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Rheum. Dis."},{"key":"10.1016\/j.immuni.2022.11.009_bib93","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.celrep.2014.09.032","article-title":"Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice","volume":"9","author":"Misharin","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2022.11.009_bib94","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41467-018-02892-y","article-title":"Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis","volume":"9","author":"Mizoguchi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2022.11.009_bib95","first-page":"1607","article-title":"Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice","volume":"149","author":"M\u00fcller-Ladner","year":"1996","journal-title":"Am. J. 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Rep."},{"key":"10.1016\/j.immuni.2022.11.009_bib114","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nrrheum.2017.132","article-title":"The case for periodontitis in the pathogenesis of rheumatoid arthritis","volume":"13","author":"Potempa","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.immuni.2022.11.009_bib115","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S2665-9913(21)00061-8","article-title":"Targeting synovial fibroblasts proliferation in rheumatoid arthritis (TRAFIC): an open-label, dose finding, phase 1b trial","volume":"3","author":"Pratt","year":"2021","journal-title":"Lancet. Rheumatol."},{"key":"10.1016\/j.immuni.2022.11.009_bib116","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/eji.201646477","article-title":"Lactate at the crossroads of metabolism, inflammation, and autoimmunity","volume":"47","author":"Pucino","year":"2017","journal-title":"Eur. J. 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Invest."},{"key":"10.1016\/j.immuni.2022.11.009_bib127","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/s41591-022-01789-0","article-title":"Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial","volume":"28","author":"Rivellese","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2022.11.009_bib128","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1136\/annrheumdis-2013-203565","article-title":"Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis","volume":"74","author":"Rombouts","year":"2013","journal-title":"Ann. Rheum. 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