article-title":"Duration, combination and timing: the signal integration model of dendritic cell activation","volume":"28","author":"Macagno","year":"2007","journal-title":"Trends Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib32","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1600-065X.2008.00602.x","article-title":"Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells","volume":"222","author":"Marigo","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2017.01.005_bib33","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1172\/JCI80005","article-title":"Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected","volume":"125","author":"Marvel","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2017.01.005_bib34","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.febslet.2006.04.033","article-title":"The logic of TGFbeta signaling","volume":"580","author":"Massagu\u00e9","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.immuni.2017.01.005_bib35","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri1457","article-title":"IDO expression by dendritic cells: tolerance and tryptophan catabolism","volume":"4","author":"Mellor","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib36","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nri2132","article-title":"Tolerogenic dendritic cells and the quest for transplant tolerance","volume":"7","author":"Morelli","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib37","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/ni.3323","article-title":"Amino acid auxotrophy as a system of immunological control nodes","volume":"17","author":"Murray","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib38","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1182\/blood.V83.5.1408.1408","article-title":"Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes","volume":"83","author":"Musso","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2017.01.005_bib39","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.immuni.2013.04.001","article-title":"The immune system as a sensor of the metabolic state","volume":"38","author":"Odegaard","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2017.01.005_bib40","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/978-1-60761-869-0_19","article-title":"Indoleamine 2,3-dioxygenase and regulatory function: tryptophan starvation and beyond","volume":"677","author":"Orabona","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.immuni.2017.01.005_bib41","doi-asserted-by":"crossref","first-page":"20828","DOI":"10.1073\/pnas.0810278105","article-title":"SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis","volume":"105","author":"Orabona","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2017.01.005_bib42","doi-asserted-by":"crossref","first-page":"834","DOI":"10.2119\/molmed.2012.00029","article-title":"Different partners, opposite outcomes: a new perspective of the immunobiology of indoleamine 2,3-dioxygenase","volume":"18","author":"Orabona","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.immuni.2017.01.005_bib43","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.semcancer.2012.01.011","article-title":"Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression","volume":"22","author":"Ostrand-Rosenberg","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.immuni.2017.01.005_bib44","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/ni.2077","article-title":"Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells","volume":"12","author":"Pallotta","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib45","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1111\/jcmm.12360","article-title":"Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes","volume":"18","author":"Pallotta","year":"2014","journal-title":"J.\u00a0Cell. Mol. Med."},{"key":"10.1016\/j.immuni.2017.01.005_bib46","doi-asserted-by":"crossref","first-page":"7565","DOI":"10.4049\/jimmunol.172.12.7565","article-title":"Enhancer-mediated control of macrophage-specific arginase I expression","volume":"172","author":"Pauleau","year":"2004","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib47","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2013.04.005","article-title":"Metabolic pathways in immune cell activation and quiescence","volume":"38","author":"Pearce","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2017.01.005_bib48","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nrc3603","article-title":"The roles of TGF\u03b2 in the tumour microenvironment","volume":"13","author":"Pickup","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.immuni.2017.01.005_bib49","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1158\/0008-5472.CAN-12-0569","article-title":"Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion","volume":"72","author":"Platten","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.immuni.2017.01.005_bib50","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/nri2163","article-title":"IDO and regulatory T\u00a0cells: a role for reverse signalling and non-canonical NF-kappaB activation","volume":"7","author":"Puccetti","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib51","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/eji.1830240631","article-title":"Use of a skin test assay to determine tumor-specific CD8+ T\u00a0cell reactivity","volume":"24","author":"Puccetti","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib52","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.cellsig.2011.12.016","article-title":"Spermine, a molecular switch regulating EGFR, integrin \u03b23, Src, and FAK scaffolding","volume":"24","author":"Ray","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.immuni.2017.01.005_bib53","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nature06471","article-title":"Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease","volume":"451","author":"Romani","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2017.01.005_bib54","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in\u00a0vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2017.01.005_bib55","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cytogfr.2014.07.014","article-title":"TGF\u03b2 in T\u00a0cell biology and tumor immunity: Angel or devil?","volume":"25","author":"Tu","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.immuni.2017.01.005_bib56","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1172\/JCI80006","article-title":"Tumor-induced myeloid deviation: when myeloid-derived suppressor cells meet tumor-associated macrophages","volume":"125","author":"Ugel","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2017.01.005_bib57","doi-asserted-by":"crossref","first-page":"11605","DOI":"10.1158\/0008-5472.CAN-06-1370","article-title":"Comparison of kinome profiles of Barrett\u2019s esophagus with normal squamous esophagus and normal gastric cardia","volume":"66","author":"van Baal","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.immuni.2017.01.005_bib58","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuropharm.2015.10.036","article-title":"Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells","volume":"102","author":"Volpi","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.immuni.2017.01.005_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3360001","article-title":"Arginine metabolism: nitric oxide and beyond","volume":"336","author":"Wu","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.immuni.2017.01.005_bib60","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1128\/MCB.00805-14","article-title":"Cross talk between histone deacetylase 4 and STAT6 in the transcriptional regulation of arginase 1 during mouse dendritic cell differentiation","volume":"35","author":"Yang","year":"2015","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.immuni.2017.01.005_bib61","doi-asserted-by":"crossref","first-page":"915","DOI":"10.4049\/jimmunol.1500729","article-title":"Targeting Ornithine Decarboxylase by \u03b1-Difluoromethylornithine Inhibits Tumor Growth by Impairing Myeloid-Derived Suppressor Cells","volume":"196","author":"Ye","year":"2016","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib62","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.4049\/jimmunol.181.8.5791","article-title":"Subsets of myeloid-derived suppressor cells in tumor-bearing mice","volume":"181","author":"Youn","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2017.01.005_bib63","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00239-007-9049-1","article-title":"Evolution of vertebrate indoleamine 2,3-dioxygenases","volume":"65","author":"Yuasa","year":"2007","journal-title":"J.\u00a0Mol. Evol."},{"key":"10.1016\/j.immuni.2017.01.005_bib64","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1084\/jem.185.10.1759","article-title":"Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counterregulatory mechanism that restrains the immune response","volume":"185","author":"Zhang","year":"1997","journal-title":"J.\u00a0Exp. Med."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761317300274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761317300274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T06:44:56Z","timestamp":1692686696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761317300274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["S1074761317300274"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2017.01.005","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2017.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}