{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:58:04Z","timestamp":1791824284277,"version":"4.3.4"},"reference-count":87,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":385,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.immuni.2019.06.005","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T10:35:27Z","timestamp":1562841327000},"page":"241-257.e9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":156,"title":["The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair"],"prefix":"10.1016","volume":"51","author":[{"given":"Anthony","family":"Kusnadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Pannellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Giannopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Hyun","family":"Park-Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel B.","family":"Ivashkiv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2019.06.005_bib1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri1184","article-title":"Signalling pathways of the TNF superfamily: a double-edged sword","volume":"3","author":"Aggarwal","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib2","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/ni.3487","article-title":"Control of the innate immune response by the mevalonate pathway","volume":"17","author":"Akula","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib3","first-page":"164","article-title":"Polyunsaturated fatty acids and their effects on cardiovascular disease","volume":"8","author":"Ander","year":"2003","journal-title":"Exp. Clin. Cardiol."},{"key":"10.1016\/j.immuni.2019.06.005_bib4","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/ni.3838","article-title":"Srebp-controlled glucose metabolism is essential for NK cell functional responses","volume":"18","author":"Assmann","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cell.2017.11.025","article-title":"Metabolic induction of trained immunity through the mevalonate pathway","volume":"172","author":"Bekkering","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2019.06.005_bib6","doi-asserted-by":"crossref","first-page":"e1000598","DOI":"10.1371\/journal.pbio.1000598","article-title":"Host defense against viral infection involves interferon mediated down-regulation\u00a0of sterol biosynthesis","volume":"9","author":"Blanc","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.immuni.2019.06.005_bib7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nri3834","article-title":"Regulation of tumour necrosis factor signalling: live or let die","volume":"15","author":"Brenner","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)80213-5","article-title":"The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor","volume":"89","author":"Brown","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2019.06.005_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.immuni.2019.06.005_bib10","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nm.2628","article-title":"An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection","volume":"18","author":"Chen","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2019.06.005_bib11","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1172\/JCI85740","article-title":"Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis","volume":"126","author":"Chia","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2019.06.005_bib12","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.cell.2017.09.029","article-title":"Oxysterol restraint of cholesterol synthesis prevents AIM2 inflammasome activation","volume":"171","author":"Dang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2019.06.005_bib13","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.tibs.2018.01.005","article-title":"SREBPs in lipid metabolism, insulin signaling, and beyond","volume":"43","author":"DeBose-Boyd","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.immuni.2019.06.005_bib14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/1752-153X-6-137","article-title":"Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation","volume":"6","author":"Dehelean","year":"2012","journal-title":"Chem. Cent. J."},{"key":"10.1016\/j.immuni.2019.06.005_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2019.06.005_bib16","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/sj.jid.5700701","article-title":"Inflammation in wound repair: molecular and cellular mechanisms","volume":"127","author":"Eming","year":"2007","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.immuni.2019.06.005_bib17","doi-asserted-by":"crossref","first-page":"265sr6","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2019.06.005_bib18","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1126\/science.aam7928","article-title":"Inflammation and metabolism in tissue repair and regeneration","volume":"356","author":"Eming","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.immuni.2019.06.005_bib19","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.it.2016.09.001","article-title":"The intracellular cholesterol landscape: dynamic integrator of the immune response","volume":"37","author":"Fessler","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.immuni.2017.02.006","article-title":"Immunopathogenesis of rheumatoid arthritis","volume":"46","author":"Firestein","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2019.06.005_bib21","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2019.06.005_bib22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/ni.3324","article-title":"New insights into the multidimensional concept of macrophage ontogeny, activation and function","volume":"17","author":"Ginhoux","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/ni.3306","article-title":"Molecular control of activation and priming in macrophages","volume":"17","author":"Glass","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cell.2015.01.036","article-title":"A century of cholesterol and coronaries: from plaques to genes to statins","volume":"161","author":"Goldstein","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2019.06.005_bib25","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2353\/ajpath.2009.081002","article-title":"A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes","volume":"175","author":"Goren","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.immuni.2019.06.005_bib26","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.immuni.2018.08.021","article-title":"Cholesterol homeostatic regulator SCAP-SREBP2 integrates NLRP3 inflammasome activation and cholesterol biosynthetic signaling in macrophages","volume":"49","author":"Guo","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2019.06.005_bib27","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.immuni.2019.06.005_bib28","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/ng.3561","article-title":"Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease","volume":"48","author":"Helgadottir","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.immuni.2019.06.005_bib29","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2019.06.005_bib30","doi-asserted-by":"crossref","first-page":"96260","DOI":"10.1172\/jci.insight.96260","article-title":"Delivery of monocyte lineage cells in a biomimetic scaffold enhances tissue repair","volume":"2","author":"Hu","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.immuni.2019.06.005_bib31","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.immuni.2008.08.016","article-title":"Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways","volume":"29","author":"Hu","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2019.06.005_bib32","doi-asserted-by":"crossref","first-page":"31959","DOI":"10.1038\/srep31959","article-title":"Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages","volume":"6","author":"Huynh","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.immuni.2019.06.005_bib33","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cmet.2011.04.001","article-title":"Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a","volume":"13","author":"Im","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2019.06.005_bib34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrrheum.2015.169","article-title":"TNF biology, pathogenic mechanisms and emerging therapeutic strategies","volume":"12","author":"Kalliolias","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.immuni.2019.06.005_bib35","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/ni.2570","article-title":"Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T\u00a0cells and adaptive immunity","volume":"14","author":"Kidani","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib36","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1128\/MCB.15.5.2582","article-title":"Dual DNA binding specificity of ADD1\/SREBP1 controlled by a single amino acid in the basic helix-loop-helix domain","volume":"15","author":"Kim","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.immuni.2019.06.005_bib37","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.immuni.2015.09.005","article-title":"Interleukin-4 receptor \u03b1 signaling in myeloid cells controls collagen fibril assembly\u00a0in skin repair","volume":"43","author":"Knipper","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2019.06.005_bib38","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/j.celrep.2015.08.033","article-title":"TNF counterbalances the emergence of M2 tumor macrophages","volume":"12","author":"Kratochvill","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2019.06.005_bib39","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.neuron.2014.07.027","article-title":"TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord","volume":"83","author":"Kroner","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2019.06.005_bib40","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2019.06.005_bib41","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nri3088","article-title":"Transcriptional regulation of macrophage polarization: enabling diversity with identity","volume":"11","author":"Lawrence","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib42","doi-asserted-by":"crossref","first-page":"H874","DOI":"10.1152\/ajpheart.00096.2012","article-title":"Cross-talk between TLR4-MyD88-NF-\u03baB and SCAP-SREBP2 pathways mediates macrophage foam cell formation","volume":"304","author":"Li","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.immuni.2019.06.005_bib43","doi-asserted-by":"crossref","first-page":"9520","DOI":"10.1074\/jbc.M111421200","article-title":"Diminished hepatic response to fasting\/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c","volume":"277","author":"Liang","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2019.06.005_bib44","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2012.11.005","article-title":"Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol","volume":"38","author":"Liu","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2019.06.005_bib45","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.4049\/jimmunol.0903356","article-title":"Differential roles of macrophages in diverse phases of skin repair","volume":"184","author":"Lucas","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1089\/wound.2016.0696","article-title":"Cutaneous scarring: basic science, current treatments, and future directions","volume":"7","author":"Marshall","year":"2018","journal-title":"Adv. Wound Care (New Rochelle)"},{"key":"10.1016\/j.immuni.2019.06.005_bib47","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1101\/gad.891301","article-title":"SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation","volume":"15","author":"Matsuda","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.immuni.2019.06.005_bib48","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1222794","article-title":"Systematic localization of common disease-associated variation in regulatory DNA","volume":"337","author":"Maurano","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.immuni.2019.06.005_bib49","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.1630","article-title":"GREAT improves functional interpretation of cis-regulatory regions","volume":"28","author":"McLean","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.immuni.2019.06.005_bib50","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2019.06.005_bib51","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2016.08.006","article-title":"Tissue-specific contribution of macrophages to wound healing","volume":"61","author":"Minutti","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.immuni.2019.06.005_bib52","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-physiol-022516-034339","article-title":"Macrophage polarization","volume":"79","author":"Murray","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.immuni.2019.06.005_bib53","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2019.06.005_bib54","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","article-title":"Nonresolving inflammation","volume":"140","author":"Nathan","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2019.06.005_bib55","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O\u2019Neill","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib56","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.cmet.2016.11.009","article-title":"SREBP1 contributes to resolution of pro-inflammatory TLR4 signaling by reprogramming fatty acid metabolism","volume":"25","author":"Oishi","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2019.06.005_bib57","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1101\/gad.1854309","article-title":"Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it\u2019s been","volume":"23","author":"Osborne","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.immuni.2019.06.005_bib58","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.yexcr.2018.03.032","article-title":"Dysfunction of cholesterol sensor SCAP promotes inflammation activation in THP-1 macrophages","volume":"367","author":"Ouyang","year":"2018","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.immuni.2019.06.005_bib59","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/ni.3818","article-title":"Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation","volume":"18","author":"Park","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib60","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/ni.2043","article-title":"Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages","volume":"12","author":"Park","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib61","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/ni.3457","article-title":"Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS","volume":"17","author":"Park","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib62","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrrheum.2016.193","article-title":"Immune resolution mechanisms in inflammatory arthritis","volume":"13","author":"Perretti","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.immuni.2019.06.005_bib63","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.1254790","article-title":"Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon","volume":"345","author":"Reboldi","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.immuni.2019.06.005_bib64","doi-asserted-by":"crossref","first-page":"e1000133","DOI":"10.1371\/journal.pgen.1000133","article-title":"Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes","volume":"4","author":"Reed","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.immuni.2019.06.005_bib65","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2019.06.005_bib66","doi-asserted-by":"crossref","first-page":"e25015","DOI":"10.7554\/eLife.25015","article-title":"Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice","volume":"6","author":"Rong","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.immuni.2019.06.005_bib67","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/ni.1920","article-title":"The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection","volume":"11","author":"Satoh","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib68","doi-asserted-by":"crossref","first-page":"13765","DOI":"10.1073\/pnas.0904246106","article-title":"Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif","volume":"106","author":"Seo","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2019.06.005_bib69","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.cmet.2011.03.005","article-title":"Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy","volume":"13","author":"Seo","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2019.06.005_bib70","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1084\/jem.20051725","article-title":"Twist mediates suppression of inflammation by type I IFNs and Axl","volume":"203","author":"Sharif","year":"2006","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2019.06.005_bib71","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1172\/JCI119746","article-title":"Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene","volume":"100","author":"Shimano","year":"1997","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2019.06.005_bib72","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1172\/JCI44490","article-title":"An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice","volume":"121","author":"Sindrilaru","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2019.06.005_bib73","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0092-8674(03)00002-3","article-title":"Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity","volume":"112","author":"\u0160o\u0161i\u0107","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2019.06.005_bib74","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.tips.2015.04.010","article-title":"Targeting SREBPs for treatment of the metabolic syndrome","volume":"36","author":"Soyal","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.immuni.2019.06.005_bib75","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cell.2012.06.054","article-title":"Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses","volume":"151","author":"Spann","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2019.06.005_bib76","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1742-481X.2006.00233.x","article-title":"Topical application of the tumour necrosis factor-\u03b1 antibody infliximab improves healing of chronic wounds","volume":"3","author":"Streit","year":"2006","journal-title":"Int. Wound J."},{"key":"10.1016\/j.immuni.2019.06.005_bib77","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.immuni.2017.09.008","article-title":"Monocyte-macrophages and T\u00a0cells in atherosclerosis","volume":"47","author":"Tabas","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2019.06.005_bib78","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nri3793","article-title":"Cholesterol, inflammation and innate immunity","volume":"15","author":"Tall","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib79","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.crohns.2013.06.003","article-title":"Rapid improvement of refractory pyoderma gangrenosum with infliximab gel in a patient with ulcerative colitis","volume":"8","author":"Teich","year":"2014","journal-title":"J.\u00a0Crohn\u2019s Colitis"},{"key":"10.1016\/j.immuni.2019.06.005_bib80","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cell.2016.01.020","article-title":"A stringent systems approach uncovers gene-specific mechanisms regulating inflammation","volume":"165","author":"Tong","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2019.06.005_bib81","doi-asserted-by":"crossref","first-page":"8288","DOI":"10.1128\/MCB.24.18.8288-8300.2004","article-title":"Selective coactivator interactions in gene activation by SREBP-1a and -1c","volume":"24","author":"Toth","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.immuni.2019.06.005_bib82","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nbt.2450","article-title":"Differential analysis of gene regulation at transcript resolution with RNA-seq","volume":"31","author":"Trapnell","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.immuni.2019.06.005_bib83","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.cmet.2015.12.010","article-title":"Ligand activation of ERR\u03b1 by cholesterol mediates statin and bisphosphonate effects","volume":"23","author":"Wei","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2019.06.005_bib84","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2019.06.005_bib85","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/ni1576","article-title":"TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes","volume":"9","author":"Yarilina","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2019.06.005_bib86","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.cell.2015.11.045","article-title":"Limiting cholesterol biosynthetic flux spontaneously engages type I IFN signaling","volume":"163","author":"York","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2019.06.005_bib87","doi-asserted-by":"crossref","first-page":"E2085","DOI":"10.3390\/ijms17122085","article-title":"Inflammation in chronic wounds","volume":"17","author":"Zhao","year":"2016","journal-title":"Int. J. Mol. Sci."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761319302754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761319302754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:07:02Z","timestamp":1761034022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761319302754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":87,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S1074761319302754"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2019.06.005","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736179682.793588171","asserted-by":"object"}]},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2019.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}