{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:48:50Z","timestamp":1789753730196,"version":"4.0.1"},"reference-count":92,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Gates Foundation","doi-asserted-by":"publisher","award":["INV019355"],"award-info":[{"award-number":["INV019355"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI141707"],"award-info":[{"award-number":["R01AI141707"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["75N93021C00014"],"award-info":[{"award-number":["75N93021C00014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["0258-A709-4609"],"award-info":[{"award-number":["0258-A709-4609"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.immuni.2023.09.003","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T10:35:41Z","timestamp":1695983741000},"page":"2442-2455.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking"],"prefix":"10.1016","volume":"56","author":[{"given":"Lihong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan G.","family":"Casner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Iketani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper Fuk-Woo.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadeta","family":"Dadonaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj S.","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mohri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eswar R.","family":"Reddem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuofeng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Kwok-Man","family":"Poon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris Chung-Sing","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok-Yung","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhang","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoxing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse D.","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1627-149X","authenticated-orcid":false,"given":"David D.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2023.09.003_bib1","series-title":"WHO coronavirus (COVID-19) dashboard","year":"2023"},{"key":"10.1016\/j.immuni.2023.09.003_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/v12050526","article-title":"SARS-CoV-2\/COVID-19: viral genomics, epidemiology, vaccines, and therapeutic interventions","volume":"12","author":"Uddin","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.immuni.2023.09.003_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2021.100794","article-title":"An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment","volume":"59","author":"Dro\u017cd\u017cal","year":"2021","journal-title":"Drug Resist. Updat."},{"key":"10.1016\/j.immuni.2023.09.003_bib4","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-021-06222-4","article-title":"Modes of transmission of SARS-CoV-2 and evidence for preventive behavioral interventions","volume":"21","author":"Zhou","year":"2021","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.immuni.2023.09.003_bib5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41577-022-00725-0","article-title":"SARS-CoV-2: from herd immunity to hybrid immunity","volume":"22","author":"Goldblatt","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.immuni.2023.09.003_bib6","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1473-3099(22)00143-8","article-title":"Risk of SARS-CoV-2 reinfection and COVID-19 hospitalisation in individuals with natural and hybrid immunity: a retrospective, total population cohort study in Sweden","volume":"22","author":"Nordstr\u00f6m","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.immuni.2023.09.003_bib7","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1056\/NEJMoa2119451","article-title":"Covid-19 vaccine effectiveness against the omicron (B.1.1.529) variant","volume":"386","author":"Andrews","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2023.09.003_bib8","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0140-6736(21)00675-9","article-title":"SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN)","volume":"397","author":"Hall","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.immuni.2023.09.003_bib9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cell.2022.12.018","article-title":"Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants","volume":"186","author":"Wang","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2023.09.003_bib10","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.chom.2022.09.002","article-title":"Antigenic characterization of the SARS-CoV-2 Omicron subvariant BA.2.75","volume":"30","author":"Wang","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2023.09.003_bib11","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/s41586-022-05053-w","article-title":"Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4 and BA.5","volume":"608","author":"Wang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib12","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41586-021-04388-0","article-title":"Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2","volume":"602","author":"Liu","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib13","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41586-022-04594-4","article-title":"Antibody evasion properties of SARS-CoV-2 Omicron sublineages","volume":"604","author":"Iketani","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41586-022-04980-y","article-title":"BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection","volume":"608","author":"Cao","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib15","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.chom.2022.09.018","article-title":"Characterization of the enhanced infectivity and antibody evasion of Omicron BA.2.75","volume":"30","author":"Cao","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2023.09.003_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/s41586-022-05644-7","article-title":"Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution","volume":"614","author":"Cao","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib17","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1056\/NEJMc2212117","article-title":"Neutralization escape by SARS-CoV-2 omicron subvariant BA.4.6","volume":"387","author":"Hachmann","year":"2022","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2023.09.003_bib18","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41586-021-04389-z","article-title":"Considerable escape of SARS-CoV-2 Omicron to antibody neutralization","volume":"602","author":"Planas","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib19","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/S1473-3099(22)00694-6","article-title":"Resistance of SARS-CoV-2 omicron subvariant BA.4.6 to antibody neutralisation","volume":"22","author":"Wang","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.immuni.2023.09.003_bib20","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S1473-3099(23)00010-5","article-title":"ACE2 binding and antibody evasion in enhanced transmissibility of XBB.1.5","volume":"23","author":"Yue","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.immuni.2023.09.003_bib21","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41586-020-2571-7","article-title":"Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike","volume":"584","author":"Liu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib22","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s41586-020-2852-1","article-title":"SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies","volume":"588","author":"Barnes","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib23","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41586-020-2456-9","article-title":"Convergent antibody responses to SARS-CoV-2 in convalescent individuals","volume":"584","author":"Robbiani","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib24","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.abc5902","article-title":"Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability","volume":"369","author":"Brouwer","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.09.003_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-36295-5","article-title":"Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients","volume":"14","author":"Rouet","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2023.09.003_bib26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/22221751.2021.2011623","article-title":"A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses","volume":"11","author":"Wang","year":"2022","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.immuni.2023.09.003_bib27","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn6859","article-title":"An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses","volume":"14","author":"Liu","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2023.09.003_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj7125","article-title":"A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice","volume":"14","author":"Martinez","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2023.09.003_bib29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41586-021-03817-4","article-title":"Broad sarbecovirus neutralization by a human monoclonal antibody","volume":"597","author":"Tortorici","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib30","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.chom.2021.03.005","article-title":"Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single Supersite","volume":"29","author":"Cerutti","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2023.09.003_bib31","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1126\/science.abc6952","article-title":"A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2","volume":"369","author":"Chi","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.09.003_bib32","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1016\/j.cell.2021.03.028","article-title":"N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2","volume":"184","author":"McCallum","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2023.09.003_bib33","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.immuni.2022.04.003","article-title":"Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins","volume":"55","author":"Wang","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2023.09.003_bib34","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.abj3321","article-title":"Broad Betacoronavirus neutralization by a stem helix-specific human antibody","volume":"373","author":"Pinto","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.09.003_bib35","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.immuni.2023.02.005","article-title":"Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease","volume":"56","author":"Zhou","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2023.09.003_bib36","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/s41586-022-04581-9","article-title":"Molecular basis of receptor binding and antibody neutralization of Omicron","volume":"604","author":"Hong","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib37","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/22221751.2021.2024455","article-title":"Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein","volume":"11","author":"Xu","year":"2022","journal-title":"Emerg. Microbes Infect."},{"key":"10.1016\/j.immuni.2023.09.003_bib38","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2220948120","article-title":"Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection","volume":"120","author":"Guenthoer","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2023.09.003_bib39","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.abd0827","article-title":"Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail","volume":"369","author":"Hansen","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.09.003_bib40","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41586-020-2548-6","article-title":"Potently neutralizing and protective human antibodies against SARS-CoV-2","volume":"584","author":"Zost","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib41","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-020-2381-y","article-title":"A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2","volume":"584","author":"Shi","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abf1906","article-title":"The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates","volume":"13","author":"Jones","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.immuni.2023.09.003_bib43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41586-020-2380-z","article-title":"Human neutralizing antibodies elicited by SARS-CoV-2 infection","volume":"584","author":"Ju","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib44","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s41586-020-2349-y","article-title":"Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody","volume":"583","author":"Pinto","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110812","article-title":"LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants","volume":"39","author":"Westendorf","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2023.09.003_bib46","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/14728222.2020.1820482","article-title":"Therapeutic antibodies and fusion inhibitors targeting the spike protein of SARS-CoV-2","volume":"25","author":"Jiang","year":"2021","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.immuni.2023.09.003_bib47","series-title":"C","author":"Wang","year":"2023"},{"key":"10.1016\/j.immuni.2023.09.003_bib48","doi-asserted-by":"crossref","first-page":"111845","DOI":"10.1016\/j.celrep.2022.111845","article-title":"Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents","volume":"41","author":"Cao","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2023.09.003_bib49","series-title":"Isolation of a pair of potent broadly neutralizing mAb binding to RBD and SD1 domains of SARS-CoV-2","author":"Stuart","year":"2023"},{"key":"10.1016\/j.immuni.2023.09.003_bib50","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41586-021-03398-2","article-title":"Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7","volume":"593","author":"Wang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib51","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.chom.2021.04.007","article-title":"Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization","volume":"29","author":"Wang","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2023.09.003_bib52","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.chom.2020.11.004","article-title":"Cryo-EM structures of SARS-CoV-2 spike without and with ACE2 reveal a pH-dependent switch to mediate endosomal positioning of receptor-binding domains","volume":"28","author":"Zhou","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.immuni.2023.09.003_bib53","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.abf2303","article-title":"Structural impact on SARS-CoV-2 spike protein by D614G substitution","volume":"372","author":"Zhang","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.09.003_bib54","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.75720","article-title":"The inherent flexibility of receptor binding domains in SARS-CoV-2 spike protein","volume":"11","author":"Dokainish","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.immuni.2023.09.003_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109928","article-title":"Neutralizing antibody 5\u20137 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain","volume":"37","author":"Cerutti","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2023.09.003_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103393","article-title":"Functional differences among the spike glycoproteins of multiple emerging severe acute respiratory syndrome coronavirus 2 variants of concern","volume":"24","author":"Wang","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.immuni.2023.09.003_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110924","article-title":"Functional properties of the spike glycoprotein of the emerging SARS-CoV-2 variant B.1.1.529","volume":"39","author":"Wang","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2023.09.003_bib58","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1016\/j.cell.2021.03.029","article-title":"Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein","volume":"184","author":"Suryadevara","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2023.09.003_bib59","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.cell.2023.02.001","article-title":"A Pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike","volume":"186","author":"Dadonaite","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2023.09.003_bib60","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/s41586-022-04466-x","article-title":"Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants","volume":"603","author":"Wang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib61","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.cell.2022.05.014","article-title":"Potent cross-reactive antibodies following Omicron breakthrough in vaccinees","volume":"185","author":"Nutalai","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2023.09.003_bib62","series-title":"Structural basis of Omicron neutralization by affinity-matured public antibodies","author":"Sheward","year":"2022"},{"key":"10.1016\/j.immuni.2023.09.003_bib63","article-title":"A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge","volume":"13","author":"Zhou","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2023.09.003_bib64","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-022-04442-5","article-title":"Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron","volume":"603","author":"Shuai","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.09.003_bib65","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.abd0826","article-title":"Structure-based design of prefusion-stabilized SARS-CoV-2 spikes","volume":"369","author":"Hsieh","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.09.003_bib66","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S1473-3099(23)00181-0","article-title":"SARS-CoV-2 neutralising antibodies after bivalent versus monovalent booster","volume":"23","author":"Wang","year":"2023","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.immuni.2023.09.003_bib67","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1126\/science.abc0870","article-title":"Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2","volume":"369","author":"Chan","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.09.003_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2016.00372","article-title":"SONAR: A high-throughput pipeline for inferring antibody ontogenies from longitudinal sequencing of B cell transcripts","volume":"7","author":"Schramm","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2023.09.003_bib69","doi-asserted-by":"crossref","first-page":"D413","DOI":"10.1093\/nar\/gku1056","article-title":"IMGT(R), the international ImMunoGeneTics information system(R) 25 years on","volume":"43","author":"Lefranc","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2023.09.003_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.immuni.2023.09.003_bib71","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","article-title":"Inference of macromolecular assemblies from crystalline state","volume":"372","author":"Krissinel","year":"2007","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.immuni.2023.09.003_bib72","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02365","article-title":"cAb-rep: A database of curated antibody repertoires for exploring antibody diversity and predicting antibody prevalence","volume":"10","author":"Guo","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.immuni.2023.09.003_bib73","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1093\/cid\/ciaa325","article-title":"Simulation of the clinical and pathological manifestations of coronavirus disease 2019 (COVID-19) in a golden Syrian hamster model: implications for disease pathogenesis and transmissibility","volume":"71","author":"Chan","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.immuni.2023.09.003_bib74","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.abn8939","article-title":"Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters","volume":"377","author":"Yuan","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.immuni.2023.09.003_bib75","doi-asserted-by":"crossref","first-page":"e00310","DOI":"10.1128\/JCM.00310-20","article-title":"Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp\/Hel real-time reverse transcription-PCR assay validated in\u00a0vitro and with clinical specimens","volume":"58","author":"Chan","year":"2020","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.immuni.2023.09.003_bib76","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/jsbi.2000.4314","article-title":"Leginon: an automated system for acquisition of images from vitreous ice specimens","volume":"132","author":"Carragher","year":"2000","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.immuni.2023.09.003_bib77","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jsb.2005.07.007","article-title":"Automated electron microscope tomography using robust prediction of specimen movements","volume":"152","author":"Mastronarde","year":"2005","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.immuni.2023.09.003_bib78","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2023.09.003_bib79","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera--a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.immuni.2023.09.003_bib80","series-title":"Protein complex prediction with AlphaFold-Multimer","author":"Evans","year":"2022"},{"key":"10.1016\/j.immuni.2023.09.003_bib81","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.immuni.2023.09.003_bib82","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1107\/S2059798318002425","article-title":"Isolde: a physically realistic environment for model building into low-resolution electron-density maps","volume":"74","author":"Croll","year":"2018","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.immuni.2023.09.003_bib83","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.immuni.2023.09.003_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059004","article-title":"A Pareto-optimal refinement method for protein design scaffolds","volume":"8","author":"Niv\u00f3n","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.immuni.2023.09.003_bib85","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/pro.2389","article-title":"Relaxation of backbone bond geometry improves protein energy landscape modeling","volume":"23","author":"Conway","year":"2014","journal-title":"Protein Sci."},{"key":"10.1016\/j.immuni.2023.09.003_bib86","doi-asserted-by":"crossref","first-page":"18949","DOI":"10.1073\/pnas.1115898108","article-title":"Algorithm discovery by protein folding game players","volume":"108","author":"Khatib","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2023.09.003_bib87","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jmb.2010.11.008","article-title":"Alternate states of proteins revealed by detailed energy landscape mapping","volume":"405","author":"Tyka","year":"2011","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.immuni.2023.09.003_bib88","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1107\/S2059798319011471","article-title":"Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix","volume":"75","author":"Liebschner","year":"2019","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.immuni.2023.09.003_bib89","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/pro.3330","article-title":"MolProbity: more and better reference data for improved all-atom structure validation","volume":"27","author":"Williams","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.immuni.2023.09.003_bib90","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2023.09.003_bib91","doi-asserted-by":"crossref","DOI":"10.3390\/v14092061","article-title":"Receptor-binding domain (RBD) antibodies contribute more to SARS-CoV-2 neutralization when target cells express high levels of ACE2","volume":"14","author":"Farrell","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.immuni.2023.09.003_bib92","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/veac110","article-title":"A biophysical model of viral escape from polyclonal antibodies","volume":"8","author":"Yu","year":"2022","journal-title":"Virus Evol."}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761323004089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761323004089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:11:17Z","timestamp":1778587877000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761323004089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":92,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1074761323004089"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2023.09.003","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2023.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}