{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:02:32Z","timestamp":1789473752386,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.immuni.2023.11.011","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T10:32:34Z","timestamp":1702377154000},"page":"2790-2802.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5429-7143","authenticated-orcid":false,"given":"C. Matthias","family":"Wilk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flurin","family":"Cathomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsolya","family":"T\u00f6r\u00f6k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Le Berichel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Bigenwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Heaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Hamon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanna","family":"Troncoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooks P.","family":"Scull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Dangoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aymeric","family":"Silvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Fleischmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Belabed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Merad Taouli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Boettcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Aubry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus G.","family":"Manz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia K.","family":"Kofler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio A.","family":"Lira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Ginhoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Crary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"McClain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Picarsic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl E.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4481-7827","authenticated-orcid":false,"given":"Miriam","family":"Merad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2023.11.011_bib1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/pbc.22326","article-title":"Neurodegenerative central nervous system Langerhans cell histiocytosis and coincident hydrocephalus treated with vincristine\/cytosine arabinoside","volume":"54","author":"Allen","year":"2010","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.immuni.2023.11.011_bib2","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1111\/bjh.15577","article-title":"Incidence and risk factors for clinical neurodegenerative Langerhans cell histiocytosis: a longitudinal cohort study","volume":"183","author":"H\u00e9ritier","year":"2018","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.immuni.2023.11.011_bib3","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/s41591-021-01304-x","article-title":"BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology","volume":"27","author":"Bigenwald","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.immuni.2023.11.011_bib4","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1056\/NEJMra1607548","article-title":"Langerhans-Cell Histiocytosis","volume":"379","author":"Allen","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2023.11.011_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26784","article-title":"Evaluation and treatment of Langerhans cell histiocytosis patients with central nervous system abnormalities: Current views and new vistas","volume":"65","author":"Yeh","year":"2018","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.immuni.2023.11.011_bib6","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/brain\/awh403","article-title":"Neuropathology of CNS disease in Langerhans cell histiocytosis","volume":"128","author":"Grois","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.immuni.2023.11.011_bib7","first-page":"S24","article-title":"Central nervous system disease in Langerhans cell histiocytosis","volume":"23","author":"Grois","year":"1994","journal-title":"Br. J. Cancer Suppl."},{"key":"10.1016\/j.immuni.2023.11.011_bib8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/pbc.20040","article-title":"Retinoic acid therapy in \u201cdegenerative-like\u201d neuro-langerhans cell histiocytosis: A prospective pilot study","volume":"43","author":"Idbaih","year":"2004","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.immuni.2023.11.011_bib9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s12185-014-1717-5","article-title":"Follow-up of pediatric patients treated by IVIG for Langerhans cell histiocytosis (LCH)-related neurodegenerative CNS disease","volume":"101","author":"Imashuku","year":"2015","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.immuni.2023.11.011_bib10","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.20130977","article-title":"BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groupsLCH: neoplasia arising from myeloid precursors","volume":"211","author":"Berres","year":"2014","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2023.11.011_bib11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1084\/jem.20161881","article-title":"RAF\/MEK\/extracellular signal\u2013related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions","volume":"215","author":"Hogstad","year":"2018","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2023.11.011_bib12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41572-021-00307-9","article-title":"Histiocytic disorders","volume":"7","author":"McClain","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.immuni.2023.11.011_bib13","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: A field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2023.11.011_bib14","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.immuni.2022.07.004","article-title":"Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration","volume":"55","author":"Silvin","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2023.11.011_bib15","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.immuni.2016.08.007","article-title":"Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals","volume":"45","author":"Sawai","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2023.11.011_bib16","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1038\/nn2015","article-title":"Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions","volume":"10","author":"Mildner","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.immuni.2023.11.011_bib17","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1002\/cncr.31348","article-title":"CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions: Hematopoietic Origin of LCH-ND","volume":"124","author":"McClain","year":"2018","journal-title":"Cancer"},{"key":"10.1016\/j.immuni.2023.11.011_bib18","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1158\/2159-8290.CD-15-0913","article-title":"Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms","volume":"6","author":"Diamond","year":"2016","journal-title":"Cancer Discov."},{"key":"10.1016\/j.immuni.2023.11.011_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41586-020-2134-y","article-title":"A conserved dendritic-cell regulatory program limits antitumour immunity","volume":"580","author":"Maier","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.11.011_bib20","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-021-03651-8","article-title":"Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells","volume":"595","author":"Casanova-Acebes","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.11.011_bib21","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1182\/blood-2017-03-771873","article-title":"Targeted therapies in 54 patients with Erdheim-Chester disease, including follow-up after interruption (the LOVE study)","volume":"130","author":"Cohen Aubart","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2023.11.011_bib22","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1182\/blood-2018-10-878363","article-title":"Clinical responses and persistent BRAF V600E+ blood cells in children with LCH treated with MAPK pathway inhibition","volume":"133","author":"Eckstein","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2023.11.011_bib23","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature23672","article-title":"A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease","volume":"549","author":"Mass","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2023.11.011_bib24","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1084\/jem.2013097701202015c","article-title":"BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups","volume":"212","author":"Berres","year":"2015","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2023.11.011_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2016.03.010","article-title":"The blood-brain barrier in systemic inflammation","volume":"60","author":"Varatharaj","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.immuni.2023.11.011_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.661838","article-title":"Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction","volume":"15","author":"Takata","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.immuni.2023.11.011_bib27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fneur.2013.00032","article-title":"Matrix Metalloproteinases and Blood-Brain Barrier Disruption in Acute Ischemic Stroke","volume":"4","author":"Lakhan","year":"2013","journal-title":"Front. Neurol."},{"key":"10.1016\/j.immuni.2023.11.011_bib28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.immuni.2017.01.007","article-title":"Dysregulation of the Cytokine GM-CSF Induces Spontaneous Phagocyte Invasion and Immunopathology in the Central Nervous System","volume":"46","author":"Spath","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2023.11.011_bib29","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1200\/JCO.19.00456","article-title":"Vemurafenib for Refractory Multisystem Langerhans Cell Histiocytosis in Children: An International Observational Study","volume":"37","author":"Donadieu","year":"2019","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.immuni.2023.11.011_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.neuron.2015.11.013","article-title":"Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse","volume":"89","author":"Zhang","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.immuni.2023.11.011_bib30","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1182\/blood-2004-08-3037","article-title":"In\u00a0vivo fate-tracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis","volume":"105","author":"G\u00f6thert","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2023.11.011_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100029","article-title":"Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry","volume":"1","author":"Liu","year":"2020","journal-title":"STAR Protoc."},{"key":"10.1016\/j.immuni.2023.11.011_bib32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nprot.2014.005","article-title":"Intravascular staining for discrimination of vascular and tissue leukocytes","volume":"9","author":"Anderson","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.immuni.2023.11.011_bib33","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1182\/blood-2016-08-732164","article-title":"CX3CR1-dependent endothelial margination modulates Ly6Chigh monocyte systemic deployment upon inflammation in mice","volume":"129","author":"Hamon","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.immuni.2023.11.011_bib35","doi-asserted-by":"crossref","first-page":"aaf6925","DOI":"10.1126\/sciimmunol.aaf6925","article-title":"In-depth tissue profiling using multiplexed immunohistochemical consecutive staining on single slide","volume":"1","author":"Remark","year":"2016","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.immuni.2023.11.011_bib36","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.cell.2016.05.007","article-title":"Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes","volume":"165","author":"Renier","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2023.11.011_bib37","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2016587118","article-title":"Pericytes regulate vascular immune homeostasis in the CNS","volume":"118","author":"T\u00f6r\u00f6k","year":"2021","journal-title":"Proc National Acad Sci"},{"key":"10.1016\/j.immuni.2023.11.011_bib38","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrn2652","article-title":"Tests to assess motor phenotype in mice: a user\u2019s guide","volume":"10","author":"Brooks","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.immuni.2023.11.011_bib39","article-title":"Low-cost Protocol of Footprint Analysis and Hanging Box Test for Mice Applied the Chronic Restraint Stress","volume":"10","author":"Sugimoto","year":"2019","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.immuni.2023.11.011_bib40","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1182\/blood.2020005867","article-title":"Overcoming T-cell exhaustion in LCH: PD-1 blockade and targeted MAPK inhibition are synergistic in a mouse model of LCH","volume":"137","author":"Sengal","year":"2021","journal-title":"Blood"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761323004934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761323004934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:22:23Z","timestamp":1761034943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761323004934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1074761323004934"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2023.11.011","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.10.10.561744","asserted-by":"object"}]},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2023.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}