{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:28:48Z","timestamp":1791325728268,"version":"4.3.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"vor","delay-in-days":382,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"NIH Intramural funding","award":["NEI EY000184"],"award-info":[{"award-number":["NEI EY000184"]}]},{"name":"NIH Intramural funding","award":["NIAID AI001175"],"award-info":[{"award-number":["NIAID AI001175"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Prevention of Blindness Society of Metropolitan Washington"},{"name":"American Association of Immunology Fellowship Award"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.immuni.2017.06.014","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T14:32:02Z","timestamp":1499783522000},"page":"148-158.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":275,"title":["An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal \u03b3\u03b4 T Cells"],"prefix":"10.1016","volume":"47","author":[{"given":"Anthony J.","family":"St. Leger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigar V.","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Drummond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abirami","family":"Kugadas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimah","family":"Almaghrabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Silver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumarkrishna","family":"Raychaudhuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Gadjeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail S.","family":"Lionakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel R.","family":"Caspi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2017.06.014_bib1","doi-asserted-by":"crossref","first-page":"5254","DOI":"10.1167\/iovs.14-14365","article-title":"In\u00a0vivo confocal microscopy of conjunctiva-associated lymphoid tissue in healthy humans","volume":"55","author":"Agnifili","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.immuni.2017.06.014_bib2","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1099\/ijsem.0.001059","article-title":"Corynebacterium lowii sp. nov. and Corynebacterium oculi sp. nov., derived from human clinical disease and an emended description of Corynebacterium mastitidis","volume":"66","author":"Bernard","year":"2016","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"10.1016\/j.immuni.2017.06.014_bib3","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.4049\/jimmunol.182.3.1247","article-title":"Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression","volume":"182","author":"Chauhan","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2017.06.014_bib4","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1167\/iovs.07-0868","article-title":"Repertoire analysis and new pathogenic epitopes of IRBP in C57BL\/6 (H-2b) and B10.RIII (H-2r) mice","volume":"49","author":"Cortes","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.immuni.2017.06.014_bib5","doi-asserted-by":"crossref","first-page":"23561","DOI":"10.1038\/srep23561","article-title":"Altered mucosal microbiome diversity and disease severity in Sj\u00f6gren syndrome","volume":"6","author":"de Paiva","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.immuni.2017.06.014_bib6","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/343714a0","article-title":"Self-reactive gamma delta T\u00a0cells are eliminated in the thymus","volume":"343","author":"Dent","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2017.06.014_bib7","doi-asserted-by":"crossref","first-page":"163582","DOI":"10.1155\/2013\/163582","article-title":"Epidemiological study of hospital-acquired bacterial conjunctivitis in a level III neonatal unit","volume":"2013","author":"Dias","year":"2013","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.immuni.2017.06.014_bib8","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1167\/iovs.10-6939","article-title":"Diversity of bacteria at healthy human conjunctiva","volume":"52","author":"Dong","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.immuni.2017.06.014_bib9","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1128\/JCM.01741-07","article-title":"High-level fluoroquinolone resistance in ophthalmic clinical isolates belonging to the species Corynebacterium macginleyi","volume":"46","author":"Eguchi","year":"2008","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.immuni.2017.06.014_bib10","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nm.3871","article-title":"Activation of HIF-1\u03b1 and LL-37 by commensal bacteria inhibits Candida albicans colonization","volume":"21","author":"Fan","year":"2015","journal-title":"Nat. Med."},{"issue":"Suppl 1","key":"10.1016\/j.immuni.2017.06.014_bib11","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0020-7292(00)00350-7","article-title":"Vaginal candidosis: epidemiological and etiological factors","volume":"71","author":"Ferrer","year":"2000","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.immuni.2017.06.014_bib12","doi-asserted-by":"crossref","first-page":"e1000826","DOI":"10.1371\/journal.ppat.1000826","article-title":"Inhibition of macrophage migration inhibitory factor ameliorates ocular Pseudomonas aeruginosa-induced keratitis","volume":"6","author":"Gadjeva","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.immuni.2017.06.014_bib13","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1084\/jem.170.5.1569","article-title":"Intraepithelial lymphocytes. Anatomical site, not T\u00a0cell receptor form, dictates phenotype and function","volume":"170","author":"Goodman","year":"1989","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2017.06.014_bib14","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1167\/iovs.07-0588","article-title":"Ocular pathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes","volume":"48","author":"Graham","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.immuni.2017.06.014_bib15","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2008.11.009","article-title":"Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses","volume":"30","author":"Ishigame","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2017.06.014_bib16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2017.06.014_bib17","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1084\/jem.184.4.1449","article-title":"Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop","volume":"184","author":"Kanamori","year":"1996","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2017.06.014_bib18","first-page":"1270","article-title":"Conjunctiva-associated lymphoid tissue in the human eye","volume":"41","author":"Knop","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.immuni.2017.06.014_bib19","first-page":"271","article-title":"The role of eye-associated lymphoid tissue in corneal immune protection","volume":"206","author":"Knop","year":"2005","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.immuni.2017.06.014_bib20","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.immuni.2015.03.014","article-title":"Dysbiosis and Staphylococcus aureus colonization drives inflammation in atopic dermatitis","volume":"42","author":"Kobayashi","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2017.06.014_bib21","doi-asserted-by":"crossref","first-page":"e1005855","DOI":"10.1371\/journal.ppat.1005855","article-title":"Impact of microbiota on resistance to ocular Pseudomonas aeruginosa-induced keratitis","volume":"12","author":"Kugadas","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.immuni.2017.06.014_bib22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.micpath.2016.12.013","article-title":"Pathogenesis of microbial keratitis","volume":"104","author":"Lakhundi","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.immuni.2017.06.014_bib23","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1167\/iovs.12-9922","article-title":"Comparative ocular microbial communities in humans with and without blepharitis","volume":"53","author":"Lee","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.immuni.2017.06.014_bib24","doi-asserted-by":"crossref","first-page":"E791","DOI":"10.1073\/pnas.1522149113","article-title":"Biogeography of a human oral microbiome at the micron scale","volume":"113","author":"Mark Welch","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2017.06.014_bib25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exer.2013.07.014","article-title":"Antimicrobial compounds in tears","volume":"117","author":"McDermott","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.immuni.2017.06.014_bib26","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1084\/jem.20110308","article-title":"T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse","volume":"208","author":"Moran","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2017.06.014_bib27","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature14052","article-title":"Commensal-dendritic-cell interaction specifies a unique protective skin immune signature","volume":"520","author":"Naik","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2017.06.014_bib28","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/aos.12708","article-title":"Candida albicans should be considered when managing keratitis in atopic keratoconjunctivitis","volume":"93","author":"Nivenius","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.immuni.2017.06.014_bib29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1093\/cid\/cir355","article-title":"Ocular manifestations of candidemia","volume":"53","author":"Oude Lashof","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.immuni.2017.06.014_bib30","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1128\/iai.63.9.3497-3501.1995","article-title":"Rapid and sensitive method for evaluating Pseudomonas aeruginosa virulence factors during corneal infections in mice","volume":"63","author":"Preston","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2017.06.014_bib31","doi-asserted-by":"crossref","first-page":"8046","DOI":"10.1073\/pnas.1508990112","article-title":"Inflammation induces dermal V\u03b34+ \u03b3\u03b4T17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses","volume":"112","author":"Ram\u00edrez-Valle","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2017.06.014_bib32","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1159\/000307726","article-title":"Treatment of external ocular Candida infections with 5-fluorocytosine","volume":"172","author":"Romano","year":"1976","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.immuni.2017.06.014_bib33","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.immuni.2015.10.016","article-title":"A wave of regulatory T\u00a0cells into neonatal skin mediates tolerance to commensal microbes","volume":"43","author":"Scharschmidt","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2017.06.014_bib34","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.immuni.2013.06.015","article-title":"\u03b3\u03b4 T\u00a0cells exhibit multifunctional and protective memory in intestinal tissues","volume":"39","author":"Sheridan","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2017.06.014_bib35","doi-asserted-by":"crossref","first-page":"e00198","DOI":"10.1128\/mBio.00198-16","article-title":"Changes in the eye microbiota associated with contact lens wearing","volume":"7","author":"Shin","year":"2016","journal-title":"MBio"},{"key":"10.1016\/j.immuni.2017.06.014_bib36","doi-asserted-by":"crossref","first-page":"e82355","DOI":"10.1371\/journal.pone.0082355","article-title":"Development, alteration and real time dynamics of conjunctiva-associated lymphoid tissue","volume":"8","author":"Siebelmann","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2017.06.014_bib37","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.4049\/jimmunol.1100736","article-title":"Role of IL-17 and Th17 cells in herpes simplex virus-induced corneal immunopathology","volume":"187","author":"Suryawanshi","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2017.06.014_bib38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00003226-200005000-00010","article-title":"Spectrum of fungal keratitis at Wills Eye Hospital, Philadelphia, Pennsylvania","volume":"19","author":"Tanure","year":"2000","journal-title":"Cornea"},{"key":"10.1016\/j.immuni.2017.06.014_bib39","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/1469-0691.12126","article-title":"Mycotic keratitis: epidemiology, diagnosis and management","volume":"19","author":"Thomas","year":"2013","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.immuni.2017.06.014_bib40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jtos.2013.10.001","article-title":"S100A proteins as molecular targets in the ocular surface inflammatory diseases","volume":"12","author":"Tong","year":"2014","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.immuni.2017.06.014_bib41","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nri3384","article-title":"Six-of-the-best: unique contributions of \u03b3\u03b4 T\u00a0cells to immunology","volume":"13","author":"Vantourout","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2017.06.014_bib42","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.exer.2013.06.003","article-title":"Characterization of the normal microbiota of the ocular surface","volume":"117","author":"Willcox","year":"2013","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.immuni.2017.06.014_bib43","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/2049-2618-2-40","article-title":"Characterization and quantification of the fungal microbiome in serial samples from individuals with cystic fibrosis","volume":"2","author":"Willger","year":"2014","journal-title":"Microbiome"},{"key":"10.1016\/j.immuni.2017.06.014_bib44","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1128\/IAI.00249-12","article-title":"Topical neutralization of interleukin-17 during experimental Pseudomonas aeruginosa corneal infection promotes bacterial clearance and reduces pathology","volume":"80","author":"Zaidi","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2017.06.014_bib45","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1128\/IAI.01951-14","article-title":"Microbiota-driven immune cellular maturation is essential for antibody-mediated adaptive immunity to Staphylococcus aureus infection in the eye","volume":"82","author":"Zaidi","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2017.06.014_bib46","doi-asserted-by":"crossref","first-page":"e36822","DOI":"10.1371\/journal.pone.0036822","article-title":"NK cells promote Th-17 mediated corneal barrier disruption in dry eye","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2017.06.014_bib47","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13073-014-0099-x","article-title":"The conjunctival microbiome in health and trachomatous disease: a case control study","volume":"6","author":"Zhou","year":"2014","journal-title":"Genome Med."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761317302741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761317302741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:02:34Z","timestamp":1761033754000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761317302741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S1074761317302741"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2017.06.014","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727800071.793535416","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.727800071.793536009","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.727800071.793534633","asserted-by":"object"}]},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal \u03b3\u03b4 T Cells","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2017.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}