{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:13:34Z","timestamp":1790792014499,"version":"4.1.0"},"reference-count":78,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":383,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000774","name":"Defense Threat Reduction Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.immuni.2020.01.001","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T10:44:15Z","timestamp":1582022655000},"page":"388-403.e12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization"],"prefix":"10.1016","volume":"52","author":[{"given":"Pavlo","family":"Gilchuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Murin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob C.","family":"Milligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad E.","family":"Mire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp A.","family":"Ilinykh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Kuzmina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar X.","family":"Altman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn M.","family":"Gunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubrey L.","family":"Bryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Doranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanwee","family":"Alkutkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Flinko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Orlandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Carnahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Nargi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin G.","family":"Bombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Vodzak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adaora","family":"Okoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morris","family":"Ibeawuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ohiaeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George K.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit","family":"Alter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bukreyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica Ollmann","family":"Saphire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Geisbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James E.","family":"Crowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2020.01.001_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.immuni.2020.01.001_bib2","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/nsmb.3115","article-title":"Privateer: software for the conformational validation of carbohydrate structures","volume":"22","author":"Agirre","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.immuni.2020.01.001_bib3","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nmeth.3541","article-title":"EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy","volume":"12","author":"Barad","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2020.01.001_bib4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1107\/S0907444910048675","article-title":"iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM","volume":"67","author":"Battye","year":"2011","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.immuni.2020.01.001_bib5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1471-2105-15-82","article-title":"Transient protein-protein interface prediction: datasets, features, algorithms, and the RAD-T predictor","volume":"15","author":"Bendell","year":"2014","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.immuni.2020.01.001_bib6","first-page":"171","article-title":"Nonhuman primate models of Ebola virus disease","volume":"411","author":"Bennett","year":"2017","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.immuni.2020.01.001_bib7","doi-asserted-by":"crossref","first-page":"W252","DOI":"10.1093\/nar\/gku340","article-title":"SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information","volume":"42","author":"Biasini","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2020.01.001_bib9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.chom.2018.12.005","article-title":"A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates","volume":"25","author":"Bornholdt","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2020.01.001_bib8","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.aad5788","article-title":"Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak","volume":"351","author":"Bornholdt","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.immuni.2020.01.001_bib10","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1086\/515386","article-title":"A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever","volume":"178","author":"Bray","year":"1998","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.immuni.2020.01.001_bib11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1107\/S0907444910051218","article-title":"Improvement of molecular-replacement models with Sculptor","volume":"67","author":"Bunkyczi","year":"2011","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.immuni.2020.01.001_bib12","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/hep.27298","article-title":"Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a","volume":"60","author":"Carlsen","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.immuni.2020.01.001_bib14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.immuni.2020.01.001_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1098\/rstb.2016.0297","article-title":"The Ebola outbreak, 2013-2016: old lessons for new epidemics","volume":"372","author":"Coltart","year":"2017","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.immuni.2020.01.001_bib16","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1126\/science.aad5224","article-title":"Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody","volume":"351","author":"Corti","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.immuni.2020.01.001_bib17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jiph.2016.04.003","article-title":"Rapid generation of a human monoclonal antibody to combat Middle East respiratory syndrome","volume":"9","author":"Corti","year":"2016","journal-title":"J.\u00a0Infect. Public Health"},{"key":"10.1016\/j.immuni.2020.01.001_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.chom.2017.07.013","article-title":"Principles of broad and potent antiviral human antibodies: Insights for Vaccine Design","volume":"22","author":"Crowe","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2020.01.001_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/imm.12323","article-title":"A high-throughput shotgun mutagenesis approach to mapping B-cell antibody epitopes","volume":"143","author":"Davidson","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.immuni.2020.01.001_bib20","doi-asserted-by":"crossref","first-page":"10982","DOI":"10.1128\/JVI.01490-15","article-title":"Mechanism of binding to Ebola virus glycoprotein by the ZMapp, ZMAb, and MB-003 cocktail antibodies","volume":"89","author":"Davidson","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.immuni.2020.01.001_bib21","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.cell.2019.04.036","article-title":"Longitudinal analysis of the human B cell response to Ebola virus infection","volume":"177","author":"Davis","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2020.01.001_bib22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nmeth.3286","article-title":"Atomic-accuracy models from 4.5-\u0415 cryo-electron microscopy data with density-guided iterative local refinement","volume":"12","author":"DiMaio","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2020.01.001_bib23","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/s41598-017-19041-y","article-title":"A single dose of modified Vaccinia Ankara expressing Ebola virus like particles protects nonhuman primates from lethal Ebola virus challenge","volume":"8","author":"Domi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.immuni.2020.01.001_bib24","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1128\/JVI.06745-11","article-title":"HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes","volume":"86","author":"Doria-Rose","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.immuni.2020.01.001_bib25","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.immuni.2020.01.001_bib26","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1107\/S0907444913000061","article-title":"How good are my data and what is the resolution?","volume":"69","author":"Evans","year":"2013","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.immuni.2020.01.001_bib27","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.aaa8651","article-title":"DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers","volume":"349","author":"Fibriansah","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.immuni.2020.01.001_bib28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.cell.2015.01.031","article-title":"Mechanism of human antibody-mediated neutralization of Marburg virus","volume":"160","author":"Flyak","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2020.01.001_bib29","doi-asserted-by":"crossref","first-page":"242ra82","DOI":"10.1126\/scitranslmed.3008929","article-title":"Therapeutic treatment of Nipah virus infection in nonhuman primates with a neutralizing human monoclonal antibody","volume":"6","author":"Geisbert","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2020.01.001_bib30","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.1093\/infdis\/jiv284","article-title":"Considerations in the use of nonhuman primate models of Ebola virus and Marburg virus infection","volume":"212","author":"Geisbert","year":"2015","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.immuni.2020.01.001_bib31","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.cell.2016.09.049","article-title":"Cross-neutralizing and protective human antibody specificities to poxvirus infections","volume":"167","author":"Gilchuk","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2020.01.001_bib32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.immuni.2018.06.018","article-title":"Multifunctional pan-ebolavirus antibody recognizes a site of broad vulnerability on the ebolavirus glycoprotein","volume":"49","author":"Gilchuk","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2020.01.001_bib33","first-page":"716","article-title":"IMGT\/junctionanalysis: IMGT standardized analysis of the V-J and V-D-J junctions of the rearranged immunoglobulins (IG) and T\u00a0cell receptors (TR)","volume":"2011","author":"Giudicelli","year":"2011","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.immuni.2020.01.001_bib35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.chom.2018.07.009","article-title":"A role for Fc function in therapeutic monoclonal antibody-mediated protection against Ebola virus","volume":"24","author":"Gunn","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2020.01.001_bib36","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.celrep.2017.03.049","article-title":"Cooperativity enables non-neutralizing antibodies to neutralize ebolavirus","volume":"19","author":"Howell","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2020.01.001_bib37","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1128\/JVI.00101-16","article-title":"Chimeric filoviruses for identification and characterization of monoclonal antibodies","volume":"90","author":"Ilinykh","year":"2016","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.immuni.2020.01.001_bib38","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.celrep.2018.10.031","article-title":"A Combination of two human monoclonal antibodies prevents Zika virus escape mutations in non-human primates","volume":"25","author":"Keeffe","year":"2018","journal-title":"Cell. Rep."},{"key":"10.1016\/j.immuni.2020.01.001_bib39","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.coviro.2019.01.003","article-title":"Achieving cross-reactivity with pan-ebolavirus antibodies","volume":"34","author":"King","year":"2019","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.immuni.2020.01.001_bib40","series-title":"Marburg- and Ebolaviruses. Curr. Top. Microbiol","first-page":"447","article-title":"Guide to the Correct Use of Filoviral Nomenclature","volume":"Volume 411","author":"Kuhn","year":"2017"},{"key":"10.1016\/j.immuni.2020.01.001_bib41","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/j.celrep.2018.07.035","article-title":"Antibody-dependent enhancement of Ebola virus infection by human antibodies isolated from survivors","volume":"24","author":"Kuzmina","year":"2018","journal-title":"Cell. Rep."},{"key":"10.1016\/j.immuni.2020.01.001_bib43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jsb.2009.01.002","article-title":"Appion: an integrated, database-driven pipeline to facilitate EM image processing","volume":"166","author":"Lander","year":"2009","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.immuni.2020.01.001_bib44","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.antiviral.2013.03.021","article-title":"Broadly neutralizing antibodies against influenza viruses","volume":"98","author":"Laursen","year":"2013","journal-title":"Antiviral Res."},{"key":"10.1016\/j.immuni.2020.01.001_bib45","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2217\/fvl.09.56","article-title":"Ebolavirus glycoprotein structure and mechanism of entry","volume":"4","author":"Lee","year":"2009","journal-title":"Future Virol."},{"key":"10.1016\/j.immuni.2020.01.001_bib46","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nri.2017.106","article-title":"Beyond binding: antibody effector functions in infectious diseases","volume":"18","author":"Lu","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2020.01.001_bib42","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2105-5-69","article-title":"pdb-care (PDB carbohydrate residue check): a program to support annotation of complex carbohydrate structures in PDB files","volume":"5","author":"L\u00fctteke","year":"2004","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.immuni.2020.01.001_bib47","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.1128\/jvi.71.10.7198-7206.1997","article-title":"Potent and\u00a0synergistic neutralization of human immunodeficiency virus (HIV) type 1 primary isolates by hyperimmune anti-HIV immunoglobulin combined with monoclonal antibodies 2F5 and 2G12","volume":"71","author":"Mascola","year":"1997","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.immuni.2020.01.001_bib48","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0161-5890(00)00101-2","article-title":"Human and murine immunoglobulin expression vector cassettes","volume":"37","author":"McLean","year":"2000","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.immuni.2020.01.001_bib49","doi-asserted-by":"crossref","first-page":"e1003065","DOI":"10.1371\/journal.ppat.1003065","article-title":"Antigenic subversion: a novel mechanism of host immune evasion by Ebola virus","volume":"8","author":"Mohan","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.immuni.2020.01.001_bib50","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1016\/j.celrep.2018.08.009","article-title":"Structural basis of pan-ebolavirus neutralization by an antibody targeting the glycoprotein fusion loop","volume":"24","author":"Murin","year":"2018","journal-title":"Cell. Rep."},{"key":"10.1016\/j.immuni.2020.01.001_bib53","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jim.2016.03.002","article-title":"A new cell line for high throughput HIV-specific antibody-dependent cellular cytotoxicity (ADCC) and cell-to-cell virus transmission studies","volume":"433","author":"Orlandi","year":"2016","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.immuni.2020.01.001_bib54","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.cell.2015.06.007","article-title":"Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone","volume":"161","author":"Park","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2020.01.001_bib55","doi-asserted-by":"crossref","first-page":"S612","DOI":"10.1093\/infdis\/jiy285","article-title":"Development of clinical-stage human monoclonal antibodies that treat advanced Ebola virus disease in nonhuman primates","volume":"218","author":"Pascal","year":"2018","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.immuni.2020.01.001_bib56","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera--a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.immuni.2020.01.001_bib57","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0304-3991(99)00043-1","article-title":"Leginon: a system for fully automated acquisition of 1000 electron micrographs a day","volume":"77","author":"Potter","year":"1999","journal-title":"Ultramicroscopy"},{"key":"10.1016\/j.immuni.2020.01.001_bib58","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2020.01.001_bib59","doi-asserted-by":"crossref","first-page":"S986","DOI":"10.1093\/infdis\/jir335","article-title":"Filovirus infection of STAT-1 knockout mice","volume":"204","author":"Raymond","year":"2011","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.immuni.2020.01.001_bib60","doi-asserted-by":"crossref","first-page":"11544","DOI":"10.1038\/ncomms11544","article-title":"Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits","volume":"7","author":"Robinson","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2020.01.001_bib61","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.virusres.2005.03.028","article-title":"Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda","volume":"113","author":"Sanchez","year":"2005","journal-title":"Virus Res."},{"key":"10.1016\/j.immuni.2020.01.001_bib62","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature20564","article-title":"Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice","volume":"540","author":"Sapparapu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2020.01.001_bib63","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jsb.2012.09.006","article-title":"RELION: implementation of a Bayesian approach to cryo-EM structure determination","volume":"180","author":"Scheres","year":"2012","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.immuni.2020.01.001_bib64","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/s41590-018-0235-7","article-title":"Recent progress in broadly neutralizing antibodies to HIV","volume":"19","author":"Sok","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2020.01.001_bib65","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.aaf8505","article-title":"Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection","volume":"353","author":"Stettler","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.immuni.2020.01.001_bib66","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.virol.2004.10.048","article-title":"Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening","volume":"332","author":"Towner","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.immuni.2020.01.001_bib67","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1038\/nprot.2016.093","article-title":"High-quality full-length immunoglobulin profiling with unique molecular barcoding","volume":"11","author":"Turchaninova","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.immuni.2020.01.001_bib68","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.cell.2016.10.013","article-title":"Human adaptation of Ebola virus during the West African outbreak","volume":"167","author":"Urbanowicz","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2020.01.001_bib69","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jsb.2009.01.004","article-title":"DoG Picker and TiltPicker: software tools to facilitate particle selection in single particle electron microscopy","volume":"166","author":"Voss","year":"2009","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.immuni.2020.01.001_bib70","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nri.2017.148","article-title":"Passive immunotherapy of viral infections: \u2018super-antibodies\u2019 enter the fray","volume":"18","author":"Walker","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2020.01.001_bib72","doi-asserted-by":"crossref","first-page":"369ra179","DOI":"10.1126\/scitranslmed.aai8336","article-title":"Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus","volume":"8","author":"Wang","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2020.01.001_bib74","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.chom.2018.12.004","article-title":"Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection","volume":"25","author":"Wec","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2020.01.001_bib73","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.cell.2017.04.037","article-title":"Antibodies from a human survivor define sites of vulnerability for broad protection against ebolaviruses","volume":"169","author":"Wec","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2020.01.001_bib75","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01674-18","article-title":"Structural basis of pan-ebolavirus neutralization by a human antibody against a conserved, yet cryptic epitope","author":"West","year":"2018","journal-title":"MBio"},{"key":"10.1016\/j.immuni.2020.01.001_bib76","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41594-019-0191-4","article-title":"Structural basis of broad Ebola virus neutralization by a human survivor antibody","volume":"26","author":"West","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.immuni.2020.01.001_bib77","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/pro.3330","article-title":"MolProbity: More and better reference data for improved all-atom structure validation","volume":"27","author":"Williams","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.immuni.2020.01.001_bib78","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jim.2008.04.008","article-title":"An optimized electrofusion-based protocol for generating virus-specific human monoclonal antibodies","volume":"336","author":"Yu","year":"2008","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.immuni.2020.01.001_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsb.2015.11.003","article-title":"Gctf: Real-time CTF determination and correction","volume":"193","author":"Zhang","year":"2016","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.immuni.2020.01.001_bib80","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jsb.2014.03.003","article-title":"Rotationally invariant image representation for viewing direction classification in cryo-EM","volume":"186","author":"Zhao","year":"2014","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.immuni.2020.01.001_bib81","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nature18615","article-title":"Toremifene interacts with and destabilizes the Ebola virus glycoprotein","volume":"535","author":"Zhao","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2020.01.001_bib82","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmeth.4193","article-title":"MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy","volume":"14","author":"Zheng","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2020.01.001_bib83","doi-asserted-by":"crossref","first-page":"e42166","DOI":"10.7554\/eLife.42166","article-title":"New tools for automated high-resolution cryo-EM structure determination in RELION-3","volume":"7","author":"Zivanov","year":"2018","journal-title":"eLife"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761320300285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761320300285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:09:27Z","timestamp":1761034167000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761320300285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":78,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S1074761320300285"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2020.01.001","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2020.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}