{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:57:16Z","timestamp":1793365036416,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.immuni.2023.01.013","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T12:52:20Z","timestamp":1676379140000},"page":"420-432.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230"],"prefix":"10.1016","volume":"56","author":[{"given":"Danton","family":"Ivanochko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Fabra-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Teelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marga","family":"van de Vegte-Bolmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert-Jan","family":"van Gemert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Semesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marloes","family":"de Bruijni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Bolscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordache","family":"Ramjith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Szabat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherie","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shwu-Maan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses R.","family":"Kamya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret E.","family":"Feeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna","family":"Jagannathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Greenhouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Sauerwein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Richter King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall S.","family":"MacGill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teun","family":"Bousema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs M.","family":"Jore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7602-3995","authenticated-orcid":false,"given":"Jean-Philippe","family":"Julien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2023.01.013_bib1","doi-asserted-by":"crossref","first-page":"e1003377","DOI":"10.1371\/journal.pmed.1003377","article-title":"Estimated impact of RTS,S\/AS01 malaria vaccine allocation strategies in sub-Saharan Africa: a modelling study","volume":"17","author":"Hogan","year":"2020","journal-title":"PLoS Med."},{"key":"10.1016\/j.immuni.2023.01.013_bib2","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa2026330","article-title":"Seasonal malaria vaccination with or without seasonal malaria chemoprevention","volume":"385","author":"Chandramohan","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2023.01.013_bib3","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(21)00943-0","article-title":"Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial","volume":"397","author":"Datoo","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.immuni.2023.01.013_bib4","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1056\/NEJMoa1505819","article-title":"Genetic diversity and protective efficacy of the RTS,S\/AS01 malaria vaccine","volume":"373","author":"Neafsey","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2023.01.013_bib5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.chom.2018.06.008","article-title":"Malaria vaccines: recent advances and new horizons","volume":"24","author":"Draper","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2023.01.013_bib6","doi-asserted-by":"crossref","first-page":"e1000406","DOI":"10.1371\/journal.pmed.1000406","article-title":"A research agenda to underpin malaria eradication","volume":"8","author":"Alonso","year":"2011","journal-title":"PLoS Med."},{"key":"10.1016\/j.immuni.2023.01.013_bib7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/14760584.2021.1878028","article-title":"Transmission-blocking vaccines: harnessing herd immunity for malaria elimination","volume":"20","author":"Duffy","year":"2021","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/j.immuni.2023.01.013_bib8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/263057a0","article-title":"Malaria transmission blocked by immunisation with gametes of the malaria parasite","volume":"263","author":"Carter","year":"1976","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.01.013_bib9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41541-020-0196-3","article-title":"Malaria vaccines since 2000: progress, priorities, products","volume":"5","author":"Duffy","year":"2020","journal-title":"npj Vaccines"},{"key":"10.1016\/j.immuni.2023.01.013_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41541-021-00366-9","article-title":"Monoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes","volume":"6","author":"de Jong","year":"2021","journal-title":"npj Vaccines"},{"key":"10.1016\/j.immuni.2023.01.013_bib11","doi-asserted-by":"crossref","first-page":"13598","DOI":"10.1073\/pnas.0502378102","article-title":"Structural models for the protein family characterized by gamete surface protein Pfs230 of Plasmodium falciparum","volume":"102","author":"Gerloff","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2023.01.013_bib12","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/j.1365-2958.2006.05284.x","article-title":"Malaria transmission-blocking antigen, Pfs230, mediates human red blood cell binding to exflagellating male parasites and oocyst production","volume":"61","author":"Eksi","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.immuni.2023.01.013_bib13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41541-021-00423-3","article-title":"Elucidating functional epitopes within the N-terminal region of malaria transmission blocking vaccine antigen Pfs230","volume":"7","author":"Miura","year":"2022","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.immuni.2023.01.013_bib14","doi-asserted-by":"crossref","first-page":"19913","DOI":"10.1074\/jbc.M116.732305","article-title":"Structural and immunological characterization of recombinant 6-cysteine domains of the Plasmodium falciparum sexual stage protein Pfs230","volume":"291","author":"MacDonald","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2023.01.013_bib16","doi-asserted-by":"crossref","first-page":"5762","DOI":"10.1016\/j.vaccine.2018.09.037","article-title":"Assessment of the impact of manufacturing changes on the physicochemical properties of the recombinant vaccine carrier ExoProtein A","volume":"37","author":"Burkhardt","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/j.immuni.2023.01.013_bib15","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.immuni.2023.01.013_bib17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/s42003-020-01123-9","article-title":"Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48\/45 proteins","volume":"3","author":"Singh","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.immuni.2023.01.013_bib18","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1038\/s41467-021-21955-1","article-title":"A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes","volume":"12","author":"Coelho","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2023.01.013_bib19","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.4049\/jimmunol.139.12.4213","article-title":"The 230-kDa gamete surface protein of Plasmodium falciparum is also a target for transmission-blocking antibodies","volume":"139","author":"Quakyi","year":"1987","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2023.01.013_bib20","doi-asserted-by":"crossref","first-page":"e146221","DOI":"10.1172\/JCI146221","article-title":"Pfs230 yields higher malaria transmission-blocking vaccine activity than Pfs25 in humans but not mice","volume":"131","author":"Healy","year":"2021","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.immuni.2023.01.013_bib21","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41467-017-02646-2","article-title":"Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity","volume":"9","author":"Stone","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2023.01.013_bib22","doi-asserted-by":"crossref","first-page":"903","DOI":"10.4269\/ajtmh.14-0312","article-title":"Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control","volume":"92","author":"Kamya","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.immuni.2023.01.013_bib23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pep.2019.04.001","article-title":"Expression and purification optimization of an N-terminal Pfs230 transmission-blocking vaccine candidate","volume":"160","author":"Lee","year":"2019","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.immuni.2023.01.013_bib24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1128\/iai.63.2.467-471.1995","article-title":"Transmission blockade of Plasmodium falciparum malaria by anti-Pfs230-specific antibodies is isotype dependent","volume":"63","author":"Roeffen","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.immuni.2023.01.013_bib25","doi-asserted-by":"crossref","first-page":"42","DOI":"10.12688\/wellcomeopenres.16168.1","article-title":"An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples","volume":"6","author":"MalariaGEN","year":"2021","journal-title":"Wellcome Open Res."},{"key":"10.1016\/j.immuni.2023.01.013_bib26","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/prot.25291","article-title":"The H3 loop of antibodies shows unique structural characteristics","volume":"85","author":"Regep","year":"2017","journal-title":"Proteins"},{"key":"10.1016\/j.immuni.2023.01.013_bib27","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1126\/science.abj8754","article-title":"Accurate prediction of protein structures and interactions using a three-track neural network","volume":"373","author":"Baek","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.01.013_bib28","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.01.013_bib29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER Suite: protein structure and function prediction","volume":"12","author":"Yang","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2023.01.013_bib30","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s42256-021-00348-5","article-title":"Improved protein structure prediction by deep learning irrespective of co-evolution information","volume":"3","author":"Xu","year":"2021","journal-title":"Nat. Mach. Intell."},{"key":"10.1016\/j.immuni.2023.01.013_bib31","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1126\/science.abb8008","article-title":"Binding mechanisms of therapeutic antibodies to human CD20","volume":"369","author":"Kumar","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.01.013_bib32","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.aaz9356","article-title":"Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab","volume":"367","author":"Roug\u00e9","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.01.013_bib33","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1126\/science.1243283","article-title":"Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus","volume":"342","author":"McLellan","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.01.013_bib34","doi-asserted-by":"crossref","first-page":"E7348","DOI":"10.1073\/pnas.1707304114","article-title":"Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen","volume":"114","author":"Pallesen","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2023.01.013_bib35","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.abb2507","article-title":"Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation","volume":"367","author":"Wrapp","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.01.013_bib36","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1073\/pnas.1217537110","article-title":"Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9","volume":"110","author":"Julien","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2023.01.013_bib37","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature10696","article-title":"Structure of HIV-1 gp120 V1\/V2 domain with broadly neutralizing antibody PG9","volume":"480","author":"McLellan","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.01.013_bib38","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1126\/science.1192819","article-title":"Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01","volume":"329","author":"Zhou","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.01.013_bib39","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1126\/science.1207227","article-title":"Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding","volume":"333","author":"Scheid","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.01.013_bib40","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.immuni.2014.04.008","article-title":"Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers","volume":"40","author":"Blattner","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2023.01.013_bib41","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nsmb.2594","article-title":"Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120","volume":"20","author":"Kong","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.immuni.2023.01.013_bib42","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1038\/nm.2985","article-title":"Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape","volume":"18","author":"Moore","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.immuni.2023.01.013_bib43","doi-asserted-by":"crossref","first-page":"aac4223","DOI":"10.1126\/science.aac4223","article-title":"HIV-1 vaccines. HIV-1 neutralizing antibodies induced by native-like envelope trimers","volume":"349","author":"Sanders","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.01.013_bib44","doi-asserted-by":"crossref","first-page":"eabh2791","DOI":"10.1126\/sciadv.abh2791","article-title":"Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization","volume":"7","author":"Turner","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.immuni.2023.01.013_bib45","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1128\/JVI.02380-15","article-title":"Immunogenicity of a prefusion HIV-1 envelope trimer in complex with a quaternary-structure-specific antibody","volume":"90","author":"Cheng","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.immuni.2023.01.013_bib46","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.immuni.2017.05.007","article-title":"Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches","volume":"46","author":"Pauthner","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2023.01.013_bib47","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.immuni.2018.07.009","article-title":"Electron-microscopy-based epitope mapping defines specificities of polyclonal antibodies elicited during HIV-1 BG505 envelope trimer immunization","volume":"49","author":"Bianchi","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2023.01.013_bib48","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1038\/s41467-017-01549-6","article-title":"Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding","volume":"8","author":"Kulp","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2023.01.013_bib49","doi-asserted-by":"crossref","first-page":"e00677-17","DOI":"10.1128\/JVI.00677-17","article-title":"Reducing V3 antigenicity and immunogenicity on soluble, native-like HIV-1 env SOSIP trimers","volume":"91","author":"Ringe","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.immuni.2023.01.013_bib50","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.celrep.2019.06.074","article-title":"Multimeric epitope-scaffold HIV vaccines target V1V2 and differentially tune polyfunctional antibody responses","volume":"28","author":"Hessell","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2023.01.013_bib51","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1128\/JVI.02608-13","article-title":"Guiding the immune response against influenza virus hemagglutinin toward the conserved stalk domain by hyperglycosylation of the globular head domain","volume":"88","author":"Eggink","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.immuni.2023.01.013_bib52","doi-asserted-by":"crossref","first-page":"eaay5051","DOI":"10.1126\/science.aay5051","article-title":"De novo protein design enables the precise induction of RSV-neutralizing antibodies","volume":"368","author":"Sesterhenn","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.01.013_bib53","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature12966","article-title":"Proof of principle for epitope-focused vaccine design","volume":"507","author":"Correia","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.01.013_bib54","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41541-021-00407-3","article-title":"Malaria transmission-blocking conjugate vaccine in ALFQ adjuvant induces durable functional immune responses in rhesus macaques","volume":"6","author":"Scaria","year":"2021","journal-title":"npj Vaccines"},{"key":"10.1016\/j.immuni.2023.01.013_bib55","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/333074a0","article-title":"A vaccine candidate from the sexual stage of human malaria that contains EGF-like domains","volume":"333","author":"Kaslow","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.01.013_bib56","doi-asserted-by":"crossref","first-page":"770821","DOI":"10.3389\/fcimb.2021.770821","article-title":"Profiling the quality and quantity of naturally induced antibody responses against Pfs230 and Pfs48\/45 among non-febrile children living in Southern Ghana: a longitudinal study","volume":"11","author":"Broni","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.immuni.2023.01.013_bib57","doi-asserted-by":"crossref","first-page":"21380","DOI":"10.1038\/s41598-021-00973-5","article-title":"Persistent Plasmodium falciparum infections enhance transmission-reducing immunity development","volume":"11","author":"Ayanful-Torgby","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.immuni.2023.01.013_bib58","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1038\/s41467-018-06742-9","article-title":"Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48\/45","volume":"9","author":"Kundu","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2023.01.013_bib59","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.1038\/s41467-019-11980-6","article-title":"Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25","volume":"10","author":"McLeod","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2023.01.013_bib60","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/s41467-021-21221-4","article-title":"Structural and biophysical correlation of anti-NANP antibodies with in\u00a0vivo protection against P. falciparum","volume":"12","author":"Pholcharee","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2023.01.013_bib61","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.3389\/fimmu.2019.01256","article-title":"Pfs230 and Pfs48\/45 fusion proteins elicit strong transmission-blocking antibody responses against Plasmodium falciparum","volume":"10","author":"Singh","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2023.01.013_bib62","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1017\/S0031182000062065","article-title":"Infectivity of cultured Plasmodium falciparum gametocytes to mosquitoes","volume":"98","author":"Ponnudurai","year":"1989","journal-title":"Parasitology"},{"key":"10.1016\/j.immuni.2023.01.013_bib63","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"Phenix: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.immuni.2023.01.013_bib64","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1107\/S0907444913000061","article-title":"How good are my data and what is the resolution?","volume":"69","author":"Evans","year":"2013","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.immuni.2023.01.013_bib65","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","article-title":"XDS","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.immuni.2023.01.013_bib66","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.immuni.2023.01.013_bib67","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1093\/bioinformatics\/btr509","article-title":"A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data","volume":"27","author":"Li","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2023.01.013_bib68","doi-asserted-by":"crossref","first-page":"eabf1906","DOI":"10.1126\/scitranslmed.abf1906","article-title":"The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates","volume":"13","author":"Jones","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2023.01.013_bib69","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1084\/jem.162.5.1460","article-title":"Sequential expression of antigens on sexual stages of Plasmodium falciparum accessible to transmission-blocking antibodies in the mosquito","volume":"162","author":"Vermeulen","year":"1985","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2023.01.013_bib70","doi-asserted-by":"crossref","first-page":"18704","DOI":"10.1038\/srep18704","article-title":"A semi-automated luminescence based standard membrane feeding assay identifies novel small molecules that inhibit transmission of malaria parasites by mosquitoes","volume":"5","author":"Vos","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.immuni.2023.01.013_bib71","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s12936-019-2989-2","article-title":"The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate","volume":"18","author":"Lee","year":"2019","journal-title":"Malar. J."},{"key":"10.1016\/j.immuni.2023.01.013_bib72","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.immuni.2023.01.013_bib73","doi-asserted-by":"crossref","first-page":"e01456","DOI":"10.7554\/eLife.01456","article-title":"Collaboration gets the most out of software","volume":"2","author":"Morin","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.immuni.2023.01.013_bib74","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.immuni.2022.07.015","article-title":"Vaccination with a structure-based stabilized version of malarial antigen Pfs48\/45 elicits ultra-potent transmission-blocking antibody responses","volume":"55","author":"McLeod","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2023.01.013_bib75","doi-asserted-by":"crossref","first-page":"909060","DOI":"10.3389\/fimmu.2022.909060","article-title":"Heterologous expression and evaluation of novel Plasmodium falciparum transmission blocking vaccine candidates","volume":"13","author":"de Jong","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2023.01.013_bib76","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/S1473-3099(22)00428-5","article-title":"Safety, tolerability, and Plasmodium falciparum transmission-reducing activity of monoclonal antibody TB31F: a single-centre, open-label, first-in-human, dose-escalation, phase 1 trial in healthy malaria-naive adults","volume":"22","author":"van der Boor","year":"2022","journal-title":"Lancet Infect. Dis."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761323000237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761323000237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:19:29Z","timestamp":1761034769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761323000237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S1074761323000237"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2023.01.013","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2023.01.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}