{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:57:28Z","timestamp":1793156248067,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":378,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DP5 OD033360"],"award-info":[{"award-number":["DP5 OD033360"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006132","name":"Office of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006151","name":"Basic Energy Sciences","doi-asserted-by":"publisher","award":["DE-AC02-06CH11357"],"award-info":[{"award-number":["DE-AC02-06CH11357"]}],"id":[{"id":"10.13039\/100006151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunity"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.immuni.2024.04.004","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T15:40:05Z","timestamp":1714578005000},"page":"973-986.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["N4BP1 coordinates ubiquitin-dependent crosstalk within the I\u03baB kinase family to limit Toll-like receptor signaling and inflammation"],"prefix":"10.1016","volume":"57","author":[{"given":"Alexander D.","family":"Gitlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allie","family":"Maltzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzuka","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Heger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Reja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander F.","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linsey J.","family":"Wierciszewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homer","family":"Pantua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharookh B.","family":"Kapadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth F.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Webster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishva M.","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.immuni.2024.04.004_bib1","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1126\/science.abi5934","article-title":"Dying cells fan the flames of inflammation","volume":"374","author":"Newton","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.04.004_bib2","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.ajhg.2010.10.028","article-title":"Whole-exome-sequencing-based discovery of human FADD deficiency","volume":"87","author":"Bolze","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.immuni.2024.04.004_bib3","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nature01063","article-title":"Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency","volume":"419","author":"Chun","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.04.004_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1053\/j.gastro.2018.09.041","article-title":"Intestinal inflammation and dysregulated immunity in patients with inherited caspase-8 deficiency","volume":"156","author":"Lehle","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.immuni.2024.04.004_bib5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.celrep.2012.03.010","article-title":"Survival function of the FADD-caspase-8-cFLIP(L) complex","volume":"1","author":"Dillon","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.immuni.2024.04.004_bib6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature09857","article-title":"RIP3 mediates the embryonic lethality of caspase-8-deficient mice","volume":"471","author":"Kaiser","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.04.004_bib7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature09852","article-title":"Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis","volume":"471","author":"Oberst","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.04.004_bib8","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature09878","article-title":"Functional complementation between FADD and RIP1 in embryos and lymphocytes","volume":"471","author":"Zhang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.04.004_bib9","doi-asserted-by":"crossref","first-page":"982","DOI":"10.15252\/embr.201438463","article-title":"Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming","volume":"15","author":"Allam","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.immuni.2024.04.004_bib10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.immuni.2018.06.011","article-title":"Caspase-8 collaborates with caspase-11 to drive tissue damage and execution of endotoxic shock","volume":"49","author":"Mandal","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2024.04.004_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005910","article-title":"Activity of uncleaved caspase-8 controls anti-bacterial immune defense and TLR-induced cytokine production independent of cell death","volume":"12","author":"Philip","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.immuni.2024.04.004_bib12","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1073\/pnas.1403477111","article-title":"Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death","volume":"111","author":"Weng","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2024.04.004_bib13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41586-020-2796-5","article-title":"Integration of innate immune signalling by caspase-8 cleavage of N4BP1","volume":"587","author":"Gitlin","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.04.004_bib14","article-title":"N4BP1 negatively regulates NF-kappaB by binding and inhibiting NEMO oligomerization","volume":"12","author":"Shi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2024.04.004_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/imr.13023","article-title":"Regnase-1-related endoribonucleases in health and immunological diseases","volume":"304","author":"Mino","year":"2021","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2024.04.004_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-03774-w","article-title":"The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration","volume":"12","author":"Gou","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.immuni.2024.04.004_bib17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2183\/pjab.85.143","article-title":"Pathogen recognition by innate immunity and its signaling","volume":"85","author":"Akira","year":"2009","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"10.1016\/j.immuni.2024.04.004_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa2630","article-title":"Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation","volume":"347","author":"Liu","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.04.004_bib19","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1038\/s41556-018-0229-6","article-title":"TBK1 and IKKepsilon prevent TNF-induced cell death by RIPK1 phosphorylation","volume":"20","author":"Lafont","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.immuni.2024.04.004_bib20","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.cell.2018.07.041","article-title":"TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging","volume":"174","author":"Xu","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2024.04.004_bib21","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.1093\/emboj\/19.18.4976","article-title":"Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription","volume":"19","author":"Bonnard","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.immuni.2024.04.004_bib22","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1084\/jem.20040520","article-title":"The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection","volume":"199","author":"Hemmi","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2024.04.004_bib23","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1084\/jem.20040528","article-title":"Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection","volume":"199","author":"Perry","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2024.04.004_bib24","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1016\/j.cell.2021.07.026","article-title":"Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death","volume":"184","author":"Taft","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.immuni.2024.04.004_bib25","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1038\/s41564-019-0460-3","article-title":"N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation","volume":"4","author":"Yamasoba","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.immuni.2024.04.004_bib26","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/ni.1771","article-title":"TANK is a negative regulator of toll-like receptor signaling and is critical for the prevention of autoimmune nephritis","volume":"10","author":"Kawagoe","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2024.04.004_bib27","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2107742119","article-title":"Myeloid cell TBK1 restricts inflammatory responses","volume":"119","author":"Gao","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2024.04.004_bib28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1042\/BJ20101701","article-title":"Novel cross-talk within the IKK family controls innate immunity","volume":"434","author":"Clark","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.immuni.2024.04.004_bib29","doi-asserted-by":"crossref","first-page":"17093","DOI":"10.1073\/pnas.1114194108","article-title":"The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during toll-like receptor signaling","volume":"108","author":"Clark","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.immuni.2024.04.004_bib30","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/ni.2423","article-title":"The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-kappaB signaling","volume":"13","author":"Jin","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2024.04.004_bib31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1124\/jpet.104.074484","volume":"312","author":"Podolin","year":"2005","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.immuni.2024.04.004_bib32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrm3644","article-title":"Molecular control of the NEMO family of ubiquitin-binding proteins","volume":"14","author":"Clark","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.immuni.2024.04.004_bib33","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.284.5412.309","article-title":"Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation","volume":"284","author":"Delhase","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.04.004_bib34","doi-asserted-by":"crossref","first-page":"35354","DOI":"10.1074\/jbc.M806258200","article-title":"Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1","volume":"283","author":"Higashimoto","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2024.04.004_bib35","doi-asserted-by":"crossref","first-page":"15268","DOI":"10.1074\/jbc.M513793200","article-title":"Regulation of IkappaB kinase (IKK) complex by IKKgamma-dependent phosphorylation of the T-loop and C terminus of IKKbeta","volume":"281","author":"Schomer-Miller","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.immuni.2024.04.004_bib36","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.molcel.2017.01.004","article-title":"An interaction landscape of ubiquitin signaling","volume":"65","author":"Zhang","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.immuni.2024.04.004_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00872-22","article-title":"A nuclear export signal in KHNYN required for its antiviral activity evolved as ZAP emerged in tetrapods","volume":"97","author":"Lista","year":"2023","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.immuni.2024.04.004_bib38","article-title":"N4BP1 is dimerization-dependent linear ubiquitin reader regulating TNFR1 signalling through linear ubiquitin binding and Caspase-8-mediated processing","author":"Kliza","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.immuni.2024.04.004_bib39","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1056\/NEJMoa2026834","article-title":"Somatic mutations in UBA1 and severe adult-onset autoinflammatory disease","volume":"383","author":"Beck","year":"2020","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.immuni.2024.04.004_bib40","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ni921","article-title":"IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway","volume":"4","author":"Fitzgerald","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.immuni.2024.04.004_bib41","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.immuni.2007.08.012","article-title":"Innate recognition of viruses","volume":"27","author":"Pichlmair","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.immuni.2024.04.004_bib42","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.04.004_bib43","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2002521","article-title":"STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway","volume":"5","author":"Tanaka","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.immuni.2024.04.004_bib44","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1126\/science.1229963","article-title":"Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA","volume":"339","author":"Wu","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.04.004_bib45","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1600-065X.2008.00727.x","article-title":"RNA recognition and signal transduction by RIG-I-like receptors","volume":"227","author":"Yoneyama","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.immuni.2024.04.004_bib46","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.4049\/jimmunol.1701492","article-title":"Intracellular nucleic acid sensing triggers necroptosis through synergistic Type I IFN and TNF signaling","volume":"200","author":"Brault","year":"2018","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.immuni.2024.04.004_bib47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature05286","article-title":"The plant immune system","volume":"444","author":"Jones","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.04.004_bib48","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41564-019-0623-2","article-title":"Effector-triggered immunity and pathogen sensing in metazoans","volume":"5","author":"Lopes Fischer","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.immuni.2024.04.004_bib49","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0968-0004(98)01311-5","article-title":"Plant disease-resistance proteins and the gene-for-gene concept","volume":"23","author":"Van der Biezen","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.immuni.2024.04.004_bib50","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1084\/jem.184.4.1397","article-title":"Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response","volume":"184","author":"Pasparakis","year":"1996","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2024.04.004_bib51","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1128\/MCB.24.4.1464-1469.2004","article-title":"Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and toll-like receptors 2 and 4","volume":"24","author":"Newton","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.immuni.2024.04.004_bib52","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1126\/science.1249361","article-title":"Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis","volume":"343","author":"Newton","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.immuni.2024.04.004_bib53","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gng012","article-title":"Rapid generation of inducible mouse mutants","volume":"31","author":"Seibler","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2024.04.004_bib54","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0014-5793(97)00313-X","article-title":"'Green mice' as a source of ubiquitous green cells","volume":"407","author":"Okabe","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.immuni.2024.04.004_bib55","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jmb.2011.12.053","article-title":"Engineering and structural characterization of a linear polyubiquitin-specific antibody","volume":"418","author":"Matsumoto","year":"2012","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.immuni.2024.04.004_bib56","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20191692","article-title":"Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9","volume":"217","author":"Freund","year":"2020","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.immuni.2024.04.004_bib57","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-018-0256-2","article-title":"OTULIN limits cell death and inflammation by deubiquitinating LUBAC","volume":"559","author":"Heger","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.04.004_bib58","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1093\/bioinformatics\/bti310","article-title":"GMAP: a genomic mapping and alignment program for mRNA and EST sequences","volume":"21","author":"Wu","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2024.04.004_bib59","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.immuni.2024.04.004_bib60","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature07517","article-title":"Accurate whole human genome sequencing using reversible terminator chemistry","volume":"456","author":"Bentley","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.immuni.2024.04.004_bib61","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.immuni.2024.04.004_bib62","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.immuni.2024.04.004_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1010378","article-title":"WhichTF is functionally important in your open chromatin data?","volume":"18","author":"Tanigawa","year":"2022","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.immuni.2024.04.004_bib64","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nmeth.1772","article-title":"The human epigenome browser at Washington University","volume":"8","author":"Zhou","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.immuni.2024.04.004_bib65","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14049","article-title":"Massively parallel digital transcriptional profiling of single cells","volume":"8","author":"Zheng","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.immuni.2024.04.004_bib66","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"}],"container-title":["Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761324002097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1074761324002097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:55:46Z","timestamp":1747191346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1074761324002097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S1074761324002097"],"URL":"https:\/\/doi.org\/10.1016\/j.immuni.2024.04.004","relation":{},"ISSN":["1074-7613"],"issn-type":[{"value":"1074-7613","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N4BP1 coordinates ubiquitin-dependent crosstalk within the I\u03baB kinase family to limit Toll-like receptor signaling and inflammation","name":"articletitle","label":"Article Title"},{"value":"Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.immuni.2024.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}