{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:21:18Z","timestamp":1793809278089,"version":"4.6.1"},"reference-count":410,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":375,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK063491"],"award-info":[{"award-number":["P30 DK063491"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK101395"],"award-info":[{"award-number":["DK101395"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["P2BSP3_200177"],"award-info":[{"award-number":["P2BSP3_200177"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.immuni.2021.12.013","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T10:52:08Z","timestamp":1641898328000},"page":"31-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2042,"title":["Inflammation in obesity, diabetes, and related disorders"],"prefix":"10.1016","volume":"55","author":[{"given":"Theresa V.","family":"Rohm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-4657","authenticated-orcid":false,"given":"Daniel T.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0392-1705","authenticated-orcid":false,"given":"Jerrold M.","family":"Olefsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3143-5045","authenticated-orcid":false,"given":"Marc Y.","family":"Donath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2021.12.013_bib1","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1161\/CIRCULATIONAHA.107.740233","article-title":"Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction","volume":"117","author":"Abbate","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.immuni.2021.12.013_bib2","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/j.amjcard.2009.12.059","article-title":"Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study)","volume":"105","author":"Abbate","year":"2010","journal-title":"Am J Cardiol."},{"key":"10.1016\/j.immuni.2021.12.013_bib3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.amjcard.2014.11.003","article-title":"Comparative safety of interleukin-1 blockade with anakinra in patients with ST-segment elevation acute myocardial infarction (from the VCU-ART and VCU-ART2 pilot studies)","volume":"115","author":"Abbate","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.immuni.2021.12.013_bib4","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/hep.20323","article-title":"Portal fibrosis and hepatic steatosis in morbidly obese subjects: A spectrum of nonalcoholic fatty liver disease","volume":"40","author":"Abrams","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.immuni.2021.12.013_bib5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.physbeh.2004.08.035","article-title":"Activity-induced GLP-1 release in lean and obese subjects","volume":"83","author":"Adam","year":"2004","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.immuni.2021.12.013_bib6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.immuni.2021.12.013_bib8","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.4049\/jimmunol.178.7.4641","article-title":"IL-1beta causes an increase in intestinal epithelial tight junction permeability","volume":"178","author":"Al-Sadi","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib9","doi-asserted-by":"crossref","first-page":"5562","DOI":"10.1073\/pnas.91.12.5562","article-title":"Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease","volume":"91","author":"Alonso","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib10","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nm0796-783","article-title":"Alzheimer\u2019s disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules","volume":"2","author":"Alonso","year":"1996","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib11","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1073\/pnas.94.1.298","article-title":"Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau","volume":"94","author":"Alonso","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib7","series-title":"Endotext","article-title":"Nonalcoholic Fatty Liver Disease: The Overlooked Complication of Type 2 Diabetes","author":"Akshintala","year":"2000"},{"key":"10.1016\/j.immuni.2021.12.013_bib12","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fncel.2018.00338","article-title":"Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability","volume":"12","author":"Alonso","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.immuni.2021.12.013_bib13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cmet.2013.11.017","article-title":"Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation","volume":"19","author":"Amano","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib14","doi-asserted-by":"crossref","first-page":"20466","DOI":"10.1073\/pnas.0710335105","article-title":"Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge","volume":"104","author":"Amar","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/emmm.201100159","article-title":"Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment","volume":"3","author":"Amar","year":"2011","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/acr.20657","article-title":"Diabetes mellitus risk in rheumatoid arthritis: reduced incidence with anti-tumor necrosis factor \u03b1 therapy","volume":"64","author":"Antohe","year":"2012","journal-title":"Arthritis Care Res. (Hoboken)"},{"key":"10.1016\/j.immuni.2021.12.013_bib17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fnmol.2017.00191","article-title":"The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS","volume":"10","author":"Arcuri","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.immuni.2021.12.013_bib18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nm1185","article-title":"IKK-beta links inflammation to obesity-induced insulin resistance","volume":"11","author":"Arkan","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib19","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.1142883","article-title":"Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior","volume":"317","author":"Auffray","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.immuni.2021.12.013_bib20","doi-asserted-by":"crossref","first-page":"15718","DOI":"10.1073\/pnas.0407076101","article-title":"The gut microbiota as an environmental factor that regulates fat storage","volume":"101","author":"B\u00e4ckhed","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib21","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1073\/pnas.0605374104","article-title":"Mechanisms underlying the resistance to diet-induced obesity in germ-free mice","volume":"104","author":"B\u00e4ckhed","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/imr.12192","article-title":"Macrophages in intestinal homeostasis and inflammation","volume":"260","author":"Bain","year":"2014","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2021.12.013_bib23","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/mi.2012.89","article-title":"Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors","volume":"6","author":"Bain","year":"2013","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib24","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/ni.2967","article-title":"Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice","volume":"15","author":"Bain","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nri.2017.99","article-title":"The spectrum of T\u00a0cell metabolism in health and disease","volume":"18","author":"Bantug","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nature16151","article-title":"Depletion of fat-resident Treg cells prevents age-associated insulin resistance","volume":"528","author":"Bapat","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib27","first-page":"R840","article-title":"Interleukin-1 stimulates aldosterone secretion: involvement of renin, ACTH, and prostaglandins","volume":"263","author":"Bataillard","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.immuni.2021.12.013_bib28","doi-asserted-by":"crossref","first-page":"609618","DOI":"10.3389\/fimmu.2020.609618","article-title":"Epigenetic Regulation of Kupffer Cell Function in Health and Disease","volume":"11","author":"Bennett","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib29","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1001\/archinte.166.8.902","article-title":"Effects of etanercept in patients with the metabolic syndrome","volume":"166","author":"Bernstein","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib30","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1172\/JCI112200","article-title":"Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines","volume":"76","author":"Bevilacqua","year":"1985","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib31","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1038\/nutd.2012.3","article-title":"Relation of depot-specific adipose inflammation to insulin resistance in human obesity","volume":"2","author":"Bigornia","year":"2012","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib32","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1523\/JNEUROSCI.4814-07.2008","article-title":"Dynamics of the microglial\/amyloid interaction indicate a role in plaque maintenance","volume":"28","author":"Bolmont","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.immuni.2021.12.013_bib33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1210\/er.2018-00107","article-title":"Emerging Biomarkers, Tools, and Treatments for Diabetic Polyneuropathy","volume":"40","author":"B\u00f6nhof","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.immuni.2021.12.013_bib34","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00281-019-00745-4","article-title":"Islet inflammation in type 2 diabetes","volume":"41","author":"B\u00f6ni-Schnetzler","year":"2019","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.immuni.2021.12.013_bib35","doi-asserted-by":"crossref","first-page":"5218","DOI":"10.1210\/en.2009-0543","article-title":"Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I","volume":"150","author":"B\u00f6ni-Schnetzler","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.immuni.2021.12.013_bib36","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.celrep.2018.01.063","article-title":"\u03b2 Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs \u03b2 Cell Proliferation and Insulin Secretion","volume":"22","author":"B\u00f6ni-Schnetzler","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2021.12.013_bib37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/CS20140179","article-title":"Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects","volume":"128","author":"Boon","year":"2015","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.immuni.2021.12.013_bib38","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.immuni.2017.01.008","article-title":"Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity","volume":"46","author":"Boulenouar","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.12.013_bib39","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/hep.1840060430","article-title":"Quantitation, tissue distribution and proliferation kinetics of Kupffer cells in normal rat liver","volume":"6","author":"Bouwens","year":"1986","journal-title":"Hepatology"},{"key":"10.1016\/j.immuni.2021.12.013_bib40","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2021.12.013_bib41","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00125-013-3116-5","article-title":"Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes","volume":"57","author":"Butcher","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib42","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib43","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice","volume":"57","author":"Cani","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib44","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.biocel.2014.06.003","article-title":"Transplantation of mesenchymal stem cells recruits trophic macrophages to induce pancreatic beta cell regeneration in diabetic mice","volume":"53","author":"Cao","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.immuni.2021.12.013_bib45","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.2337\/db05-1404","article-title":"Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in\u00a0vitro via AMP-activated protein kinase","volume":"55","author":"Carey","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib46","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.2337\/dc11-1196","article-title":"Inhibition of IL-1beta improves fatigue in type 2 diabetes","volume":"34","author":"Cavelti-Weder","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.immuni.2021.12.013_bib47","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.2337\/dc11-2219","article-title":"Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes","volume":"35","author":"Cavelti-Weder","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.immuni.2021.12.013_bib48","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cmet.2012.04.002","article-title":"A ceramide-centric view of insulin resistance","volume":"15","author":"Chavez","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib49","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nri3071","article-title":"Macrophage-mediated inflammation in metabolic disease","volume":"11","author":"Chawla","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib50","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1017\/S1461145711000149","article-title":"Increased NF-\u03baB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer\u2019s disease","volume":"15","author":"Chen","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.immuni.2021.12.013_bib51","doi-asserted-by":"crossref","first-page":"e42971","DOI":"10.1371\/journal.pone.0042971","article-title":"Inducible microRNA-223 down-regulation promotes TLR-triggered IL-6 and IL-1\u03b2 production in macrophages by targeting STAT3","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2021.12.013_bib52","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1038\/s41366-020-0618-3","article-title":"Potential therapeutic applications of the gut microbiome in obesity: from brain function to body detoxification","volume":"44","author":"Choi","year":"2020","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.immuni.2021.12.013_bib53","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature11132","article-title":"PPAR-\u03b3 is a major driver of the accumulation and phenotype of adipose tissue Treg cells","volume":"486","author":"Cipolletta","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib54","first-page":"151","article-title":"Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes","volume":"9","author":"Clark","year":"1988","journal-title":"Diabetes Res."},{"key":"10.1016\/j.immuni.2021.12.013_bib55","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1073\/pnas.0915018107","article-title":"Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation","volume":"107","author":"Cohen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib56","doi-asserted-by":"crossref","first-page":"19256","DOI":"10.1073\/pnas.0812681106","article-title":"A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota","volume":"106","author":"Cong","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib57","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0021-9150(99)00312-3","article-title":"C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors","volume":"149","author":"Cook","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.immuni.2021.12.013_bib58","doi-asserted-by":"crossref","first-page":"eabe9383","DOI":"10.1126\/science.abe9383","article-title":"Diet-regulated production of PDGFcc by macrophages controls energy storage","volume":"373","author":"Cox","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.immuni.2021.12.013_bib59","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1128\/MCB.00181-16","article-title":"Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance","volume":"36","author":"Dagdeviren","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.immuni.2021.12.013_bib60","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.2337\/db13-1511","article-title":"T cell-derived IL-22 amplifies IL-1\u03b2-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes","volume":"63","author":"Dalmas","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib61","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.immuni.2017.10.015","article-title":"Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production","volume":"47","author":"Dalmas","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.12.013_bib62","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.it.2003.10.013","article-title":"Inflammation: the link between insulin resistance, obesity and diabetes","volume":"25","author":"Dandona","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib63","doi-asserted-by":"crossref","first-page":"351","DOI":"10.7150\/ijbs.28522","article-title":"Exosomal transfer of obesity adipose tissue for decreased miR-141-3p mediate insulin resistance of hepatocytes","volume":"15","author":"Dang","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.immuni.2021.12.013_bib64","first-page":"2740","article-title":"Microglial activation correlates in\u00a0vivo with both tau and amyloid in Alzheimer\u2019s disease","volume":"141","author":"Dani","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.immuni.2021.12.013_bib65","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1006\/bbrc.1995.1372","article-title":"Enhanced processing of APP induced by IL-1 beta can be reduced by indomethacin and nordihydroguaiaretic acid","volume":"208","author":"Dash","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.immuni.2021.12.013_bib66","doi-asserted-by":"crossref","first-page":"17070","DOI":"10.1074\/jbc.M312021200","article-title":"Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner","volume":"279","author":"de Alvaro","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2021.12.013_bib67","doi-asserted-by":"crossref","first-page":"G440","DOI":"10.1152\/ajpgi.00098.2010","article-title":"Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation","volume":"299","author":"de La Serre","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"Suppl 2","key":"10.1016\/j.immuni.2021.12.013_bib68","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.2337\/dc09-S302","article-title":"Skeletal muscle insulin resistance is the primary defect in type 2 diabetes","volume":"32","author":"DeFronzo","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.immuni.2021.12.013_bib69","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0304-3940(95)11384-9","article-title":"Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and beta-amyloid production in cultures","volume":"188","author":"Del Bo","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.immuni.2021.12.013_bib70","doi-asserted-by":"crossref","first-page":"7653","DOI":"10.1038\/s41598-017-07923-0","article-title":"Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation","volume":"7","author":"Desai","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.immuni.2021.12.013_bib71","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1530\/JOE-16-0598","article-title":"Skeletal muscle insulin resistance: role of mitochondria and other ROS sources","volume":"233","author":"Di Meo","year":"2017","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.immuni.2021.12.013_bib72","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib73","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","article-title":"Interleukin-1 in the pathogenesis and treatment of inflammatory diseases","volume":"117","author":"Dinarello","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2021.12.013_bib74","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1159\/000088261","article-title":"Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes","volume":"42","author":"Dominguez","year":"2005","journal-title":"J.\u00a0Vasc. Res."},{"key":"10.1016\/j.immuni.2021.12.013_bib75","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrd4275","article-title":"Targeting inflammation in the treatment of type 2 diabetes: time to start","volume":"13","author":"Donath","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.immuni.2021.12.013_bib76","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"Donath","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib77","first-page":"1734","article-title":"Study of 27 aqueous humor cytokines in patients with type 2 diabetes with or without retinopathy","volume":"19","author":"Dong","year":"2013","journal-title":"Mol. Vis."},{"key":"10.1016\/j.immuni.2021.12.013_bib78","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib79","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/ni.3659","article-title":"Postprandial macrophage-derived IL-1\u03b2 stimulates insulin, and both synergistically promote glucose disposal and inflammation","volume":"18","author":"Dror","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib80","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"Duewell","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib81","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1210\/jc.2018-00739","article-title":"IL-1 Antagonism in Men with Metabolic Syndrome and Low Testosterone: A Randomized Clinical Trial","volume":"103","author":"Ebrahimi","year":"2018","journal-title":"J Clin Endocrinol Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib82","first-page":"337","article-title":"Zur Therapie des Diabetes Mellitus, insbesondere \u00fcber die Anwendung des Salicylsauren Natron bei demselben","volume":"24","author":"Ebstein","year":"1876","journal-title":"Berliner Klinische Wochenschrift."},{"key":"10.1016\/j.immuni.2021.12.013_bib83","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s00125-014-3224-x","article-title":"Myokines in insulin resistance and type 2 diabetes","volume":"57","author":"Eckardt","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib84","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.cmet.2012.01.023","article-title":"Saturated fatty acid and TLR signaling link \u03b2 cell dysfunction and islet inflammation","volume":"15","author":"Eguchi","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib85","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.2337\/db06-1650","article-title":"Increased number of islet-associated macrophages in type 2 diabetes","volume":"56","author":"Ehses","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib86","doi-asserted-by":"crossref","first-page":"13998","DOI":"10.1073\/pnas.0810087106","article-title":"IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat","volume":"106","author":"Ehses","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib87","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nm.2513","article-title":"Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells","volume":"17","author":"Ellingsgaard","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib88","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.immuni.2021.12.013_bib89","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1016\/j.jacc.2018.03.002","article-title":"Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes","volume":"71","author":"Everett","year":"2018","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.immuni.2021.12.013_bib90","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1161\/CIRCULATIONAHA.118.038010","article-title":"Anti-Inflammatory Therapy with Canakinumab for the Prevention of Hospitalization for Heart Failure","volume":"139","author":"Everett","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.immuni.2021.12.013_bib91","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00592-011-0329-2","article-title":"Salsalate improves glycemic control in patients with newly diagnosed type 2 diabetes","volume":"50","author":"Faghihimani","year":"2013","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.immuni.2021.12.013_bib92","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.4049\/jimmunol.178.8.5288","article-title":"Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis","volume":"178","author":"Fallowfield","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib93","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.immuni.2021.12.013_bib94","doi-asserted-by":"crossref","first-page":"e72344","DOI":"10.1371\/journal.pone.0072344","article-title":"Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells","volume":"8","author":"Fang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2021.12.013_bib95","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.tem.2014.02.004","article-title":"Role of interleukins in obesity: implications for metabolic disease","volume":"25","author":"Febbraio","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib96","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1016\/j.cmet.2021.09.004","article-title":"\u201cSweet death\u201d: Fructose as a metabolic toxin that targets the gut-liver axis","volume":"33","author":"Febbraio","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib97","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1096\/fj.01-0876rev","article-title":"Muscle-derived interleukin-6: mechanisms for activation and possible biological roles","volume":"16","author":"Febbraio","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.immuni.2021.12.013_bib98","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cmet.2018.10.012","article-title":"Preclinical Models for Studying NASH-Driven HCC: How Useful Are They?","volume":"29","author":"Febbraio","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib99","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1172\/JCI113991","article-title":"Effect of tumor necrosis factor (TNF) on lipid metabolism in the diabetic rat. Evidence that inhibition of adipose tissue lipoprotein lipase activity is not required for TNF-induced hyperlipidemia","volume":"83","author":"Feingold","year":"1989","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib100","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0026-0495(88)90033-9","article-title":"The disposal of an oral glucose load in patients with non-insulin-dependent diabetes","volume":"37","author":"Ferrannini","year":"1988","journal-title":"Metabolism"},{"key":"10.1016\/j.immuni.2021.12.013_bib101","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nm.2002","article-title":"Lean, but not obese, fat is enriched for a unique population of regulatory T\u00a0cells that affect metabolic parameters","volume":"15","author":"Feuerer","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib102","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41586-019-1601-9","article-title":"Treatment of type 2 diabetes with the designer cytokine IC7Fc","volume":"574","author":"Findeisen","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib103","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/oby.20615","article-title":"Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans","volume":"22","author":"Fink","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.immuni.2021.12.013_bib104","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.2337\/db14-1098","article-title":"Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1\u03b2 secretion and insulin resistance despite obesity","volume":"64","author":"Finucane","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib105","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2337\/dc07-1338","article-title":"Salsalate improves glycemia and inflammatory parameters in obese young adults","volume":"31","author":"Fleischman","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.immuni.2021.12.013_bib106","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1007\/s00125-008-0998-8","article-title":"Overexpression of Il6 leads to hyperinsulinaemia, liver inflammation and reduced body weight in mice","volume":"51","author":"Franckhauser","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib107","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/nature09968","article-title":"Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity","volume":"473","author":"Fu","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib108","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1053\/j.gastro.2021.05.008","article-title":"Associations Among Adipose Tissue Immunology, Inflammation, Exosomes and Insulin Sensitivity in People With Obesity and Nonalcoholic Fatty Liver Disease","volume":"161","author":"Fuchs","year":"2021","journal-title":"Gastroenterology."},{"key":"10.1016\/j.immuni.2021.12.013_bib109","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1161\/ATVBAHA.115.305896","article-title":"Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1\u03b1-Dependent Senescence-Associated Secretory Phenotype","volume":"35","author":"Gardner","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.immuni.2021.12.013_bib110","doi-asserted-by":"crossref","first-page":"653940","DOI":"10.3389\/fphar.2021.653940","article-title":"Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory","volume":"12","author":"Geng","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.immuni.2021.12.013_bib111","first-page":"181","article-title":"The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions","volume":"103","author":"Gerrity","year":"1981","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.immuni.2021.12.013_bib112","doi-asserted-by":"crossref","first-page":"eaai7616","DOI":"10.1126\/sciimmunol.aai7616","article-title":"Type I Interferon Responses Drive Intrahepatic T\u00a0cells to Promote Metabolic Syndrome","volume":"2","author":"Ghazarian","year":"2017","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib113","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1572-0241.2006.01041.x","article-title":"Nonalcoholic fatty liver disease in severely obese subjects","volume":"102","author":"Gholam","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.immuni.2021.12.013_bib114","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1752-8062.2008.00026.x","article-title":"Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes","volume":"1","author":"Goldfine","year":"2008","journal-title":"Clin. Transl. Sci."},{"key":"10.1016\/j.immuni.2021.12.013_bib115","doi-asserted-by":"crossref","first-page":"346","DOI":"10.7326\/0003-4819-152-6-201003160-00004","article-title":"The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial","volume":"152","author":"Goldfine","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib116","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s00125-012-2819-3","article-title":"A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance","volume":"56","author":"Goldfine","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib117","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-159-1-201307020-00003","article-title":"Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial","volume":"159","author":"Goldfine","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib118","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1073\/pnas.86.19.7606","article-title":"Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells","volume":"86","author":"Goldgaber","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib119","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1126\/science.aat8515","article-title":"High-fructose corn syrup enhances intestinal tumor growth in mice","volume":"363","author":"Goncalves","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.immuni.2021.12.013_bib120","first-page":"83","article-title":"Anti-tumor necrosis factor-alpha blockade improves insulin resistance in patients with rheumatoid arthritis","volume":"24","author":"Gonzalez-Gay","year":"2006","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.immuni.2021.12.013_bib121","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1478-3231.2008.01826.x","article-title":"Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases","volume":"28","author":"Gressner","year":"2008","journal-title":"Liver Int."},{"key":"10.1016\/j.immuni.2021.12.013_bib122","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12964-015-0097-7","article-title":"Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells","volume":"13","author":"Guay","year":"2015","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.immuni.2021.12.013_bib123","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer\u2019s disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib124","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrm2391","article-title":"Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes","volume":"9","author":"Guilherme","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.immuni.2021.12.013_bib125","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib126","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s00125-013-3139-y","article-title":"Local proliferation of macrophages in adipose tissue during obesity-induced inflammation","volume":"57","author":"Haase","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib127","doi-asserted-by":"crossref","first-page":"e86055","DOI":"10.1172\/jci.insight.86055","article-title":"Interleukin-1 signaling contributes to acute islet compensation","volume":"1","author":"Hajmrle","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.immuni.2021.12.013_bib128","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1128\/MCB.00192-09","article-title":"Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue","volume":"29","author":"Halberg","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.immuni.2021.12.013_bib129","doi-asserted-by":"crossref","first-page":"527","DOI":"10.4049\/jimmunol.1301035","article-title":"Immune regulation in obesity-associated adipose inflammation","volume":"191","author":"Han","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib130","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/glia.10161","article-title":"Microglia as a source and target of cytokines","volume":"40","author":"Hanisch","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.immuni.2021.12.013_bib131","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.201709069","article-title":"Microglia in Alzheimer\u2019s disease","volume":"217","author":"Hansen","year":"2018","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.immuni.2021.12.013_bib132","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/nm.3705","article-title":"Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress","volume":"20","author":"Hasnain","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib133","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-3940(02)00888-1","article-title":"Pathological relationships between microglial cell activity and tau and amyloid beta protein in patients with Alzheimer\u2019s disease","volume":"331","author":"Hayes","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.immuni.2021.12.013_bib134","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0168-8278(99)80010-5","article-title":"The role of TGFbeta1 in initiating hepatic stellate cell activation in\u00a0vivo","volume":"30","author":"Hellerbrand","year":"1999","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.immuni.2021.12.013_bib135","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib136","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.immuni.2021.12.013_bib137","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/ni.3102","article-title":"Innate immunity in Alzheimer\u2019s disease","volume":"16","author":"Heneka","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib138","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.cmet.2020.02.013","article-title":"Postprandial Hypoglycemia in Patients after Gastric Bypass Surgery Is Mediated by Glucose-Induced IL-1beta","volume":"31","author":"Hepprich","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib139","doi-asserted-by":"crossref","first-page":"680","DOI":"10.2337\/dc08-2011","article-title":"Subclinical inflammation and diabetic polyneuropathy: MONICA\/KORA Survey F3 (Augsburg, Germany)","volume":"32","author":"Herder","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.immuni.2021.12.013_bib140","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.2337\/dc13-0382","article-title":"Association of subclinical inflammation with polyneuropathy in the older population: KORA F4 study","volume":"36","author":"Herder","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.immuni.2021.12.013_bib141","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2337\/dc16-2259","article-title":"Proinflammatory Cytokines Predict the Incidence and Progression of Distal Sensorimotor Polyneuropathy: KORA F4\/FF4 Study","volume":"40","author":"Herder","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.immuni.2021.12.013_bib142","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.2337\/db18-0060","article-title":"A Systemic Inflammatory Signature Reflecting Cross Talk Between Innate and Adaptive Immunity Is Associated With Incident Polyneuropathy: KORA F4\/FF4 Study","volume":"67","author":"Herder","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib143","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.tem.2019.02.007","article-title":"Novel Insights into Sensorimotor and Cardiovascular Autonomic Neuropathy from Recent-Onset Diabetes and Population-Based Cohorts","volume":"30","author":"Herder","year":"2019","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib144","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.cmet.2021.09.010","article-title":"Molecular aspects of fructose metabolism and metabolic disease","volume":"33","author":"Herman","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib145","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1523\/JNEUROSCI.0616-08.2008","article-title":"Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer\u2019s disease mice","volume":"28","author":"Hickman","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.immuni.2021.12.013_bib146","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/s41590-021-00922-4","article-title":"Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity","volume":"22","author":"Hildreth","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib147","doi-asserted-by":"crossref","first-page":"E5096","DOI":"10.1073\/pnas.1802611115","article-title":"Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue","volume":"115","author":"Hill","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib148","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature01137","article-title":"A central role for JNK in obesity and insulin resistance","volume":"420","author":"Hirosumi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib149","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1172\/JCI43378","article-title":"Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice","volume":"121","author":"Holland","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib150","first-page":"1","article-title":"Type 2 diabetes and psoriasis: links and risks","volume":"9","author":"Holm","year":"2019","journal-title":"Psoriasis (Auckl)"},{"key":"10.1016\/j.immuni.2021.12.013_bib151","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.2337\/db05-1526","article-title":"Islet inflammation and fibrosis in a spontaneous model of type 2 diabetes, the GK rat","volume":"55","author":"Homo-Delarche","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib152","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.2337\/db08-1261","article-title":"Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle","volume":"58","author":"Hong","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib153","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1053\/j.gastro.2017.02.016","article-title":"Gut-Specific Delivery of T-Helper 17 Cells Reduces Obesity and Insulin Resistance in Mice","volume":"152","author":"Hong","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.immuni.2021.12.013_bib154","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2337\/db06-0911","article-title":"Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation","volume":"56","author":"Hosogai","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib155","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nri2449","article-title":"Nutrient sensing and inflammation in metabolic diseases","volume":"8","author":"Hotamisligil","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib156","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.immuni.2021.12.013_bib157","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1073\/pnas.91.11.4854","article-title":"Tumor necrosis factor alpha inhibits signaling from the insulin receptor","volume":"91","author":"Hotamisligil","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib158","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature04634","article-title":"Reactive oxygen species have a causal role in multiple forms of insulin resistance","volume":"440","author":"Houstis","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib159","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1136\/ard.2006.062323","article-title":"Improved insulin sensitivity by anti-TNFalpha antibody treatment in patients with rheumatic diseases","volume":"66","author":"Huvers","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.immuni.2021.12.013_bib160","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00125-010-1707-y","article-title":"Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes","volume":"53","author":"Igoillo-Esteve","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib161","first-page":"105","article-title":"Hypoxia-inducible factors as essential regulators of inflammation","volume":"345","author":"Imtiyaz","year":"2010","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib162","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1210\/en.2006-0692","article-title":"Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression","volume":"148","author":"Jager","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.immuni.2021.12.013_bib163","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.cell.2019.05.054","article-title":"Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner","volume":"178","author":"Jaitin","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2021.12.013_bib164","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s42255-020-0222-9","article-title":"The small intestine shields the liver from fructose-induced steatosis","volume":"2","author":"Jang","year":"2020","journal-title":"Nat Metab"},{"key":"10.1016\/j.immuni.2021.12.013_bib165","doi-asserted-by":"crossref","first-page":"109613","DOI":"10.1016\/j.celrep.2021.109613","article-title":"Pro-inflammatory \u03b2 cell small extracellular vesicles induce \u03b2 cell failure through activation of the CXCL10\/CXCR3 axis in diabetes","volume":"36","author":"Javeed","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2021.12.013_bib166","series-title":"Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075","author":"Ji","year":"2021"},{"key":"10.1016\/j.immuni.2021.12.013_bib167","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jdiacomp.2014.07.003","article-title":"Global Toll-like receptor 4 knockout results in decreased renal inflammation, fibrosis and podocytopathy","volume":"28","author":"Jialal","year":"2014","journal-title":"J.\u00a0Diabetes Complications"},{"key":"10.1016\/j.immuni.2021.12.013_bib168","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.2337\/db11-0174","article-title":"Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice","volume":"60","author":"Jiang","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib169","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jhep.2019.09.014","article-title":"Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1","volume":"72","author":"Jiang","year":"2020","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.immuni.2021.12.013_bib170","doi-asserted-by":"crossref","first-page":"e0122195","DOI":"10.1371\/journal.pone.0122195","article-title":"High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability","volume":"10","author":"Johnson","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2021.12.013_bib171","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S1043-4666(05)80001-8","article-title":"Cytokines and hypothalamic-pituitary function","volume":"5","author":"Jones","year":"1993","journal-title":"Cytokine"},{"key":"10.1016\/j.immuni.2021.12.013_bib172","first-page":"1568","article-title":"TREM2 and neurodegenerative disease","volume":"369","author":"Jonsson","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib173","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer\u2019s disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib174","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1096\/fj.03-1476fje","article-title":"A central role for inflammation in the pathogenesis of diabetic retinopathy","volume":"18","author":"Joussen","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.immuni.2021.12.013_bib175","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1016\/j.ajpath.2011.02.036","article-title":"\u03b2-cell loss and \u03b2-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition","volume":"178","author":"Jurgens","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.immuni.2021.12.013_bib176","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/13506129.2014.937857","article-title":"Islet amyloid with macrophage migration correlates with augmented \u03b2-cell deficits in type 2 diabetic patients","volume":"21","author":"Kamata","year":"2014","journal-title":"Amyloid"},{"key":"10.1016\/j.immuni.2021.12.013_bib177","doi-asserted-by":"crossref","first-page":"26602","DOI":"10.1074\/jbc.M601284200","article-title":"Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance","volume":"281","author":"Kamei","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2021.12.013_bib178","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI26498","article-title":"MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity","volume":"116","author":"Kanda","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib179","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.it.2019.07.006","article-title":"Innate Immune Control of Adipose Tissue Homeostasis","volume":"40","author":"Kane","year":"2019","journal-title":"Trends Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib180","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00281-019-00743-6","article-title":"Treatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patients","volume":"41","author":"Kataria","year":"2019","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.immuni.2021.12.013_bib181","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cmet.2016.07.009","article-title":"Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2\/Ccr2-Dependent Manner","volume":"24","author":"Kawano","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib182","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1210\/jcem.86.6.7580","article-title":"Low grade chronic inflammation in women with polycystic ovarian syndrome","volume":"86","author":"Kelly","year":"2001","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib183","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A Unique Microglia Type Associated with Restricting Development of Alzheimer\u2019s Disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2021.12.013_bib184","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1038\/ijo.2015.104","article-title":"Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T\u00a0cell and macrophage infiltration and insulin resistance","volume":"39","author":"Khan","year":"2015","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.immuni.2021.12.013_bib185","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1038\/s41467-021-22727-7","article-title":"Emerging concepts in intestinal immune control of obesity-related metabolic disease","volume":"12","author":"Khan","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2021.12.013_bib186","doi-asserted-by":"crossref","first-page":"e47713","DOI":"10.1371\/journal.pone.0047713","article-title":"High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2021.12.013_bib187","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1038\/ncomms2852","article-title":"The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43","volume":"4","author":"Kimura","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2021.12.013_bib188","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer\u2019s disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimers Dement. (N. Y.)"},{"key":"10.1016\/j.immuni.2021.12.013_bib189","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1136\/ard.2004.026534","article-title":"Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis","volume":"64","author":"Kiortsis","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.immuni.2021.12.013_bib190","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1172\/JCI129193","article-title":"Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome","volume":"129","author":"Kita","year":"2019","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib191","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0140-6736(09)60008-8","article-title":"Rheumatoid arthritis","volume":"373","author":"Klareskog","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.immuni.2021.12.013_bib192","doi-asserted-by":"crossref","DOI":"10.2337\/diabetes.52.11.2784","article-title":"Acute or chronic exposure to interleukin-6 induces hepatic insulin resistance in\u00a0vivo","volume":"52","author":"Klover","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib193","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.2337\/diabetes.52.11.2784","article-title":"Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice","volume":"52","author":"Klover","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib194","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1016\/S2665-9913(20)30065-5","article-title":"Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial","volume":"2","author":"Kl\u00fcck","year":"2020","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.immuni.2021.12.013_bib195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9758\/cpn.2017.15.1.1","article-title":"Mechanisms of Alzheimer\u2019s Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors","volume":"15","author":"Kocahan","year":"2017","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"10.1016\/j.immuni.2021.12.013_bib196","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0303-7207(98)00260-3","article-title":"The rat intraovarian interleukin (IL)-1 system: cellular localization, cyclic variation and hormonal regulation of IL-1beta and of the type I and type II IL-1 receptors","volume":"149","author":"Kol","year":"1999","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.immuni.2021.12.013_bib197","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00125-008-1239-x","article-title":"The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study","volume":"52","author":"Koska","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib198","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cmet.2015.02.006","article-title":"Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance","volume":"21","author":"Kraakman","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib199","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1002\/oby.20847","article-title":"Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells","volume":"22","author":"Kranendonk","year":"2014","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.immuni.2021.12.013_bib200","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.cmet.2014.08.010","article-title":"Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages","volume":"20","author":"Kratz","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib201","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrendo.2015.189","article-title":"Regulation of metabolism by the innate immune system","volume":"12","author":"Lackey","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.immuni.2021.12.013_bib202","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.bbrc.2003.10.013","article-title":"Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone","volume":"311","author":"Lagathu","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.immuni.2021.12.013_bib203","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1007\/s00125-006-0335-z","article-title":"Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes","volume":"49","author":"Lagathu","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib204","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1007\/s00125-018-4559-5","article-title":"Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes","volume":"61","author":"Lakhter","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib205","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1210\/endo.130.1.1727716","article-title":"Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output","volume":"130","author":"Lang","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.immuni.2021.12.013_bib207","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1056\/NEJMoa065213","article-title":"Interleukin-1-receptor antagonist in type 2 diabetes mellitus","volume":"356","author":"Larsen","year":"2007","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib208","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2337\/dc09-0533","article-title":"Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes","volume":"32","author":"Larsen","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.immuni.2021.12.013_bib209","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1210\/jc.2015-4125","article-title":"Adipose Tissue Hypoxia, Inflammation, and Fibrosis in Obese Insulin-Sensitive and Obese Insulin-Resistant Subjects","volume":"101","author":"Lawler","year":"2016","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib210","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.immuni.2020.08.013","article-title":"Dietary Regulation of Immunity","volume":"53","author":"Lee","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.12.013_bib211","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1101\/gad.346312.120","article-title":"Chronic tissue inflammation and metabolic disease","volume":"35","author":"Lee","year":"2021","journal-title":"Genes Dev."},{"key":"10.1016\/j.immuni.2021.12.013_bib212","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.cell.2014.05.012","article-title":"Increased adipocyte O2 consumption triggers HIF-1\u03b1, causing inflammation and insulin resistance in obesity","volume":"157","author":"Lee","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2021.12.013_bib213","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cmet.2016.03.002","article-title":"Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity","volume":"23","author":"Lee","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib214","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.molmet.2018.04.001","article-title":"The role of IL-1 in postprandial fatigue","volume":"12","author":"Lehrskov","year":"2018","journal-title":"Mol. Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib215","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.immuni.2021.12.013_bib216","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nm.3800","article-title":"LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes","volume":"21","author":"Li","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib217","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.cell.2016.10.025","article-title":"Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance","volume":"167","author":"Li","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2021.12.013_bib218","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/imr.12850","article-title":"Visceral adipose tissue Tregs and the cells that nurture them","volume":"295","author":"Li","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2021.12.013_bib219","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/01.ATV.5.2.186","article-title":"Differential effects of human interleukin-1 on growth of human fibroblasts and vascular smooth muscle cells","volume":"5","author":"Libby","year":"1985","journal-title":"Arteriosclerosis"},{"key":"10.1016\/j.immuni.2021.12.013_bib220","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib221","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1681\/ASN.2010111210","article-title":"Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy","volume":"23","author":"Lin","year":"2012","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.immuni.2021.12.013_bib222","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fneur.2018.00008","article-title":"Microglia and CNS Interleukin-1: Beyond Immunological Concepts","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.immuni.2021.12.013_bib223","doi-asserted-by":"crossref","first-page":"e96685","DOI":"10.1172\/jci.insight.96685","article-title":"DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis","volume":"3","author":"Loomba","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.immuni.2021.12.013_bib224","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2021.12.013_bib225","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.cmet.2015.03.001","article-title":"Regulation of obesity-related insulin resistance with gut anti-inflammatory agents","volume":"21","author":"Luck","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib226","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1038\/s41467-019-11370-y","article-title":"Gut-associated IgA+ immune cells regulate obesity-related insulin resistance","volume":"10","author":"Luck","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2021.12.013_bib227","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"Lumeng","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib228","doi-asserted-by":"crossref","first-page":"e97985","DOI":"10.1371\/journal.pone.0097985","article-title":"TLR4 activation promotes podocyte injury and interstitial fibrosis in diabetic nephropathy","volume":"9","author":"Ma","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2021.12.013_bib229","first-page":"481","article-title":"Requirement for TLR2 in the development of albuminuria, inflammation and fibrosis in experimental diabetic nephropathy","volume":"7","author":"Ma","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.immuni.2021.12.013_bib230","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jhep.2006.06.013","article-title":"Hepatic histology in obese patients undergoing bariatric surgery","volume":"45","author":"Machado","year":"2006","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.immuni.2021.12.013_bib231","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1172\/JCI200215318","article-title":"Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets","volume":"110","author":"Maedler","year":"2002","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib232","doi-asserted-by":"crossref","first-page":"8138","DOI":"10.1073\/pnas.0305683101","article-title":"Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets","volume":"101","author":"Maedler","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib233","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1177\/039463200702000408","article-title":"Effect of etanercept on insulin sensitivity in nine patients with psoriasis","volume":"20","author":"Marra","year":"2007","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.immuni.2021.12.013_bib234","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1056\/NEJMoa1603827","article-title":"Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes","volume":"375","author":"Marso","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib235","doi-asserted-by":"crossref","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"Martinez","year":"2014","journal-title":"F1000Prime Rep."},{"key":"10.1016\/j.immuni.2021.12.013_bib236","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1007\/s00125-015-3734-1","article-title":"Mast cells infiltrate pancreatic islets in human type 1 diabetes","volume":"58","author":"Martino","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib237","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.immuni.2021.12.013_bib238","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib239","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ni.1935","article-title":"Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1\u03b2 in type 2 diabetes","volume":"11","author":"Masters","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib240","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s00428-006-0176-7","article-title":"Atherosclerosis research from past to present--on the track of two pathologists with opposing views, Carl von Rokitansky and Rudolf Virchow","volume":"449","author":"Mayerl","year":"2006","journal-title":"Virchows Arch."},{"key":"10.1016\/j.immuni.2021.12.013_bib241","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.2337\/db10-1278","article-title":"Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis","volume":"60","author":"McGillicuddy","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib242","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1172\/JCI88876","article-title":"Role of innate and adaptive immunity in obesity-associated metabolic disease","volume":"127","author":"McLaughlin","year":"2017","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib243","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrendo.2017.56","article-title":"Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance","volume":"13","author":"Meex","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.immuni.2021.12.013_bib244","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1007\/s00125-014-3304-y","article-title":"Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice","volume":"57","author":"Meier","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib245","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/cei.12295","article-title":"Interleukin-6 blockade in ocular inflammatory diseases","volume":"176","author":"Mesquida","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib246","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00281-019-00750-7","article-title":"The role of inflammation in diabetic eye disease","volume":"41","author":"Mesquida","year":"2019","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.immuni.2021.12.013_bib247","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cmet.2015.05.020","article-title":"Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling","volume":"22","author":"Monteiro-Sepulveda","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib248","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.2337\/db14-1238","article-title":"Characterization of distinct subpopulations of hepatic macrophages in HFD\/obese mice","volume":"64","author":"Morinaga","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib249","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1111\/febs.12338","article-title":"Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword?","volume":"280","author":"Mu\u00f1oz-C\u00e1noves","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.immuni.2021.12.013_bib250","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1194\/jlr.M800019-JLR200","article-title":"Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice","volume":"49","author":"Murano","year":"2008","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.immuni.2021.12.013_bib251","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3233\/JAD-2010-1221","article-title":"Alzheimer\u2019s disease and the amyloid-beta peptide","volume":"19","author":"Murphy","year":"2010","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.immuni.2021.12.013_bib252","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2018.07.030","article-title":"Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers","volume":"174","author":"Murphy","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2021.12.013_bib253","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cmet.2014.03.029","article-title":"Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity","volume":"19","author":"Nagareddy","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib254","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jcp.22708","article-title":"Regulation of VEGF expression in human retinal cells by cytokines: implications for the role of inflammation in age-related macular degeneration","volume":"227","author":"Nagineni","year":"2012","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.immuni.2021.12.013_bib255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jlb.46.1.1","article-title":"Development, differentiation, and maturation of fetal mouse yolk sac macrophages in cultures","volume":"46","author":"Naito","year":"1989","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.immuni.2021.12.013_bib256","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccr.2014.07.001","article-title":"ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development","volume":"26","author":"Nakagawa","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.immuni.2021.12.013_bib257","doi-asserted-by":"crossref","first-page":"e1003364","DOI":"10.1371\/journal.pgen.1003364","article-title":"A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation","volume":"9","author":"Nakano","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.immuni.2021.12.013_bib258","doi-asserted-by":"crossref","first-page":"35279","DOI":"10.1074\/jbc.M706762200","article-title":"A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways","volume":"282","author":"Nguyen","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2021.12.013_bib259","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.3390\/ijms21093165","article-title":"Type 3 Diabetes and Its Role Implications in Alzheimer\u2019s Disease","volume":"21","author":"Nguyen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.immuni.2021.12.013_bib260","first-page":"101","article-title":"Kupffer Cell Metabolism and Function","volume":"1","author":"Nguyen-Lefebvre","year":"2015","journal-title":"J Enzymol Metab"},{"key":"10.1016\/j.immuni.2021.12.013_bib261","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm.1964","article-title":"CD8+ effector T\u00a0cells contribute to macrophage recruitment and adipose tissue inflammation in obesity","volume":"15","author":"Nishimura","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib262","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.1038\/s41598-017-06731-w","article-title":"The Role of Inflammation in \u03b2-cell Dedifferentiation","volume":"7","author":"Nordmann","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.immuni.2021.12.013_bib263","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1126\/science.aay0793","article-title":"Brain cell type-specific enhancer-promoter interactome maps and disease-risk association","volume":"366","author":"Nott","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.immuni.2021.12.013_bib264","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.immuni.2016.06.016","article-title":"Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance","volume":"45","author":"O\u2019Sullivan","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.12.013_bib265","doi-asserted-by":"crossref","first-page":"916","DOI":"10.2337\/db09-1403","article-title":"C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis","volume":"59","author":"Obstfeld","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib266","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2337\/diab.45.7.881","article-title":"Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM","volume":"45","author":"Ofei","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib267","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2021.12.013_bib268","doi-asserted-by":"crossref","first-page":"346","DOI":"10.2337\/db11-0860","article-title":"Increased macrophage migration into adipose tissue in obese mice","volume":"61","author":"Oh","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib269","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s10753-017-0718-y","article-title":"Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1\u03b2 on White Adipocyte Browning","volume":"41","author":"Okla","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.immuni.2021.12.013_bib270","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1381\/0960892053576820","article-title":"Predictors of nonalcoholic steatohepatitis and advanced fibrosis in morbidly obese patients","volume":"15","author":"Ong","year":"2005","journal-title":"Obes. Surg."},{"key":"10.1016\/j.immuni.2021.12.013_bib271","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3389\/fimmu.2019.01084","article-title":"Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages","volume":"10","author":"Orecchioni","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib272","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41423-021-00670-3","article-title":"An update on\u00a0the regulatory mechanisms of NLRP3 inflammasome activation","volume":"18","author":"Paik","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib273","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1084\/jem.194.9.1361","article-title":"Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues","volume":"194","author":"Palframan","year":"2001","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib274","first-page":"1316","article-title":"No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients","volume":"85","author":"Paquot","year":"2000","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib275","doi-asserted-by":"crossref","first-page":"718","DOI":"10.2337\/db08-1098","article-title":"Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response","volume":"58","author":"Pasarica","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib276","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1210\/jc.2009-2377","article-title":"Reduced oxygenation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis","volume":"95","author":"Pasarica","year":"2010","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib277","doi-asserted-by":"crossref","first-page":"e110653","DOI":"10.1371\/journal.pone.0110653","article-title":"Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans","volume":"9","author":"Patsouris","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2021.12.013_bib278","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1152\/physrev.90100.2007","article-title":"Muscle as an endocrine organ: focus on muscle-derived interleukin-6","volume":"88","author":"Pedersen","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.immuni.2021.12.013_bib279","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrendo.2012.49","article-title":"Muscles, exercise and obesity: skeletal muscle as a secretory organ","volume":"8","author":"Pedersen","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.immuni.2021.12.013_bib280","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev-biochem-013118-111902","article-title":"Exosomes","volume":"88","author":"Pegtel","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.immuni.2021.12.013_bib281","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.immuni.2015.11.022","article-title":"The Origin of Tissue-Resident Macrophages: When an Erythro-myeloid Progenitor Is an Erythro-myeloid Progenitor","volume":"43","author":"Perdiguero","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.12.013_bib282","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.2337\/diabetes.54.10.2939","article-title":"Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation","volume":"54","author":"Plomgaard","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib283","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.metabol.2018.11.014","article-title":"Obesity and nonalcoholic fatty liver disease: From pathophysiology to therapeutics","volume":"92","author":"Polyzos","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.immuni.2021.12.013_bib284","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00281-019-00737-4","article-title":"Chronic low-grade inflammation in polycystic ovary syndrome: is there a (patho)-physiological role for interleukin-1?","volume":"41","author":"Popovic","year":"2019","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.immuni.2021.12.013_bib285","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.jcmgh.2015.07.007","article-title":"Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-gamma","volume":"1","author":"Povero","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol."},{"key":"10.1016\/j.immuni.2021.12.013_bib286","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1053\/j.gastro.2007.10.039","article-title":"Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease","volume":"134","author":"Puri","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.immuni.2021.12.013_bib287","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yexcr.2004.01.002","article-title":"Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5\/p35 pathway","volume":"295","author":"Quintanilla","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.immuni.2021.12.013_bib288","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00125-007-0861-3","article-title":"Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle","volume":"51","author":"Radin","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib289","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nm.3467","article-title":"Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity","volume":"20","author":"Ramkhelawon","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib290","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.2337\/dc11-0357","article-title":"Effect of diacerein on insulin secretion and metabolic control in drug-naive patients with type 2 diabetes: a randomized clinical trial","volume":"34","author":"Ramos-Zavala","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.immuni.2021.12.013_bib291","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nrendo.2013.122","article-title":"Testosterone and insulin resistance in the metabolic syndrome and T2DM in men","volume":"9","author":"Rao","year":"2013","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.immuni.2021.12.013_bib292","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1615\/CritRevEukaryotGeneExpr.2017019712","article-title":"Role of Interleukin-6 in Development of Insulin Resistance and Type 2 Diabetes Mellitus","volume":"27","author":"Rehman","year":"2017","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.immuni.2021.12.013_bib293","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1007\/s00125-009-1410-z","article-title":"Islet-associated macrophages in type 2 diabetes","volume":"52","author":"Richardson","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib294","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib295","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(17)32814-3","article-title":"Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial","volume":"391","author":"Ridker","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.immuni.2021.12.013_bib296","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1056\/NEJMoa1809798","article-title":"Low-Dose Methotrexate for the Prevention of Atherosclerotic Events","volume":"380","author":"Ridker","year":"2019","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib297","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1016\/S0140-6736(21)00520-1","article-title":"IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial","volume":"397","author":"Ridker","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.immuni.2021.12.013_bib298","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/j.1463-1326.2012.01637.x","article-title":"Effect of anti-IL-1\u03b2 antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo-controlled trial","volume":"14","author":"Rissanen","year":"2012","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib299","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.2337\/db14-0549","article-title":"Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes","volume":"63","author":"Rodriguez-Calvo","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib300","first-page":"51","article-title":"Increased Inflammatory Intestinal Macrophage Subpopulations after High-Fat Diet","volume":"66","author":"Rohm","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib301","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2337\/db18-283-OR","article-title":"Targeting Intestinal Macrophages as a Potential Therapeutic Option in Obesity","volume":"67","author":"Rohm","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib302","doi-asserted-by":"crossref","first-page":"668654","DOI":"10.3389\/fimmu.2021.668654","article-title":"Obesity in Humans Is Characterized by Gut Inflammation as Shown by Pro-Inflammatory Intestinal Macrophage Accumulation","volume":"12","author":"Rohm","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib303","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3389\/fimmu.2018.01625","article-title":"Expanded Regulatory T Cells Induce Alternatively Activated Monocytes With a Reduced Capacity to Expand T Helper-17 Cells","volume":"9","author":"Romano","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib304","doi-asserted-by":"crossref","first-page":"45777","DOI":"10.1074\/jbc.M301977200","article-title":"Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects","volume":"278","author":"Rotter","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2021.12.013_bib305","doi-asserted-by":"crossref","first-page":"942","DOI":"10.3390\/ijms19040942","article-title":"Role of Inflammation in Diabetic Retinopathy","volume":"19","author":"R\u00fcbsam","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.immuni.2021.12.013_bib306","doi-asserted-by":"crossref","first-page":"e1002901","DOI":"10.1371\/journal.pmed.1002901","article-title":"Anti-interleukin-1 treatment in patients with rheumatoid arthritis and type 2 diabetes (TRACK): a multicentre, randomised, open-label, prospective, controlled, parallel-group tria","volume":"16","author":"Ruscitti","year":"2019","journal-title":"PLoS Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib307","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/cei.12667","volume":"182","author":"Ruscitti","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib308","doi-asserted-by":"crossref","first-page":"e7896","DOI":"10.1097\/MD.0000000000007896","article-title":"Prevalence of type 2 diabetes and impaired fasting glucose in patients affected by rheumatoid arthritis: Results from a cross-sectional study","volume":"96","author":"Ruscitti","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.immuni.2021.12.013_bib309","doi-asserted-by":"crossref","first-page":"e0181203","DOI":"10.1371\/journal.pone.0181203","article-title":"Poor clinical response in rheumatoid arthritis is the main risk factor for diabetes development in the short-term: A 1-year, single-centre, longitudinal study","volume":"12","author":"Ruscitti","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.immuni.2021.12.013_bib310","doi-asserted-by":"crossref","first-page":"e14587","DOI":"10.1097\/MD.0000000000014587","article-title":"IL-1 inhibition improves insulin resistance and adipokines in rheumatoid arthritis patients with comorbid type 2 diabetes: An observational study","volume":"98","author":"Ruscitti","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.immuni.2021.12.013_bib311","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.devcel.2008.10.015","article-title":"UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators","volume":"15","author":"Rutkowski","year":"2008","journal-title":"Dev. Cell"},{"key":"10.1016\/j.immuni.2021.12.013_bib312","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1172\/JCI77812","article-title":"The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux","volume":"126","author":"Samuel","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib313","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/brv.12178","article-title":"De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose","volume":"91","author":"Sanders","year":"2016","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.immuni.2021.12.013_bib314","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.celrep.2019.06.016","article-title":"Innate Lymphoid Cells in the Induction of Obesity","volume":"28","author":"Sasaki","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.immuni.2021.12.013_bib315","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.2337\/db14-1282","article-title":"Angiotensin II induces interleukin-1\u03b2-mediated islet inflammation and \u03b2-cell dysfunction independently of vasoconstrictive effects","volume":"64","author":"Sauter","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib316","doi-asserted-by":"crossref","first-page":"240","DOI":"10.2337\/dc18-1842","article-title":"General and Abdominal Obesity and Incident Distal Sensorimotor Polyneuropathy: Insights Into Inflammatory Biomarkers as Potential Mediators in the KORA F4\/FF4 Cohort","volume":"42","author":"Schlesinger","year":"2019","journal-title":"Diabetes care."},{"key":"10.1016\/j.immuni.2021.12.013_bib317","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/s41581-019-0182-z","article-title":"Mechanisms of hypoxia signalling: new implications for nephrology","volume":"15","author":"Sch\u00f6del","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.immuni.2021.12.013_bib318","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.immuni.2020.04.001","article-title":"Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis","volume":"52","author":"Seidman","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.12.013_bib319","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev.ne.17.030194.002421","article-title":"Normal and abnormal biology of the beta-amyloid precursor protein","volume":"17","author":"Selkoe","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.immuni.2021.12.013_bib320","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev-pharmtox-010818-021637","article-title":"Pharmacologic Targeting of Hypoxia-Inducible Factors","volume":"59","author":"Semenza","year":"2019","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.immuni.2021.12.013_bib321","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s42255-018-0003-x","article-title":"Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity","volume":"1","author":"Seo","year":"2019","journal-title":"Nat Metab"},{"key":"10.1016\/j.immuni.2021.12.013_bib322","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1042\/BJ20060706","article-title":"Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively","volume":"399","author":"Shabalina","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/j.immuni.2021.12.013_bib323","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1681\/ASN.2015060676","article-title":"Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy","volume":"27","author":"Shahzad","year":"2016","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.immuni.2021.12.013_bib324","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2337\/db09-1402","article-title":"Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet--induced obesity in mice","volume":"59","author":"Shaul","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib325","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid-induced insulin resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib326","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2013.09.001","article-title":"Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity","volume":"18","author":"Shimizu","year":"2013","journal-title":"Cell Metab."},{"issue":"Suppl 3","key":"10.1016\/j.immuni.2021.12.013_bib327","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1038\/sj.ijo.0802501","article-title":"Inflammation and the IKK beta\/I kappa B\/NF-kappa B axis in obesity- and diet-induced insulin resistance","volume":"27","author":"Shoelson","year":"2003","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"10.1016\/j.immuni.2021.12.013_bib328","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","article-title":"Inflammation and insulin resistance","volume":"116","author":"Shoelson","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib329","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2337\/dc13-2002","article-title":"Ocular Anti-VEGF therapy for diabetic retinopathy: the role of VEGF in the pathogenesis of diabetic retinopathy","volume":"37","author":"Sim\u00f3","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.immuni.2021.12.013_bib330","doi-asserted-by":"crossref","first-page":"872978","DOI":"10.1155\/2012\/872978","article-title":"Usefulness of the vitreous fluid analysis in the translational research of diabetic retinopathy","volume":"2012","author":"Sim\u00f3-Servat","year":"2012","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.immuni.2021.12.013_bib331","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/ng.3916","article-title":"Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer\u2019s disease","volume":"49","author":"Sims","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.immuni.2021.12.013_bib332","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.2337\/dc12-1835","article-title":"Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1\u03b2 antibody, in patients with type 2 diabetes","volume":"36","author":"Sloan-Lancaster","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.immuni.2021.12.013_bib333","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainresbull.2011.10.004","article-title":"Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases","volume":"87","author":"Smith","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.immuni.2021.12.013_bib334","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1172\/JCI129186","article-title":"Metabolically healthy obesity: facts and fantasies","volume":"129","author":"Smith","year":"2019","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib335","doi-asserted-by":"crossref","first-page":"R28","DOI":"10.1186\/ar2143","article-title":"A pilot study of IL-1 inhibition by anakinra in acute gout","volume":"9","author":"So","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.immuni.2021.12.013_bib336","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1001\/jama.2011.878","article-title":"Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis","volume":"305","author":"Solomon","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.immuni.2021.12.013_bib337","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3390\/nu10101383","article-title":"Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues","volume":"10","author":"Song","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.immuni.2021.12.013_bib338","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.4049\/jimmunol.1100196","article-title":"Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity","volume":"187","author":"Spite","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib339","doi-asserted-by":"crossref","first-page":"812","DOI":"10.2337\/diabetes.52.3.812","article-title":"Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study","volume":"52","author":"Spranger","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib340","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.3389\/fimmu.2018.02883","article-title":"Intestinal Dendritic Cells in Health and Gut Inflammation","volume":"9","author":"Stagg","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib341","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/IAE.0000000000000701","article-title":"SYSTEMIC INTERLEUKIN 1\u03b2 INHIBITION IN PROLIFERATIVE DIABETIC RETINOPATHY: A Prospective Open-Label Study Using Canakinumab","volume":"36","author":"Stahel","year":"2016","journal-title":"Retina"},{"key":"10.1016\/j.immuni.2021.12.013_bib342","doi-asserted-by":"crossref","first-page":"E146","DOI":"10.1210\/jc.2010-1170","article-title":"TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome","volume":"96","author":"Stanley","year":"2011","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib343","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1074\/jbc.272.2.971","article-title":"Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction","volume":"272","author":"Stephens","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2021.12.013_bib344","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2010.11.011","article-title":"The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity","volume":"12","author":"Stienstra","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib345","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.2337\/db07-0767","article-title":"Adipocyte death, adipose tissue remodeling, and obesity complications","volume":"56","author":"Strissel","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib346","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.jhep.2011.09.020","article-title":"Obesity, inflammation, and liver cancer","volume":"56","author":"Sun","year":"2012","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.immuni.2021.12.013_bib347","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1128\/MCB.00951-12","article-title":"Selective inhibition of hypoxia-inducible factor 1\u03b1 ameliorates adipose tissue dysfunction","volume":"33","author":"Sun","year":"2013","journal-title":"Mol. Cell. Biol."},{"issue":"Suppl 1","key":"10.1016\/j.immuni.2021.12.013_bib348","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1073\/pnas.1006734107","article-title":"Systemic gut microbial modulation of bile acid metabolism in host tissue compartments","volume":"108","author":"Swann","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib349","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.2337\/db16-0012","article-title":"HIF-1\u03b1 in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance","volume":"65","author":"Takikawa","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib350","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nm.2885","article-title":"Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase","volume":"18","author":"Talukdar","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib351","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1002\/eji.201242847","article-title":"CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis","volume":"42","author":"Tamoutounour","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib352","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.immuni.2013.10.004","article-title":"Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin","volume":"39","author":"Tamoutounour","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.12.013_bib353","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41581-019-0234-4","article-title":"Innate immunity in diabetic kidney disease","volume":"16","author":"Tang","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.immuni.2021.12.013_bib354","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41586-021-03827-2","article-title":"Dietary fructose improves intestinal cell survival and nutrient absorption","volume":"597","author":"Taylor","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib355","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1042\/CS20160636","article-title":"Diabetic nephropathy - is this an immune disorder?","volume":"131","author":"Tesch","year":"2017","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.immuni.2021.12.013_bib356","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13195-015-0125-2","article-title":"The dynamics of monocytes and microglia in Alzheimer\u2019s disease","volume":"7","author":"Th\u00e9riault","year":"2015","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.immuni.2021.12.013_bib357","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2009.08.001","article-title":"TGR5-mediated bile acid sensing controls glucose homeostasis","volume":"10","author":"Thomas","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib358","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/356768a0","article-title":"A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes","volume":"356","author":"Thornberry","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib359","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.2337\/dc13-0199","article-title":"Infliximab in the treatment of Crohn disease and type 1 diabetes","volume":"36","author":"Timper","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.immuni.2021.12.013_bib360","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/s42255-020-0261-2","article-title":"Fructose stimulated de novo lipogenesis is promoted by inflammation","volume":"2","author":"Todoric","year":"2020","journal-title":"Nat Metab"},{"key":"10.1016\/j.immuni.2021.12.013_bib361","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2337\/db11-1019","article-title":"Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2","volume":"61","author":"Tolhurst","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib362","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1038\/s41467-020-17307-0","article-title":"Mucosal-associated invariant T\u00a0cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity","volume":"11","author":"Toubal","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2021.12.013_bib363","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1172\/JCI83260","article-title":"Fasting and refeeding differentially regulate NLRP3 inflammasome activation in human subjects","volume":"125","author":"Traba","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib364","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1016\/j.celrep.2017.03.005","article-title":"Pancreatic \u03b1 Cell-Derived Glucagon-Related Peptides Are Required for \u03b2 Cell Adaptation and Glucose Homeostasis","volume":"18","author":"Traub","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2021.12.013_bib365","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/nm1206-1359","article-title":"Fat fuels insulin resistance through Toll-like receptors","volume":"12","author":"Tsch\u00f6p","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib366","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1210\/jc.2010-2992","article-title":"Treatment with Anakinra improves disposition index but not insulin sensitivity in nondiabetic subjects with the metabolic syndrome: a randomized, double-blind, placebo-controlled study","volume":"96","author":"van Asseldonk","year":"2011","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib412","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.clim.2015.06.003","article-title":"One week treatment with the IL-1 receptor antagonist anakinra leads to a sustained improvement in insulin sensitivity in insulin resistant patients with type 1 diabetes mellitus","volume":"160","author":"van Asseldonk","year":"2015","journal-title":"Clin Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib368","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/dom.12357","article-title":"The interleukin-1 receptor antagonist anakinra improves first-phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance","volume":"16","author":"van Poppel","year":"2014","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib369","doi-asserted-by":"crossref","first-page":"e004373","DOI":"10.1161\/CIRCHEARTFAILURE.117.004373","article-title":"Interleukin-1 Blockade in Recently Decompensated Systolic Heart Failure: Results From REDHART (Recently Decompensated Heart Failure Anakinra Response Trial)","volume":"10","author":"Van Tassell","year":"2017","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.immuni.2021.12.013_bib370","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/clc.22988","article-title":"Rationale and design of the Virginia Commonwealth University-Anakinra Remodeling Trial-3 (VCU-ART3): A randomized, placebo-controlled, double-blinded, multicenter study","volume":"41","author":"Van Tassell","year":"2018","journal-title":"Clin. Cardiol."},{"key":"10.1016\/j.immuni.2021.12.013_bib371","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib372","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1172\/JCI91646","article-title":"Recipient mucosal-associated invariant T\u00a0cells control GVHD within the colon","volume":"128","author":"Varelias","year":"2018","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib373","doi-asserted-by":"crossref","first-page":"E1300","DOI":"10.1152\/ajpendo.90885.2008","article-title":"Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action","volume":"296","author":"Varma","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib374","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1681\/ASN.2010020143","article-title":"The NLRP3 inflammasome promotes renal inflammation and contributes to CKD","volume":"21","author":"Vilaysane","year":"2010","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.immuni.2021.12.013_bib375","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1007\/s10067-014-2601-7","article-title":"Anakinra treatment in patients with gout and type 2 diabetes","volume":"34","author":"Vitale","year":"2015","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.immuni.2021.12.013_bib376","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature13564","article-title":"Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes","volume":"514","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib377","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1038\/s41467-019-11270-1","article-title":"Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2021.12.013_bib378","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1161\/ATVBAHA.112.300941","article-title":"Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention","volume":"33","author":"Wanschel","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.immuni.2021.12.013_bib379","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.cmet.2018.12.007","article-title":"Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial","volume":"29","author":"Wedell-Neergaard","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib380","doi-asserted-by":"crossref","first-page":"R673","DOI":"10.1152\/ajpregu.00561.2007","article-title":"Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species","volume":"294","author":"Wei","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.immuni.2021.12.013_bib381","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib382","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1172\/JCI24335","article-title":"CCR2 modulates inflammatory and metabolic effects of high-fat feeding","volume":"116","author":"Weisberg","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib383","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ni.2022","article-title":"Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib384","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ni.3120","article-title":"NK cells link obesity-induced adipose stress to inflammation and insulin resistance","volume":"16","author":"Wensveen","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib385","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.2337\/db09-0287","article-title":"Pro-inflammatory CD11c+CD206+ adipose tissue macrophages are associated with insulin resistance in human obesity","volume":"59","author":"Wentworth","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib386","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cmet.2014.05.005","article-title":"Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling","volume":"20","author":"Wernstedt Asterholm","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib387","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00125-014-3447-x","article-title":"IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice","volume":"58","author":"Westwell-Roper","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.immuni.2021.12.013_bib388","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/nm.2001","article-title":"Normalization of obesity-associated insulin resistance through immunotherapy","volume":"15","author":"Winer","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2021.12.013_bib389","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/FJC.0000000000000931","article-title":"Phase 1B, Randomized, Double-Blinded, Dose Escalation, Single-Center, Repeat Dose Safety and Pharmacodynamics Study of the Oral NLRP3 Inhibitor Dapansutrile in Subjects With NYHA II-III Systolic Heart Failure","volume":"77","author":"Wohlford","year":"2020","journal-title":"J.\u00a0Cardiovasc. Pharmacol."},{"key":"10.1016\/j.immuni.2021.12.013_bib390","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2337\/diabetes.49.3.325","article-title":"Insulin signaling and insulin sensitivity after exercise in human skeletal muscle","volume":"49","author":"Wojtaszewski","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib391","doi-asserted-by":"crossref","first-page":"E1211","DOI":"10.1073\/pnas.1321347111","article-title":"M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7","volume":"111","author":"Xiao","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2021.12.013_bib392","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"Xu","year":"2003","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib393","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.cmet.2013.11.001","article-title":"Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation","volume":"18","author":"Xu","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib394","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.3390\/biom5031563","article-title":"Roles of Chemokines and Chemokine Receptors in Obesity-Associated Insulin Resistance and Nonalcoholic Fatty Liver Disease","volume":"5","author":"Xu","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.immuni.2021.12.013_bib395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2050-7771-2-1","article-title":"Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases","volume":"2","author":"Yang","year":"2014","journal-title":"Biomark. Res."},{"key":"10.1016\/j.immuni.2021.12.013_bib396","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1046\/j.1471-4159.2000.0741017.x","article-title":"Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia","volume":"74","author":"Yates","year":"2000","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.immuni.2021.12.013_bib397","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1365-2362.2004.01390.x","article-title":"Improvement of insulin sensitivity in insulin resistant subjects during prolonged treatment with the anti-TNF-alpha antibody infliximab","volume":"34","author":"Yazdani-Biuki","year":"2004","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.immuni.2021.12.013_bib398","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.2337\/dc06-0636","article-title":"Relapse of diabetes after interruption of chronic administration of anti-tumor necrosis factor-alpha antibody infliximab: a case observation","volume":"29","author":"Yazdani-Biuki","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.immuni.2021.12.013_bib399","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.cell.2017.08.035","article-title":"Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In\u00a0Vivo and In\u00a0Vitro Insulin Sensitivity","volume":"171","author":"Ying","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2021.12.013_bib400","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cmet.2018.12.003","article-title":"Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting \u03b2 Cell Proliferation and Function in Obesity","volume":"29","author":"Ying","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib401","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.cmet.2020.12.019","article-title":"MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice","volume":"33","author":"Ying","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.immuni.2021.12.013_bib402","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.12.013_bib403","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.immuni.2021.12.013_bib404","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1126\/science.1061620","article-title":"Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta","volume":"293","author":"Yuan","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.immuni.2021.12.013_bib405","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.immuni.2019.01.012","article-title":"Spatial and Temporal Mapping of Human Innate Lymphoid Cells Reveals Elements of Tissue Specificity","volume":"50","author":"Yudanin","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2021.12.013_bib406","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2337\/db16-0500","article-title":"Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice","volume":"66","author":"Zamarron","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.immuni.2021.12.013_bib407","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.3389\/fphys.2019.01607","article-title":"Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes","volume":"10","author":"Zatterale","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.immuni.2021.12.013_bib408","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-020-2101-7","article-title":"Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate","volume":"579","author":"Zhao","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2021.12.013_bib409","doi-asserted-by":"crossref","first-page":"e2167","DOI":"10.1038\/cddis.2016.54","article-title":"Local proliferation initiates macrophage accumulation in adipose tissue during obesity","volume":"7","author":"Zheng","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.immuni.2021.12.013_bib410","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ni.1831","article-title":"Thioredoxin-interacting protein links oxidative stress to inflammasome activation","volume":"11","author":"Zhou","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2021.12.013_bib411","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1056\/NEJMoa1504720","article-title":"Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes","volume":"373","author":"Zinman","year":"2015","journal-title":"N.\u00a0Engl. J. Med."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761321005495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761321005495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:11:01Z","timestamp":1778587861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761321005495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":410,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S1074761321005495"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2021.12.013","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation in obesity, diabetes, and related disorders","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2021.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}