{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:21:56Z","timestamp":1792808516505,"version":"4.5.0"},"reference-count":78,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.immuni.2022.03.018","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T11:08:25Z","timestamp":1650366505000},"page":"879-894.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":252,"title":["Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid \u03b2 plaques"],"prefix":"10.1016","volume":"55","author":[{"given":"Ethan R.","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas E.","family":"Propson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupa","family":"Kanchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Coarfa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2022.03.018_bib1","doi-asserted-by":"crossref","first-page":"17510","DOI":"10.1073\/pnas.1921324117","article-title":"Type I IFN is siloed in endosomes","volume":"117","author":"Altman","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2022.03.018_bib2","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.pnpbp.2005.03.006","article-title":"Interferon-induced depression: strategies in treatment","volume":"29","author":"Asnis","year":"2005","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.immuni.2022.03.018_bib3","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1002\/glia.23074","article-title":"Microglia contributes to plaque growth by cell death due to uptake of amyloid beta in the brain of Alzheimer's disease mouse model","volume":"64","author":"Baik","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.immuni.2022.03.018_bib4","doi-asserted-by":"crossref","first-page":"D1228","DOI":"10.1093\/nar\/gks1147","article-title":"InnateDB: systems biology of innate immunity and beyond--recent updates and continuing curation","volume":"41","author":"Breuer","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2022.03.018_bib5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.neuron.2020.08.002","article-title":"Sensory experience engages microglia to shape neural connectivity through a non-phagocytic mechanism","volume":"108","author":"Cheadle","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2022.03.018_bib6","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.cell.2020.06.038","article-title":"Spatial transcriptomics and in situ sequencing to study Alzheimer's disease","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2022.03.018_bib7","doi-asserted-by":"crossref","first-page":"9373","DOI":"10.1073\/pnas.0903487106","article-title":"Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes","volume":"106","author":"Cheon","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2022.03.018_bib8","doi-asserted-by":"crossref","first-page":"35581","DOI":"10.18632\/oncotarget.26272","article-title":"Nasal administration of mesenchymal stem cells restores cisplatin-induced cognitive impairment and brain damage in mice","volume":"9","author":"Chiu","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.immuni.2022.03.018_bib9","doi-asserted-by":"crossref","first-page":"13945","DOI":"10.1523\/JNEUROSCI.0704-12.2012","article-title":"Hypoxia\/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1","volume":"32","author":"Chiu","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.immuni.2022.03.018_bib10","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1158\/0008-5472.CAN-16-1817","article-title":"Pifithrin-mu prevents cisplatin-induced chemobrain by preserving neuronal mitochondrial function","volume":"77","author":"Chiu","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.immuni.2022.03.018_bib11","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nm.3108","article-title":"Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses","volume":"19","author":"Cho","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2022.03.018_bib12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbrc.2009.06.006","article-title":"Constitutive JAK2\/STAT1 activation regulates endogenous BACE1 expression in neurons","volume":"386","author":"Cho","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.immuni.2022.03.018_bib13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/glia.20451","article-title":"IFN-gamma-induced BACE1 expression is mediated by activation of JAK2 and ERK1\/2 signaling pathways and direct binding of STAT1 to BACE1 promoter in astrocytes","volume":"55","author":"Cho","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.immuni.2022.03.018_bib14","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature12776","article-title":"Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways","volume":"504","author":"Chung","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2022.03.018_bib15","doi-asserted-by":"crossref","first-page":"102919","DOI":"10.1016\/j.ebiom.2020.102919","article-title":"Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain","volume":"58","author":"Crapser","year":"2020","journal-title":"EBiomedicine"},{"key":"10.1016\/j.immuni.2022.03.018_bib16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2015.12.056","article-title":"The cellular phase of Alzheimer's disease","volume":"164","author":"De Strooper","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2022.03.018_bib17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41593-021-00951-0","article-title":"Microglia contribute to the propagation of Abeta into unaffected brain tissue","volume":"25","author":"d'Errico","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2022.03.018_bib18","doi-asserted-by":"crossref","first-page":"12887","DOI":"10.1523\/JNEUROSCI.2107-13.2013","article-title":"Antisense reduction of tau in adult mice protects against seizures","volume":"33","author":"Devos","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.immuni.2022.03.018_bib19","article-title":"Direct intraventricular delivery of drugs to the rodent central nervous system","volume":"75","author":"Devos","year":"2013","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.immuni.2022.03.018_bib20","doi-asserted-by":"crossref","first-page":"14550","DOI":"10.1073\/pnas.1206923109","article-title":"Nucleic acid-containing amyloid fibrils potently induce type I interferon and stimulate systemic autoimmunity","volume":"109","author":"Di Domizio","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2022.03.018_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bbi.2015.12.011","article-title":"Interferon-alpha acutely impairs whole-brain functional connectivity network architecture\u2014a preliminary study","volume":"58","author":"Dipasquale","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.immuni.2022.03.018_bib22","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2015.08.069","article-title":"Lack of neuronal IFN-beta-IFNAR causes Lewy body- and Parkinson's disease-like dementia","volume":"163","author":"Ejlerskov","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2022.03.018_bib23","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.immuni.2018.04.016","article-title":"The microglial innate immune receptor TREM2 is required for synapse elimination and normal brain connectivity","volume":"48","author":"Filipello","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2022.03.018_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cytogfr.2012.01.001","article-title":"Interferon-alpha (IFNalpha) neurotoxicity","volume":"23","author":"Fritz-French","year":"2012","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.immuni.2022.03.018_bib25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.immuni.2018.11.004","article-title":"Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes","volume":"50","author":"Hammond","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2022.03.018_bib26","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/s41593-021-00905-6","article-title":"Neuroinflammatory astrocyte subtypes in the mouse brain","volume":"24","author":"Hasel","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2022.03.018_bib27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bbi.2012.07.023","article-title":"Central administration of murine interferon-alpha induces depressive-like behavioral, brain cytokine and neurochemical alterations in mice: a mini-review and original experiments","volume":"31","author":"Hayley","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.immuni.2022.03.018_bib28","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.immuni.2022.03.018_bib29","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/npp.2013.263","article-title":"STAT1 negatively regulates spatial memory formation and mediates the memory-impairing effect of Abeta","volume":"39","author":"Hsu","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.immuni.2022.03.018_bib30","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/nn.4587","article-title":"A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease","volume":"20","author":"Huang","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2022.03.018_bib31","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41590-021-00913-5","article-title":"Microglia use TAM receptors to detect and engulf amyloid beta plaques","volume":"22","author":"Huang","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2022.03.018_bib32","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41586-020-2681-2","article-title":"The innate immunity protein IFITM3 modulates gamma-secretase in Alzheimer's disease","volume":"586","author":"Hur","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2022.03.018_bib33","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer's disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2022.03.018_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.immuni.2022.03.018_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1750-1326-6-63","article-title":"Alzheimer's disease: synapses gone cold","volume":"6","author":"Koffie","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.immuni.2022.03.018_bib36","doi-asserted-by":"crossref","first-page":"559342","DOI":"10.3389\/fimmu.2020.559342","article-title":"Triggering receptor expressed on myeloid Cell 2 R47H exacerbates immune response in Alzheimer's disease brain","volume":"11","author":"Korvatska","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2022.03.018_bib37","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","article-title":"The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases","volume":"47","author":"Krasemann","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2022.03.018_bib38","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41577-019-0167-y","article-title":"How macrophages deal with death","volume":"19","author":"Lemke","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2022.03.018_bib39","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019104136","article-title":"A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding","volume":"39","author":"Li","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.immuni.2022.03.018_bib40","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1002\/glia.23460","article-title":"Microglia have a more extensive and divergent response to interferon-alpha compared with astrocytes","volume":"66","author":"Li","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.immuni.2022.03.018_bib41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neuron.2014.11.018","article-title":"NFkappaB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease","volume":"85","author":"Lian","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2022.03.018_bib42","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2022.03.018_bib43","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.eurpsy.2004.09.030","article-title":"Cognitive impairment in patients with chronic hepatitis treated with interferon alpha (IFNalpha): results from a prospective study","volume":"21","author":"Lieb","year":"2006","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.immuni.2022.03.018_bib44","doi-asserted-by":"crossref","first-page":"e293","DOI":"10.1038\/tp.2013.69","article-title":"CSF protein biomarkers predicting longitudinal reduction of CSF beta-amyloid42 in cognitively healthy elders","volume":"3","author":"Mattsson","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.immuni.2022.03.018_bib45","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s40478-016-0341-4","article-title":"Deletion of the type-1 interferon receptor in APPSWE\/PS1DeltaE9 mice preserves cognitive function and alters glial phenotype","volume":"4","author":"Minter","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.immuni.2022.03.018_bib46","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.immuni.2022.03.018_bib47","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1038\/s41467-020-19737-2","article-title":"Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease","volume":"11","author":"Olah","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2022.03.018_bib48","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12974-022-02397-y","article-title":"Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP\/PS1 model of Alzheimer's disease","volume":"19","author":"Owlett","year":"2022","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.immuni.2022.03.018_bib49","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","article-title":"Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor","volume":"155","author":"Parkhurst","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2022.03.018_bib50","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105924","article-title":"Please eat (only part) of me: synaptic phosphatidylserine cues microglia to feast: two new studies identify how a common apoptotic cell flag is used to sculpt neural circuits","volume":"39","author":"Peet","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.immuni.2022.03.018_bib79","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1523\/JNEUROSCI.1065-09.2009","article-title":"Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology","volume":"29","author":"Polydoro","year":"2009","journal-title":"J Neurosci."},{"key":"10.1016\/j.immuni.2022.03.018_bib52","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-immunol-093019-110159","article-title":"Microglia and central nervous system-associated macrophages-from origin to disease modulation","volume":"39","author":"Prinz","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.immuni.2022.03.018_bib53","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140966","article-title":"Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging","volume":"131","author":"Propson","year":"2021","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2022.03.018_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008549","article-title":"Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs","volume":"16","author":"Ramdhani","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.immuni.2022.03.018_bib55","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/s41593-020-00728-x","article-title":"Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease","volume":"23","author":"Richetin","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2022.03.018_bib56","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1172\/JCI133737","article-title":"Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease","volume":"130","author":"Roy","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2022.03.018_bib57","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00401-016-1558-9","article-title":"Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Abeta generation in Alzheimer's disease","volume":"132","author":"Sadleir","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2022.03.018_bib58","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3233\/JAD-160599","article-title":"Growth arrest Specific 6 concentration is increased in the cerebrospinal fluid of patients with Alzheimer's disease","volume":"55","author":"Sainaghi","year":"2017","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.immuni.2022.03.018_bib59","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.celrep.2019.03.099","article-title":"The major risk factors for Alzheimer's disease: age, sex, and genes modulate the microglia response to Abeta plaques","volume":"27","author":"Sala Frigerio","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2022.03.018_bib60","doi-asserted-by":"crossref","first-page":"fcz022","DOI":"10.1093\/braincomms\/fcz022","article-title":"Genetic variability in response to amyloid beta deposition influences Alzheimer's disease risk","volume":"1","author":"Salih","year":"2019","journal-title":"Brain Commun."},{"key":"10.1016\/j.immuni.2022.03.018_bib61","article-title":"Implantation of miniosmotic pumps and delivery of tract tracers to study brain reorganization in pathophysiological conditions","volume":"107","author":"Sanchez-Mendoza","year":"2016","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.immuni.2022.03.018_bib62","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00401-011-0896-x","article-title":"Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus","volume":"123","author":"Sanchez-Varo","year":"2012","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.immuni.2022.03.018_bib63","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105380","article-title":"Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia","volume":"39","author":"Scott-Hewitt","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.immuni.2022.03.018_bib64","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54083","article-title":"Fibrillar Abeta triggers microglial proteome alterations and dysfunction in Alzheimer mouse models","volume":"9","author":"Sebastian Monasor","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.immuni.2022.03.018_bib65","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf6295","article-title":"Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP\/PS1 mice","volume":"9","author":"Shi","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2022.03.018_bib66","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1038\/s41467-019-11674-z","article-title":"Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model","volume":"10","author":"Spangenberg","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2022.03.018_bib67","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.121109","article-title":"Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer's disease","volume":"3","author":"Swartzlander","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.immuni.2022.03.018_bib68","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/emboj.2010.290","article-title":"Novel role and mechanism of protein inhibitor of activated STAT1 in spatial learning","volume":"30","author":"Tai","year":"2011","journal-title":"EMBO J."},{"issue":"Suppl. 1","key":"10.1016\/j.immuni.2022.03.018_bib69","first-page":"39","article-title":"Mood and cognitive side effects of interferon-alpha therapy","volume":"25","author":"Valentine","year":"1998","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.immuni.2022.03.018_bib70","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature25158","article-title":"Microglia-derived ASC specks cross-seed amyloid-beta in Alzheimer's disease","volume":"552","author":"Venegas","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2022.03.018_bib71","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbi.2015.09.016","article-title":"Microglia activation is associated with IFN-alpha induced depressive-like behavior","volume":"55","author":"Wachholz","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.immuni.2022.03.018_bib72","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev-neuro-070918-050306","article-title":"Neuron-glia signaling in synapse elimination","volume":"42","author":"Wilton","year":"2019","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.immuni.2022.03.018_bib73","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.celrep.2019.07.060","article-title":"Complement C3 is activated in human AD brain and is required for neurodegeneration in mouse models of amyloidosis and Tauopathy","volume":"28","author":"Wu","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2022.03.018_bib74","doi-asserted-by":"crossref","first-page":"8760","DOI":"10.1073\/pnas.132045399","article-title":"The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms","volume":"99","author":"Xia","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2022.03.018_bib75","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.neuron.2021.03.006","article-title":"An activity-dependent determinant of synapse elimination in the mammalian brain","volume":"109","author":"Yasuda","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2022.03.018_bib76","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2013.03.030","article-title":"Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease","volume":"153","author":"Zhang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2022.03.018_bib77","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.stemcr.2014.05.015","article-title":"Mechanisms for interferon-alpha-induced depression and neural stem cell dysfunction","volume":"3","author":"Zheng","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.immuni.2022.03.018_bib78","doi-asserted-by":"crossref","first-page":"W234","DOI":"10.1093\/nar\/gkz240","article-title":"NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis","volume":"47","author":"Zhou","year":"2019","journal-title":"Nucleic Acids Res."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761322001418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761322001418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:18:39Z","timestamp":1761034719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761322001418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":78,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S1074761322001418"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2022.03.018","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid \u03b2 plaques","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2022.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}