{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:16:03Z","timestamp":1793445363301,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":373,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA125123"],"award-info":[{"award-number":["CA125123"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL140398"],"award-info":[{"award-number":["HL140398"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R41AI124997"],"award-info":[{"award-number":["R41AI124997"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI135803"],"award-info":[{"award-number":["R01AI135803"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL117181"],"award-info":[{"award-number":["R01HL117181"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32AI053831"],"award-info":[{"award-number":["T32AI053831"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RR024574"],"award-info":[{"award-number":["RR024574"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006379","name":"Office of Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006190","name":"VA Office of Research & Development","doi-asserted-by":"publisher","award":["I01BX004828"],"award-info":[{"award-number":["I01BX004828"]}],"id":[{"id":"10.13039\/100006190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["214229_Z_18_Z"],"award-info":[{"award-number":["214229_Z_18_Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["R37-DE022550"],"award-info":[{"award-number":["R37-DE022550"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770024"],"award-info":[{"award-number":["81770024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["CPRIT-RP180672"],"award-info":[{"award-number":["CPRIT-RP180672"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.immuni.2021.08.009","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T10:32:53Z","timestamp":1631183573000},"page":"2595-2610.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization"],"prefix":"10.1016","volume":"54","author":[{"given":"Yifan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0417-9752","authenticated-orcid":false,"given":"Zhimin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill E.","family":"Weatherhead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Bimler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Valladolid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Hube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian R.","family":"Naglik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber U.","family":"Luong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farrah","family":"Kheradmand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Corry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2021.08.009_bib1","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.jmb.2006.10.067","article-title":"Conformational stability and domain unfolding of the Von Willebrand factor A domains","volume":"366","author":"Auton","year":"2007","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.immuni.2021.08.009_bib2","doi-asserted-by":"crossref","first-page":"12342","DOI":"10.1016\/S0021-9258(18)98902-7","article-title":"Independent assembly and secretion of a dimeric adhesive domain of von Willebrand factor containing the glycoprotein Ib-binding site","volume":"266","author":"Azuma","year":"1991","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2021.08.009_bib3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1056\/NEJM196007142630204","article-title":"The significance of Candida albicans in human sputum","volume":"263","author":"Baum","year":"1960","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2021.08.009_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0014-2999(01)00733-6","article-title":"Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist","volume":"412","author":"Baurand","year":"2001","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.immuni.2021.08.009_bib5","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.4049\/jimmunol.1800554","article-title":"The Canonical but Not the Noncanonical Wnt Pathway Inhibits the Development of Allergic Airway Disease","volume":"201","author":"Beckert","year":"2018","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib6","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/all.12416","article-title":"Atopic dermatitis, STAT3- and DOCK8-hyper-IgE syndromes differ in IgE-based sensitization pattern","volume":"69","author":"Boos","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.immuni.2021.08.009_bib7","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3181\/00379727-208-43863A","article-title":"On the structure and function of platelet integrin \u03b1 IIb \u03b2 3, the fibrinogen receptor","volume":"208","author":"Calvete","year":"1995","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.immuni.2021.08.009_bib8","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.immuni.2016.01.008","article-title":"The Wnt antagonist Dickkopf-1 promotes pathological type 2 cell-mediated inflammation","volume":"44","author":"Chae","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.08.009_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1001\/archdermatol.2011.262","article-title":"Cutaneous manifestations of DOCK8 deficiency syndrome","volume":"148","author":"Chu","year":"2012","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.immuni.2021.08.009_bib10","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1182\/blood-2015-04-640300","article-title":"Platelet microparticles inhibit IL-17 production by regulatory T\u00a0cells through P-selectin","volume":"127","author":"Dinkla","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2021.08.009_bib11","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jaci.2014.12.1945","article-title":"The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency","volume":"136","author":"Engelhardt","year":"2015","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib12","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0091-6749(99)70023-0","article-title":"Sensitization to Aspergillus species in the congenital neutrophil disorders chronic granulomatous disease and hyper-IgE syndrome","volume":"104","author":"Eppinger","year":"1999","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib13","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1164\/ajrccm.164.supplement_2.2106066","article-title":"Remodeling of the airway epithelium in asthma","volume":"164","author":"Fahy","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.immuni.2021.08.009_bib14","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.molimm.2009.08.019","article-title":"The yeast Candida albicans evades human complement attack by secretion of aspartic proteases","volume":"47","author":"Gropp","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib15","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/s41590-020-0777-3","article-title":"A regulatory T\u00a0cell Notch4-GDF15 axis licenses tissue inflammation in asthma","volume":"1","author":"Harb","year":"2020","journal-title":"Nat Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib16","doi-asserted-by":"crossref","first-page":"E699","DOI":"10.3390\/cells9030699","article-title":"Candidalysin Is a Potent Trigger of Alarmin and Antimicrobial Peptide Release in Epithelial Cells","volume":"9","author":"Ho","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.immuni.2021.08.009_bib17","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/jcb.22184","article-title":"Common features of megakaryocytes and hematopoietic stem cells: what\u2019s the connection?","volume":"107","author":"Huang","year":"2009","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.immuni.2021.08.009_bib18","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.anai.2018.07.044","article-title":"Chronic rhinosinusitis with severe nasal polyposis in hyper-IgE syndrome","volume":"121","author":"Huang","year":"2018","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib19","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1128\/iai.65.9.3529-3538.1997","article-title":"Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence","volume":"65","author":"Hube","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2021.08.009_bib20","first-page":"191","article-title":"Topographic distribution of a granule membrane protein (GMP-140) that is expressed\u00a0on the platelet surface after activation: an immunogold-surface replica study","volume":"12","author":"Isenberg","year":"1986","journal-title":"Blood Cells"},{"key":"10.1016\/j.immuni.2021.08.009_bib21","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T\u00a0helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2021.08.009_bib22","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1167\/iovs.07-0114","article-title":"The role of secreted aspartyl proteinases in Candida albicans keratitis","volume":"48","author":"Jackson","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.immuni.2021.08.009_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02435-20","article-title":"Survival Strategies of Pathogenic Candida Species in Human Blood Show Independent and Specific Adaptations","volume":"11","author":"Kammer","year":"2020","journal-title":"mBio."},{"key":"10.1016\/j.immuni.2021.08.009_bib24","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1182\/blood-2004-03-0893","article-title":"Megakaryocyte proliferation and ploidy regulated by the cytoplasmic tail of glycoprotein Ibalpha","author":"Kanaji","year":"2004","journal-title":"Blood. 104"},{"key":"10.1016\/j.immuni.2021.08.009_bib25","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1038\/s41467-018-06607-1","article-title":"The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes","volume":"9","author":"Kasper","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2021.08.009_bib26","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.4049\/jimmunol.169.10.5904","article-title":"A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease","volume":"169","author":"Kheradmand","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib27","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jaci.2011.12.970","article-title":"Fungi and allergic lower respiratory tract diseases","volume":"129","author":"Knutsen","year":"2012","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib28","doi-asserted-by":"crossref","first-page":"e198","DOI":"10.1038\/emm.2015.91","article-title":"The Wnt\/\u03b2-catenin signaling pathway regulates the development of airway remodeling in patients with asthma","volume":"47","author":"Kwak","year":"2015","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.immuni.2021.08.009_bib29","doi-asserted-by":"crossref","first-page":"H468","DOI":"10.1152\/ajpheart.00491.2010","article-title":"Platelets enhance neutrophil transendothelial migration via P-selectin glycoprotein ligand-1","volume":"300","author":"Lam","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.immuni.2021.08.009_bib30","doi-asserted-by":"crossref","first-page":"8834","DOI":"10.1074\/jbc.RA118.006724","article-title":"Selective cleavage of fibrinogen by diverse proteinases initiates innate allergic and antifungal immunity through CD11b","volume":"294","author":"Landers","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2021.08.009_bib31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature21706","article-title":"The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors","volume":"544","author":"Lefran\u00e7ais","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.08.009_bib32","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/iid3.215","article-title":"Benefits of antifungal therapy in asthma patients with airway mycosis: A retrospective cohort analysis","volume":"6","author":"Li","year":"2018","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.immuni.2021.08.009_bib33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/bs.ai.2019.05.002","article-title":"Airway mycosis in allergic airway disease","volume":"142","author":"Li","year":"2019","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib34","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1084\/jem.20080218","article-title":"Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3","volume":"205","author":"Ma","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2021.08.009_bib35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.clim.2012.11.005","article-title":"Tracheobronchial mycosis in a retrospective case-series study of five status asthmaticus patients","volume":"146","author":"Mak","year":"2013","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.anai.2017.07.008","article-title":"Characteristics of severe asthma with fungal sensitization","volume":"119","author":"Masaki","year":"2017","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib37","doi-asserted-by":"crossref","first-page":"e5039","DOI":"10.1371\/journal.pone.0005039","article-title":"A novel immune evasion strategy of candida albicans: proteolytic cleavage of a salivary antimicrobial peptide","volume":"4","author":"Meiller","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2021.08.009_bib38","doi-asserted-by":"crossref","first-page":"e0154342","DOI":"10.1371\/journal.pone.0154342","article-title":"Repercussion of Megakaryocyte-Specific Gata1 Loss on Megakaryopoiesis and the Hematopoietic Precursor Compartment","volume":"11","author":"Meinders","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2021.08.009_bib39","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1126\/science.1240342","article-title":"Cleavage of fibrinogen by proteinases elicits allergic responses through Toll-like receptor 4","volume":"341","author":"Millien","year":"2013","journal-title":"Science"},{"issue":"Suppl 5","key":"10.1016\/j.immuni.2021.08.009_bib40","doi-asserted-by":"crossref","first-page":"S277","DOI":"10.1513\/AnnalsATS.201403-105AW","article-title":"Airway fibrinogenolysis and the initiation of allergic inflammation","volume":"11","author":"Millien","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.immuni.2021.08.009_bib41","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nature06764","article-title":"Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome","volume":"452","author":"Milner","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.08.009_bib42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature17625","article-title":"Candidalysin is a fungal peptide toxin critical for mucosal infection","volume":"532","author":"Moyes","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.08.009_bib43","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1128\/MMBR.67.3.400-428.2003","article-title":"Candida albicans secreted aspartyl proteinases in virulence and pathogenesis","volume":"67","author":"Naglik","year":"2003","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.immuni.2021.08.009_bib44","first-page":"124","article-title":"Flow cytometric investigation of classical and alternative platelet activation markers","volume":"23","author":"Nagy","year":"2013","journal-title":"EJIFCC"},{"key":"10.1016\/j.immuni.2021.08.009_bib46","doi-asserted-by":"crossref","first-page":"7423","DOI":"10.4049\/jimmunol.180.11.7423","article-title":"Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes","volume":"180","author":"P\u00e8ne","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib47","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1182\/blood-2003-05-1707","article-title":"Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation","volume":"103","author":"Pitchford","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2021.08.009_bib48","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1164\/rccm.200702-214OC","article-title":"Allergen induces the migration of platelets to lung tissue in allergic asthma","volume":"177","author":"Pitchford","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.immuni.2021.08.009_bib49","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/mi.2009.102","article-title":"Link between allergic asthma and airway mucosal infection suggested by proteinase-secreting household fungi","volume":"2","author":"Porter","year":"2009","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib50","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1128\/IAI.05209-11","article-title":"Necessary and sufficient role for T\u00a0helper cells to prevent fungal dissemination during mucosal airway infection","volume":"79","author":"Porter","year":"2011","journal-title":"Infect. Immun."},{"issue":"Suppl 1","key":"10.1016\/j.immuni.2021.08.009_bib51","doi-asserted-by":"crossref","first-page":"S158","DOI":"10.3109\/13693786.2010.509743","article-title":"Respiratory tract allergic disease and atopy: experimental evidence for a fungal infectious etiology","volume":"49","author":"Porter","year":"2011","journal-title":"Med. Mycol."},{"key":"10.1016\/j.immuni.2021.08.009_bib52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.it.2010.11.007","article-title":"Seeking common pathophysiology in asthma, atopy and sinusitis","volume":"32","author":"Porter","year":"2011","journal-title":"Trends Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib53","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jaci.2014.04.028","article-title":"Airway surface mycosis in chronic TH2-associated airway disease","volume":"134","author":"Porter","year":"2014","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib54","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/rth2.12266","article-title":"The dual role of platelet-innate immune cell interactions in thrombo-inflammation","volume":"4","author":"Rayes","year":"2019","journal-title":"Res Pract Thromb Haemost"},{"key":"10.1016\/j.immuni.2021.08.009_bib55","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/35092573","article-title":"Role of thrombin signalling in platelets in haemostasis and thrombosis","volume":"413","author":"Sambrano","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.08.009_bib56","first-page":"235","article-title":"Role of Aspergillus and Candida species in allergic bronchopulmonary mycoses. A comparative study","volume":"60","author":"Sandhu","year":"1979","journal-title":"Scand. J. Respir. Dis."},{"key":"10.1016\/j.immuni.2021.08.009_bib57","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1128\/iai.65.9.3539-3546.1997","article-title":"A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence","volume":"65","author":"Sanglard","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2021.08.009_bib58","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2958.1999.01590.x","article-title":"Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis","volume":"34","author":"Schaller","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.immuni.2021.08.009_bib59","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1046\/j.1523-1747.2000.00935.x","article-title":"Invasion of Candida albicans correlates with expression of secreted aspartic proteinases during experimental infection of human epidermis","volume":"114","author":"Schaller","year":"2000","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.immuni.2021.08.009_bib60","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1128\/EC.00210-10","article-title":"Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10","volume":"10","author":"Schild","year":"2011","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.immuni.2021.08.009_bib61","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fmed.2017.00129","article-title":"Platelet-Eosinophil Interactions As a Potential Therapeutic Target in Allergic Inflammation and Asthma","volume":"4","author":"Shah","year":"2017","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.immuni.2021.08.009_bib62","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1055\/s-0037-1615849","article-title":"Signaling through platelet integrin \u03b1 IIb \u03b2 3: inside-out, outside-in, and sideways","volume":"82","author":"Shattil","year":"1999","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.immuni.2021.08.009_bib63","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1172\/JCI71858","article-title":"Platelet factor 4 limits Th17 differentiation and cardiac allograft rejection","volume":"124","author":"Shi","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.08.009_bib64","doi-asserted-by":"crossref","first-page":"855","DOI":"10.3390\/cells9040855","article-title":"Platelet-Leukocyte Interplay in Cancer Development and Progression","volume":"9","author":"Stoiber","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.immuni.2021.08.009_bib65","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/jcmm.12727","article-title":"P2Y12 antagonist attenuates eosinophilic inflammation and airway hyperresponsiveness in a mouse model of asthma","volume":"20","author":"Suh","year":"2016","journal-title":"J.\u00a0Cell. Mol. Med."},{"key":"10.1016\/j.immuni.2021.08.009_bib66","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1159\/000067466","article-title":"Platelet dynamics following allergen challenge in allergic asthmatics","volume":"67","author":"Sullivan","year":"2000","journal-title":"Respiration"},{"key":"10.1016\/j.immuni.2021.08.009_bib67","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3389\/fmed.2017.00158","article-title":"Asthma Endotypes and an Overview of Targeted Therapy for Asthma","volume":"4","author":"Svenningsen","year":"2017","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.immuni.2021.08.009_bib68","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0092-8674(00)80702-3","article-title":"A novel transcription factor, T-bet, directs Th1 lineage commitment","volume":"100","author":"Szabo","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2021.08.009_bib69","doi-asserted-by":"crossref","first-page":"e101209","DOI":"10.1371\/journal.pone.0101209","article-title":"Discovery of novel GPVI receptor antagonists by structure-based repurposing","volume":"9","author":"Taylor","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2021.08.009_bib70","doi-asserted-by":"crossref","first-page":"e1008544","DOI":"10.1371\/journal.ppat.1008544","article-title":"Platelets are critical for survival and tissue integrity during murine pulmonary Aspergillus fumigatus infection","volume":"16","author":"Tischler","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.immuni.2021.08.009_bib71","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1182\/bloodadvances.2018016261","article-title":"Cobalt hematoporphyrin inhibits CLEC-2-podoplanin interaction, tumor metastasis, and arterial\/venous thrombosis in mice","volume":"2","author":"Tsukiji","year":"2018","journal-title":"Blood Adv."},{"key":"10.1016\/j.immuni.2021.08.009_bib72","doi-asserted-by":"crossref","first-page":"eaam8834","DOI":"10.1126\/sciimmunol.aam8834","article-title":"Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin","volume":"2","author":"Verma","year":"2017","journal-title":"Sci Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib73","doi-asserted-by":"crossref","first-page":"627","DOI":"10.4049\/jimmunol.1800515","article-title":"IL-36 and IL-1\/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms","volume":"201","author":"Verma","year":"2018","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib74","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/sj.bjp.0702276","article-title":"Specific inhibition of ADP-induced platelet aggregation by clopidogrel in\u00a0vitro","volume":"126","author":"Weber","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.immuni.2021.08.009_bib75","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/s41467-018-07991-4","article-title":"Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits","volume":"10","author":"Wu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2021.08.009_bib76","doi-asserted-by":"crossref","first-page":"36241","DOI":"10.1074\/jbc.274.51.36241","article-title":"The von Willebrand factor-glycoprotein Ib\/V\/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib\/V\/IX-transfected cells","volume":"274","author":"Yuan","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2021.08.009_bib77","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000250438","article-title":"Th17 immunity in patients with allergic asthma","volume":"151","author":"Zhao","year":"2010","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.immuni.2021.08.009_bib78","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0092-8674(00)80240-8","article-title":"The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T\u00a0cells","volume":"89","author":"Zheng","year":"1997","journal-title":"Cell"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761321003393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761321003393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:10:18Z","timestamp":1778587818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761321003393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":77,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S1074761321003393"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2021.08.009","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2021.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}