{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:53:49Z","timestamp":1793379229034,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":378,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CPRIT RR180061"],"award-info":[{"award-number":["CPRIT RR180061"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31CA232554"],"award-info":[{"award-number":["F31CA232554"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA225028"],"award-info":[{"award-number":["R01 CA225028"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 CA227996"],"award-info":[{"award-number":["R21 CA227996"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA231325"],"award-info":[{"award-number":["CA231325"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA205965"],"award-info":[{"award-number":["R01 CA205965"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA054174"],"award-info":[{"award-number":["R01 CA054174"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["CPRIT RR180061"],"award-info":[{"award-number":["CPRIT RR180061"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.immuni.2021.08.019","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T11:40:49Z","timestamp":1631619649000},"page":"2117-2132.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":147,"title":["Resident memory CD8+ T\u00a0cells in regional lymph nodes mediate immunity to metastatic melanoma"],"prefix":"10.1016","volume":"54","author":[{"given":"Aleksey K.","family":"Molodtsov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Khatwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Vella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanding","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jichang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delaney E.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler G.","family":"Searles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas K.","family":"Preiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer B.","family":"Shabaneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peisheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron R.","family":"Hawkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"IV","given":"Fred W.","family":"Kolling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Usherwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina V.","family":"Angeles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaofeng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler J.","family":"Curiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yina H.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Jo","family":"Turk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2021.08.019_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.immuni.2010.12.011","article-title":"CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens","volume":"34","author":"Asano","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.08.019_bib2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.immuni.2018.01.015","article-title":"T Cells in Nonlymphoid Tissues Give Rise to Lymph-Node-Resident Memory T Cells","volume":"48","author":"Beura","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.08.019_bib3","doi-asserted-by":"crossref","first-page":"dmm036236","DOI":"10.1242\/dmm.036236","article-title":"Immune regulation of metastasis: mechanistic insights and therapeutic opportunities","volume":"11","author":"Blomberg","year":"2018","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.immuni.2021.08.019_bib4","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1126\/science.aal3662","article-title":"Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice","volume":"359","author":"Brown","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.immuni.2021.08.019_bib5","doi-asserted-by":"crossref","first-page":"eaar4526","DOI":"10.1126\/sciimmunol.aar4526","article-title":"Identification and characterization of HIV-specific resident memory CD8+ T\u00a0cells in human lymphoid tissue","volume":"3","author":"Buggert","year":"2018","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.immuni.2021.08.019_bib7","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1172\/JCI44849","article-title":"Autoimmune melanocyte destruction is required for robust CD8+ memory T\u00a0cell responses to mouse melanoma","volume":"121","author":"Byrne","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.08.019_bib8","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.4049\/jimmunol.1302139","article-title":"Autoimmune vitiligo does not require the ongoing priming of naive CD8 T\u00a0cells for disease progression or associated protection against melanoma","volume":"192","author":"Byrne","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.smim.2012.04.010","article-title":"IL-7 signaling and CD127 receptor regulation in the control of T\u00a0cell homeostasis","volume":"24","author":"Carrette","year":"2012","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib10","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.immuni.2019.09.013","article-title":"TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8\u00a0T Cell-Fate Decision","volume":"51","author":"Chen","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.08.019_bib11","doi-asserted-by":"crossref","first-page":"e26491","DOI":"10.1371\/journal.pone.0026491","article-title":"Protective CD8 memory T\u00a0cell responses to mouse melanoma are generated in the absence of CD4 T\u00a0cell help","volume":"6","author":"C\u00f4t\u00e9","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2021.08.019_bib12","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1200\/JCO.2004.12.177","article-title":"The microanatomic location of metastatic melanoma in sentinel lymph nodes predicts nonsentinel lymph node involvement","volume":"22","author":"Dewar","year":"2004","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.immuni.2021.08.019_bib13","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMoa1611299","article-title":"Prolonged Survival in Stage III Melanoma with Ipilimumab Adjuvant Therapy","volume":"375","author":"Eggermont","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2021.08.019_bib14","doi-asserted-by":"crossref","first-page":"16073","DOI":"10.1038\/ncomms16073","article-title":"Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T\u00a0cells","volume":"8","author":"Enamorado","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2021.08.019_bib15","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1172\/JCI42002","article-title":"Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma","volume":"120","author":"Eyles","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.08.019_bib16","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1056\/NEJMoa1613210","article-title":"Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma","volume":"376","author":"Faries","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2021.08.019_bib17","doi-asserted-by":"crossref","first-page":"eaay9283","DOI":"10.1126\/sciimmunol.aay9283","article-title":"Organ-specific isoform selection of fatty acid-binding proteins in tissue-resident lymphocytes","volume":"5","author":"Frizzell","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/imr.12650","article-title":"Tissue-resident memory T\u00a0cells in tissue homeostasis, persistent infection, and cancer surveillance","volume":"283","author":"Gebhardt","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2021.08.019_bib19","doi-asserted-by":"crossref","DOI":"10.3791\/54903","article-title":"A Portal Vein Injection Model to Study Liver Metastasis of Breast Cancer","author":"Goddard","year":"2016","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.immuni.2021.08.019_bib20","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1101\/gad.314617.118","article-title":"Roles of the immune system in cancer: from tumor initiation to metastatic progression","volume":"32","author":"Gonzalez","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.immuni.2021.08.019_bib21","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.3389\/fimmu.2018.02472","article-title":"CD169+ Macrophages Capture and Dendritic Cells Instruct: The Interplay of the Gatekeeper and the General of the Immune System","volume":"9","author":"Grabowska","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib22","first-page":"300","article-title":"Resident and circulating memory T\u00a0cells persist for years in melanoma patients with durable responses to immunotherapy","volume":"2","author":"Han","year":"2021","journal-title":"Nat. Can."},{"key":"10.1016\/j.immuni.2021.08.019_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41590-019-0584-x","article-title":"Environmental cues regulate epigenetic reprogramming of airway-resident memory CD8+ T\u00a0cells","volume":"21","author":"Hayward","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/jamadermatol.2015.2707","article-title":"Association of Vitiligo With Tumor Response in Patients With Metastatic Melanoma Treated With Pembrolizumab","volume":"152","author":"Hua","year":"2016","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.immuni.2021.08.019_bib25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nature22079","article-title":"T-cell invigoration to tumour burden ratio associated with anti-PD-1 response","volume":"545","author":"Huang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.08.019_bib26","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.immuni.2019.11.002","article-title":"Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection","volume":"51","author":"Hudson","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.08.019_bib27","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.immuni.2018.02.010","article-title":"Understanding Subset Diversity in T Cell Memory","volume":"48","author":"Jameson","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.08.019_bib28","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41586-019-1836-5","article-title":"An intra-tumoral niche maintains and differentiates stem-like CD8 T\u00a0cells","volume":"576","author":"Jansen","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.08.019_bib29","first-page":"e51031","article-title":"Intralymphatic immunotherapy and vaccination in mice","author":"Johansen","year":"2014","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.immuni.2021.08.019_bib30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3389\/fonc.2018.00036","article-title":"Growth and Immune Evasion of Lymph Node Metastasis","volume":"8","author":"Jones","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.immuni.2021.08.019_bib31","first-page":"50556","article-title":"Parabiosis in mice: a detailed protocol","author":"Kamran","year":"2013","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.immuni.2021.08.019_bib32","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.immuni.2010.06.016","article-title":"Type I interferons regulate cytolytic activity of memory CD8(+) T\u00a0cells in the lung airways during respiratory virus challenge","volume":"33","author":"Kohlmeier","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.08.019_bib33","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1016\/j.celrep.2017.08.078","article-title":"Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites","volume":"20","author":"Kumar","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2021.08.019_bib34","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","article-title":"RNA velocity of single cells","volume":"560","author":"La Manno","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.08.019_bib35","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1056\/NEJMoa1910836","article-title":"Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma","volume":"381","author":"Larkin","year":"2019","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2021.08.019_bib36","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4049\/jimmunol.180.1.130","article-title":"Distinct role for CD8 T\u00a0cells toward cutaneous tumors and visceral metastases","volume":"180","author":"Lengagne","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib37","doi-asserted-by":"crossref","first-page":"eabd8636","DOI":"10.1126\/scitranslmed.abd8636","article-title":"Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses","volume":"13","author":"Lo","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2021.08.019_bib38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3389\/fimmu.2019.00347","article-title":"Lymph Node Subcapsular Sinus Macrophages as the Frontline of Lymphatic Immune Defense","volume":"10","author":"Louie","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib39","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/ni.2744","article-title":"The developmental pathway for CD103(+)CD8+ tissue-resident memory T\u00a0cells of skin","volume":"14","author":"Mackay","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib40","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.4049\/jimmunol.1402256","article-title":"Cutting edge: CD69 interference with sphingosine-1-phosphate receptor function regulates peripheral T\u00a0cell retention","volume":"194","author":"Mackay","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib41","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1126\/science.aad2035","article-title":"Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes","volume":"352","author":"Mackay","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.immuni.2021.08.019_bib42","doi-asserted-by":"crossref","first-page":"eaam6346","DOI":"10.1126\/sciimmunol.aam6346","article-title":"Resident memory T\u00a0cells in the skin mediate durable immunity to melanoma","volume":"2","author":"Malik","year":"2017","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib43","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.3389\/fimmu.2018.02692","article-title":"Defining Memory CD8\u00a0T Cell","volume":"9","author":"Martin","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib44","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/nature14468","article-title":"T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection","volume":"523","author":"McKinney","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.08.019_bib45","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nature24993","article-title":"Runx3 programs CD8+ T\u00a0cell residency in non-lymphoid tissues and tumours","volume":"552","author":"Milner","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.08.019_bib46","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.3389\/fimmu.2018.02810","article-title":"Tissue Resident CD8 Memory T Cell Responses in Cancer and Autoimmunity","volume":"9","author":"Molodtsov","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib47","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1084\/jem.20021348","article-title":"Route of immunization with peptide-pulsed dendritic cells controls the distribution of memory and effector T\u00a0cells in lymphoid tissues and determines the pattern of regional tumor control","volume":"198","author":"Mullins","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2021.08.019_bib48","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1600-065X.2006.00444.x","article-title":"The tumor-draining lymph node as an immune-privileged site","volume":"213","author":"Munn","year":"2006","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2021.08.019_bib49","doi-asserted-by":"crossref","first-page":"15221","DOI":"10.1038\/ncomms15221","article-title":"Induction of resident memory T\u00a0cells enhances the efficacy of cancer vaccine","volume":"8","author":"Nizard","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2021.08.019_bib50","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1038\/s41467-020-17046-2","article-title":"Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients","volume":"11","author":"N\u00fa\u00f1ez","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2021.08.019_bib51","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1084\/jem.20030590","article-title":"Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T\u00a0cells","volume":"198","author":"Overwijk","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2021.08.019_bib52","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1056\/NEJMoa051424","article-title":"Effector memory T\u00a0cells, early metastasis, and survival in colorectal cancer","volume":"353","author":"Pag\u00e8s","year":"2005","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2021.08.019_bib53","doi-asserted-by":"crossref","first-page":"e20200050","DOI":"10.1084\/jem.20200050","article-title":"Longevity and replenishment of human liver-resident memory T\u00a0cells and mononuclear phagocytes","volume":"217","author":"Pallett","year":"2020","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2021.08.019_bib54","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nature21379","article-title":"Survival of tissue-resident memory T\u00a0cells requires exogenous lipid uptake and metabolism","volume":"543","author":"Pan","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.08.019_bib55","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1126\/science.aal3622","article-title":"Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice","volume":"359","author":"Pereira","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.immuni.2021.08.019_bib56","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nmeth.4150","article-title":"Single-cell mRNA quantification and differential analysis with Census","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2021.08.019_bib57","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmeth.4402","article-title":"Reversed graph embedding resolves complex single-cell trajectories","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2021.08.019_bib58","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/imr.12657","article-title":"The function and dysfunction of memory CD8+ T\u00a0cells in tumor immunity","volume":"283","author":"Reading","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2021.08.019_bib59","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/ni.1715","article-title":"Cytokine-secreting follicular T\u00a0cells shape the antibody repertoire","volume":"10","author":"Reinhardt","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib60","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41573-018-0006-z","article-title":"Delivery technologies for cancer immunotherapy","volume":"18","author":"Riley","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.immuni.2021.08.019_bib61","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.08.019_bib62","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.4049\/jimmunol.1400003","article-title":"Cutting edge: resident memory CD8 T\u00a0cells occupy frontline niches in secondary lymphoid organs","volume":"192","author":"Schenkel","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2021.08.019_bib63","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature04606","article-title":"CD69 acts downstream of interferon-alpha\/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs","volume":"440","author":"Shiow","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.08.019_bib64","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s40425-019-0677-y","article-title":"First-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors","volume":"7","author":"Shitara","year":"2019","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.immuni.2021.08.019_bib65","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single-Cell Data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2021.08.019_bib66","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.cell.2012.08.015","article-title":"Chemokine guidance of central memory T\u00a0cells is critical for antiviral recall responses in lymph nodes","volume":"150","author":"Sung","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2021.08.019_bib67","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1200\/JCO.2014.57.4756","article-title":"Vitiligo-like depigmentation in patients with stage III-IV melanoma receiving immunotherapy and its association with survival: a systematic review and meta-analysis","volume":"33","author":"Teulings","year":"2015","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.immuni.2021.08.019_bib68","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ejca.2016.12.031","article-title":"The proportion of circulating CD45RO+CD8+ memory T\u00a0cells is correlated with clinical response in melanoma patients treated with ipilimumab","volume":"75","author":"Tietze","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.immuni.2021.08.019_bib69","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.immuni.2021.08.019_bib70","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1084\/jem.20041130","article-title":"Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T\u00a0cells","volume":"200","author":"Turk","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2021.08.019_bib71","doi-asserted-by":"crossref","first-page":"10248","DOI":"10.1038\/ncomms10248","article-title":"Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles","volume":"7","author":"Varn","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2021.08.019_bib72","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1158\/0008-5472.CAN-16-2490","article-title":"Systematic Pan-Cancer Analysis Reveals Immune Cell Interactions in the Tumor Microenvironment","volume":"77","author":"Varn","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.immuni.2021.08.019_bib73","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1470-2045(15)70076-8","article-title":"Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial","volume":"16","author":"Weber","year":"2015","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.immuni.2021.08.019_bib74","doi-asserted-by":"crossref","first-page":"6468","DOI":"10.1158\/0008-5472.CAN-07-1264","article-title":"Induction of postsurgical tumor immunity and T-cell memory by a poorly immunogenic tumor","volume":"67","author":"Zhang","year":"2007","journal-title":"Cancer Res."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761321003514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761321003514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:26:12Z","timestamp":1778797572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761321003514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":74,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1074761321003514"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2021.08.019","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resident memory CD8+ T\u00a0cells in regional lymph nodes mediate immunity to metastatic melanoma","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2021.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}